EA016297B1 - Способ сульфоксидирования биологически активных соединений - Google Patents

Способ сульфоксидирования биологически активных соединений Download PDF

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Publication number
EA016297B1
EA016297B1 EA201070021A EA201070021A EA016297B1 EA 016297 B1 EA016297 B1 EA 016297B1 EA 201070021 A EA201070021 A EA 201070021A EA 201070021 A EA201070021 A EA 201070021A EA 016297 B1 EA016297 B1 EA 016297B1
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EA
Eurasian Patent Office
Prior art keywords
solvent
formula
added
base
compound
Prior art date
Application number
EA201070021A
Other languages
English (en)
Russian (ru)
Other versions
EA201070021A1 (ru
Inventor
Милинд Морешвар Гхарпур
Голакчандра Сударшан Майкап
Раджендра Дагесинг Махал
Сатиш Раманлал Мехта
Мукунд Кешав Гурджар
Махеш Рамсинг Раджпут
Прашант Садашив Гавари
Original Assignee
Эмкьюр Фармасьютикалз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Эмкьюр Фармасьютикалз Лимитед filed Critical Эмкьюр Фармасьютикалз Лимитед
Publication of EA201070021A1 publication Critical patent/EA201070021A1/ru
Publication of EA016297B1 publication Critical patent/EA016297B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B45/00—Formation or introduction of functional groups containing sulfur
    • C07B45/04—Formation or introduction of functional groups containing sulfur of sulfonyl or sulfinyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA201070021A 2007-06-15 2008-06-04 Способ сульфоксидирования биологически активных соединений EA016297B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1124MU2007 2007-06-15
IN35MU2008 2008-01-07
PCT/IB2008/001423 WO2008152462A1 (en) 2007-06-15 2008-06-04 A process of sulfoxidation of biologically active compounds

Publications (2)

Publication Number Publication Date
EA201070021A1 EA201070021A1 (ru) 2010-06-30
EA016297B1 true EA016297B1 (ru) 2012-03-30

Family

ID=39790870

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070021A EA016297B1 (ru) 2007-06-15 2008-06-04 Способ сульфоксидирования биологически активных соединений

Country Status (5)

Country Link
KR (1) KR101432866B1 (ko)
BR (1) BRPI0813191B1 (ko)
EA (1) EA016297B1 (ko)
WO (1) WO2008152462A1 (ko)
ZA (1) ZA200908887B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009024863A2 (en) * 2007-06-26 2009-02-26 Actavis Group Ptc Ehf Process for the preparation of modafinil enantiomers
KR20120114356A (ko) * 2010-02-12 2012-10-16 에스티브 퀴미카 에스.에이. 에스오메프라졸 나트륨염의 제조공정
CN102329302A (zh) * 2011-10-22 2012-01-25 刘强 一种埃索美拉唑及其盐的制备方法
CN102432412A (zh) * 2011-10-28 2012-05-02 成都欣捷高新技术开发有限公司 一种手性亚砜类质子泵抑制剂或其可药用盐的制备方法
EP2615083A1 (en) 2012-01-10 2013-07-17 Studiengesellschaft Kohle mbH Process for the asymmetric oxidation of organic compounds with peroxides in the presence of a chiral acid catalyst
CN102603621B (zh) * 2012-02-07 2013-09-04 成都苑东药业有限公司 一种新型手性亚砜化合物和以该化合物制备埃索美拉唑钠的方法
CN102924434B (zh) * 2012-10-18 2014-06-18 江苏诚信制药有限公司 一种右旋雷贝拉唑钠单水合物晶型及其制备方法
CN105294652A (zh) * 2012-10-25 2016-02-03 天津汉瑞药业有限公司 雷贝拉唑钠化合物
CN103113350A (zh) * 2013-02-27 2013-05-22 安徽省新星药物开发有限责任公司 R-雷贝拉唑钠水合物的新晶型及制备方法和应用
CN104327049B (zh) * 2014-09-27 2015-10-14 湖南五洲通药业有限责任公司 右旋雷贝拉唑钠单水合物晶体的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929244A (en) * 1995-07-03 1999-07-27 Astra Aktiebolag Process for the optical purification of enantiomerically enriched benzimidazole derivatives
US6919459B2 (en) * 2001-07-16 2005-07-19 Rudy Laurent Maria Broeckx Process for preparing benzimidazole-type compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929244A (en) * 1995-07-03 1999-07-27 Astra Aktiebolag Process for the optical purification of enantiomerically enriched benzimidazole derivatives
US6919459B2 (en) * 2001-07-16 2005-07-19 Rudy Laurent Maria Broeckx Process for preparing benzimidazole-type compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FRANKLIN A. DAVIS ET AL.: "Chemistry of Oxaziridines.17. N-(Phenylsulfonyl)(3,3-dichlorocamphoryl)oxaziridine: A Highly Efficient Reagent for the Asymmetric Oxidation of Sulfides to Sulfoxides" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 114, 1992, pages 1428-1437, XP002499828 cited in the application Scheme 1 page 1429; compounds 2, 12 *
GUDRUN GLAHSL ET AL.: "(+)-(3-Oxocamphorsulphonyl)oxaziridine as a Highly Stereoselective Reagent for the Oxidation of Sulphides to Chiral Sulphoxides" JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, 1988, pages 1753-1757, XP002499829 cited in the application table 3 *
TERNOIS ET AL.: "Asymmetric synthesis of modafinil and its derivatives by enantioselective oxidation of thioethers: comparison of various methods including synthesis in ionic liquids" TETRAHEDRON ASYMMETRY, PERGAMON, OXFORD; GB vol. 18, no. 24, 21 December 2007 (2007-12-21), pages 2959-2964, XP022400759 ISSN: 0957-4166 cited in the application the whole document *

Also Published As

Publication number Publication date
BRPI0813191B1 (pt) 2021-09-08
KR20100020035A (ko) 2010-02-19
KR101432866B1 (ko) 2014-08-26
WO2008152462A1 (en) 2008-12-18
EA201070021A1 (ru) 2010-06-30
BRPI0813191A2 (pt) 2014-12-23
ZA200908887B (en) 2011-02-23

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