|
US4842868A
(en)
*
|
1986-09-26 |
1989-06-27 |
Helwing Robert F |
Covalently bonded active agents with carbonium ion base groups
|
|
US5214132A
(en)
*
|
1986-12-23 |
1993-05-25 |
Kyowa Hakko Kogyo Co., Ltd. |
Polypeptide derivatives of human granulocyte colony stimulating factor
|
|
IE64284B1
(en)
*
|
1987-08-03 |
1995-07-26 |
Ddi Pharmaceuticals |
Conjugates of superoxide dismutase
|
|
NZ225880A
(en)
*
|
1987-08-21 |
1991-07-26 |
Wellcome Found |
A complex of polyethylene glycol and tissue plasminogen activator
|
|
JPH079429B2
(ja)
*
|
1988-10-12 |
1995-02-01 |
財団法人化学及血清療法研究所 |
人工担体およびその製造方法
|
|
US5091176A
(en)
*
|
1988-11-02 |
1992-02-25 |
W. R. Grace & Co.-Conn. |
Polymer-modified peptide drugs having enhanced biological and pharmacological activities
|
|
US5565519A
(en)
*
|
1988-11-21 |
1996-10-15 |
Collagen Corporation |
Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
|
|
US5510418A
(en)
*
|
1988-11-21 |
1996-04-23 |
Collagen Corporation |
Glycosaminoglycan-synthetic polymer conjugates
|
|
US5162430A
(en)
*
|
1988-11-21 |
1992-11-10 |
Collagen Corporation |
Collagen-polymer conjugates
|
|
US5306500A
(en)
*
|
1988-11-21 |
1994-04-26 |
Collagen Corporation |
Method of augmenting tissue with collagen-polymer conjugates
|
|
EP0395918A3
(en)
*
|
1989-04-13 |
1991-10-23 |
Vascular Laboratory, Inc. |
Plasminogen activator complex of pure pro-urokinase covalently bound by a disulfide bridge to human serum albumin
|
|
FI920131A0
(fi)
*
|
1989-07-14 |
1992-01-13 |
Praxis Biolog Inc |
Cytokin- och hormonbaerare foer konjugatvaccin.
|
|
US5767072A
(en)
*
|
1989-09-14 |
1998-06-16 |
Board Of Regents, The University Of Texas System |
Therapeutic compositions comprising a CD4 peptide and methods of treatment of HIV infections
|
|
IE912365A1
(en)
*
|
1990-07-23 |
1992-01-29 |
Zeneca Ltd |
Continuous release pharmaceutical compositions
|
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
EP0676965B1
(en)
*
|
1992-11-16 |
2007-07-25 |
Centocor Inc. |
Method of reducing immunogenicity of variable region of antibodies
|
|
EP0675727B1
(en)
*
|
1992-12-10 |
2002-04-10 |
Enzon, Inc. |
Glycolipid enzyme-polymer conjugates
|
|
HUT75533A
(en)
*
|
1993-11-10 |
1997-05-28 |
Schering Corp |
Improved interferon polymer conjugates
|
|
US5951974A
(en)
*
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
US6458762B1
(en)
|
1994-03-28 |
2002-10-01 |
Baxter International, Inc. |
Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
|
|
EP0773975A4
(en)
*
|
1994-08-04 |
1998-06-10 |
Gordon George Wallace |
CONDUCTIVE ELECTROACTIVE BIOMATERIALS
|
|
US5738846A
(en)
*
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US5770577A
(en)
*
|
1994-11-14 |
1998-06-23 |
Amgen Inc. |
BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
|
|
JPH10510516A
(ja)
*
|
1994-12-07 |
1998-10-13 |
ノボ ノルディスク アクティーゼルスカブ |
アレルゲン性を減らしたポリペプチド
|
|
US5695760A
(en)
*
|
1995-04-24 |
1997-12-09 |
Boehringer Inglehiem Pharmaceuticals, Inc. |
Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation
|
|
US6428790B1
(en)
*
|
1995-04-27 |
2002-08-06 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services |
Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use
|
|
US5874500A
(en)
*
|
1995-12-18 |
1999-02-23 |
Cohesion Technologies, Inc. |
Crosslinked polymer compositions and methods for their use
|
|
US7883693B2
(en)
|
1995-12-18 |
2011-02-08 |
Angiodevice International Gmbh |
Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
|
|
US6458889B1
(en)
|
1995-12-18 |
2002-10-01 |
Cohesion Technologies, Inc. |
Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
|
|
US6833408B2
(en)
*
|
1995-12-18 |
2004-12-21 |
Cohesion Technologies, Inc. |
Methods for tissue repair using adhesive materials
|
|
JPH11502255A
(ja)
*
|
1995-12-29 |
1999-02-23 |
ザ、プロクター、エンド、ギャンブル、カンパニー |
固定化酵素を含有する洗剤組成物
|
|
CA2242488A1
(en)
*
|
1996-02-15 |
1997-08-21 |
Novo Nordisk A/S |
Conjugation of polypeptides
|
|
US6106828A
(en)
*
|
1996-02-15 |
2000-08-22 |
Novo Nordisk A/S |
Conjugation of polypeptides
|
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
AU4907897A
(en)
|
1996-10-11 |
1998-05-11 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method
|
|
US6416756B1
(en)
|
1997-01-10 |
2002-07-09 |
Novozymes A/S |
Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care
|
|
JPH10276776A
(ja)
*
|
1997-04-07 |
1998-10-20 |
Toyobo Co Ltd |
可逆的に不活化された耐熱性dnaポリメラーゼ
|
|
AU3977499A
(en)
*
|
1998-05-08 |
1999-11-29 |
University Of Southern California |
Size enhanced fibrinolytic enzymes
|
|
IL139786A0
(en)
*
|
1998-06-08 |
2002-02-10 |
Hoffmann La Roche |
Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c
|
|
US6461849B1
(en)
|
1998-10-13 |
2002-10-08 |
Novozymes, A/S |
Modified polypeptide
|
|
TWI242000B
(en)
|
1998-12-10 |
2005-10-21 |
Univ Southern California |
Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
|
|
US7112337B2
(en)
|
1999-04-23 |
2006-09-26 |
Alza Corporation |
Liposome composition for delivery of nucleic acid
|
|
US7238368B2
(en)
*
|
1999-04-23 |
2007-07-03 |
Alza Corporation |
Releasable linkage and compositions containing same
|
|
US7303760B2
(en)
*
|
1999-04-23 |
2007-12-04 |
Alza Corporation |
Method for treating multi-drug resistant tumors
|
|
KR100642955B1
(ko)
*
|
1999-04-23 |
2006-11-10 |
알자 코포레이션 |
방출성 결합 및 그를 함유하는 조성물
|
|
WO2001004287A1
(en)
*
|
1999-07-07 |
2001-01-18 |
Maxygen Aps |
A method for preparing modified polypeptides
|
|
US6423666B1
(en)
|
1999-10-05 |
2002-07-23 |
Bio-Rad Laboratories, Inc. |
Large-pore chromatographic beads prepared by suspension polymerization
|
|
US6413507B1
(en)
*
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
DK1250154T3
(da)
|
2000-01-10 |
2009-08-17 |
Maxygen Holdings Ltd |
G-CSF-konjugater
|
|
ATE428445T1
(de)
|
2000-02-11 |
2009-05-15 |
Bayer Healthcare Llc |
Gerinnungsfaktor vii oder viia konjugate
|
|
US7829074B2
(en)
*
|
2001-10-18 |
2010-11-09 |
Nektar Therapeutics |
Hydroxypatite-targeting poly(ethylene glycol) and related polymers
