CN1612856A - 1,3－二芳基丙－2－烯－1－酮、含有它们的组合物及其用途 - Google Patents

1,3－二芳基丙－2－烯－1－酮、含有它们的组合物及其用途 Download PDF

Info

Publication number
CN1612856A
CN1612856A CNA028268601A CN02826860A CN1612856A CN 1612856 A CN1612856 A CN 1612856A CN A028268601 A CNA028268601 A CN A028268601A CN 02826860 A CN02826860 A CN 02826860A CN 1612856 A CN1612856 A CN 1612856A
Authority
CN
China
Prior art keywords
propenone
amino
methoxy
methyl
trimethoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028268601A
Other languages
English (en)
Chinese (zh)
Inventor
P·马耶
C·孔博
M-C·比斯里
M-P·谢里耶
T·考尔菲勒
G·蒂拉博斯奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0115739A external-priority patent/FR2833008B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of CN1612856A publication Critical patent/CN1612856A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Bending Of Plates, Rods, And Pipes (AREA)
  • Detergent Compositions (AREA)
CNA028268601A 2001-12-05 2002-12-03 1,3－二芳基丙－2－烯－1－酮、含有它们的组合物及其用途 Pending CN1612856A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR01/15739 2001-12-05
FR0115739A FR2833008B1 (fr) 2001-12-05 2001-12-05 1,3-diarylprop-2-en-1-ones, compositions les contenant et utilisation
FR02/14217 2002-11-14
FR0214217 2002-11-14

Publications (1)

Publication Number Publication Date
CN1612856A true CN1612856A (zh) 2005-05-04

Family

ID=26213287

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028268601A Pending CN1612856A (zh) 2001-12-05 2002-12-03 1,3－二芳基丙－2－烯－1－酮、含有它们的组合物及其用途

Country Status (23)

Country Link
EP (1) EP1453790A2 (fr)
JP (1) JP2005531494A (fr)
KR (1) KR20050044712A (fr)
CN (1) CN1612856A (fr)
AR (1) AR037479A1 (fr)
AU (1) AU2002365644A1 (fr)
BR (1) BR0214694A (fr)
CA (1) CA2469193A1 (fr)
CO (1) CO5580759A2 (fr)
EA (1) EA006803B1 (fr)
HR (1) HRP20040508A2 (fr)
HU (1) HUP0500100A2 (fr)
IL (1) IL162223A0 (fr)
MA (1) MA27351A1 (fr)
MX (1) MXPA04005226A (fr)
NZ (1) NZ533224A (fr)
PA (1) PA8558501A1 (fr)
PE (1) PE20030758A1 (fr)
PL (1) PL370676A1 (fr)
RS (1) RS47804A (fr)
SV (1) SV2003001422A (fr)
TW (1) TW200300685A (fr)
WO (1) WO2003048106A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109467549A (zh) * 2018-12-07 2019-03-15 中国药科大学 喹啉取代查尔酮类化合物、其制备方法及用途

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854399B1 (fr) * 2003-04-30 2006-11-17 Aventis Pharma Sa 1-aryl-3-(indol-5-yl)-prop-2-en-1-ones, compositions les contenant et utilisation
EP1598353A1 (fr) 2004-05-17 2005-11-23 Boehringer Ingelheim International GmbH Pyrrolobenzimidazolones et leur utilisation en tant qu'agents antiproliferatifs
WO2017103637A1 (fr) 2015-12-18 2017-06-22 Blirt S.A. Composés de diphénylpropane et leur activité cytotoxique

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904697A (en) * 1987-04-09 1990-02-27 Merrell Dow Pharmaceuticals Inc. Controlling the growth of certain tumor tissue with chalcone derivatives
JPH08277242A (ja) * 1995-02-08 1996-10-22 Kyowa Hakko Kogyo Co Ltd プロペノン誘導体
EP0812825B1 (fr) * 1995-12-01 2004-02-11 Kyowa Hakko Kogyo Co., Ltd. Derives du propenone
AU7908098A (en) * 1997-06-26 1999-01-19 Statens Serum Institut Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109467549A (zh) * 2018-12-07 2019-03-15 中国药科大学 喹啉取代查尔酮类化合物、其制备方法及用途
CN109467549B (zh) * 2018-12-07 2021-02-09 中国药科大学 喹啉取代查尔酮类化合物、其制备方法及用途

