EA004403B1 - Производные пиразолотриазинов, фармацевтические композиции, содержащие их, способы лечения - Google Patents
Производные пиразолотриазинов, фармацевтические композиции, содержащие их, способы лечения Download PDFInfo
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- EA004403B1 EA004403B1 EA199900158A EA199900158A EA004403B1 EA 004403 B1 EA004403 B1 EA 004403B1 EA 199900158 A EA199900158 A EA 199900158A EA 199900158 A EA199900158 A EA 199900158A EA 004403 B1 EA004403 B1 EA 004403B1
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- 239000012730 sustained-release form Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical compound C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000003064 xanthine oxidase inhibitor Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Coloring (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2329096P | 1996-07-24 | 1996-07-24 | |
| US68604796A | 1996-07-24 | 1996-07-24 | |
| US08/899,242 US6124289A (en) | 1996-07-24 | 1997-07-23 | Azolo triazines and pyrimidines |
| PCT/US1997/013072 WO1998003510A1 (en) | 1996-07-24 | 1997-07-23 | AZOLO TRIAZINES AND PYRIMIDINES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA199900158A1 EA199900158A1 (ru) | 1999-10-28 |
| EA004403B1 true EA004403B1 (ru) | 2004-04-29 |
Family
ID=27362048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199900158A EA004403B1 (ru) | 1996-07-24 | 1997-07-23 | Производные пиразолотриазинов, фармацевтические композиции, содержащие их, способы лечения |
Country Status (15)
| Country | Link |
|---|---|
| JP (2) | JP4704521B2 (cs) |
| CN (3) | CN1104432C (cs) |
| AR (1) | AR049583A2 (cs) |
| BR (1) | BR9710544A (cs) |
| CA (1) | CA2259583C (cs) |
| CZ (1) | CZ299451B6 (cs) |
| EA (1) | EA004403B1 (cs) |
| EE (1) | EE04316B1 (cs) |
| HR (1) | HRP970413A2 (cs) |
| IL (4) | IL127871A0 (cs) |
| NO (1) | NO315610B3 (cs) |
| NZ (1) | NZ333777A (cs) |
| PL (1) | PL195762B1 (cs) |
| SI (1) | SI9720045B (cs) |
| SK (1) | SK286461B6 (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100875595B1 (ko) * | 2001-03-13 | 2008-12-23 | 브리스톨-마이어스 스퀴브 파마 컴파니 | 코르티코트로핀 방출인자 수용체 리간드로서4-(2-부틸아미노)-2,7-디메틸-8-(2-메틸-6-메톡시피리드-3-일) 피라졸로-[1,5-에이]-1,3,5-트리아진, 그의 거울상이성질체 및 약학적으로 허용가능한 염 |
| WO2004110454A1 (ja) * | 2003-06-13 | 2004-12-23 | Ishihara Sangyo Kaisha, Ltd. | アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物 |
| US7329662B2 (en) * | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
| GB0519957D0 (en) * | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
| DE602007009305D1 (de) * | 2006-09-20 | 2010-10-28 | Lilly Co Eli | Thiazolpyrazolopyrimidine als antagonisten des crf1-rezeptors |
| CN103694242B (zh) * | 2013-12-10 | 2016-01-06 | 昆明翔昊科技有限公司 | 吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用 |
| AU2018317398A1 (en) | 2017-08-14 | 2019-11-21 | Spruce Biosciences, Inc. | Corticotropin releasing factor receptor antagonists |
| CN112028891B (zh) * | 2019-07-30 | 2022-07-05 | 厦门宝太生物科技股份有限公司 | 腺苷受体拮抗剂 |
| JP2023537598A (ja) | 2020-08-12 | 2023-09-04 | スプルース バイオサイエンシーズ，インク． | 多嚢胞性卵巣症候群を処置するための方法および組成物 |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3995039A (en) * | 1975-05-27 | 1976-11-30 | Merck & Co., Inc. | Pyrazolo [1,5-a] [1,3,5] triazines |
| JPS6157587A (ja) * | 1984-08-29 | 1986-03-24 | Shionogi & Co Ltd | 縮合複素環誘導体および抗潰瘍剤 |
| US4824834A (en) * | 1986-10-31 | 1989-04-25 | Otsuka Pharmaceutical Company, Limited | Pyrazolotriazine compounds |
| JP2691317B2 (ja) * | 1989-08-25 | 1997-12-17 | 株式会社大塚製薬工場 | ４―ヒドロキシ―８―（３―低級アルコキシ―４―フェニルスルフィニルフェニル）ピラゾロ〔１，５―ａ〕―１，３，５―トリアジン光学活性体の塩類及びその製造方法 |
| KR927003595A (ko) * | 1990-10-09 | 1992-12-18 | 오츠카 아키히코 | 피리미딘 유도체, 이의 제조방법 및 안드로겐 저해제 |
| EP0591528B1 (en) * | 1991-04-22 | 1998-12-23 | Otsuka Pharmaceutical Factory, Inc. | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME |
| US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
-
1997
- 1997-07-23 BR BR9710544A patent/BR9710544A/pt not_active IP Right Cessation
- 1997-07-23 SI SI9720045A patent/SI9720045B/sl active Search and Examination
- 1997-07-23 NZ NZ333777A patent/NZ333777A/en not_active IP Right Cessation
- 1997-07-23 CZ CZ0018499A patent/CZ299451B6/cs not_active IP Right Cessation
- 1997-07-23 SK SK97-99A patent/SK286461B6/sk not_active IP Right Cessation
- 1997-07-23 JP JP50723398A patent/JP4704521B2/ja not_active Expired - Fee Related
- 1997-07-23 EA EA199900158A patent/EA004403B1/ru not_active IP Right Cessation
- 1997-07-23 CA CA002259583A patent/CA2259583C/en not_active Expired - Lifetime
- 1997-07-23 PL PL97331523A patent/PL195762B1/pl unknown
- 1997-07-23 EE EEP199900019A patent/EE04316B1/xx unknown
- 1997-07-23 CN CN97196525A patent/CN1104432C/zh not_active Expired - Lifetime
- 1997-07-23 IL IL12787197A patent/IL127871A0/xx unknown
- 1997-07-24 HR HRP970413 patent/HRP970413A2/hr not_active Application Discontinuation
-
1998
- 1998-12-30 IL IL127871A patent/IL127871A/en not_active IP Right Cessation
-
1999
- 1999-01-21 NO NO19990264A patent/NO315610B3/no not_active IP Right Cessation
-
2001
- 2001-05-30 CN CN 01120849 patent/CN1250223C/zh not_active Expired - Lifetime
-
2002
- 2002-04-25 CN CN 02118589 patent/CN1388126A/zh active Pending
- 2002-06-11 IL IL150163A patent/IL150163A/en not_active IP Right Cessation
-
2004
- 2004-07-23 JP JP2004216483A patent/JP4194539B2/ja not_active Expired - Fee Related
- 2004-10-12 IL IL164513A patent/IL164513A/en not_active IP Right Cessation
-
2005
- 2005-07-11 AR ARP050102868A patent/AR049583A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4194539B2 (ja) | 2008-12-10 |
| CN1388126A (zh) | 2003-01-01 |
| IL164513A0 (en) | 2005-12-18 |
| CA2259583A1 (en) | 1998-01-29 |
| SI9720045B (sl) | 2008-02-29 |
| CA2259583C (en) | 2009-11-17 |
| NO990264L (no) | 1999-03-10 |
| SK9799A3 (sk) | 2005-04-01 |
| EA199900158A1 (ru) | 1999-10-28 |
| SK286461B6 (sk) | 2008-10-07 |
| SI9720045A (sl) | 1999-10-31 |
| CZ299451B6 (cs) | 2008-07-30 |
| NZ333777A (en) | 2000-07-28 |
| PL195762B1 (pl) | 2007-10-31 |
| CN1327793A (zh) | 2001-12-26 |
| JP2002513382A (ja) | 2002-05-08 |
| CZ18499A3 (cs) | 1999-11-17 |
| IL164513A (en) | 2010-04-29 |
| HRP970413A2 (en) | 1998-10-31 |
| EE9900019A (et) | 1999-08-16 |
| CN1250223C (zh) | 2006-04-12 |
| JP4704521B2 (ja) | 2011-06-15 |
| EE04316B1 (et) | 2004-06-15 |
| CN1104432C (zh) | 2003-04-02 |
| IL150163A (en) | 2010-12-30 |
| IL127871A0 (en) | 1999-10-28 |
| NO315610B1 (no) | 2003-09-29 |
| PL331523A1 (en) | 1999-07-19 |
| AR049583A2 (es) | 2006-08-16 |
| NO990264D0 (no) | 1999-01-21 |
| BR9710544A (pt) | 1999-08-17 |
| IL127871A (en) | 2010-04-29 |
| JP2005097257A (ja) | 2005-04-14 |
| NO315610B3 (no) | 2003-09-29 |
| CN1225637A (zh) | 1999-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Patent expired |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |