DOP2012000312A - Triazolopiridinas sustituidas - Google Patents
Triazolopiridinas sustituidasInfo
- Publication number
- DOP2012000312A DOP2012000312A DO2012000312A DO2012000312A DOP2012000312A DO P2012000312 A DOP2012000312 A DO P2012000312A DO 2012000312 A DO2012000312 A DO 2012000312A DO 2012000312 A DO2012000312 A DO 2012000312A DO P2012000312 A DOP2012000312 A DO P2012000312A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- cornposts
- substituted
- triazolopiridins
- pharmaceutical
- prepare
- Prior art date
Links
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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Abstract
Cornpuestos de triazo]opiridina sustituida de la fórrnula general (I) donde R, R2, F3, R4 y R5 tienen los valores que se definen en la descripcián y en las reivindicaciones. Iétodos para preparar dichos cornpuestos. Cornposiciones y cornbinaciones farrnacéuticas que cornprenden dichos cornpuestos. Us de dichos cornpuestos para preparar una cornposición farrnacéutica para el tratarniento o la profilaxis de una enferrnedad. Cornpuestos interinediarios útiles para preparar dichos cornpuestos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10166149 | 2010-06-16 | ||
EP11167139 | 2011-05-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2012000312A true DOP2012000312A (es) | 2013-04-15 |
Family
ID=44259707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2012000312A DOP2012000312A (es) | 2010-06-16 | 2012-12-14 | Triazolopiridinas sustituidas |
Country Status (25)
Country | Link |
---|---|
US (1) | US9555022B2 (es) |
EP (1) | EP2582699A1 (es) |
JP (1) | JP5833644B2 (es) |
KR (1) | KR20130116067A (es) |
CN (1) | CN103189373B (es) |
AR (1) | AR081934A1 (es) |
AU (1) | AU2011267143A1 (es) |
BR (1) | BR112012031837A2 (es) |
CA (1) | CA2802629A1 (es) |
CL (1) | CL2012003540A1 (es) |
CO (1) | CO6650348A2 (es) |
CR (1) | CR20120637A (es) |
CU (1) | CU20120171A7 (es) |
DO (1) | DOP2012000312A (es) |
EA (1) | EA201390010A1 (es) |
EC (1) | ECSP12012338A (es) |
MA (1) | MA34308B1 (es) |
MX (1) | MX2012014766A (es) |
NZ (1) | NZ604443A (es) |
PE (1) | PE20130611A1 (es) |
SG (1) | SG186342A1 (es) |
TN (1) | TN2012000595A1 (es) |
TW (1) | TW201204722A (es) |
UY (1) | UY33452A (es) |
WO (1) | WO2011157688A1 (es) |
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WO2011119154A1 (en) | 2010-03-24 | 2011-09-29 | Hewlett-Packard Development Company, L.P. | Gesture mapping for display device |
WO2012143329A1 (en) * | 2011-04-21 | 2012-10-26 | Bayer Intellectual Property Gmbh | Triazolopyridines |
WO2012160029A1 (en) | 2011-05-23 | 2012-11-29 | Bayer Intellectual Property Gmbh | Substituted triazolopyridines |
UA112096C2 (uk) * | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
CN102617339A (zh) * | 2012-03-05 | 2012-08-01 | 山西仟源制药股份有限公司 | 3-环丙基甲氧基-4-卤代苯甲酸或其衍生物及应用 |
PE20150354A1 (es) * | 2012-07-10 | 2015-03-21 | Bayer Pharma AG | Metodos para preparar triazolopiridinas sustituidas |
WO2014020041A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
WO2014020043A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
PE20160156A1 (es) * | 2013-06-11 | 2016-04-20 | Bayer Pharma AG | Derivados de prodroga de triazolpiridinas sustituidas |
KR20160018534A (ko) * | 2013-06-11 | 2016-02-17 | 바이엘 파마 악티엔게젤샤프트 | Mps-1 키나제 억제제 및 유사분열 억제제를 포함하는 암의 치료를 위한 조합물 |
KR20180011089A (ko) | 2015-04-17 | 2018-01-31 | 네덜런즈 트랜슬레이셔널 리서치 센터 비.브이. | Ttk 억제제 화학요법을 위한 예후 바이오마커 |
KR101775682B1 (ko) | 2015-11-30 | 2017-09-06 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
EP3484528B1 (en) | 2016-07-18 | 2020-11-25 | Janssen Pharmaceutica NV | Tau pet imaging ligands |
RU2764655C2 (ru) * | 2017-03-16 | 2022-01-19 | Цзянсу Хэнжуй Медицин Ко., Лтд. | ПРОИЗВОДНОЕ ГЕТЕРОАРИЛ[4,3-с]ПИРИМИДИН-5-АМИНА, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО МЕДИЦИНСКИЕ ПРИМЕНЕНИЯ |
CN108947782B (zh) * | 2018-08-15 | 2021-08-24 | 上海罕道医药科技有限公司 | 一种溴氟多取代苯甲醛衍生物和制备方法 |
AU2020257301A1 (en) | 2019-04-18 | 2021-11-11 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-(1,2,4)triazolo(1,5a) pyridine derivatives and use thereof |
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US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
CA2530679A1 (en) | 2003-06-30 | 2005-04-07 | Hif Bio, Inc. | Compounds for treating angiogenesis |
AU2005274277A1 (en) | 2004-08-17 | 2006-02-23 | Galderma Research & Development, S.N.C. | Novel biaromatic compounds which activate receptors of PPAR type and their use in cosmetic or pharmaceutical compositions |
WO2007065010A2 (en) | 2005-12-02 | 2007-06-07 | Hif Bio, Inc. | Anti-angiogenesis compounds |
BRPI0716239A2 (pt) | 2006-08-30 | 2013-08-13 | Cellzome Ltd | derivados de triazol como inibidores de cinase |
CN101801966A (zh) | 2007-07-18 | 2010-08-11 | 诺瓦提斯公司 | 双环杂芳基化合物和它们作为激酶抑制剂的用途 |
EA201000341A1 (ru) | 2007-08-23 | 2010-10-29 | Астразенека Аб | 2-анилинопурин-8-оны в качестве ингибиторов ttk/mps1 для лечения пролиферативных нарушений |
EP2181112A1 (en) * | 2007-08-31 | 2010-05-05 | Merck Serono S.A. | Triazolopyridine compounds and their use as ask inhibitors |
GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
CN101910158A (zh) | 2007-10-25 | 2010-12-08 | 阿斯利康(瑞典)有限公司 | 可用于治疗细胞增殖性病症的吡啶衍生物和吡嗪衍生物 |
CA2706578A1 (en) * | 2007-11-27 | 2009-06-04 | Cellzome Limited | Amino triazoles as pi3k inhibitors |
JP2010111624A (ja) * | 2008-11-06 | 2010-05-20 | Shionogi & Co Ltd | Ttk阻害作用を有するインダゾール誘導体 |
WO2010092015A1 (en) | 2009-02-10 | 2010-08-19 | Cellzome Limited | Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors |
PE20120110A1 (es) * | 2009-02-13 | 2012-02-20 | Fovea Pharmaceuticals | [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa |
US8729082B2 (en) | 2009-04-29 | 2014-05-20 | Bayer Intellectual Property Gmbh | Substituted imidazoquinoxalines |
EP2473498A1 (en) | 2009-09-04 | 2012-07-11 | Bayer Pharma Aktiengesellschaft | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors |
EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
EP2343295A1 (en) * | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridine derivates |
EP2343294A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Substituted triazolopyridines |
ES2512840T3 (es) | 2010-01-15 | 2014-10-24 | Janssen Pharmaceuticals, Inc. | Derivados de triazol bicíclicos sustituidos novedosos como moduladores de gamma-secretasa |
