WO2003048106A3 - 1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation - Google Patents

1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation Download PDF

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Publication number
WO2003048106A3
WO2003048106A3 PCT/FR2002/004143 FR0204143W WO03048106A3 WO 2003048106 A3 WO2003048106 A3 WO 2003048106A3 FR 0204143 W FR0204143 W FR 0204143W WO 03048106 A3 WO03048106 A3 WO 03048106A3
Authority
WO
WIPO (PCT)
Prior art keywords
diarylprop
ones
compositions containing
containing same
invention concerns
Prior art date
Application number
PCT/FR2002/004143
Other languages
English (en)
Other versions
WO2003048106A2 (fr
Inventor
Patrick Mailliet
Cecile Combeau
Marie-Christine Bissery
Marie-Pierre Cherrier
Thomas Caulfield
Gilles Tiraboschi
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0115739A external-priority patent/FR2833008B1/fr
Priority to HU0500100A priority Critical patent/HUP0500100A2/hu
Priority to BR0214694-0A priority patent/BR0214694A/pt
Priority to EP02804242A priority patent/EP1453790A2/fr
Priority to JP2003549299A priority patent/JP2005531494A/ja
Priority to YU47804A priority patent/RS47804A/sr
Priority to MXPA04005226A priority patent/MXPA04005226A/es
Priority to EA200400764A priority patent/EA006803B1/ru
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Priority to IL16222302A priority patent/IL162223A0/xx
Priority to AU2002365644A priority patent/AU2002365644A1/en
Priority to CA002469193A priority patent/CA2469193A1/fr
Priority to NZ533224A priority patent/NZ533224A/xx
Publication of WO2003048106A2 publication Critical patent/WO2003048106A2/fr
Publication of WO2003048106A3 publication Critical patent/WO2003048106A3/fr
Priority to HR20040508A priority patent/HRP20040508A2/hr
Priority to NO20042803A priority patent/NO20042803L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Abstract

1,3-Diarylprop-2-èn-1-ones et dérivés, compositions les contenant, procédé de fabrication et utilisation. La présente invention concerne notamment de nouvelles 1,3-diarylprop-2-èn-1-ones substituées ayant une activité thérapeutique, utilisables en particulier en oncologie.
PCT/FR2002/004143 2001-12-05 2002-12-03 1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation WO2003048106A2 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
NZ533224A NZ533224A (en) 2001-12-05 2002-12-03 1,3-diarylprop-2-en-1-ones, compositions containing same and use thereof
EA200400764A EA006803B1 (ru) 2001-12-05 2002-12-03 1,3-диарилпроп-2-ен-1-оны, композиция на их основе и применение
EP02804242A EP1453790A2 (fr) 2001-12-05 2002-12-03 1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation
JP2003549299A JP2005531494A (ja) 2001-12-05 2002-12-03 １，３−ジアリールプロパ−２−エン−１−オン、これを含有する組成物及びその使用
IL16222302A IL162223A0 (en) 2001-12-05 2002-12-03 1,3-Diarylprop-2-en-1-ones, compositions containing same and use thereof
MXPA04005226A MXPA04005226A (es) 2001-12-05 2002-12-03 1,3-diarilprop-2-en-1-onas, composiciones que las contienen y su utilizacion.
BR0214694-0A BR0214694A (pt) 2001-12-05 2002-12-03 1,3-diarilprop-2-en-1-onas, composições que as contêm e utilização
HU0500100A HUP0500100A2 (hu) 2001-12-05 2002-12-03 1,3-Diarilprop-2-én-1-on-származékok, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
YU47804A RS47804A (en) 2001-12-05 2002-12-03 1,3-diarylprop-2-en-1-ones, compositions containing same and use thereof
AU2002365644A AU2002365644A1 (en) 2001-12-05 2002-12-03 1,3-diarylprop-2-en-1-ones, compositions containing same and use thereof
CA002469193A CA2469193A1 (fr) 2001-12-05 2002-12-03 1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation
HR20040508A HRP20040508A2 (en) 2001-12-05 2004-06-04 1,3-diarylprop-2-en-1-ones, compositions containing the same and use thereof
NO20042803A NO20042803L (no) 2001-12-05 2004-07-02 1,3-diarylprop-2en-1-oner, preparater inneholdende forbindelsene samt anvendelse derav

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0115739A FR2833008B1 (fr) 2001-12-05 2001-12-05 1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation
FR01/15739 2001-12-05
FR0214217 2002-11-14
FR02/14217 2002-11-14

Publications (2)

Publication Number Publication Date
WO2003048106A2 WO2003048106A2 (fr) 2003-06-12
WO2003048106A3 true WO2003048106A3 (fr) 2004-03-25

Family

ID=26213287

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/004143 WO2003048106A2 (fr) 2001-12-05 2002-12-03 1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation

Country Status (23)

