KR101397407B1 - Ｅｇ5 및 ＶＥＧＦ 유전자의 발현을 억제하기 위한 조성물 및 방법 - Google Patents

Ｅｇ5 및 ＶＥＧＦ 유전자의 발현을 억제하기 위한 조성물 및 방법 Download PDF

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KR101397407B1
KR101397407B1 KR1020107021929A KR20107021929A KR101397407B1 KR 101397407 B1 KR101397407 B1 KR 101397407B1 KR 1020107021929 A KR1020107021929 A KR 1020107021929A KR 20107021929 A KR20107021929 A KR 20107021929A KR 101397407 B1 KR101397407 B1 KR 101397407B1
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dsrna
note
artificial sequence
vegf
synthetic oligonucleotide
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KR20100126461A (ko
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데이비드 범크로트
다이나 웬-이 사
이반카 토드자스카
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알닐람 파마슈티칼스 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2320/00—Applications; Uses
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    • C12N2320/31—Combination therapy
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
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  • Biochemistry (AREA)
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  • Plant Pathology (AREA)
  • Biophysics (AREA)
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  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020107021929A 2008-03-05 2009-03-05 Ｅｇ5 및 ＶＥＧＦ 유전자의 발현을 억제하기 위한 조성물 및 방법 Expired - Fee Related KR101397407B1 (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US3401908P 2008-03-05 2008-03-05
US61/034,019 2008-03-05
US8336708P 2008-07-24 2008-07-24
US61/083,367 2008-07-24
US8638108P 2008-08-05 2008-08-05
US61/086,381 2008-08-05
US11207908P 2008-11-06 2008-11-06
US61/112,079 2008-11-06
US15066409P 2009-02-06 2009-02-06
US61/150,664 2009-02-06
PCT/US2009/036223 WO2009111658A2 (en) 2008-03-05 2009-03-05 Compositions and methods for inhibiting expression of eg5 and vegf genes

Publications (2)

Publication Number Publication Date
KR20100126461A KR20100126461A (ko) 2010-12-01
KR101397407B1 true KR101397407B1 (ko) 2014-06-19

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US (3) US20100087508A1 (enExample)
EP (2) EP2712926A2 (enExample)
JP (2) JP2011518117A (enExample)
KR (1) KR101397407B1 (enExample)
CN (2) CN102014932B (enExample)
AU (1) AU2009221775B2 (enExample)
BR (1) BRPI0909779A2 (enExample)
CA (1) CA2716793A1 (enExample)
EA (2) EA019531B1 (enExample)
IL (1) IL207956A0 (enExample)
MX (1) MX2010009611A (enExample)
NZ (1) NZ588280A (enExample)
SG (1) SG188121A1 (enExample)
WO (1) WO2009111658A2 (enExample)

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US8058069B2 (en) 2008-04-15 2011-11-15 Protiva Biotherapeutics, Inc. Lipid formulations for nucleic acid delivery
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CN103370054A (zh) * 2010-11-09 2013-10-23 阿尔尼拉姆医药品有限公司 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法
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CN111481677B (zh) * 2019-01-25 2021-08-17 浙江大学 血脑屏障渗透性调控剂及其应用
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CN112111488A (zh) * 2019-06-21 2020-12-22 苏州吉玛基因股份有限公司 siRNA修饰物及其在抑制血管新生中的应用
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