PT81946B - Processo para a preparacao de novos derivados do acido alfa-{2-oxo-2,4,5,6,7,7a-hexahidro-(3,2-c)-tieno-5-piridil}-fenilacetico e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados do acido alfa-{2-oxo-2,4,5,6,7,7a-hexahidro-(3,2-c)-tieno-5-piridil}-fenilacetico e de composicoes farmaceuticas que os contem

Info

Publication number
PT81946B
PT81946B PT81946A PT8194686A PT81946B PT 81946 B PT81946 B PT 81946B PT 81946 A PT81946 A PT 81946A PT 8194686 A PT8194686 A PT 8194686A PT 81946 B PT81946 B PT 81946B
Authority
PT
Portugal
Prior art keywords
thenen
hexahidro
pyridyl
oxo
alpha
Prior art date
Application number
PT81946A
Other languages
English (en)
Other versions
PT81946A (fr
Inventor
Alain Badorc
Daniel Frehel
Jean-Pierre Maffrand
Eric Vallee
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PT81946A publication Critical patent/PT81946A/pt
Publication of PT81946B publication Critical patent/PT81946B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
PT81946A 1985-01-31 1986-01-30 Processo para a preparacao de novos derivados do acido alfa-{2-oxo-2,4,5,6,7,7a-hexahidro-(3,2-c)-tieno-5-piridil}-fenilacetico e de composicoes farmaceuticas que os contem PT81946B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8501908A FR2576901B1 (fr) 1985-01-31 1985-01-31 Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique

Publications (2)

Publication Number Publication Date
PT81946A PT81946A (fr) 1986-02-01
PT81946B true PT81946B (pt) 1987-12-30

Family

ID=9316132

Family Applications (1)

Application Number Title Priority Date Filing Date
PT81946A PT81946B (pt) 1985-01-31 1986-01-30 Processo para a preparacao de novos derivados do acido alfa-{2-oxo-2,4,5,6,7,7a-hexahidro-(3,2-c)-tieno-5-piridil}-fenilacetico e de composicoes farmaceuticas que os contem

Country Status (24)

Country Link
US (1) US4740510A (pt)
EP (1) EP0192535A1 (pt)
JP (1) JPS61246186A (pt)
AU (1) AU581487B2 (pt)
CA (1) CA1265517A (pt)
CS (1) CS253741B2 (pt)
DD (1) DD242229A5 (pt)
DK (1) DK157553C (pt)
ES (1) ES8703881A1 (pt)
FI (1) FI860473A (pt)
FR (1) FR2576901B1 (pt)
GR (1) GR860287B (pt)
HU (1) HU193625B (pt)
IL (1) IL77598A (pt)
MA (1) MA20619A1 (pt)
NO (1) NO162965C (pt)
NZ (1) NZ214982A (pt)
OA (1) OA08196A (pt)
PL (1) PL145159B1 (pt)
PT (1) PT81946B (pt)
SU (1) SU1389679A3 (pt)
TN (1) TNSN86012A1 (pt)
YU (1) YU11986A (pt)
ZA (1) ZA86407B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
FI101150B (fi) * 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
JP3840662B2 (ja) * 1994-10-07 2006-11-01 宇部興産株式会社 ２−シリルオキシ−テトラヒドロチエノピリジン類、その塩およびその製造方法
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
KR100567950B1 (ko) 1998-02-27 2006-04-05 상꾜 가부시키가이샤 환상 아미노화합물
ES2308633T3 (es) 2000-07-06 2008-12-01 Daiichi Sankyo Company, Limited Sal de adicion de maleato de derivados de la hidropiridina.
EP1350511B1 (en) * 2000-12-25 2008-09-10 Daiichi Sankyo Company, Limited Medicinal compositions containing aspirin
GB0125708D0 (en) * 2001-10-26 2001-12-19 Generics Uk Ltd Novel compounds and processes
CZ302135B6 (cs) * 2007-07-09 2010-11-10 Zentiva, A. S. Zpusob výroby 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]pyridin-2-yl acetátu (prasugrelu)
US20100261908A1 (en) * 2007-11-09 2010-10-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel , and its salts and polymorphs
WO2009066326A2 (en) * 2007-11-19 2009-05-28 Msn Laboratories Limited Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
CN101289454B (zh) * 2008-06-10 2011-02-16 上海医药工业研究院 2-氧-2,4,5,6,7,7α-六氢噻吩并[3,2-c]吡啶的制备方法
DE102008046630A1 (de) * 2008-09-10 2010-03-11 Emitec Gesellschaft Für Emissionstechnologie Mbh Modulares Tanksystem für ein flüssiges Reduktionsmittel mit einem Sumpfelement
CN101402593A (zh) * 2008-11-11 2009-04-08 上海现代制药股份有限公司 用于制备普拉格雷的中间体及其制备方法
CN101402642B (zh) * 2008-11-11 2013-01-09 上海现代制药股份有限公司 一种新型环保制备普拉格雷的方法
CN101402643B (zh) * 2008-11-11 2012-11-28 上海现代制药股份有限公司 一种适于工业生产的普拉格雷的制备方法
CZ2008748A3 (cs) 2008-11-26 2010-06-02 Zentiva, A. S Zpusob výroby vysoce cistého 5-[2-cyklopropyl-1-(2-fluorfenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c] pyridin-2-yl acetátu, prasugrelu
WO2011042918A2 (en) * 2009-10-07 2011-04-14 Msn Laboratories Limited Novel and improved processes for the preparation of prasugrel, its intermediates and pharmaceutically acceptable salts
HU229031B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel and its intermediate
HU229035B1 (en) 2009-12-21 2013-07-29 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Process for producing prasurgel
CN102120744B (zh) * 2010-02-02 2013-01-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
EP2545059A1 (en) 2010-03-09 2013-01-16 Synthon BV A process for making prasugrel
CN102212069A (zh) * 2010-04-06 2011-10-12 刘桂坤 环烷衍生物及其制备方法和在心脑血管病药物上的应用
CN101845052B (zh) * 2010-06-11 2012-01-11 天津药物研究院 一类含氮杂环的噻吩并吡啶酮衍生物、其制备方法和用途
BR112013004165B1 (pt) * 2010-08-26 2021-07-20 Ipca Laboratories Limited Composição para o tratamento ou profilaxia da trombose ou embolia
CN101948479B (zh) * 2010-09-29 2013-01-30 横店集团家园化工有限公司 普拉格雷中间体及其制备方法
CN101985451B (zh) * 2010-11-02 2012-04-25 北京赛科药业有限责任公司 普拉格雷中间体的制备方法
CN102002056B (zh) * 2010-11-02 2012-04-25 北京赛科药业有限责任公司 一种普拉格雷中间体的制备方法
CN102276623A (zh) * 2011-06-13 2011-12-14 安徽省虹升生物科技有限公司 一种利用有机硅保护剂进行制备普拉格雷的新方法
EP2675813A4 (en) * 2011-06-27 2014-04-30 Ipca Lab Ltd ANTI THROMBOSIS CONNECTIONS
CN104341433B (zh) * 2013-08-02 2017-12-15 鲁南制药集团股份有限公司 一种普拉格雷中间体的制备方法
CN104447867B (zh) * 2013-09-17 2017-12-26 江苏天士力帝益药业有限公司 一种噻吩并哌啶衍生物、制备方法及其应用
CN107698620A (zh) 2015-06-23 2018-02-16 江苏天士力帝益药业有限公司 一种氘代噻吩并哌啶衍生物、制备方法及其应用
CN108570060A (zh) * 2018-05-13 2018-09-25 日照市普达医药科技有限公司 一种4,5,6,7-四氢噻吩并[3,2-c]吡啶类衍生物对血栓的治疗作用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2495157A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Procede nouveau de preparation des tetrahydro-5, 6, 7, 7a 4h-thieno (3, 2-c) pyridinones-2
FR2495156A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique
FR2528848A1 (fr) * 1982-06-16 1983-12-23 Sanofi Sa Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung

Also Published As

Publication number Publication date
AU581487B2 (en) 1989-02-23
CS253741B2 (en) 1987-12-17
HU193625B (en) 1987-11-30
CA1265517A (fr) 1990-02-06
MA20619A1 (fr) 1986-10-01
ES8703881A1 (es) 1987-03-01
TNSN86012A1 (fr) 1990-01-01
EP0192535A1 (fr) 1986-08-27
DK47186A (da) 1986-08-01
AU5242486A (en) 1986-08-07
DK47186D0 (da) 1986-01-30
YU11986A (en) 1987-08-31
PL257691A1 (en) 1986-11-04
NZ214982A (en) 1988-04-29
SU1389679A3 (ru) 1988-04-15
ZA86407B (en) 1986-09-24
IL77598A (en) 1988-12-30
FR2576901B1 (fr) 1987-03-20
NO162965B (no) 1989-12-04
FR2576901A1 (fr) 1986-08-08
FI860473A0 (fi) 1986-01-31
FI860473A (fi) 1986-08-01
HUT40440A (en) 1986-12-28
DK157553B (da) 1990-01-22
US4740510A (en) 1988-04-26
JPS61246186A (ja) 1986-11-01
GR860287B (en) 1986-06-02
OA08196A (fr) 1987-10-30
PT81946A (fr) 1986-02-01
DK157553C (da) 1990-06-11
DD242229A5 (de) 1987-01-21
ES550448A0 (es) 1987-03-01
NO860332L (no) 1986-08-01
NO162965C (no) 1990-03-14
PL145159B1 (en) 1988-08-31

Similar Documents

Publication Publication Date Title
PT81946B (pt) Processo para a preparacao de novos derivados do acido alfa-{2-oxo-2,4,5,6,7,7a-hexahidro-(3,2-c)-tieno-5-piridil}-fenilacetico e de composicoes farmaceuticas que os contem
PT84698B (pt) Processo para a preparacao de derivados de acido acrilico e de composicoes fungicidas que os contem
PT82941B (pt) Processo para a preparacao de esteres do acido hialuronico e de composicoes farmaceuticas que os contem
PT82226B (pt) Processo para a preparacao de 3-ariluracilos e de composicoes herbicidas que os contem
PT83233B (pt) Processo para a preparacao de derivados de esteres de acido acrilico com efeito fungicida e de composicoes fungicidas que os contem
PT82591B (pt) Processo para a preparacao de derivados do acido ascorbico e de composicoes farmaceuticas que os contem
PT82862B (pt) Processo para a preparacao de produtos de aloes e de composicoes farmaceuticas que os contem
PT93089A (pt) Processo para a preparacao de derivados do acido propenoico e de composicoes fungicidas que os contem
PT84319B (pt) Processo para a preparacao de derivados substituidos de tienoimidazol e de composicoes farmaceuticas que os contem
PT83186B (pt) Processo para a preparacao de uma modificacao estavel de1-isopropil-3-{(4-m-toluidino-3-piridil)-sulfonil}-ureia (torasemida) e de composicoes farmaceuticas que os contem
PT82780B (pt) Processo para a preparacao de derivados heterociclicos de acido acrilico com propriedades fungicidas e de composicoes fungicidas que os contem
PT84704B (pt) Processo para a preparacao de derivados do acido tiolactam-n-acetico e de composicoes farmaceuticas que os contem
PT91287A (pt) Processo de preparacao de derivados do acido indazol-3-carboxilico e de composicoes farmaceuticas que os contem
PT82985B (pt) Processo para a preparacao de derivados de distamicina e de composicoes farmaceuticas que os contem
PT80363B (pt) Processo para a preparacao de derivados de fenol e de composicoes farmaceuticas que os contem
PT81636B (pt) Processo para a preparacao de novos benzotiofenos e benzofurados e de composicoes farmaceuticas que os contem
PT84364B (pt) Processo para a preparacao de derivados do acido 1h-imidazol-5-carboxilico e de composicoes herbicidas que os contem
PT84462B (pt) Rocesso para a preparacao de novos tiazois e oxazois substituidos e de composicoes farmaceuticas que os contem
PT83558B (pt) Processo para a preparacao de derivados da carboxamida e de composicoes farmaceuticas que os contem
PT83604B (pt) Processo para a preparacao de derivados da flavona e de composicoes farmaceuticas que os contem
PT88335A (pt) Processo para a preparacao de derivados do acido 1,4-dihidro-4-oxo-3-quinolinocarboxilico e de composicoes farmaceuticas que os contem
PT82901B (pt) Processo para a preparacao de derivados do acido antranilico dotados de accao terapeutica e de composicoes farmaceuticas que os contem
PT82399B (pt) Processo para a preparacao de derivados de fenetanolamina e de composicoes farmaceuticas que os contem
PT82440B (pt) Processo para a preparacao de eteres ciclopentilicos e de composicoes farmaceuticas que os contem
PT83565B (pt) Processo para a preparacao de derivados do acido aril-heterociclil-alcoxi-acetico e de composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19911205