EA007903B1 - Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора - Google Patents
Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора Download PDFInfo
- Publication number
- EA007903B1 EA007903B1 EA200401137A EA200401137A EA007903B1 EA 007903 B1 EA007903 B1 EA 007903B1 EA 200401137 A EA200401137 A EA 200401137A EA 200401137 A EA200401137 A EA 200401137A EA 007903 B1 EA007903 B1 EA 007903B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inn
- tetrahydro
- phthalazin
- mnn
- dimethoxyphenyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 25
- 239000003112 inhibitor Substances 0.000 title abstract description 30
- 229940122236 Histamine receptor antagonist Drugs 0.000 title abstract description 18
- 101100135868 Dictyostelium discoideum pde3 gene Proteins 0.000 title abstract 2
- 239000000739 antihistaminic agent Substances 0.000 title description 12
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 title 1
- 208000023504 respiratory system disease Diseases 0.000 claims abstract description 12
- 238000011282 treatment Methods 0.000 claims abstract description 12
- -1 4-diisopropylaminocarbonylphenyl Chemical group 0.000 claims description 284
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 126
- 239000004480 active ingredient Substances 0.000 claims description 56
- 239000013543 active substance Substances 0.000 claims description 44
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- 238000002360 preparation method Methods 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 29
- 229960001803 cetirizine Drugs 0.000 claims description 27
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims description 24
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- VSOSXKMEQPYESP-UHFFFAOYSA-N 1,6-naphthyridine Chemical compound C1=CN=CC2=CC=CN=C21 VSOSXKMEQPYESP-UHFFFAOYSA-N 0.000 claims description 17
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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| PCT/EP2003/001876 WO2003074055A1 (en) | 2002-03-06 | 2003-02-25 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist |
Publications (2)
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| EA200601592A EA010886B1 (ru) | 2002-03-06 | 2003-02-25 | Фармацевтическая композиция, способ ее получения и ее применение для лечения респираторных заболеваний, фармацевтический продукт и его применение, набор |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2673458C1 (ru) * | 2014-10-09 | 2018-11-27 | Гуандун Чжуншэн Фармасьютикал Ко., Лтд | Гидроксипуриновые соединения и пути их применения |
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|---|---|---|---|---|
| RU2008122978A (ru) * | 2005-11-09 | 2009-12-20 | Комбинаторкс, Инкорпорейтед (Us) | Способы, композиции и наборы для лечения медицинских состояний |
| AR064424A1 (es) * | 2006-12-20 | 2009-04-01 | Glaxo Group Ltd | Derivados sustituidos de 1-oxo-ftalazinas y 1-oxo-pirido-piridazinas,composiciones farmaceuticas que los contienen y usos para prevenir y/o tratar enfermedades inflamatorias y alergicas del tracto respiratorio. |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| JP2010523695A (ja) * | 2007-04-11 | 2010-07-15 | アルコン リサーチ， リミテッド | アレルギー性鼻炎およびアレルギー性結膜炎を処置するためのＴＮＦαのインヒビターおよび抗ヒスタミン薬の使用 |
| US8877816B2 (en) | 2007-11-21 | 2014-11-04 | Decode Genetics Ehf | 4-(or 5-) substituted catechol derivatives |
| KR20090061972A (ko) * | 2007-12-12 | 2009-06-17 | 한미약품 주식회사 | 베포타스틴 ｐ-톨루엔술폰산염의 결정형, 이의 제조방법 및이를 포함하는 약학 조성물 |
| EA029760B1 (ru) | 2011-02-07 | 2018-05-31 | Сифарм Сарл | ПРИМЕНЕНИЕ КОМПОЗИЦИИ ПРОСТАЦИКЛИНА И ИНГИБИТОРА ФОСФОДИЭСТЕРАЗЫ 4 ИЛИ ИХ АНАЛОГОВ ДЛЯ ЛЕЧЕНИЯ МУКОВИСЦИДОЗА И УВЕЛИЧЕНИЯ цАМФ В ЭПИТЕЛИАЛЬНЫХ КЛЕТКАХ |
| KR102226833B1 (ko) * | 2013-06-28 | 2021-03-12 | 한미약품 주식회사 | 레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형 |
| CA2993462A1 (en) * | 2014-08-26 | 2016-03-03 | Fundacion Para La Investigacion Medica Aplicada | Products for the treatment and prevention of neurological disorders coursing with a cognition deficit or impairment, and of neurodegenerative diseases |
