AR037479A1 - 1,3-diarilprop-2-en-1-onas, composiciones que las contienen y su utilizacion - Google Patents
1,3-diarilprop-2-en-1-onas, composiciones que las contienen y su utilizacionInfo
- Publication number
- AR037479A1 AR037479A1 ARP020104618A ARP020104618A AR037479A1 AR 037479 A1 AR037479 A1 AR 037479A1 AR P020104618 A ARP020104618 A AR P020104618A AR P020104618 A ARP020104618 A AR P020104618A AR 037479 A1 AR037479 A1 AR 037479A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- substituted
- cycloalkyl
- methoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
- C07C279/32—N-nitroguanidines
- C07C279/36—Substituted N-nitroguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Bending Of Plates, Rods, And Pipes (AREA)
- Detergent Compositions (AREA)
Abstract
1,3-Diarilprop-2-en-1-onas y derivados, composiciones que los contienen, procedimiento para la fabricación y utilización. La presente se refiere, principalmente, a nuevas 1,3-diarilprop-2-en-1-onas sustituidas, que tienen una actividad terapéutica, utilizadas, en particular, en oncología. Reivindicación 1: Producto que responde a la fórmula (1) en la que: a) Y se elige el grupo formado por halógeno, alquilo lineal C1-7, alquilo ramificado C1-7, alquilo lineal C1-7 sustituido, alquilo ramificado C1-7 sustituido, cicloalquilo, cicloalquilo sustituido, NH2, NH(R4), N(R4)2, aralquilo, aralquilo sustituido, COOH, COO(R4), CONH2, CONH(R4), CON(R4)2, CN, en el que R4 representa un grupo alquilo o cicloalquilo C1-7 eventualmente sustituido, y cuando estén presente dos R4, pueden estar enlazados entre sí para formar un ciclo; b) Ar2 se elige del grupo formado por: fórmula (2), (3) en la que: 1) cuando Ar2 es fórmula (2), entonces uno de R1, R2 se elige del grupo formado por NH2, NH2 HZ, NHC(O)-ácido aminado, NH-(GP); N=(GP); en el que el ácido aminado es preferentemente la serina; en el que GP es un sustituyente metabolizable que permita el cambio de grupo funcional: NH-(GP) ---NH2 ó N=(GP) --- NH2 y en el que HZ es un ácido orgánico ó mineral; y el otro de R1, R2 se elige del grupo formado por CH3, C2H5, OCH3, OC2H5, SCH3, NH(R5), N(R5)2, N(R5)(GP), N(R5)C(O)-ácido aminado, en el que R5 representa un grupo alquilo C1-2 y cuando dos R5 estén presente, pueden estar enlazados entre sí para formar un ciclo; 2) cuando Ar2 es fórmula (3), entonces A es un heterociclo con 5 ó 6 eslabones, condensado sobre un ciclo bencénico B, siendo el citado heterociclo A aromático ó no-aromático, que comprende 1 ó 2 heteroátomos, uno de los cuales, al menos, es un átomo de nitrógeno directamente enlazado con B y portador de una cadena lateral R8, en el que R8 se elige del grupo constituido por H, alquilo C1-3, alquilo C1-3-OH, alquilo C1-3-O alquilo C1-3, alquilo C1-3-NH2, alquilo C1-3-NH(R7), alquilo C1-3-N(R7)2, fórmula (4) en el que R9 se elige entre H, alquilo C1-3, en el que cada R7 representa independientemente un grupo alquilo C1-3 ó cicloalquilo C1-3, ó bien, cuando dos R7 estén presentes, están enlazadas entre sí para formar un heterociclo con 5 eslabones; c) X se elige del grupo formado por O, NOH, NO(R3), en el que R3 se elige del grupo formado por H, alquilo lineal C1-7, alquilo ramificado C1-7, cicloalquilo, alquilo lineal C1-7 halogenado, alquilo ramificado C1-7 halogenado, cicloalquilo sustituido, cicloalquilo halogenado, aralquilo, aralquilo sustituido; y d) Ar se elige del grupo formado por 2,5-dimetoxifenilo, 2,3,4-trimetoxifenilo, 3,4-5-trimetoxifenilo, 2,3-5-trimetoxifenilo, 2,4,5-trimetoxifenilo, 2,3,4,5-tetrametoxifenilo, 3-metoxi-4,5-metilendioxi, 3-metoxi-4,5-etilendioxi, 2-metoxi-4,5-metilendioxi, 2-metoxi-4,5-etilendioxi, 2-metoxi-3,4-metilendioxi, 2-metoxi-3,4-etilendioxi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0115739A FR2833008B1 (fr) | 2001-12-05 | 2001-12-05 | 1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation |
| FR0214217 | 2002-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037479A1 true AR037479A1 (es) | 2004-11-10 |
Family
ID=26213287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104618A AR037479A1 (es) | 2001-12-05 | 2002-11-29 | 1,3-diarilprop-2-en-1-onas, composiciones que las contienen y su utilizacion |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1453790A2 (es) |
| JP (1) | JP2005531494A (es) |
