EA006803B1 - 1,3-диарилпроп-2-ен-1-оны, композиция на их основе и применение - Google Patents

1,3-диарилпроп-2-ен-1-оны, композиция на их основе и применение Download PDF

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Publication number
EA006803B1
EA006803B1 EA200400764A EA200400764A EA006803B1 EA 006803 B1 EA006803 B1 EA 006803B1 EA 200400764 A EA200400764 A EA 200400764A EA 200400764 A EA200400764 A EA 200400764A EA 006803 B1 EA006803 B1 EA 006803B1
Authority
EA
Eurasian Patent Office
Prior art keywords
propenone
amino
methoxy
methyl
trimethoxyphenyl
Prior art date
Application number
EA200400764A
Other languages
English (en)
Russian (ru)
Other versions
EA200400764A1 (ru
Inventor
Патрик Майлие
Сесиль Комбо
Мари-Кристин Биссери
Мари-Пьер Шеррье
Томас Кауфилд
Жилль Тирабоши
Original Assignee
Авентис Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0115739A external-priority patent/FR2833008B1/fr
Application filed by Авентис Фарма С.А. filed Critical Авентис Фарма С.А.
Publication of EA200400764A1 publication Critical patent/EA200400764A1/ru
Publication of EA006803B1 publication Critical patent/EA006803B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Bending Of Plates, Rods, And Pipes (AREA)
  • Detergent Compositions (AREA)
EA200400764A 2001-12-05 2002-12-03 1,3-диарилпроп-2-ен-1-оны, композиция на их основе и применение EA006803B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0115739A FR2833008B1 (fr) 2001-12-05 2001-12-05 1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation
FR0214217 2002-11-14
PCT/FR2002/004143 WO2003048106A2 (fr) 2001-12-05 2002-12-03 1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation

Publications (2)

Publication Number Publication Date
EA200400764A1 EA200400764A1 (ru) 2004-12-30
EA006803B1 true EA006803B1 (ru) 2006-04-28

Family

ID=26213287

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400764A EA006803B1 (ru) 2001-12-05 2002-12-03 1,3-диарилпроп-2-ен-1-оны, композиция на их основе и применение

Country Status (23)

Country Link
EP (1) EP1453790A2 (fr)
JP (1) JP2005531494A (fr)
KR (1) KR20050044712A (fr)
CN (1) CN1612856A (fr)
AR (1) AR037479A1 (fr)
AU (1) AU2002365644A1 (fr)
BR (1) BR0214694A (fr)
CA (1) CA2469193A1 (fr)
CO (1) CO5580759A2 (fr)
EA (1) EA006803B1 (fr)
HR (1) HRP20040508A2 (fr)
HU (1) HUP0500100A2 (fr)
IL (1) IL162223A0 (fr)
MA (1) MA27351A1 (fr)
MX (1) MXPA04005226A (fr)
NZ (1) NZ533224A (fr)
PA (1) PA8558501A1 (fr)
PE (1) PE20030758A1 (fr)
PL (1) PL370676A1 (fr)
RS (1) RS47804A (fr)
SV (1) SV2003001422A (fr)
TW (1) TW200300685A (fr)
WO (1) WO2003048106A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854399B1 (fr) * 2003-04-30 2006-11-17 Aventis Pharma Sa 1-aryl-3-(indol-5-yl)-prop-2-en-1-ones, compositions les contenant et utilisation
EP1598353A1 (fr) 2004-05-17 2005-11-23 Boehringer Ingelheim International GmbH Pyrrolobenzimidazolones et leur utilisation en tant qu'agents antiproliferatifs
WO2017103637A1 (fr) 2015-12-18 2017-06-22 Blirt S.A. Composés de diphénylpropane et leur activité cytotoxique
CN109467549B (zh) * 2018-12-07 2021-02-09 中国药科大学 喹啉取代查尔酮类化合物、其制备方法及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904697A (en) * 1987-04-09 1990-02-27 Merrell Dow Pharmaceuticals Inc. Controlling the growth of certain tumor tissue with chalcone derivatives
JPH08277242A (ja) * 1995-02-08 1996-10-22 Kyowa Hakko Kogyo Co Ltd プロペノン誘導体
EP0812825B1 (fr) * 1995-12-01 2004-02-11 Kyowa Hakko Kogyo Co., Ltd. Derives du propenone
AU7908098A (en) * 1997-06-26 1999-01-19 Statens Serum Institut Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones

Also Published As

Publication number Publication date
MXPA04005226A (es) 2004-10-11
BR0214694A (pt) 2004-12-14
EP1453790A2 (fr) 2004-09-08
TW200300685A (en) 2003-06-16
CN1612856A (zh) 2005-05-04
AU2002365644A1 (en) 2003-06-17
JP2005531494A (ja) 2005-10-20
AR037479A1 (es) 2004-11-10
IL162223A0 (en) 2005-11-20
KR20050044712A (ko) 2005-05-12
WO2003048106A2 (fr) 2003-06-12
HUP0500100A2 (hu) 2005-05-30
EA200400764A1 (ru) 2004-12-30
SV2003001422A (es) 2003-07-10
PA8558501A1 (es) 2003-09-05
PL370676A1 (en) 2005-05-30
MA27351A1 (fr) 2005-06-01
RS47804A (en) 2006-12-15
HRP20040508A2 (en) 2005-08-31
PE20030758A1 (es) 2003-10-07
CA2469193A1 (fr) 2003-06-12
NZ533224A (en) 2006-03-31
WO2003048106A3 (fr) 2004-03-25
CO5580759A2 (es) 2005-11-30

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Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU