DK544588D0 - I 2-stillingen heterocyclisk substituerede 4-aryl-5-carbamoyl-6-methyl-1,4-dihydropyridin-3-carboxylsyre-forbindelser, deres anvendelse til fremstilling af et laegemiddel til behandling af allergiske og inflammatoriske tilstande og farmaceutiske praeparater indeholdende disse forbindelser samt 2-acyl-3-aryl-propensyreestere til anvendelse som udgangsmateriale ved deres fremstilling - Google Patents

I 2-stillingen heterocyclisk substituerede 4-aryl-5-carbamoyl-6-methyl-1,4-dihydropyridin-3-carboxylsyre-forbindelser, deres anvendelse til fremstilling af et laegemiddel til behandling af allergiske og inflammatoriske tilstande og farmaceutiske praeparater indeholdende disse forbindelser samt 2-acyl-3-aryl-propensyreestere til anvendelse som udgangsmateriale ved deres fremstilling

Info

Publication number
DK544588D0
DK544588D0 DK544588A DK544588A DK544588D0 DK 544588 D0 DK544588 D0 DK 544588D0 DK 544588 A DK544588 A DK 544588A DK 544588 A DK544588 A DK 544588A DK 544588 D0 DK544588 D0 DK 544588D0
Authority
DK
Denmark
Prior art keywords
aryl
compounds
dihydropyridine
carbamoyl
allergic
Prior art date
Application number
DK544588A
Other languages
English (en)
Other versions
DK544588A (da
DK170376B1 (da
Inventor
Kelvin Cooper
Michael Jonathan Fray
Kenneth Richardson
John Steele
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878722977A external-priority patent/GB8722977D0/en
Priority claimed from GB888804441A external-priority patent/GB8804441D0/en
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of DK544588D0 publication Critical patent/DK544588D0/da
Publication of DK544588A publication Critical patent/DK544588A/da
Application granted granted Critical
Publication of DK170376B1 publication Critical patent/DK170376B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK544588A 1987-09-30 1988-09-29 I 2-stillingen heterocyclisk substituerede 4-aryl-5-carbamoyl-6-methyl-1,4-dihydropyridin-3-carboxylsyre-forbindelser, forbindelserne til medicinsk anvendelse, anvendelse af forbindelserne til fremstilling af et lægemiddel til behandling af allergiske og inflammatoriske tilstande, farmaceutiske præparater indeholdende forbindelserne samt 2-acyl-3-aryl-propensyreestere til anvendelse som mellemprod DK170376B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8722977 1987-09-30
GB878722977A GB8722977D0 (en) 1987-09-30 1987-09-30 Therapeutic agents
GB8804441 1988-02-25
GB888804441A GB8804441D0 (en) 1988-02-25 1988-02-25 Therapeutic agents

Publications (3)

Publication Number Publication Date
DK544588D0 true DK544588D0 (da) 1988-09-29
DK544588A DK544588A (da) 1989-05-11
DK170376B1 DK170376B1 (da) 1995-08-14

Family

ID=26292797

Family Applications (1)

Application Number Title Priority Date Filing Date
DK544588A DK170376B1 (da) 1987-09-30 1988-09-29 I 2-stillingen heterocyclisk substituerede 4-aryl-5-carbamoyl-6-methyl-1,4-dihydropyridin-3-carboxylsyre-forbindelser, forbindelserne til medicinsk anvendelse, anvendelse af forbindelserne til fremstilling af et lægemiddel til behandling af allergiske og inflammatoriske tilstande, farmaceutiske præparater indeholdende forbindelserne samt 2-acyl-3-aryl-propensyreestere til anvendelse som mellemprod

Country Status (26)

Country Link
US (3) US4935430A (da)
EP (1) EP0310386B1 (da)
JP (2) JP2660016B2 (da)
KR (1) KR900008318B1 (da)
CN (1) CN1032648C (da)
AU (2) AU597190B2 (da)
CA (1) CA1340785C (da)
CY (1) CY1722A (da)
DE (1) DE3866077D1 (da)
DK (1) DK170376B1 (da)
EG (1) EG18563A (da)
ES (1) ES2038766T3 (da)
FI (1) FI93444C (da)
GR (1) GR3003468T3 (da)
HK (1) HK66093A (da)
HU (1) HU201061B (da)
IE (1) IE61045B1 (da)
IL (1) IL101332A0 (da)
MY (1) MY104933A (da)
NO (1) NO168107C (da)
NZ (1) NZ226397A (da)
PH (1) PH26046A (da)
PL (1) PL157186B1 (da)
PT (1) PT88614B (da)
SG (1) SG49393G (da)
YU (1) YU46698B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8906324D0 (en) * 1989-03-20 1989-05-04 Pfizer Ltd 1,4-dihydropyridines
US4990518A (en) * 1989-09-13 1991-02-05 G. D. Searle & Co. Pharmacologically active heteroaryl substituted imidazo (4,5-c) pyridines
GB9010404D0 (en) * 1990-05-09 1990-06-27 Pfizer Ltd Therapeutic agents
GB9015524D0 (en) * 1990-07-13 1990-08-29 Pfizer Ltd Therapeutic agents
GB9019409D0 (en) * 1990-09-05 1990-10-17 Pfizer Ltd Therapeutic agents
KR100195433B1 (ko) * 1990-11-30 1999-06-15 오쓰까 아끼히꼬 활성산소 억제제
US5288866A (en) * 1991-12-20 1994-02-22 American Cyanamid Company 5,6-disubstituted-3-pyridylmethyl ammonium halide compounds useful for the preparation of 5- (substituted methyl)-2,3-pyridinedicarboxylic acids
DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
MY128323A (en) 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
BR9910864A (pt) * 1998-06-04 2002-02-05 Abbott Lab Compostos anti-inflamatórios para inibição de aderência celular
EP1181296A1 (en) * 1999-06-03 2002-02-27 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
AU7931301A (en) * 2000-08-04 2002-02-18 Dmi Biosciences Inc Method of using diketopiperazines and composition containing them
KR20120091266A (ko) 2003-05-15 2012-08-17 디엠아이 바이오사이언시스, 인크 Ｔ-세포 매개성 질환의 치료 방법
CN113999167B (zh) * 2021-10-18 2023-09-29 蚌埠中实化学技术有限公司 一种4-氯-2,6-二甲基-3-硝基吡啶的制备方法
CN117568743B (zh) * 2024-01-15 2024-03-19 江苏普坦科金属科技有限公司 一种铁基材料的表面耐腐蚀耐磨处理工艺

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971791A (en) * 1972-03-06 1976-07-27 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
DE2738153A1 (de) * 1977-08-24 1979-03-08 Bayer Ag 2-pyridyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2752820A1 (de) * 1977-11-26 1979-05-31 Bayer Ag Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4285955A (en) * 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
US4317909A (en) * 1980-03-24 1982-03-02 Sterling Drug Inc. Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones
US4353905A (en) 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
ATE20064T1 (de) 1982-07-22 1986-06-15 Pfizer Anti-ischaemische und antihypertensive dihydropyridin-derivate.
EP0125803A3 (en) * 1983-04-27 1987-01-21 FISONS plc Pharmaceutically active dihydropyridines
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
GB8620880D0 (en) * 1986-08-29 1986-10-08 Pfizer Ltd Therapeutic agents
US4871745A (en) * 1986-09-22 1989-10-03 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo(1,2-A)pyridines and their use as antisecretory agents
NO874194L (no) 1986-11-07 1988-05-09 Pfizer Ltd Fremgangsmaate ved fremstilling av dihydro-pyridinderivater
US4820842A (en) * 1986-11-19 1989-04-11 Warner-Lambert Company 2-substituted-1,4-dihydropyridines
GB8712747D0 (en) * 1987-05-30 1987-07-01 Pfizer Ltd Therapeutic agents
GB8803963D0 (en) * 1988-02-19 1988-03-23 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
AU597190B2 (en) 1990-05-24
CY1722A (en) 1994-05-06
SG49393G (en) 1993-07-09
US4935430A (en) 1990-06-19
NO168107C (no) 1992-01-15
HUT48872A (en) 1989-07-28
FI884471A (fi) 1989-03-31
US5063237A (en) 1991-11-05
AU617256B2 (en) 1991-11-21
US5120747A (en) 1992-06-09
IE882944L (en) 1989-03-30
NO884333L (no) 1989-03-31
KR900008318B1 (ko) 1990-11-12
PL274977A1 (en) 1989-08-21
CN1032648C (zh) 1996-08-28
KR890005054A (ko) 1989-05-11
PT88614B (pt) 1993-07-30
HU201061B (en) 1990-09-28
PH26046A (en) 1992-01-29
DK544588A (da) 1989-05-11
FI93444B (fi) 1994-12-30
YU46698B (sh) 1994-04-05
FI884471A0 (fi) 1988-09-29
YU182088A (en) 1990-06-30
JP2898256B2 (ja) 1999-05-31
PL157186B1 (pl) 1992-05-29
IL101332A0 (en) 1992-11-15
AU2297388A (en) 1989-04-06
FI93444C (fi) 1995-04-10
JP2660016B2 (ja) 1997-10-08
HK66093A (en) 1993-07-16
GR3003468T3 (en) 1993-02-17
NZ226397A (en) 1990-11-27
PT88614A (pt) 1989-07-31
EG18563A (en) 1993-08-30
DK170376B1 (da) 1995-08-14
CN1032439A (zh) 1989-04-19
CA1340785C (en) 1999-10-12
JPH09315973A (ja) 1997-12-09
IE61045B1 (en) 1994-09-07
DE3866077D1 (de) 1991-12-12
JPH01113367A (ja) 1989-05-02
NO884333D0 (no) 1988-09-29
NO168107B (no) 1991-10-07
MY104933A (en) 1994-07-30
ES2038766T3 (es) 1993-08-01
EP0310386A2 (en) 1989-04-05
EP0310386B1 (en) 1991-11-06
AU6126190A (en) 1990-11-29
EP0310386A3 (en) 1989-11-15

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