EA005411B1 - Применение антитела против полипептида april для получения лекарственного препарата для лечения опухолей - Google Patents

Применение антитела против полипептида april для получения лекарственного препарата для лечения опухолей Download PDF

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Publication number
EA005411B1
EA005411B1 EA200000310A EA200000310A EA005411B1 EA 005411 B1 EA005411 B1 EA 005411B1 EA 200000310 A EA200000310 A EA 200000310A EA 200000310 A EA200000310 A EA 200000310A EA 005411 B1 EA005411 B1 EA 005411B1
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EA
Eurasian Patent Office
Prior art keywords
cells
sequences
dna
specified
receptor
Prior art date
Application number
EA200000310A
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English (en)
Russian (ru)
Other versions
EA200000310A1 (ru
Inventor
Юрг Чопп
Original Assignee
Апотек Р Энд Д Са
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Application filed by Апотек Р Энд Д Са filed Critical Апотек Р Энд Д Са
Publication of EA200000310A1 publication Critical patent/EA200000310A1/ru
Publication of EA005411B1 publication Critical patent/EA005411B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA200000310A 1997-09-12 1998-09-11 Применение антитела против полипептида april для получения лекарственного препарата для лечения опухолей EA005411B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5878697P 1997-09-12 1997-09-12
US7938498P 1998-03-26 1998-03-26
PCT/US1998/019191 WO1999012965A2 (en) 1997-09-12 1998-09-11 April- a novel protein with growth effects

Publications (2)

Publication Number Publication Date
EA200000310A1 EA200000310A1 (ru) 2000-10-30
EA005411B1 true EA005411B1 (ru) 2005-02-24

Family

ID=26738027

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000310A EA005411B1 (ru) 1997-09-12 1998-09-11 Применение антитела против полипептида april для получения лекарственного препарата для лечения опухолей

Country Status (20)

Country Link
US (3) US20030138884A1 (enExample)
EP (1) EP1027431A2 (enExample)
JP (1) JP2001515712A (enExample)
KR (1) KR100618492B1 (enExample)
CN (1) CN1195849C (enExample)
AU (1) AU759717B2 (enExample)
BR (1) BR9812634A (enExample)
CA (1) CA2303615A1 (enExample)
CZ (1) CZ294615B6 (enExample)
EA (1) EA005411B1 (enExample)
EE (1) EE200000147A (enExample)
HU (1) HUP0004611A3 (enExample)
IL (1) IL134537A0 (enExample)
IS (1) IS5378A (enExample)
NO (1) NO20001242L (enExample)
NZ (1) NZ503850A (enExample)
PL (1) PL339463A1 (enExample)
SK (1) SK3542000A3 (enExample)
TR (1) TR200000669T2 (enExample)
WO (1) WO1999012965A2 (enExample)

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RU2671101C1 (ru) * 2013-11-19 2018-10-29 Регенерон Фармасьютикалс, Инк. Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда

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US20030095967A1 (en) 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
US20030022233A1 (en) 1999-04-30 2003-01-30 Raymond G. Goodwin Methods of use of the taci/taci-l interaction
DK1210425T4 (en) * 1999-08-17 2015-08-10 Apotech R & D Sa BAFF receptor (BCMA), an immunoregulatory agent
UA74798C2 (uk) * 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
WO2001025256A2 (en) * 1999-10-06 2001-04-12 University Of Utah Research Foundation Trdl-1-gamma, a novel tumor necrosis-like ligand
ATE521634T1 (de) 2000-02-11 2011-09-15 Biogen Idec Inc Heterologes polypeptid der tnf familie
AU2006201471B2 (en) * 2000-02-16 2009-07-23 Genentech, Inc. Uses of agonists and antagonists to modulate activity of TNF-related molecules
EP1666052B1 (en) * 2000-02-16 2011-06-08 Genentech, Inc. Anti-APRIL monoclonal antibody and its use for the treatment of an immune related disease or cancer
EP1280826B1 (en) * 2000-05-12 2007-05-02 Amgen Inc. Polypeptides for inhibiting april-mediated b- and t-cell proliferation.
EP1294949A4 (en) * 2000-06-15 2004-08-25 Human Genome Sciences Inc HUMAN TUMORNESCROSE FACTOR DELTA AND EPSILON
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
GB2370273A (en) * 2000-12-20 2002-06-26 Viaxxel Biotech Gmbh Compounds that affect CD83 expression
DE60234202D1 (de) 2001-05-24 2009-12-10 Zymogenetics Inc Taci-immunoglobulin-fusionsproteine
EP1401870A4 (en) 2001-05-24 2006-04-19 Human Genome Sciences ANTIBODIES AGAINST TUMOR NECROSIS FACTOR DELTA (APRIL)
JP2005530482A (ja) 2002-01-04 2005-10-13 ゼンコー・インコーポレイテッド ドミナントネガティブタンパク質およびそれらの用法
US7381792B2 (en) 2002-01-04 2008-06-03 Xencor, Inc. Variants of RANKL protein
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
WO2004089982A2 (en) * 2003-01-06 2004-10-21 Xencor April variants and methods thereof
CA2520097C (en) 2003-03-28 2014-10-07 Biogen Idec Ma Inc. Truncated baff receptors
CA2554526A1 (en) * 2004-01-29 2005-08-18 Genentech, Inc. Variants of the extracellular domain of bcma and uses thereof
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
WO2005113598A2 (en) * 2004-05-21 2005-12-01 Xencor, Inc. Tnf super family members with altered immunogenicity
CA2590461A1 (en) 2004-12-23 2006-06-29 Laboratoires Serono S.A. Bcma polypeptides and uses thereof
MX2008001661A (es) 2005-08-09 2008-04-07 Ares Trading Sa Metodos para tratar afecciones malignas de celulas b que utilizan una molecula de fusion del activador de transmembrana o interactor del ligando de ciclofilina de modulacion de calcio-ig.
AU2006278227B2 (en) 2005-08-09 2011-10-20 Ares Trading S.A. Methods for the treatment and prevention of abnormal cell proliferation using TACI-fusion molecules
US8609821B2 (en) 2005-09-26 2013-12-17 Enzo Therapeutics, Inc. Antibodies against APRIL as biomarkers for early prognosis of lymphoma patients
EP1933873A4 (en) 2005-10-13 2009-12-02 Human Genome Sciences Inc METHODS AND COMPOSITIONS FOR THE TREATMENT OF PATIENTS WITH POSITIVE DISEASES FOR SELF-ANTIBODIES
ES2618543T3 (es) 2005-11-23 2017-06-21 Genentech, Inc. Métodos y composiciones relacionados con ensayos de linfocitos B
US8784812B2 (en) 2006-05-15 2014-07-22 Zymogenetics, Inc. Methods for treating autoimmune diseases using a TACI-Ig fusion molecule
PT2403528E (pt) 2009-03-02 2016-06-08 Aduro Biotech Holdings Europe B V Anticorpos contra um ligando indutor da proliferação (april)
WO2011109280A1 (en) 2010-03-05 2011-09-09 Lerner Research Institute Methods and compositions to treat immune-mediated disorders
US8981057B2 (en) * 2010-03-05 2015-03-17 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam B-cell stimulating fusion proteins of an antigen with BAFF or APRIL
NL2011406C2 (en) * 2013-09-06 2015-03-10 Bionovion Holding B V Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides.
LT3175706T (lt) * 2013-09-23 2019-02-25 Regeneron Pharmaceuticals, Inc. Gyvūnai, išskyrus žmogų, turintys humanizuotą signalą reguliuojančio baltymo geną
GB201317929D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Chimeric antigen receptor
NL2014108B1 (en) 2015-01-09 2016-09-30 Aduro Biotech Holdings Europe B V Altered april binding antibodies.
HUE064791T2 (hu) 2015-11-25 2024-04-28 Visterra Inc APRIL ellenes antitest molekulák és alkalmazásaik
KR20230135562A (ko) 2020-10-29 2023-09-25 인더스트리얼 폴리머스 앤드 케미컬스, 인크. 병원체 모니터링 및 불활성화를 갖는 공기 필터
CA3228678A1 (en) 2021-08-11 2023-02-16 Amato J. Giaccia Methods of reducing production of iga, igm and/or igg using sbcma variants and fc fusion proteins thereof
US12173081B2 (en) 2023-03-21 2024-12-24 Biograph 55, Inc. CD19/CD38 multispecific antibodies
CN118909083A (zh) * 2024-07-30 2024-11-08 江苏省农业科学院 一种猪b细胞增殖诱导配体蛋白及其制备方法和应用

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2671101C1 (ru) * 2013-11-19 2018-10-29 Регенерон Фармасьютикалс, Инк. Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда

Also Published As

Publication number Publication date
NO20001242L (no) 2000-05-11
SK3542000A3 (en) 2000-08-14
TR200000669T2 (tr) 2000-08-21
IL134537A0 (en) 2001-04-30
JP2001515712A (ja) 2001-09-25
WO1999012965A2 (en) 1999-03-18
CN1270632A (zh) 2000-10-18
CA2303615A1 (en) 1999-03-18
HUP0004611A2 (hu) 2001-04-28
HUP0004611A3 (en) 2002-04-29
KR20010023893A (ko) 2001-03-26
NZ503850A (en) 2002-12-20
WO1999012965A3 (en) 1999-06-03
PL339463A1 (en) 2000-12-18
CN1195849C (zh) 2005-04-06
KR100618492B1 (ko) 2006-08-31
AU9316298A (en) 1999-03-29
CZ2000869A3 (cs) 2000-09-13
US20050112596A1 (en) 2005-05-26
BR9812634A (pt) 2000-08-22
EA200000310A1 (ru) 2000-10-30
US20030138884A1 (en) 2003-07-24
EE200000147A (et) 2001-02-15
NO20001242D0 (no) 2000-03-09
EP1027431A2 (en) 2000-08-16
AU759717B2 (en) 2003-04-17
IS5378A (is) 2000-02-18
US20060084148A1 (en) 2006-04-20
CZ294615B6 (cs) 2005-02-16

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