DK47186D0 - Alfa-(2-oxo-2,4,5,6,7,7a-hexahydrothieno(3,2-c)-5-pyridyl)phenyleddikesyrederivater og fremgangsmaade til fremstilling deraf samt deres terapeutiske anvendelse - Google Patents

Alfa-(2-oxo-2,4,5,6,7,7a-hexahydrothieno(3,2-c)-5-pyridyl)phenyleddikesyrederivater og fremgangsmaade til fremstilling deraf samt deres terapeutiske anvendelse

Info

Publication number
DK47186D0
DK47186D0 DK47186A DK47186A DK47186D0 DK 47186 D0 DK47186 D0 DK 47186D0 DK 47186 A DK47186 A DK 47186A DK 47186 A DK47186 A DK 47186A DK 47186 D0 DK47186 D0 DK 47186D0
Authority
DK
Denmark
Prior art keywords
phenyledic
hexahydrothieno
alfa
pyridyl
oxo
Prior art date
Application number
DK47186A
Other languages
English (en)
Other versions
DK157553C (da
DK157553B (da
DK47186A (da
Inventor
Alain Badorc
Daniel Frehel
Jean-Pierre Maffrand
Eric Vallee
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of DK47186D0 publication Critical patent/DK47186D0/da
Publication of DK47186A publication Critical patent/DK47186A/da
Publication of DK157553B publication Critical patent/DK157553B/da
Application granted granted Critical
Publication of DK157553C publication Critical patent/DK157553C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DK047186A 1985-01-31 1986-01-30 Alfa-(2-oxo-2,4,5,6,7,7a-hexahydrothieno(3,2-c)-5-pyridyl)phenyleddikesyrer eller derivater deraf og laegemidler indeholdende disse DK157553C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8501908A FR2576901B1 (fr) 1985-01-31 1985-01-31 Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
FR8501908 1985-01-31

Publications (4)

Publication Number Publication Date
DK47186D0 true DK47186D0 (da) 1986-01-30
DK47186A DK47186A (da) 1986-08-01
DK157553B DK157553B (da) 1990-01-22
DK157553C DK157553C (da) 1990-06-11

Family

ID=9316132

Family Applications (1)

Application Number Title Priority Date Filing Date
DK047186A DK157553C (da) 1985-01-31 1986-01-30 Alfa-(2-oxo-2,4,5,6,7,7a-hexahydrothieno(3,2-c)-5-pyridyl)phenyleddikesyrer eller derivater deraf og laegemidler indeholdende disse

Country Status (24)

Country Link
US (1) US4740510A (da)
EP (1) EP0192535A1 (da)
JP (1) JPS61246186A (da)
AU (1) AU581487B2 (da)
CA (1) CA1265517A (da)
CS (1) CS253741B2 (da)
DD (1) DD242229A5 (da)
DK (1) DK157553C (da)
ES (1) ES8703881A1 (da)
FI (1) FI860473A (da)
FR (1) FR2576901B1 (da)
GR (1) GR860287B (da)
HU (1) HU193625B (da)
IL (1) IL77598A (da)
MA (1) MA20619A1 (da)
NO (1) NO162965C (da)
NZ (1) NZ214982A (da)
OA (1) OA08196A (da)
PL (1) PL145159B1 (da)
PT (1) PT81946B (da)
SU (1) SU1389679A3 (da)
TN (1) TNSN86012A1 (da)
YU (1) YU11986A (da)
ZA (1) ZA86407B (da)

