JP2001515712A - 増殖効果を有する新規タンパク質−ａｐｒｉｌ - Google Patents
増殖効果を有する新規タンパク質−ａｐｒｉｌInfo
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- JP2001515712A JP2001515712A JP2000510770A JP2000510770A JP2001515712A JP 2001515712 A JP2001515712 A JP 2001515712A JP 2000510770 A JP2000510770 A JP 2000510770A JP 2000510770 A JP2000510770 A JP 2000510770A JP 2001515712 A JP2001515712 A JP 2001515712A
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5878697P | 1997-09-12 | 1997-09-12 | |
| US60/058,786 | 1997-09-12 | ||
| US7938498P | 1998-03-26 | 1998-03-26 | |
| US60/079,384 | 1998-03-26 | ||
| PCT/US1998/019191 WO1999012965A2 (en) | 1997-09-12 | 1998-09-11 | April- a novel protein with growth effects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001515712A true JP2001515712A (ja) | 2001-09-25 |
| JP2001515712A5 JP2001515712A5 (enExample) | 2006-01-05 |
Family
ID=26738027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000510770A Pending JP2001515712A (ja) | 1997-09-12 | 1998-09-11 | 増殖効果を有する新規タンパク質−ａｐｒｉｌ |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20030138884A1 (enExample) |
| EP (1) | EP1027431A2 (enExample) |
| JP (1) | JP2001515712A (enExample) |
| KR (1) | KR100618492B1 (enExample) |
| CN (1) | CN1195849C (enExample) |
| AU (1) | AU759717B2 (enExample) |
| BR (1) | BR9812634A (enExample) |
| CA (1) | CA2303615A1 (enExample) |
| CZ (1) | CZ294615B6 (enExample) |
| EA (1) | EA005411B1 (enExample) |
| EE (1) | EE200000147A (enExample) |
| HU (1) | HUP0004611A3 (enExample) |
| IL (1) | IL134537A0 (enExample) |
| IS (1) | IS5378A (enExample) |
| NO (1) | NO20001242L (enExample) |
| NZ (1) | NZ503850A (enExample) |
| PL (1) | PL339463A1 (enExample) |
| SK (1) | SK3542000A3 (enExample) |
| TR (1) | TR200000669T2 (enExample) |
| WO (1) | WO1999012965A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003522800A (ja) * | 2000-02-16 | 2003-07-29 | ジェネンテック・インコーポレーテッド | Ｔｎｆ関連分子の活性を調節するためのアゴニスト及びアンタゴニストの使用 |
| JP2009509948A (ja) * | 2005-09-26 | 2009-03-12 | アポテック コーポレーション | リンパ腫患者の早期予後用のバイオマーカーとしてのａｐｒｉｌに対する抗体 |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7217788B2 (en) | 1996-03-14 | 2007-05-15 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta polypeptides |
| US6541224B2 (en) | 1996-03-14 | 2003-04-01 | Human Genome Sciences, Inc. | Tumor necrosis factor delta polypeptides |
| US6440694B1 (en) * | 1997-09-30 | 2002-08-27 | Pharmacia & Upjohn Company | TNF-related death ligand |
| WO1999026976A1 (en) * | 1997-11-26 | 1999-06-03 | Eli Lilly And Company | Tnf ligand family gene |
| US7833529B1 (en) | 1999-01-07 | 2010-11-16 | Zymogenetics, Inc. | Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor |
| DK1415659T3 (da) | 1999-01-25 | 2011-10-03 | Biogen Idec Inc | BAFF, inhibitorer og anvendelse deraf i modulering af B-cellerespons |
| US20030095967A1 (en) | 1999-01-25 | 2003-05-22 | Mackay Fabienne | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders |
| US20030022233A1 (en) | 1999-04-30 | 2003-01-30 | Raymond G. Goodwin | Methods of use of the taci/taci-l interaction |
| DK1210425T4 (en) * | 1999-08-17 | 2015-08-10 | Apotech R & D Sa | BAFF receptor (BCMA), an immunoregulatory agent |
| UA74798C2 (uk) * | 1999-10-06 | 2006-02-15 | Байоджен Айдек Ма Інк. | Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами |
| WO2001025256A2 (en) * | 1999-10-06 | 2001-04-12 | University Of Utah Research Foundation | Trdl-1-gamma, a novel tumor necrosis-like ligand |
| ATE521634T1 (de) | 2000-02-11 | 2011-09-15 | Biogen Idec Inc | Heterologes polypeptid der tnf familie |
| AU2006201471B2 (en) * | 2000-02-16 | 2009-07-23 | Genentech, Inc. | Uses of agonists and antagonists to modulate activity of TNF-related molecules |
| EP1280826B1 (en) * | 2000-05-12 | 2007-05-02 | Amgen Inc. | Polypeptides for inhibiting april-mediated b- and t-cell proliferation. |