|
|
US6436386B1
(en)
|
2000-11-14 |
2002-08-20 |
Shearwater Corporation |
Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
|
|
JP2004534523A
(ja)
|
2001-02-27 |
2004-11-18 |
マキシゲン・エイピーエス |
新規なインターフェロンβ様分子
|
|
GB0123232D0
(en)
*
|
2001-09-26 |
2001-11-21 |
Smith & Nephew |
Polymers
|
|
JP2005508162A
(ja)
|
2001-10-02 |
2005-03-31 |
ジェネンテック・インコーポレーテッド |
Apo−2リガンド変異体とその使用法
|
|
UA86744C2
(en)
|
2002-06-21 |
2009-05-25 |
Ново Нордиск Хэлс Кеа Аг |
Pegylated factor vii glycoforms
|
|
CA2489348A1
(en)
|
2002-06-24 |
2003-12-31 |
Genentech, Inc. |
Apo-2 ligand/trail variants and uses thereof
|
|
AU2003285200A1
(en)
*
|
2002-11-09 |
2004-06-03 |
Nobex Corporation |
Modified carbamate-containing prodrugs and methods of synthesizing same
|
|
EP1594459B1
(en)
*
|
2002-12-30 |
2010-02-17 |
Angiotech International Ag |
Drug delivery from rapid gelling polymer composition
|
|
JP2006519766A
(ja)
*
|
2002-12-30 |
2006-08-31 |
アンジオテック インターナショナル アクツィエン ゲゼルシャフト |
組織反応性化合物および組成物、ならびにそれらの使用法
|
|
US20040151766A1
(en)
*
|
2003-01-30 |
2004-08-05 |
Monahan Sean D. |
Protein and peptide delivery to mammalian cells in vitro
|
|
GB0305989D0
(en)
*
|
2003-03-15 |
2003-04-23 |
Delta Biotechnology Ltd |
Agent
|
|
WO2005035565A1
(en)
|
2003-10-10 |
2005-04-21 |
Novo Nordisk A/S |
Il-21 derivatives
|
|
EP2641611A3
(en)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Combination therapy
|
|
AU2005209926B2
(en)
|
2004-02-02 |
2007-09-06 |
Ambrx, Inc. |
Modified human four helical bundle polypeptides and their uses
|
|
US20100028995A1
(en)
*
|
2004-02-23 |
2010-02-04 |
Anaphore, Inc. |
Tetranectin Trimerizing Polypeptides
|
|
CN1997399A
(zh)
*
|
2004-04-21 |
2007-07-11 |
阿尔扎公司 |
可在温和硫解条件下释放的聚合物共轭物
|
|
KR101148445B1
(ko)
|
2004-04-28 |
2012-07-05 |
안지오디바이스 인터내셔널 게엠베하 |
가교된 생합성물질을 형성하기 위한 조성물 및 시스템, 및 이와 관련된 제조 및 사용 방법
|
|
JP2008503217A
(ja)
|
2004-06-18 |
2008-02-07 |
アンブレツクス・インコーポレイテツド |
新規抗原結合ポリペプチド及びそれらの使用
|
|
US7638299B2
(en)
|
2004-07-21 |
2009-12-29 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
|
WO2006034128A2
(en)
|
2004-09-17 |
2006-03-30 |
Angiotech Biomaterials Corporation |
Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
|
|
NZ584597A
(en)
|
2004-12-22 |
2011-09-30 |
Ambrx Inc |
Modified human growth hormone
|
|
US20060188498A1
(en)
|
2005-02-18 |
2006-08-24 |
Genentech, Inc. |
Methods of using death receptor agonists and EGFR inhibitors
|
|
EP2360170A3
(en)
|
2005-06-17 |
2012-03-28 |
Novo Nordisk Health Care AG |
Selective reduction and derivatization of engineered proteins comprinsing at least one non-native cysteine
|
|
ES2547554T3
(es)
|
2005-11-16 |
2015-10-07 |
Ambrx, Inc. |
Métodos y composiciones que comprenden aminoácidos no naturales
|
|
RU2008145084A
(ru)
|
2006-05-24 |
2010-06-27 |
Ново Нордиск Хелс Кеа Аг (Ch) |
Аналоги фактора ix, имеющие пролонгированное время полужизни in vivo
|
|
MX2009002523A
(es)
|
2006-09-08 |
2009-03-20 |
Ambrx Inc |
Polipeptido de plasma humano modificado o andamios fc y sus usos.