| CN109956947A (zh) * | 2017-12-25 | 2019-07-02 | 江苏恒瑞医药股份有限公司 | 一种cns抑制剂的新晶型、制备方法及用途 |
Citations (4)
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| US5962464A (en) * | 1997-02-11 | 1999-10-05 | Sepracor Inc. | Methods and compositions for treating allergic asthma using descarboethoxyloratadine |
| EP1005865A1 (en) * | 1998-11-10 | 2000-06-07 | Panacea Biotec Limited | A anti-allergy anti-inflammatory composition comprising nimesulide and cetirizine |
| WO2001030777A1 (en) * | 1999-10-25 | 2001-05-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors |
| WO2003000289A1 (en) * | 2001-06-20 | 2003-01-03 | Glaxo Group Limited | Composition comprising a pde-4 inhibitor and h1-receptor antagonist and the use thereof for the manufacture of a medicament for the treatment of respiratory diseases |
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|---|---|---|---|---|
| DE2847693A1 (de) * | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| EP0706513B1 (de) * | 1993-07-02 | 2002-05-15 | Byk Gulden Lomberg Chemische Fabrik GmbH | Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren |
| US5990147A (en) * | 1997-11-07 | 1999-11-23 | Schering Corporation | H3 receptor ligands of the phenyl-alkyl-imidazoles type |
| US6174878B1 (en) * | 1999-08-31 | 2001-01-16 | Alcon Laboratories, Inc. | Topical use of kappa opioid agonists to treat otic pain |
| US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
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- 2003-02-25 SI SI200332245T patent/SI1849468T1/sl unknown
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- 2003-02-25 RS YUP-780/04A patent/RS51018B/sr unknown
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- 2003-02-25 SG SG200606154-3A patent/SG160197A1/en unknown
- 2003-02-25 DK DK03708130T patent/DK1482938T3/da active
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- 2003-02-25 EP EP03708130A patent/EP1482938B1/en not_active Expired - Lifetime
- 2003-02-25 ES ES07112823T patent/ES2400670T3/es not_active Expired - Lifetime
- 2003-02-25 EA EA200601592A patent/EA010886B1/ru not_active IP Right Cessation
- 2003-02-25 AT AT03708130T patent/ATE369134T1/de active
- 2003-02-25 DE DE60315426T patent/DE60315426T2/de not_active Expired - Lifetime
- 2003-02-25 JP JP2003572572A patent/JP5150034B2/ja not_active Expired - Fee Related
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2004
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2007
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2008
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2013
- 2013-02-21 CY CY20131100163T patent/CY1113894T1/el unknown
Patent Citations (4)
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| US5962464A (en) * | 1997-02-11 | 1999-10-05 | Sepracor Inc. | Methods and compositions for treating allergic asthma using descarboethoxyloratadine |
| EP1005865A1 (en) * | 1998-11-10 | 2000-06-07 | Panacea Biotec Limited | A anti-allergy anti-inflammatory composition comprising nimesulide and cetirizine |
| WO2001030777A1 (en) * | 1999-10-25 | 2001-05-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors |
| WO2003000289A1 (en) * | 2001-06-20 | 2003-01-03 | Glaxo Group Limited | Composition comprising a pde-4 inhibitor and h1-receptor antagonist and the use thereof for the manufacture of a medicament for the treatment of respiratory diseases |
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| ANDRI L. ET AL.: "Combined treatment of allergic rhinitis with terfenadine and nimesulide, a non-steroidal antiinflammatory drug"., ALLERGIE ET IMMUNOLOGIE, NOUVELLES EDITIONS MEDICALES FRANCAISES, PARIS, FR, vol. 24, no. 8, October 1992 (1992-10), pages 313-314,317-319, XP002102388, ISSN: 0397-9148, abstract, page 314, column 1, last paragraph * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2673458C1 (ru) * | 2014-10-09 | 2018-11-27 | Гуандун Чжуншэн Фармасьютикал Ко., Лтд | Гидроксипуриновые соединения и пути их применения |
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