Also Published As

Publication number Publication date
MXPA04005226A (es) 2004-10-11
BR0214694A (pt) 2004-12-14
EP1453790A2 (fr) 2004-09-08
TW200300685A (en) 2003-06-16
AU2002365644A1 (en) 2003-06-17
JP2005531494A (ja) 2005-10-20
AR037479A1 (es) 2004-11-10
IL162223A0 (en) 2005-11-20
KR20050044712A (ko) 2005-05-12
WO2003048106A2 (fr) 2003-06-12
HUP0500100A2 (hu) 2005-05-30
EA200400764A1 (ru) 2004-12-30
EA006803B1 (ru) 2006-04-28
SV2003001422A (es) 2003-07-10
PA8558501A1 (es) 2003-09-05
PL370676A1 (en) 2005-05-30
MA27351A1 (fr) 2005-06-01
RS47804A (en) 2006-12-15
HRP20040508A2 (en) 2005-08-31
PE20030758A1 (es) 2003-10-07
CA2469193A1 (fr) 2003-06-12
NZ533224A (en) 2006-03-31
WO2003048106A3 (fr) 2004-03-25
CO5580759A2 (es) 2005-11-30

Similar Documents

Publication Publication Date Title
CN1247567C (zh) 2－氨基－3－烷基嘧啶酮衍生物作为GSK3β抑制剂
CN1067071C (zh) 咔啉衍生物
CN1060761C (zh) 新的芳基(烷基)丙基酰胺,制备此类酰胺的方法和含此类酰胺的药物组合物
CN1177830C (zh) 苯并杂环和它们作为mek抑制剂的用途
CN1280267C (zh) 磺酰氨基羧酸
CN1067387C (zh) 1,2,3,4－四氢喹喔啉二酮衍生物
CN1741999A (zh) 用作GSK－3β抑制剂的哒嗪酮衍生物
CN1694889A (zh) 用于调节lgE和抑制细胞增殖的苯基－氮杂－苯并咪唑化合物
CN1115330C (zh) N－(4－脒基苯基)甘氨酰胺衍生物
CN87105680A (zh) 咪唑化合物及其制备方法，和包含该化合物的药物组合物
CN87100707A (zh) 含氮稠合杂环化合物，其制备方法及含有它们的药物配方
CN1560035A (zh) 5－羟基吲哚－3－羧酸脂类衍生物
CN1268116A (zh) 3－脒基苯胺衍生物,活化血凝固因子x抑制剂和制备这些物质的中间体
CN1726204A (zh) 噻吩异羟肟酸衍生物的对映异构体及其作为hdac抑制剂的应用
CN1196724A (zh) 新哌嗪衍生物及其制造方法
CN86104085A (zh) 四氢噻唑羧酸衍生物的制备方法
CN1068815A (zh) 用做抗炎及抗变性剂的新的取代氮杂环丁酮
CN1155562C (zh) 新的萘化合物、其制备方法及其药物组合物
CN1031532A (zh) 杂环化合物
CN1254334A (zh) 新颖的对苯二甲酰胺衍生物
CN1040366A (zh) 丁烯酸或丙烯酸衍生物
CN1834090A (zh) 苯并咪唑类化合物、其制备方法以及用途
CN1281585C (zh) 具有稠环基团的环二胺化合物
CN1795179A (zh) 新的咪唑衍生物、其制备方法和其作为药物的用途
CN1373766A (zh) 有羧基肽酶b抑制活性的膦酸衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1071885

Country of ref document: HK

AD01 Patent right deemed abandoned
C20 Patent right or utility model deemed to be abandoned or is abandoned
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1071885

Country of ref document: HK