AR035196A1 - Derivados de guanidina o biguanidina y el uso de los mismos para la fabricacion de medicamentos antivirales y antimicrobianos - Google Patents

Derivados de guanidina o biguanidina y el uso de los mismos para la fabricacion de medicamentos antivirales y antimicrobianos

Info

Publication number
AR035196A1
AR035196A1 ARP010104097A ARP010104097A AR035196A1 AR 035196 A1 AR035196 A1 AR 035196A1 AR P010104097 A ARP010104097 A AR P010104097A AR P010104097 A ARP010104097 A AR P010104097A AR 035196 A1 AR035196 A1 AR 035196A1
Authority
AR
Argentina
Prior art keywords
hydrogen
antiviral
alkyl
branched
straight
Prior art date
Application number
ARP010104097A
Other languages
English (en)
Original Assignee
Shetty B Vithal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shetty B Vithal filed Critical Shetty B Vithal
Publication of AR035196A1 publication Critical patent/AR035196A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Derivados de guanidina o biguanidina, que comprenden un compuesto que tiene una de las estructuras de fórmula (1), (2), (3) ó (4) en donde (a) cada A es igual o diferente, y se selecciona entre el grupo que consiste de hidrógeno, nitrilo, amino, un agente antibacteriano, un antibiótico, una quinolona, una azaquinolona y uno de los grupos representados por las fórmulas (5) a (10), donde R12 es hidrógeno o alquilo C1-6 recto o ramificado y R11 es hidrógeno, alquilo inferior, un grupo aromático o un grupo heterocíclico, con la condición que con respecto a las estructuras (1) - (3), ambos A no pueden ser la estructura de adamantano anterior al mismo tiempo; (b) B es un grupo alquilo C1-30 de cadena recta o ramificado, que puede ser interrumpido por oxígeno, azufre, núcleos aromáticos opcionalmente sustituidos, sulfóxido, ciclohexano opcionalmente sustituido, nitrógeno opcionalmente sustituido con -NH-C(NH)-NH-C(NH)-A donde A es como se define anteriormente, tris(2-aminoetilo)amina, un heterociclo de fórmula (11) donde D es C1-3 y Q es hidrógeno, halógeno o alquilo inferior; o de fórmula (12) donde Q es hidrógeno, halógeno o alquilo inferior; o de fórmulas (13) ó (14); y una porción hidrofílica; y (c) R es hidrógeno o alquilo C1-6 recto o ramificado; que tienen actividad antiviral y antibacteriana. Además se describe el uso de los mismos para la fabricación de medicamentos antivirales y antibacterianos.
ARP010104097A 2000-08-28 2001-08-28 Derivados de guanidina o biguanidina y el uso de los mismos para la fabricacion de medicamentos antivirales y antimicrobianos AR035196A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/649,014 US6699989B1 (en) 2000-08-28 2000-08-28 Antiviral and antimicrobial guanidine or biguanidine derivatives

Publications (1)

Publication Number Publication Date
AR035196A1 true AR035196A1 (es) 2004-05-05

Family

ID=24603128

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010104097A AR035196A1 (es) 2000-08-28 2001-08-28 Derivados de guanidina o biguanidina y el uso de los mismos para la fabricacion de medicamentos antivirales y antimicrobianos

Country Status (5)

Country Link
US (2) US6699989B1 (es)
EP (1) EP1406619A4 (es)
AR (1) AR035196A1 (es)
AU (1) AU2001286604A1 (es)
WO (1) WO2002017916A1 (es)

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AUPR879601A0 (en) * 2001-11-09 2001-12-06 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
US20030226987A1 (en) * 2002-06-06 2003-12-11 Gallmeyer Christopher F. Method and apparatus for seat detection and soft seating in a piezoelectric device actuated valve system
US7772284B2 (en) * 2003-08-27 2010-08-10 Labib Mohamed E Method for the treatment or prevention of virus infection using polybiguanide-based compounds
KR101077755B1 (ko) 2003-09-10 2011-10-27 교린 세이야꾸 가부시키 가이샤 7-(4-치환-3-시클로프로필아미노메틸-1-피롤리디닐)퀴놀론카르본산 유도체
KR100981351B1 (ko) * 2003-10-29 2010-09-10 주식회사 엘지생명과학 7-클로로-1-사이클로프로필-6-플루오로-4-옥소-1,4-디하이드로-1,8-나프티리딘-3-카복실산의 제조방법
EP1802306A2 (en) * 2004-09-17 2007-07-04 Cylene Pharmaceuticals, Inc. Quinolone analog as cell proliferation inhibitors
US7652134B2 (en) 2004-09-17 2010-01-26 Cylene Pharmaceuticals, Inc. Methods for converting quinolone esters into quinolone amides
US20110230479A1 (en) * 2005-04-15 2011-09-22 Longo Frank M Neurotrophin mimetics and uses thereof
EP1871420A4 (en) * 2005-04-15 2010-09-22 Univ North Carolina PROCESS FOR ENABLING CELL SURVIVAL VIA NEUROTROPHINE MIMETICS
JP5322927B2 (ja) * 2007-05-24 2013-10-23 杏林製薬株式会社 １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
EP3470402B1 (en) 2009-11-12 2021-01-06 Pharmatrophix Inc. Crystalline forms of neurotrophin mimetic compounds and their salts
US10273219B2 (en) 2009-11-12 2019-04-30 Pharmatrophix, Inc. Crystalline forms of neurotrophin mimetic compounds and their salts
WO2013188452A1 (en) * 2012-06-11 2013-12-19 The Regents Of The University Of California Compounds and methods of treating cancer
CN105622506A (zh) * 2016-01-04 2016-06-01 河北北方学院 一种丙氨环丙沙星半抗原及其制备方法和用途
WO2019051317A1 (en) * 2017-09-07 2019-03-14 Isi Life Sciences, Inc. MODIFIED IMMUNE CELLS AND USES THEREOF
CN108191890B (zh) * 2018-01-11 2019-06-28 河南大学 1-(n-依诺沙星酰胺基)-6-氟-7-哌嗪-萘啶酮酸化合物及其制备方法和应用
CN108558863B (zh) * 2018-01-11 2019-06-07 河南大学 1-(n-诺氟沙星酰胺基)-6-氟-7-哌嗪-萘啶酮酸化合物及其制备方法和应用
CN108047220B (zh) * 2018-01-11 2019-05-24 河南大学 1-(n-氟罗沙星酰胺基)-6-氟-7-哌嗪-萘啶酮酸化合物及其制备方法和应用
CN108191854B (zh) * 2018-01-11 2019-05-24 河南大学 1-(n-环丙沙星酰胺基)-6-氟-7-哌嗪-萘啶酮酸化合物及其制备方法和应用
CN110283168B (zh) * 2019-06-06 2021-05-28 赤峰万泽药业股份有限公司 一种甲苯磺酸妥舒沙星环合物的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281138A (en) 1979-11-08 1981-07-28 The Purdue Frederick Company Antimicrobial bis-benzimidazale compounds
US4560694A (en) * 1982-06-04 1985-12-24 Bayer Aktiengesellschaft Fungicidal alkylene(cycloalkylene)-bis-heterocyclyl-biguanides
US5221693A (en) 1990-08-24 1993-06-22 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Antimicrobial and antiviral bis-adamantanamine compounds

Also Published As

Publication number Publication date
US20040132993A1 (en) 2004-07-08
AU2001286604A1 (en) 2002-03-13
EP1406619A4 (en) 2005-02-02
EP1406619A1 (en) 2004-04-14
US6699989B1 (en) 2004-03-02
WO2002017916A1 (en) 2002-03-07

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