|
US4842868A
(en)
*
|
1986-09-26 |
1989-06-27 |
Helwing Robert F |
Covalently bonded active agents with carbonium ion base groups
|
|
US5214132A
(en)
*
|
1986-12-23 |
1993-05-25 |
Kyowa Hakko Kogyo Co., Ltd. |
Polypeptide derivatives of human granulocyte colony stimulating factor
|
|
IE64284B1
(en)
*
|
1987-08-03 |
1995-07-26 |
Ddi Pharmaceuticals |
Conjugates of superoxide dismutase
|
|
JPS6471490A
(en)
*
|
1987-08-21 |
1989-03-16 |
Wellcome Found |
Novel complex
|
|
JPH079429B2
(ja)
*
|
1988-10-12 |
1995-02-01 |
財団法人化学及血清療法研究所 |
人工担体およびその製造方法
|
|
US5091176A
(en)
*
|
1988-11-02 |
1992-02-25 |
W. R. Grace & Co.-Conn. |
Polymer-modified peptide drugs having enhanced biological and pharmacological activities
|
|
US5510418A
(en)
*
|
1988-11-21 |
1996-04-23 |
Collagen Corporation |
Glycosaminoglycan-synthetic polymer conjugates
|
|
US5306500A
(en)
*
|
1988-11-21 |
1994-04-26 |
Collagen Corporation |
Method of augmenting tissue with collagen-polymer conjugates
|
|
US5162430A
(en)
*
|
1988-11-21 |
1992-11-10 |
Collagen Corporation |
Collagen-polymer conjugates
|
|
US5565519A
(en)
*
|
1988-11-21 |
1996-10-15 |
Collagen Corporation |
Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
|
|
EP0395918A3
(en)
*
|
1989-04-13 |
1991-10-23 |
Vascular Laboratory, Inc. |
Plasminogen activator complex of pure pro-urokinase covalently bound by a disulfide bridge to human serum albumin
|
|
KR920703114A
(ko)
*
|
1989-07-14 |
1992-12-17 |
원본미기재 |
접합체 백신을 위한 시토킨 및 호르몬 운반체
|
|
US5767072A
(en)
*
|
1989-09-14 |
1998-06-16 |
Board Of Regents, The University Of Texas System |
Therapeutic compositions comprising a CD4 peptide and methods of treatment of HIV infections
|
|
IE912365A1
(en)
*
|
1990-07-23 |
1992-01-29 |
Zeneca Ltd |
Continuous release pharmaceutical compositions
|
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
WO1994011028A1
(en)
*
|
1992-11-16 |
1994-05-26 |
Centocor, Inc. |
Compounds having reduced immunogenicity and a method of reducing the immunogenicity of compounds
|
|
DE69331805T2
(de)
*
|
1992-12-10 |
2002-11-28 |
Enzon, Inc. |
Glycolipid enzym-polymer konjugate
|
|
AU691225B2
(en)
*
|
1993-11-10 |
1998-05-14 |
Schering Corporation |
Improved interferon polymer conjugates
|
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
US6458762B1
(en)
|
1994-03-28 |
2002-10-01 |
Baxter International, Inc. |
Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
|
|
WO1996004340A1
(en)
*
|
1994-08-04 |
1996-02-15 |
Gordon George Wallace |
Conducting electroactive biomaterials
|
|
US5738846A
(en)
*
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US5770577A
(en)
*
|
1994-11-14 |
1998-06-23 |
Amgen Inc. |
BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
|
|
EP0796324A1
(en)
*
|
1994-12-07 |
1997-09-24 |
Novo Nordisk A/S |
Polypeptide with reduced allergenicity
|
|
US5695760A
(en)
*
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
US6428790B1
(en)
*
|
1995-04-27 |
2002-08-06 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services |
Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
|
|
US6833408B2
(en)
*
|
1995-12-18 |
2004-12-21 |
Cohesion Technologies, Inc. |
Methods for tissue repair using adhesive materials
|
|
US7883693B2
(en)
*
|
1995-12-18 |
2011-02-08 |
Angiodevice International Gmbh |
Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
|
|
US6458889B1
(en)
|
1995-12-18 |
2002-10-01 |
Cohesion Technologies, Inc. |
Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
|
|
PT2111876E
(pt)
*
|
1995-12-18 |
2011-12-23 |
Angiodevice Internat Gmbh |
Composições de polímero reticulado e seus métodos de utilização
|
|
EP0874893A2
(en)
*
|
1995-12-29 |
1998-11-04 |
The Procter & Gamble Company |
Detergent compositions comprising immobilized enzymes
|
|
US6106828A
(en)
*
|
1996-02-15 |
2000-08-22 |
Novo Nordisk A/S |
Conjugation of polypeptides
|
|
CN1273589C
(zh)
*
|
1996-02-15 |
2006-09-06 |
诺沃奇梅兹有限公司 |
多肽缀合
|
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
EP0932390A1
(en)
|
1996-10-11 |
1999-08-04 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method
|
|
US6416756B1
(en)
|
1997-01-10 |
2002-07-09 |
Novozymes A/S |
Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care
|
|
JPH10276776A
(ja)
*
|
1997-04-07 |
1998-10-20 |
Toyobo Co Ltd |
可逆的に不活化された耐熱性dnaポリメラーゼ
|
|
EP1075511A1
(en)
|
1998-05-08 |
2001-02-14 |
University Of Southern California |
Size enhanced fibrinolytic enzymes
|
|
TR200003635T2
(tr)
*
|
1998-06-08 |
2001-04-20 |
F.Hoffmann-La Roche Ag |
Peg-IFN-ALFA ve ribavirinin kronik hepatit C tedavisinde kullanılması.