|
|
US8486384B2
(en)
|
2006-10-27 |
2013-07-16 |
University Of Southern California |
Lipidized interferon and methods of treating viral hepatitis
|
|
ES2385114T3
(es)
|
2007-03-30 |
2012-07-18 |
Ambrx, Inc. |
Polipéptidos de FGF-21 modificados y sus usos
|
|
JP2010538655A
(ja)
*
|
2007-09-12 |
2010-12-16 |
アナフォア インコーポレイテッド |
自己免疫疾患についてのhsp70に基づく治療
|
|
JP5823125B2
(ja)
|
2007-10-23 |
2015-11-25 |
ウェルズ ファーゴ バンク ナショナル アソシエイション |
ヒドロキシアパタイト標的化多腕ポリマーならびに、このポリマーから作られるコンジュゲート
|
|
AU2008323678A1
(en)
*
|
2007-11-09 |
2009-05-14 |
Anaphore, Inc. |
Fusion proteins of mannose binding lectins for treatment of disease
|
|
MX2010005317A
(es)
|
2007-11-20 |
2010-06-02 |
Ambrx Inc |
Polipeptidos de insulina modificados y sus usos.
|
|
SG188143A1
(en)
|
2008-02-08 |
2013-03-28 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
|
NZ600382A
(en)
|
2008-07-23 |
2013-11-29 |
Ambrx Inc |
Modified bovine G-CSF polypeptides and their uses
|
|
NO2337846T3
(OSRAM)
|
2008-09-26 |
2018-06-16 |
|
|
|
UA106731C2
(uk)
|
2008-09-26 |
2014-10-10 |
Амбркс, Інк. |
Модифіковані поліпептиди еритропоетину тварин та їх застосування
|
|
AU2009303304A1
(en)
*
|
2008-10-10 |
2010-04-15 |
Anaphore, Inc. |
Polypeptides that bind TRAIL-RI and TRAIL-R2
|
|
WO2010080720A2
(en)
*
|
2009-01-12 |
2010-07-15 |
Nektar Therapeutics |
Conjugates of a lysosomal enzyme moiety and a water soluble polymer
|
|
CN102686606A
(zh)
*
|
2009-10-09 |
2012-09-19 |
阿纳福公司 |
结合il-23r的多肽
|
|
US20110086806A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that Bind IL-23R
|
|
CA2784800A1
(en)
|
2009-12-21 |
2011-07-21 |
Ambrx, Inc. |
Modified porcine somatotropin polypeptides and their uses
|
|
EP2805964A1
(en)
|
2009-12-21 |
2014-11-26 |
Ambrx, Inc. |
Modified bovine somatotropin polypeptides and their uses
|
|
AU2011222883B2
(en)
|
2010-03-05 |
2016-05-26 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
|
EP2569331A1
(en)
|
2010-05-10 |
2013-03-20 |
Perseid Therapeutics LLC |
Polypeptide inhibitors of vla4
|
|
WO2012024452A2
(en)
|
2010-08-17 |
2012-02-23 |
Ambrx, Inc. |
Modified relaxin polypeptides and their uses
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
|
MX2013012716A
(es)
|
2011-05-03 |
2014-03-21 |
Genentech Inc |
Agentes de disociacion vascular y sus usos.
|
|
BR112014000055A2
(pt)
|
2011-07-01 |
2017-06-13 |
Bayer Ip Gmbh |
polipeptídeos de fusão de relaxina e usos dos mesmos
|
|
GB201117428D0
(en)
*
|
2011-10-07 |
2011-11-23 |
Bicycle Therapeutics Ltd |
Structured polypeptides with sarcosine linkers
|
|
EP2606884A1
(en)
|
2011-12-21 |
2013-06-26 |
Ecole Polytechnique Fédérale de Lausanne (EPFL) |
Inhibitors of notch signaling pathway and use thereof in treatment of cancers
|
|
KR102172897B1
(ko)
|
2012-06-08 |
2020-11-02 |
서트로 바이오파마, 인크. |
부위-특이적 비-천연 아미노산 잔기를 포함하는 항체, 그의 제조 방법 및 그의 사용 방법
|
|
DK2863955T3
(en)
|
2012-06-26 |
2017-01-23 |
Sutro Biopharma Inc |
MODIFIED FC PROTEINS, INCLUDING LOCATION-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, CONJUGATES THEREOF, METHODS OF PRODUCING ITS AND PROCEDURES FOR USE THEREOF
|
|
JP6826367B2
(ja)
|
2012-08-31 |
2021-02-03 |
ストロ バイオファーマ インコーポレーテッド |
アジド基を含む修飾アミノ酸
|
|
US9764039B2
(en)
|
2013-07-10 |
2017-09-19 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
EA201690213A1
(ru)
|
2013-08-12 |
2016-07-29 |
Дженентек, Инк. |
Композиции и способ лечения связанных с комплементом состояний
|
|
US9840493B2
(en)
|
2013-10-11 |
2017-12-12 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
WO2015168468A1
(en)
|
2014-05-01 |
2015-11-05 |
Genentech, Inc. |
Anti-factor d antibody variants and uses thereof
|
|
PL3412302T3
(pl)
|
2014-10-24 |
2021-11-02 |
Bristol-Myers Squibb Company |
Zmodyfikowane polipeptydy fgf-21 i ich zastosowania
|
|
CA2989400A1
(en)
|
2015-06-15 |
2016-12-22 |
Angiochem Inc. |
Ang1005 for the treatment of leptomeningeal carcinomatosis
|
|
HK1257422A1
(zh)
|
2015-10-30 |
2019-10-18 |
豪夫迈‧罗氏有限公司 |
抗-因子d抗体变体缀合物及其用途
|
|
CN108289951A
(zh)
|
2015-10-30 |
2018-07-17 |
豪夫迈·罗氏有限公司 |
抗-因子d抗体和缀合物
|
|
EP3474901B1
(en)
|
2016-06-27 |
2025-08-06 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
|
MY193457A
(en)
|
2017-02-08 |
2022-10-14 |
Bristol Myers Squibb Co |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
|
KR20210034587A
(ko)
|
2018-06-21 |
2021-03-30 |
셀레스티아 바이오테크 아게 |
아미노 디아릴 에테르 및 아미노 디아릴 에테르 하이드로클로라이드염의 제조 방법
|
|
ES2972137T3
(es)
|
2018-09-11 |
2024-06-11 |
Ambrx Inc |
Conjugados de polipéptidos de interleucina-2 y sus usos
|
|
JP2022512746A
(ja)
|
2018-10-19 |
2022-02-07 |
アンブルックス,インコーポレイテッド |
インターロイキン-10ポリペプチド複合体、その二量体、およびそれらの使用
|
|
EP3923991A1
(en)
|
2019-02-12 |
2021-12-22 |
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|
|
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(ru)
|
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2022-01-24 |
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|
|
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(en)
|
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2021-09-16 |
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|
|
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(en)
|
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|
|
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(ja)
|
2020-08-20 |
2023-09-06 |
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|
|
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(en)
|
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2022-06-08 |
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|
|
WO2022122667A1
(en)
|
2020-12-07 |
2022-06-16 |
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|
|
CN112451681B
(zh)
*
|
2020-12-09 |
2023-08-25 |
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|
|
AU2022249223A1
(en)
|
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2023-10-12 |
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|
|
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(zh)
|
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2023-04-01 |
瑞士商西萊絲蒂亞生物科技股份有限公司 |
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|
|
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(en)
|
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2025-01-02 |
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|
|
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(en)
|
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|