US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
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2011
- 2011-06-13 UY UY0001033452A patent/UY33452A/es not_active Application Discontinuation
- 2011-06-14 WO PCT/EP2011/059806 patent/WO2011157688A1/en active Application Filing
- 2011-06-14 CA CA2802629A patent/CA2802629A1/en not_active Abandoned
- 2011-06-14 MA MA35454A patent/MA34308B1/fr unknown
- 2011-06-14 EP EP11725437.5A patent/EP2582699A1/en not_active Withdrawn
- 2011-06-14 US US13/704,859 patent/US9555022B2/en not_active Expired - Fee Related
- 2011-06-14 PE PE2012002421A patent/PE20130611A1/es not_active Application Discontinuation
- 2011-06-14 CN CN201180039503.4A patent/CN103189373B/zh not_active Expired - Fee Related
- 2011-06-14 MX MX2012014766A patent/MX2012014766A/es not_active Application Discontinuation
- 2011-06-14 AU AU2011267143A patent/AU2011267143A1/en not_active Abandoned
- 2011-06-14 BR BR112012031837A patent/BR112012031837A2/pt not_active IP Right Cessation
- 2011-06-14 JP JP2013514680A patent/JP5833644B2/ja not_active Expired - Fee Related
- 2011-06-14 SG SG2012091906A patent/SG186342A1/en unknown
- 2011-06-14 KR KR1020137001039A patent/KR20130116067A/ko not_active Application Discontinuation
- 2011-06-14 EA EA201390010A patent/EA201390010A1/ru unknown
- 2011-06-14 NZ NZ604443A patent/NZ604443A/en not_active IP Right Cessation
- 2011-06-15 AR ARP110102073A patent/AR081934A1/es unknown
- 2011-06-15 TW TW100120915A patent/TW201204722A/zh unknown
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2012
- 2012-12-13 TN TNP2012000595A patent/TN2012000595A1/en unknown
- 2012-12-14 CL CL2012003540A patent/CL2012003540A1/es unknown
- 2012-12-14 EC ECSP12012338 patent/ECSP12012338A/es unknown
- 2012-12-14 CR CR20120637A patent/CR20120637A/es unknown
- 2012-12-14 CO CO12227307A patent/CO6650348A2/es not_active Application Discontinuation
- 2012-12-14 CU CU2012000171A patent/CU20120171A7/es unknown
- 2012-12-14 DO DO2012000312A patent/DOP2012000312A/es unknown
Also Published As
Publication number | Publication date |
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JP2013532147A (ja) | 2013-08-15 |
CU20120171A7 (es) | 2013-05-31 |
WO2011157688A1 (en) | 2011-12-22 |
BR112012031837A2 (pt) | 2016-11-08 |
CA2802629A1 (en) | 2011-12-22 |
EP2582699A1 (en) | 2013-04-24 |
MA34308B1 (fr) | 2013-06-01 |
UY33452A (es) | 2012-01-31 |
CN103189373B (zh) | 2016-04-06 |
CR20120637A (es) | 2013-03-13 |
NZ604443A (en) | 2014-07-25 |
TW201204722A (en) | 2012-02-01 |
MX2012014766A (es) | 2013-01-29 |
AU2011267143A1 (en) | 2013-01-31 |
US20130156756A1 (en) | 2013-06-20 |
CO6650348A2 (es) | 2013-04-15 |
SG186342A1 (en) | 2013-01-30 |
TN2012000595A1 (en) | 2014-04-01 |
ECSP12012338A (es) | 2012-12-28 |
AR081934A1 (es) | 2012-10-31 |
JP5833644B2 (ja) | 2015-12-16 |
US9555022B2 (en) | 2017-01-31 |
KR20130116067A (ko) | 2013-10-22 |
EA201390010A1 (ru) | 2013-06-28 |
PE20130611A1 (es) | 2013-05-25 |
CN103189373A (zh) | 2013-07-03 |
CL2012003540A1 (es) | 2013-04-01 |
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