|
|
US6461849B1
(en)
|
1998-10-13 |
2002-10-08 |
Novozymes, A/S |
Modified polypeptide
|
|
TWI242000B
(en)
|
1998-12-10 |
2005-10-21 |
Univ Southern California |
Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
|
|
US7238368B2
(en)
*
|
1999-04-23 |
2007-07-03 |
Alza Corporation |
Releasable linkage and compositions containing same
|
|
US7303760B2
(en)
*
|
1999-04-23 |
2007-12-04 |
Alza Corporation |
Method for treating multi-drug resistant tumors
|
|
US6342244B1
(en)
*
|
1999-04-23 |
2002-01-29 |
Alza Corporation |
Releasable linkage and compositions containing same
|
|
US7112337B2
(en)
|
1999-04-23 |
2006-09-26 |
Alza Corporation |
Liposome composition for delivery of nucleic acid
|
|
AU5805500A
(en)
*
|
1999-07-07 |
2001-01-30 |
Maxygen Aps |
A method for preparing modified polypeptides
|
|
US6423666B1
(en)
|
1999-10-05 |
2002-07-23 |
Bio-Rad Laboratories, Inc. |
Large-pore chromatographic beads prepared by suspension polymerization
|
|
US6413507B1
(en)
*
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
AR027509A1
(es)
|
2000-01-10 |
2003-04-02 |
Maxygen Aps |
Conjugados g-csf
|
|
JP2003521930A
(ja)
|
2000-02-11 |
2003-07-22 |
マキシゲン・エイピーエス |
第VII因子または第VIIa因子様分子
|
|
US6436386B1
(en)
|
2000-11-14 |
2002-08-20 |
Shearwater Corporation |
Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
|
|
US7829074B2
(en)
|
2001-10-18 |
2010-11-09 |
Nektar Therapeutics |
Hydroxypatite-targeting poly(ethylene glycol) and related polymers
|
|
ATE432288T1
(de)
|
2001-02-27 |
2009-06-15 |
Maxygen Aps |
Neue interferon-beta-ähnliche moleküle
|
|
GB0123232D0
(en)
*
|
2001-09-26 |
2001-11-21 |
Smith & Nephew |
Polymers
|
|
IL161051A0
(en)
*
|
2001-10-02 |
2004-08-31 |
Genentech Inc |
Apo-2 ligand variants and uses thereof
|
|
PT1517710E
(pt)
|
2002-06-21 |
2011-07-08 |
Novo Nordisk Healthcare Ag |
Glicoformas do factor vii peguilado
|
|
CA2489348A1
(en)
|
2002-06-24 |
2003-12-31 |
Genentech, Inc. |
Apo-2 ligand/trail variants and uses thereof
|
|
WO2004043396A2
(en)
*
|
2002-11-09 |
2004-05-27 |
Nobex Corporation |
Modified carbamate-containing prodrugs and methods of synthesizing same
|
|
CA2511486A1
(en)
*
|
2002-12-30 |
2004-07-22 |
Angiotech International Ag |
Tissue reactive compounds and compositions and uses thereof
|
|
ATE457716T1
(de)
|
2002-12-30 |
2010-03-15 |
Angiotech Int Ag |
Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
|
|
US20040151766A1
(en)
*
|
2003-01-30 |
2004-08-05 |
Monahan Sean D. |
Protein and peptide delivery to mammalian cells in vitro
|
|
GB0305989D0
(en)
*
|
2003-03-15 |
2003-04-23 |
Delta Biotechnology Ltd |
Agent
|
|
CN102516386A
(zh)
|
2003-10-10 |
2012-06-27 |
诺沃挪第克公司 |
Il-21衍生物
|
|
EP2633866A3
(en)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Combination therapy
|
|
WO2005074546A2
(en)
|
2004-02-02 |
2005-08-18 |
Ambrx, Inc. |
Modified human growth hormone polypeptides and their uses
|
|
US20100028995A1
(en)
*
|
2004-02-23 |
2010-02-04 |
Anaphore, Inc. |
Tetranectin Trimerizing Polypeptides
|
|
CN1997399A
(zh)
*
|
2004-04-21 |
2007-07-11 |
阿尔扎公司 |
可在温和硫解条件下释放的聚合物共轭物
|
|
WO2006083260A2
(en)
|
2004-04-28 |
2006-08-10 |
Angiotech Biomaterials Corporation |
Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
|
|
NZ582684A
(en)
|
2004-06-18 |
