EA019531B1 - КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ ГЕНОВ Eg5 И VEGF - Google Patents

КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ ГЕНОВ Eg5 И VEGF Download PDF

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EA019531B1
EA019531B1 EA201071033A EA201071033A EA019531B1 EA 019531 B1 EA019531 B1 EA 019531B1 EA 201071033 A EA201071033 A EA 201071033A EA 201071033 A EA201071033 A EA 201071033A EA 019531 B1 EA019531 B1 EA 019531B1
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Eurasian Patent Office
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dsrna
nucleotide
acid
sequence
composition according
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EA201071033A
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English (en)
Russian (ru)
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EA201071033A1 (ru
Inventor
Дэвид Бумкрот
Динах Вен-Йи Сах
Иванка Тудьярска
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Элнилэм Фармасьютикалз, Инк.
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Publication of EA201071033A1 publication Critical patent/EA201071033A1/ru
Publication of EA019531B1 publication Critical patent/EA019531B1/ru

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2320/00—Applications; Uses
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    • C12N2320/31—Combination therapy
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EA201071033A 2008-03-05 2009-03-05 КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ ГЕНОВ Eg5 И VEGF EA019531B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US3401908P 2008-03-05 2008-03-05
US8336708P 2008-07-24 2008-07-24
US8638108P 2008-08-05 2008-08-05
US11207908P 2008-11-06 2008-11-06
US15066409P 2009-02-06 2009-02-06
PCT/US2009/036223 WO2009111658A2 (en) 2008-03-05 2009-03-05 Compositions and methods for inhibiting expression of eg5 and vegf genes

Publications (2)

Publication Number Publication Date
EA201071033A1 EA201071033A1 (ru) 2011-04-29
EA019531B1 true EA019531B1 (ru) 2014-04-30

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
EA201071033A EA019531B1 (ru) 2008-03-05 2009-03-05 КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ЭКСПРЕССИИ ГЕНОВ Eg5 И VEGF
EA201301171A EA201301171A1 (ru) 2008-03-05 2009-03-05 Композиции и способы ингибирования экспрессии генов eg5 и vegf

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201301171A EA201301171A1 (ru) 2008-03-05 2009-03-05 Композиции и способы ингибирования экспрессии генов eg5 и vegf

Country Status (14)

Country Link
US (3) US20100087508A1 (enExample)
EP (2) EP2712926A2 (enExample)
JP (2) JP2011518117A (enExample)
KR (1) KR101397407B1 (enExample)
CN (2) CN105267233B (enExample)
AU (1) AU2009221775B2 (enExample)
BR (1) BRPI0909779A2 (enExample)
CA (1) CA2716793A1 (enExample)
EA (2) EA019531B1 (enExample)
IL (1) IL207956A0 (enExample)
MX (1) MX2010009611A (enExample)
NZ (1) NZ588280A (enExample)
SG (1) SG188121A1 (enExample)
WO (1) WO2009111658A2 (enExample)

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CN111481677B (zh) * 2019-01-25 2021-08-17 浙江大学 血脑屏障渗透性调控剂及其应用
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