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FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
FI101150B (fi) * 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
EP0785205B1 (en) * 1994-10-07 2002-04-17 Ube Industries, Ltd. 2-silyloxytetrahydrothienopyridine, salt thereof, and process for producing the same
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
RU2203887C2 (ru) 1998-02-27 2003-05-10 Санкио Компани, Лимитед Циклические аминопроизводные, фармацевтическая композиция и способ профилактики заболевания
ES2276801T3 (es) 2000-07-06 2007-07-01 Sankyo Company, Limited Sales de adicion acidas de derivados de la hidropiridina.
PL206138B1 (pl) * 2000-12-25 2010-07-30 Daiichi Sankyo Company Limiteddaiichi Sankyo Company Limited Kompozycja farmaceutyczna zawierająca aspirynę oraz zestaw i zastosowanie składników kompozycji
GB0125708D0 (en) * 2001-10-26 2001-12-19 Generics Uk Ltd Novel compounds and processes
CZ302135B6 (cs) * 2007-07-09 2010-11-10 Zentiva, A. S. Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
WO2009062044A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel, and its salts and polymorphs
WO2009066326A2 (en) * 2007-11-19 2009-05-28 Msn Laboratories Limited Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
CN101289454B (zh) * 2008-06-10 2011-02-16 上海医药工业研究院 2-氧-2,4,5,6,7,7α-六氢噻吩并[3,2-c]吡啶的制备方法
DE102008046630A1 (de) * 2008-09-10 2010-03-11 Emitec Gesellschaft Für Emissionstechnologie Mbh Modulares Tanksystem für ein flüssiges Reduktionsmittel mit einem Sumpfelement
CN101402643B (zh) * 2008-11-11 2012-11-28 上海现代制药股份有限公司 一种适于工业生产的普拉格雷的制备方法
CN101402642B (zh) * 2008-11-11 2013-01-09 上海现代制药股份有限公司 一种新型环保制备普拉格雷的方法
CN101402593A (zh) * 2008-11-11 2009-04-08 上海现代制药股份有限公司 用于制备普拉格雷的中间体及其制备方法
CZ2008748A3 (cs) 2008-11-26 2010-06-02 Zentiva, A. S Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c] pyridin-2-yl acetátu, prasugrelu
WO2011042918A2 (en) * 2009-10-07 2011-04-14 Msn Laboratories Limited Novel and improved processes for the preparation of prasugrel, its intermediates and pharmaceutically acceptable salts
HU229031B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel and its intermediate
HU229035B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel
CN102863457B (zh) * 2010-02-02 2013-10-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
EP2545059A1 (en) 2010-03-09 2013-01-16 Synthon BV A process for making prasugrel
CN102212069A (zh) * 2010-04-06 2011-10-12 刘桂坤 环烷衍生物及其制备方法和在心脑血管病药物上的应用
CN101845052B (zh) * 2010-06-11 2012-01-11 天津药物研究院 一类含氮杂环的噻吩并吡啶酮衍生物、其制备方法和用途
NZ606903A (en) * 2010-08-26 2015-05-29 Ipca Lab Ltd Methods for the treatment or prophylaxis of thrombosis or embolism
CN101948479B (zh) * 2010-09-29 2013-01-30 横店集团家园化工有限公司 普拉格雷中间体及其制备方法
CN101985451B (zh) * 2010-11-02 2012-04-25 北京赛科药业有限责任公司 普拉格雷中间体的制备方法
CN102002056B (zh) * 2010-11-02 2012-04-25 北京赛科药业有限责任公司 一种普拉格雷中间体的制备方法
CN102276623A (zh) * 2011-06-13 2011-12-14 安徽省虹升生物科技有限公司 一种利用有机硅保护剂进行制备普拉格雷的新方法
CN104245707A (zh) * 2011-06-27 2014-12-24 Ipca实验室有限公司 抗血栓化合物
CN104341433B (zh) * 2013-08-02 2017-12-15 鲁南制药集团股份有限公司 一种普拉格雷中间体的制备方法
CN104447867B (zh) * 2013-09-17 2017-12-26 江苏天士力帝益药业有限公司 一种噻吩并哌啶衍生物、制备方法及其应用
CN107698620A (zh) 2015-06-23 2018-02-16 江苏天士力帝益药业有限公司 一种氘代噻吩并哌啶衍生物、制备方法及其应用
CN108570060A (zh) * 2018-05-13 2018-09-25 日照市普达医药科技有限公司 一种4,5,6,7-四氢噻吩并[3,2-c]吡啶类衍生物对血栓的治疗作用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2495157A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Procede nouveau de preparation des tetrahydro-5, 6, 7, 7a 4h-thieno (3, 2-c) pyridinones-2
FR2495156A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique
FR2528848A1 (fr) * 1982-06-16 1983-12-23 Sanofi Sa Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung

Also Published As

Publication number Publication date
CS253741B2 (en) 1987-12-17
JPS61246186A (ja) 1986-11-01
DK157553C (da) 1990-06-11
NO162965B (no) 1989-12-04
EP0192535A1 (fr) 1986-08-27
NO860332L (no) 1986-08-01
FR2576901B1 (fr) 1987-03-20
PT81946B (pt) 1987-12-30
MA20619A1 (fr) 1986-10-01
OA08196A (fr) 1987-10-30
SU1389679A3 (ru) 1988-04-15
YU11986A (en) 1987-08-31
ZA86407B (en) 1986-09-24
TNSN86012A1 (fr) 1990-01-01
HU193625B (en) 1987-11-30
IL77598A (en) 1988-12-30
FI860473A0 (fi) 1986-01-31
FR2576901A1 (fr) 1986-08-08
DD242229A5 (de) 1987-01-21
GR860287B (en) 1986-06-02
US4740510A (en) 1988-04-26
CA1265517A (fr) 1990-02-06
FI860473A (fi) 1986-08-01
PL145159B1 (en) 1988-08-31
ES550448A0 (es) 1987-03-01
HUT40440A (en) 1986-12-28
AU5242486A (en) 1986-08-07
PL257691A1 (en) 1986-11-04
ES8703881A1 (es) 1987-03-01
NZ214982A (en) 1988-04-29
DK157553B (da) 1990-01-22
AU581487B2 (en) 1989-02-23
DK47186A (da) 1986-08-01
PT81946A (fr) 1986-02-01
NO162965C (no) 1990-03-14

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