2011-05-27 |
Ambrx Inc |
Use of an antibody or binding fragment thereof comprising a non naturally encoded amino acid coupled to a linker
|
|
JP2008507280A
(ja)
|
2004-07-21 |
2008-03-13 |
アンブレツクス・インコーポレイテツド |
非天然コードアミノ酸を用いた生合成ポリペプチド
|
|
EP1796602A4
(en)
|
2004-09-17 |
2016-10-19 |
Angiotech Pharm Inc |
MULTIFUNCTIONAL COMPOUNDS FOR PRODUCING NETWORKED BIOMATERIALS AND MANUFACTURING AND USE METHOD THEREFOR
|
|
KR20070090023A
(ko)
|
2004-12-22 |
2007-09-04 |
암브룩스, 인코포레이티드 |
변형 인간 성장 호르몬
|
|
US20060188498A1
(en)
|
2005-02-18 |
2006-08-24 |
Genentech, Inc. |
Methods of using death receptor agonists and EGFR inhibitors
|
|
ES2553160T3
(es)
|
2005-06-17 |
2015-12-04 |
Novo Nordisk Health Care Ag |
Reducción y derivatización selectivas de proteínas Factor VII transformadas por ingeniería que comprenden al menos una cisteína no nativa
|
|
EP1951890A4
(en)
|
2005-11-16 |
2009-06-24 |
Ambrx Inc |
PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
|
|
EP2213733A3
(en)
|
2006-05-24 |
2010-12-29 |
Novo Nordisk Health Care AG |
Factor IX analogues having prolonged in vivo half life
|
|
CN104193815A
(zh)
|
2006-09-08 |
2014-12-10 |
Ambrx公司 |
经修饰的人类血浆多肽或Fc骨架和其用途
|
|
EP2083866A4
(en)
|
2006-10-27 |
2011-12-28 |
Wei-Chiang Shen |
LIPIDIZED INTERFERON AND USES THEREOF
|
|
KR20140012199A
(ko)
|
2007-03-30 |
2014-01-29 |
암브룩스, 인코포레이티드 |
변형된 fgf-21 폴리펩티드 및 그 용도
|
|
EP2195333A1
(en)
*
|
2007-09-12 |
2010-06-16 |
Anaphore, Inc. |
Hsp70-based treatment for autoimmune diseases
|
|
MX2010004400A
(es)
|
2007-10-23 |
2010-05-20 |
Nektar Therapeutics |
Polimeros de multiples brazos dirigidos a la hidroxiapatita y conjugados de estos.
|
|
US20110027267A1
(en)
*
|
2007-11-09 |
2011-02-03 |
Anaphore, Inc. |
Fusion Proteins of Mannose Binding Lectins for Treatment of Disease
|
|
EP2930182A1
(en)
|
2007-11-20 |
2015-10-14 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
|
EP3103880A1
(en)
|
2008-02-08 |
2016-12-14 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
|
AU2009274076C1
(en)
|
2008-07-23 |
2014-04-17 |
Ambrx, Inc. |
Modified bovine G-CSF polypeptides and their uses
|
|
US9121024B2
(en)
|
2008-09-26 |
2015-09-01 |
Ambrx, Inc. |
Non-natural amino acid replication-dependent microorganisms and vaccines
|
|
PL2342223T3
(pl)
|
2008-09-26 |
2017-09-29 |
Ambrx, Inc. |
Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania
|
|
AU2009303304A1
(en)
|
2008-10-10 |
2010-04-15 |
Anaphore, Inc. |
Polypeptides that bind TRAIL-RI and TRAIL-R2
|
|
US20110318322A1
(en)
*
|
2009-01-12 |
2011-12-29 |
Nektar Therapeutics |
Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer
|
|
US20110086806A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that Bind IL-23R
|
|
WO2011043835A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that bind il-23r
|
|
BR112012015461A2
(pt)
|
2009-12-21 |
2017-01-10 |
Ambrx Inc |
polipeptídeos de somatotropina boviina modificados e seus usos
|
|
WO2011087810A1
(en)
|
2009-12-21 |
2011-07-21 |
Ambrx, Inc. |
Modified porcine somatotropin polypeptides and their uses
|
|
EP2542569B1
(en)
|
2010-03-05 |
2020-09-16 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
|
EP2569331A1
(en)
|
2010-05-10 |
2013-03-20 |
Perseid Therapeutics LLC |
Polypeptide inhibitors of vla4