| KR (1) | KR20050044712A (es) |
| CN (1) | CN1612856A (es) |
| AR (1) | AR037479A1 (es) |
| AU (1) | AU2002365644A1 (es) |
| BR (1) | BR0214694A (es) |
| CA (1) | CA2469193A1 (es) |
| CO (1) | CO5580759A2 (es) |
| EA (1) | EA006803B1 (es) |
| HR (1) | HRP20040508A2 (es) |
| HU (1) | HUP0500100A2 (es) |
| IL (1) | IL162223A0 (es) |
| MA (1) | MA27351A1 (es) |
| MX (1) | MXPA04005226A (es) |
| NZ (1) | NZ533224A (es) |
| PA (1) | PA8558501A1 (es) |
| PE (1) | PE20030758A1 (es) |
| PL (1) | PL370676A1 (es) |
| RS (1) | RS47804A (es) |
| SV (1) | SV2003001422A (es) |
| TW (1) | TW200300685A (es) |
| WO (1) | WO2003048106A2 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2854399B1 (fr) * | 2003-04-30 | 2006-11-17 | Aventis Pharma Sa | 1-aryl-3-(indol-5-yl)-prop-2-en-1-ones, compositions les contenant et utilisation |
| EP1598353A1 (en) | 2004-05-17 | 2005-11-23 | Boehringer Ingelheim International GmbH | Pyrrolobenzimidazolones and their use as antiproliferative agents |
| WO2017103637A1 (en) | 2015-12-18 | 2017-06-22 | Blirt S.A. | Diphenylpropane compounds and their cytotoxic activity |
| CN109467549B (zh) * | 2018-12-07 | 2021-02-09 | 中国药科大学 | 喹啉取代查尔酮类化合物、其制备方法及用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904697A (en) * | 1987-04-09 | 1990-02-27 | Merrell Dow Pharmaceuticals Inc. | Controlling the growth of certain tumor tissue with chalcone derivatives |
| JPH08277242A (ja) * | 1995-02-08 | 1996-10-22 | Kyowa Hakko Kogyo Co Ltd | プロペノン誘導体 |
| EP0812825B1 (en) * | 1995-12-01 | 2004-02-11 | Kyowa Hakko Kogyo Co., Ltd. | Propenone derivatives |
| AU7908098A (en) * | 1997-06-26 | 1999-01-19 | Statens Serum Institut | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones |
-
2002
- 2002-11-21 PE PE2002001118A patent/PE20030758A1/es not_active Application Discontinuation
- 2002-11-22 PA PA20028558501A patent/PA8558501A1/es unknown
- 2002-11-26 TW TW091134346A patent/TW200300685A/zh unknown
- 2002-11-29 AR ARP020104618A patent/AR037479A1/es unknown
- 2002-12-02 SV SV2002001422A patent/SV2003001422A/es not_active Application Discontinuation
- 2002-12-03 EP EP02804242A patent/EP1453790A2/fr not_active Withdrawn
- 2002-12-03 WO PCT/FR2002/004143 patent/WO2003048106A2/fr not_active Application Discontinuation
- 2002-12-03 IL IL16222302A patent/IL162223A0/xx unknown
- 2002-12-03 NZ NZ533224A patent/NZ533224A/xx unknown
- 2002-12-03 MX MXPA04005226A patent/MXPA04005226A/es unknown
- 2002-12-03 AU AU2002365644A patent/AU2002365644A1/en not_active Abandoned
- 2002-12-03 JP JP2003549299A patent/JP2005531494A/ja not_active Abandoned
- 2002-12-03 PL PL02370676A patent/PL370676A1/xx unknown
- 2002-12-03 CA CA002469193A patent/CA2469193A1/fr not_active Abandoned
- 2002-12-03 HU HU0500100A patent/HUP0500100A2/hu unknown
- 2002-12-03 BR BR0214694-0A patent/BR0214694A/pt not_active IP Right Cessation
- 2002-12-03 EA EA200400764A patent/EA006803B1/ru not_active IP Right Cessation
- 2002-12-03 KR KR1020047008656A patent/KR20050044712A/ko not_active Application Discontinuation
- 2002-12-03 RS YU47804A patent/RS47804A/sr unknown
- 2002-12-03 CN CNA028268601A patent/CN1612856A/zh active Pending
-
2004
- 2004-06-01 MA MA27708A patent/MA27351A1/fr unknown
- 2004-06-03 CO CO04052091A patent/CO5580759A2/es not_active Application Discontinuation
- 2004-06-04 HR HR20040508A patent/HRP20040508A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04005226A (es) | 2004-10-11 |
| BR0214694A (pt) | 2004-12-14 |
| EP1453790A2 (fr) | 2004-09-08 |
| TW200300685A (en) | 2003-06-16 |
| CN1612856A (zh) | 2005-05-04 |
| AU2002365644A1 (en) | 2003-06-17 |
| JP2005531494A (ja) | 2005-10-20 |
| IL162223A0 (en) | 2005-11-20 |
| KR20050044712A (ko) | 2005-05-12 |
| WO2003048106A2 (fr) | 2003-06-12 |
| HUP0500100A2 (hu) | 2005-05-30 |
| EA200400764A1 (ru) | 2004-12-30 |
| EA006803B1 (ru) | 2006-04-28 |
| SV2003001422A (es) | 2003-07-10 |
| PA8558501A1 (es) | 2003-09-05 |
| PL370676A1 (en) | 2005-05-30 |
| MA27351A1 (fr) | 2005-06-01 |
| RS47804A (en) | 2006-12-15 |
| HRP20040508A2 (en) | 2005-08-31 |
| PE20030758A1 (es) | 2003-10-07 |
| CA2469193A1 (fr) | 2003-06-12 |
| NZ533224A (en) | 2006-03-31 |
| WO2003048106A3 (fr) | 2004-03-25 |
| CO5580759A2 (es) | 2005-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |