DOP2024000069A - Compuestos de quinolina como inhibidores de kras - Google Patents

Compuestos de quinolina como inhibidores de kras

Info

Publication number
DOP2024000069A
DOP2024000069A DO2024000069A DO2024000069A DOP2024000069A DO P2024000069 A DOP2024000069 A DO P2024000069A DO 2024000069 A DO2024000069 A DO 2024000069A DO 2024000069 A DO2024000069 A DO 2024000069A DO P2024000069 A DOP2024000069 A DO P2024000069A
Authority
DO
Dominican Republic
Prior art keywords
compounds
quinoline compounds
kras inhibitors
kras
inhibitors
Prior art date
Application number
DO2024000069A
Other languages
English (en)
Inventor
Hu Bin
Yao Wenqing
Ye Qinda
Mccammant Matthew
Shvartsbart Artem
Zhu Wenyu
ROACH Jeremy
Hoang Gia
Li Gencheng
Susick Robert
Polam Padmaja
Zhang Fenglei
Qi Chao
Wang Xiaozhao
Sokolsky Alexander
Yin Haolin
Zhao Le
Carlsen Peter
Policarpo Rocco
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of DOP2024000069A publication Critical patent/DOP2024000069A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos de fórmula I, métodos de uso de los compuestos para inhibir la actividad de KRAS y composiciones farmacéuticas que comprenden dichos compuestos. Los compuestos son útiles en el tratamiento, prevención o mejoramiento de enfermedades o trastornos asociados con la actividad de KRAS tales como el cáncer.
DO2024000069A 2021-10-14 2024-04-15 Compuestos de quinolina como inhibidores de kras DOP2024000069A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163255610P 2021-10-14 2021-10-14
US202163279464P 2021-11-15 2021-11-15
US202263363270P 2022-04-20 2022-04-20
US202263368563P 2022-07-15 2022-07-15
PCT/US2022/078048 WO2023064857A1 (en) 2021-10-14 2022-10-13 Quinoline compounds as inhibitors of kras

Publications (1)

Publication Number Publication Date
DOP2024000069A true DOP2024000069A (es) 2024-07-15

Family

ID=84330780

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2024000069A DOP2024000069A (es) 2021-10-14 2024-04-15 Compuestos de quinolina como inhibidores de kras

Country Status (12)

Country Link
US (1) US11939328B2 (es)
EP (1) EP4415824A1 (es)
KR (1) KR20240101561A (es)
AU (1) AU2022367432A1 (es)
CA (1) CA3235146A1 (es)
CO (1) CO2024006030A2 (es)
DO (1) DOP2024000069A (es)
EC (1) ECSP24035717A (es)
IL (1) IL312114A (es)
MX (1) MX2024004444A (es)
TW (1) TW202322810A (es)
WO (1) WO2023064857A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023154766A1 (en) 2022-02-09 2023-08-17 Quanta Therapeutics, Inc. Kras modulators and uses thereof
WO2024015731A1 (en) * 2022-07-11 2024-01-18 Incyte Corporation Fused tricyclic compounds as inhibitors of kras g12v mutants
WO2024206858A1 (en) 2023-03-30 2024-10-03 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof

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