| EP1294949A4 (en) * | 2000-06-15 | 2004-08-25 | Human Genome Sciences Inc | HUMAN TUMORNESCROSE FACTOR DELTA AND EPSILON |
| UA83458C2 (uk) | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
| GB2370273A (en) * | 2000-12-20 | 2002-06-26 | Viaxxel Biotech Gmbh | Compounds that affect CD83 expression |
| DE60234202D1 (de) | 2001-05-24 | 2009-12-10 | Zymogenetics Inc | Taci-immunoglobulin-fusionsproteine |
| EP1401870A4 (en) | 2001-05-24 | 2006-04-19 | Human Genome Sciences | ANTIBODIES AGAINST TUMOR NECROSIS FACTOR DELTA (APRIL) |
| JP2005530482A (ja) | 2002-01-04 | 2005-10-13 | ゼンコー・インコーポレイテッド | ドミナントネガティブタンパク質およびそれらの用法 |
| US7381792B2 (en) | 2002-01-04 | 2008-06-03 | Xencor, Inc. | Variants of RANKL protein |
| US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
| WO2004089982A2 (en) * | 2003-01-06 | 2004-10-21 | Xencor | April variants and methods thereof |
| CA2520097C (en) | 2003-03-28 | 2014-10-07 | Biogen Idec Ma Inc. | Truncated baff receptors |
| CA2554526A1 (en) * | 2004-01-29 | 2005-08-18 | Genentech, Inc. | Variants of the extracellular domain of bcma and uses thereof |
| US20050186577A1 (en) | 2004-02-20 | 2005-08-25 | Yixin Wang | Breast cancer prognostics |
| WO2005113598A2 (en) * | 2004-05-21 | 2005-12-01 | Xencor, Inc. | Tnf super family members with altered immunogenicity |
| CA2590461A1 (en) | 2004-12-23 | 2006-06-29 | Laboratoires Serono S.A. | Bcma polypeptides and uses thereof |
| MX2008001661A (es) | 2005-08-09 | 2008-04-07 | Ares Trading Sa | Metodos para tratar afecciones malignas de celulas b que utilizan una molecula de fusion del activador de transmembrana o interactor del ligando de ciclofilina de modulacion de calcio-ig. |
| AU2006278227B2 (en) | 2005-08-09 | 2011-10-20 | Ares Trading S.A. | Methods for the treatment and prevention of abnormal cell proliferation using TACI-fusion molecules |
| EP1933873A4 (en) | 2005-10-13 | 2009-12-02 | Human Genome Sciences Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PATIENTS WITH POSITIVE DISEASES FOR SELF-ANTIBODIES |
| ES2618543T3 (es) | 2005-11-23 | 2017-06-21 | Genentech, Inc. | Métodos y composiciones relacionados con ensayos de linfocitos B |
| US8784812B2 (en) | 2006-05-15 | 2014-07-22 | Zymogenetics, Inc. | Methods for treating autoimmune diseases using a TACI-Ig fusion molecule |
| PT2403528E (pt) | 2009-03-02 | 2016-06-08 | Aduro Biotech Holdings Europe B V | Anticorpos contra um ligando indutor da proliferação (april) |
| WO2011109280A1 (en) | 2010-03-05 | 2011-09-09 | Lerner Research Institute | Methods and compositions to treat immune-mediated disorders |
| US8981057B2 (en) * | 2010-03-05 | 2015-03-17 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | B-cell stimulating fusion proteins of an antigen with BAFF or APRIL |
| NL2011406C2 (en) * | 2013-09-06 | 2015-03-10 | Bionovion Holding B V | Method for obtaining april-binding peptides, process for producing the peptides, april-binding peptides obtainable with said method/process and use of the april-binding peptides. |
| LT3175706T (lt) * | 2013-09-23 | 2019-02-25 | Regeneron Pharmaceuticals, Inc. | Gyvūnai, išskyrus žmogų, turintys humanizuotą signalą reguliuojančio baltymo geną |
| GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| US20150143559A1 (en) * | 2013-11-19 | 2015-05-21 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized a proliferation-inducing ligand gene |
| NL2014108B1 (en) | 2015-01-09 | 2016-09-30 | Aduro Biotech Holdings Europe B V | Altered april binding antibodies. |
| HUE064791T2 (hu) | 2015-11-25 | 2024-04-28 | Visterra Inc | APRIL ellenes antitest molekulák és alkalmazásaik |
| KR20230135562A (ko) | 2020-10-29 | 2023-09-25 | 인더스트리얼 폴리머스 앤드 케미컬스, 인크. | 병원체 모니터링 및 불활성화를 갖는 공기 필터 |
| CA3228678A1 (en) | 2021-08-11 | 2023-02-16 | Amato J. Giaccia | Methods of reducing production of iga, igm and/or igg using sbcma variants and fc fusion proteins thereof |
| US12173081B2 (en) | 2023-03-21 | 2024-12-24 | Biograph 55, Inc. | CD19/CD38 multispecific antibodies |
| CN118909083A (zh) * | 2024-07-30 | 2024-11-08 | 江苏省农业科学院 | 一种猪b细胞增殖诱导配体蛋白及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5176996A (en) * | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5256775A (en) * | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5264564A (en) * | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| AU6166396A (en) * | 1995-06-07 | 1996-12-30 | Biogen, Inc. | Complexes of modified lymphotoxins as pharmaceutical prepara tions |
| DE69630710T2 (de) * | 1996-03-14 | 2004-09-23 | Human Genome Sciences Inc. | Humaner tumornekrosefaktor delta und epsilon |
| US6509170B1 (en) * | 1996-03-14 | 2003-01-21 | Human Genome Sciences, Inc. | Polynucleotides encoding human tumor necrosis factor delta |
| US6171787B1 (en) * | 1997-06-26 | 2001-01-09 | Abbott Laboratories | Member of the TNF family useful for treatment and diagnosis of disease |
-
1998
- 1998-09-11 CA CA002303615A patent/CA2303615A1/en not_active Abandoned
- 1998-09-11 KR KR1020007002577A patent/KR100618492B1/ko not_active Expired - Fee Related
- 1998-09-11 EE EEP200000147A patent/EE200000147A/xx unknown
- 1998-09-11 CN CNB988090384A patent/CN1195849C/zh not_active Expired - Fee Related
- 1998-09-11 IL IL13453798A patent/IL134537A0/xx unknown
- 1998-09-11 TR TR2000/00669T patent/TR200000669T2/xx unknown
- 1998-09-11 EP EP98946066A patent/EP1027431A2/en not_active Withdrawn
- 1998-09-11 CZ CZ2000869A patent/CZ294615B6/cs not_active IP Right Cessation
- 1998-09-11 EA EA200000310A patent/EA005411B1/ru unknown
- 1998-09-11 HU HU0004611A patent/HUP0004611A3/hu unknown
- 1998-09-11 AU AU93162/98A patent/AU759717B2/en not_active Ceased
- 1998-09-11 NZ NZ503850A patent/NZ503850A/xx unknown
- 1998-09-11 WO PCT/US1998/019191 patent/WO1999012965A2/en not_active Ceased
- 1998-09-11 JP JP2000510770A patent/JP2001515712A/ja active Pending
- 1998-09-11 PL PL98339463A patent/PL339463A1/xx unknown
- 1998-09-11 BR BR9812634-2A patent/BR9812634A/pt not_active Application Discontinuation
- 1998-09-11 SK SK354-2000A patent/SK3542000A3/sk unknown
-
2000
- 2000-02-18 IS IS5378A patent/IS5378A/is unknown
- 2000-03-09 NO NO20001242A patent/NO20001242L/no unknown
-
2002
- 2002-05-01 US US10/138,073 patent/US20030138884A1/en not_active Abandoned
-
2004
- 2004-02-12 US US10/778,890 patent/US20050112596A1/en not_active Abandoned
-
2005
- 2005-12-06 US US11/296,049 patent/US20060084148A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003522800A (ja) * | 2000-02-16 | 2003-07-29 | ジェネンテック・インコーポレーテッド | Ｔｎｆ関連分子の活性を調節するためのアゴニスト及びアンタゴニストの使用 |
| JP2009509948A (ja) * | 2005-09-26 | 2009-03-12 | アポテック コーポレーション | リンパ腫患者の早期予後用のバイオマーカーとしてのａｐｒｉｌに対する抗体 |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20001242L (no) | 2000-05-11 |
| SK3542000A3 (en) | 2000-08-14 |
| TR200000669T2 (tr) | 2000-08-21 |
| IL134537A0 (en) | 2001-04-30 |
| WO1999012965A2 (en) | 1999-03-18 |
| CN1270632A (zh) | 2000-10-18 |
| CA2303615A1 (en) | 1999-03-18 |
| HUP0004611A2 (hu) | 2001-04-28 |
| HUP0004611A3 (en) | 2002-04-29 |
| KR20010023893A (ko) | 2001-03-26 |
| NZ503850A (en) | 2002-12-20 |
| WO1999012965A3 (en) | 1999-06-03 |
| EA005411B1 (ru) | 2005-02-24 |
| PL339463A1 (en) | 2000-12-18 |
| CN1195849C (zh) | 2005-04-06 |
| KR100618492B1 (ko) | 2006-08-31 |
| AU9316298A (en) | 1999-03-29 |
| CZ2000869A3 (cs) | 2000-09-13 |
| US20050112596A1 (en) | 2005-05-26 |
| BR9812634A (pt) | 2000-08-22 |
| EA200000310A1 (ru) | 2000-10-30 |
| US20030138884A1 (en) | 2003-07-24 |
| EE200000147A (et) | 2001-02-15 |
| NO20001242D0 (no) | 2000-03-09 |
| EP1027431A2 (en) | 2000-08-16 |
| AU759717B2 (en) | 2003-04-17 |
| IS5378A (is) | 2000-02-18 |
| US20060084148A1 (en) | 2006-04-20 |
| CZ294615B6 (cs) | 2005-02-16 |
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