Country Link
EP (1) EP1453790A2 (fr)
JP (1) JP2005531494A (fr)
KR (1) KR20050044712A (fr)
CN (1) CN1612856A (fr)
AR (1) AR037479A1 (fr)
AU (1) AU2002365644A1 (fr)
BR (1) BR0214694A (fr)
CA (1) CA2469193A1 (fr)
CO (1) CO5580759A2 (fr)
EA (1) EA006803B1 (fr)
HR (1) HRP20040508A2 (fr)
HU (1) HUP0500100A2 (fr)
IL (1) IL162223A0 (fr)
MA (1) MA27351A1 (fr)
MX (1) MXPA04005226A (fr)
NZ (1) NZ533224A (fr)
PA (1) PA8558501A1 (fr)
PE (1) PE20030758A1 (fr)
PL (1) PL370676A1 (fr)
RS (1) RS47804A (fr)
SV (1) SV2003001422A (fr)
TW (1) TW200300685A (fr)
WO (1) WO2003048106A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854399B1 (fr) * 2003-04-30 2006-11-17 Aventis Pharma Sa 1-aryl-3-(indol-5-yl)-prop-2-en-1-ones, compositions les contenant et utilisation
EP1598353A1 (fr) 2004-05-17 2005-11-23 Boehringer Ingelheim International GmbH Pyrrolobenzimidazolones et leur utilisation en tant qu'agents antiproliferatifs
WO2017103637A1 (fr) 2015-12-18 2017-06-22 Blirt S.A. Composés de diphénylpropane et leur activité cytotoxique
CN109467549B (zh) * 2018-12-07 2021-02-09 中国药科大学 喹啉取代查尔酮类化合物、其制备方法及用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288794A2 (fr) * 1987-04-09 1988-11-02 Merrell Dow Pharmaceuticals Inc. Contrôle de la croissance des tumeurs des tissus avec des dérivés de chalcone
JPH08277242A (ja) * 1995-02-08 1996-10-22 Kyowa Hakko Kogyo Co Ltd プロペノン誘導体
EP0812825A1 (fr) * 1995-12-01 1997-12-17 Kyowa Hakko Kogyo Co., Ltd. Derives du propenone
WO1999000114A2 (fr) * 1997-06-26 1999-01-07 Statens Serum Institut 1,3-bis-aromatique-prop-2-en-1-ones, 1,3-bis-aromatique-propane-1-ones et 1,3-bis-aromatique-prop-2-yn-1-ones a action biologique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288794A2 (fr) * 1987-04-09 1988-11-02 Merrell Dow Pharmaceuticals Inc. Contrôle de la croissance des tumeurs des tissus avec des dérivés de chalcone
JPH08277242A (ja) * 1995-02-08 1996-10-22 Kyowa Hakko Kogyo Co Ltd プロペノン誘導体
EP0812825A1 (fr) * 1995-12-01 1997-12-17 Kyowa Hakko Kogyo Co., Ltd. Derives du propenone
WO1999000114A2 (fr) * 1997-06-26 1999-01-07 Statens Serum Institut 1,3-bis-aromatique-prop-2-en-1-ones, 1,3-bis-aromatique-propane-1-ones et 1,3-bis-aromatique-prop-2-yn-1-ones a action biologique

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DUCKI S ET AL: "Potent antimitotic and cell growth inhibitory properties of substituted chalcones", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 9, 1 May 1998 (1998-05-01), pages 1051 - 1056, XP004137018, ISSN: 0960-894X *
EDWARDS M L ET AL: "CHALCONES: A NEW CLASS OF ANTIMITOTIC AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 33, no. 7, July 1990 (1990-07-01), pages 1948 - 1954, XP001015662, ISSN: 0022-2623 *
PATENT ABSTRACTS OF JAPAN vol. 1997, no. 02 28 February 1997 (1997-02-28) *

Also Published As

Publication number Publication date
WO2003048106A2 (fr) 2003-06-12
MA27351A1 (fr) 2005-06-01
AU2002365644A1 (en) 2003-06-17
RS47804A (en) 2006-12-15
CO5580759A2 (es) 2005-11-30
EP1453790A2 (fr) 2004-09-08
PA8558501A1 (es) 2003-09-05
JP2005531494A (ja) 2005-10-20
SV2003001422A (es) 2003-07-10
BR0214694A (pt) 2004-12-14
NZ533224A (en) 2006-03-31
IL162223A0 (en) 2005-11-20
HRP20040508A2 (en) 2005-08-31
CA2469193A1 (fr) 2003-06-12
MXPA04005226A (es) 2004-10-11
EA006803B1 (ru) 2006-04-28
AR037479A1 (es) 2004-11-10
KR20050044712A (ko) 2005-05-12
HUP0500100A2 (hu) 2005-05-30
PL370676A1 (en) 2005-05-30
TW200300685A (en) 2003-06-16
EA200400764A1 (ru) 2004-12-30
PE20030758A1 (es) 2003-10-07
CN1612856A (zh) 2005-05-04

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