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
ES2742296T3
(es)
|
2010-08-17 |
2020-02-13 |
Ambrx Inc |
Polipéptidos de relaxina modificados y sus usos
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
EP2704735A1
(en)
|
2011-05-03 |
2014-03-12 |
Genentech, Inc. |
Vascular disruption agents and uses thereof
|
|
AU2012280474A1
(en)
|
2011-07-01 |
2014-01-16 |
Bayer Intellectual Property Gmbh |
Relaxin fusion polypeptides and uses thereof
|
|
GB201117428D0
(en)
*
|
2011-10-07 |
2011-11-23 |
Bicycle Therapeutics Ltd |
Structured polypeptides with sarcosine linkers
|
|
EP2606884A1
(en)
|
2011-12-21 |
2013-06-26 |
Ecole Polytechnique Fédérale de Lausanne (EPFL) |
Inhibitors of notch signaling pathway and use thereof in treatment of cancers
|
|
DK2859017T3
(da)
|
2012-06-08 |
2019-05-13 |
Sutro Biopharma Inc |
Antistoffer omfattrende stedsspecifikke ikke-naturlige aminosyrerester, fremgangsmåder til fremstilling heraf og fremgangsmåder til anvendelse heraf
|
|
ES2611788T3
(es)
|
2012-06-26 |
2017-05-10 |
Sutro Biopharma, Inc. |
Proteínas de Fc modificadas que comprenden residuos de aminoácidos no naturales específicos del sitio, conjugados de las mismas, métodos para su preparación y métodos para su uso
|
|
EP3584255B1
(en)
|
2012-08-31 |
2022-02-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising an azido group
|
|
ES2865473T3
(es)
|
2013-07-10 |
2021-10-15 |
Sutro Biopharma Inc |
Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso
|
|
CN107318267B
(zh)
|
2013-08-12 |
2021-08-17 |
豪夫迈·罗氏有限公司 |
用于治疗补体相关的病症的组合物和方法
|
|
WO2015054658A1
(en)
|
2013-10-11 |
2015-04-16 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
PE20161440A1
(es)
|
2014-05-01 |
2017-01-26 |
Genentech Inc |
Variantes del anticuerpo anti-factor d y sus usos
|
|
CN107108710B
(zh)
|
2014-10-24 |
2022-02-15 |
百时美施贵宝公司 |
修饰的fgf-21多肽及其用途
|
|
DK3307326T3
(da)
|
2015-06-15 |
2020-10-19 |
Angiochem Inc |
Fremgangsmåder til behandling af leptomeningeal karcinomatose
|
|
EP3368090A1
(en)
|
2015-10-30 |
2018-09-05 |
H. Hoffnabb-La Roche Ag |
Anti-factor d antibody variant conjugates and uses thereof
|
|
TW201730211A
(zh)
|
2015-10-30 |
2017-09-01 |
建南德克公司 |
抗因子d抗體及結合物
|
|
WO2018004338A1
(en)
|
2016-06-27 |
2018-01-04 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
|
KR102670432B1
(ko)
|
2017-02-08 |
2024-05-28 |
브리스톨-마이어스 스큅 컴퍼니 |
약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도
|
|
MA52954A
(fr)
|
2018-06-21 |
2021-04-28 |
Cellestia Biotech Ag |
Procédé pour la fabrication d'aminoéthers de diaryle et sels de chlorhydrate d'aminoéthers de diaryle
|
|
JP7441826B2
(ja)
|
2018-09-11 |
2024-03-01 |
アンブルックス,インコーポレイテッド |
インターロイキン-2ポリペプチド抱合物およびその使用
|
|
WO2020082057A1
(en)
|
2018-10-19 |
2020-04-23 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
|
CN119455003A
(zh)
|
2019-02-12 |
2025-02-18 |
Ambrx公司 |
包含抗体-tlr激动剂缀合物的组合物、方法和用途
|
|
CN118994001A
(zh)
|
2019-04-10 |
2024-11-22 |
塞莱斯蒂亚生物技术股份公司 |
Notch信号传导途径抑制剂及其在癌症治疗的用途
|
|
CN115243726B
(zh)
|
2020-03-11 |
2025-07-15 |
北京泰德制药股份有限公司 |
白介素-2多肽偶联物及其使用方法
|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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(zh)
*
|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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