DK382986A - Aktivering af makrofag tumoricid aktivitet med granulocytmakrofag kolonistimulationsfaktor - Google Patents

Aktivering af makrofag tumoricid aktivitet med granulocytmakrofag kolonistimulationsfaktor Download PDF

Info

Publication number
DK382986A
DK382986A DK382986A DK382986A DK382986A DK 382986 A DK382986 A DK 382986A DK 382986 A DK382986 A DK 382986A DK 382986 A DK382986 A DK 382986A DK 382986 A DK382986 A DK 382986A
Authority
DK
Denmark
Prior art keywords
granulocyte
stimulating factor
colony stimulating
macrophag
macrophage colony
Prior art date
Application number
DK382986A
Other languages
English (en)
Other versions
DK382986D0 (da
DK174603B1 (da
Inventor
Dirk M Anderson
Michael A Cantrell
Douglas P Cerretti
Iii Paul J Conlon
David J Cosman
Kenneth H Grabstein
Alf D Larsen
Virginia L Price
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27117812&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK382986(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunex Corp filed Critical Immunex Corp
Publication of DK382986D0 publication Critical patent/DK382986D0/da
Publication of DK382986A publication Critical patent/DK382986A/da
Application granted granted Critical
Publication of DK174603B1 publication Critical patent/DK174603B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/53Colony-stimulating factor [CSF]
    • C07K14/535Granulocyte CSF; Granulocyte-macrophage CSF
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827Proteins from mammals or birds
    • Y10S530/828Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198603829A 1985-08-16 1986-08-11 Anvendelse af granulocyt makrofag kolonistimulerende faktor til fremstilling af et medikament til fremme af tumoricid aktivitet DK174603B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76689385A 1985-08-16 1985-08-16
US76689385 1985-08-16
US88899586 1986-07-31
US06/888,995 US5078996A (en) 1985-08-16 1986-07-31 Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor

Publications (3)

Publication Number Publication Date
DK382986D0 DK382986D0 (da) 1986-08-11
DK382986A true DK382986A (da) 1987-02-17
DK174603B1 DK174603B1 (da) 2003-07-14

Family

ID=27117812

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198603829A DK174603B1 (da) 1985-08-16 1986-08-11 Anvendelse af granulocyt makrofag kolonistimulerende faktor til fremstilling af et medikament til fremme af tumoricid aktivitet

Country Status (8)

Country Link
US (1) US5078996A (da)
EP (1) EP0211684B1 (da)
JP (1) JPH0780781B2 (da)
AT (1) ATE77958T1 (da)
AU (1) AU586876B2 (da)
CA (1) CA1341142C (da)
DE (1) DE3685918T2 (da)
DK (1) DK174603B1 (da)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2130493C1 (ru) * 1984-07-06 1999-05-20 Новартис Аг Способ получения белка с активностью gm-csf приматов
US5795568A (en) * 1984-09-19 1998-08-18 Novartis Corporation Method of treating infectious disease with GM-CSF
US5556620A (en) * 1985-02-05 1996-09-17 Cetus Oncology Corporation Use of recombinant colony stimulating factor-1 to enhance wound healing
US5104650A (en) * 1985-02-05 1992-04-14 Cetus Corporation Uses of recombinant colony stimulating factor-1
US5837229A (en) * 1985-02-05 1998-11-17 Chiron Corporation Uses of recombinant colony stimulating factor-1
US5422105A (en) * 1985-02-05 1995-06-06 Cetus Oncology Corporation Use of recombinant colony stimulating factor 1
US5093115A (en) * 1985-06-11 1992-03-03 The United States Of America As Represented By The Department Of Health And Human Services Method of preparing activated killer monocytes for treating colorectal cancer
US5391706A (en) * 1987-07-16 1995-02-21 Schering Plough Corporation Purification of GM-CSF
WO1989004173A1 (en) * 1987-11-12 1989-05-18 Schering Corporation Acceleration of bone formation with gm-csf
BE1002141A5 (fr) * 1988-01-13 1990-07-31 Bartholeyns Jacques Procede de culture et d'activation de cellules humaines et conditionnement pour le traitement du cancer.
JPH01193227A (ja) * 1988-01-29 1989-08-03 Res Dev Corp Of Japan 癌免疫療法補助剤
AU4219689A (en) * 1988-08-19 1990-03-23 Genetics Institute Inc. Treatment for malignant melanoma
GB8824591D0 (en) * 1988-10-20 1988-11-23 Royal Free Hosp School Med Fractionation process
DK0382381T3 (da) * 1989-01-30 1993-07-12 Schering Corp Behandling af leukocyt-dysfunktion med GM-CSF
US5154921A (en) * 1990-07-13 1992-10-13 Dana-Farber Cancer Institute, Inc. Promotion of maturation of hematopoietic progenitor cells
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5637483A (en) * 1991-10-04 1997-06-10 Whitehead Institute For Biomedical Research Irradiated tumor cell vaccine engineered to express GM-CSF
US5904920A (en) * 1991-10-04 1999-05-18 Whitehead Institute For Biomedical Research Regulation of systemic immune responses utilizing cytokines and antigens
US5292513A (en) * 1992-05-18 1994-03-08 Anthony G. Gristina Method for nonspecific cellular immune stimulation
US6001351A (en) * 1993-05-18 1999-12-14 I.D.M. Immuno-Designed Molecules Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
DE9390311U1 (de) * 1993-05-18 1996-05-09 I.D.M. Immuno-Designed Molecules, Paris Neue Makrophagen mit Eignung als Wirkstoffe von pharmazeutischen Zusammensetzungen
US6103694A (en) * 1995-07-21 2000-08-15 The United States Of America As Represented By The Department Of Health And Human Services Method of decreasing radiation of radio-mimetic chemotherapy for hematopoietic pluripotent cell engraftment
US5800812A (en) * 1995-09-15 1998-09-01 Yeda Research And Development Co. Ltd. Methods of use of mononuclear phagocytes to promote axonal regeneration
US6267955B1 (en) 1995-09-15 2001-07-31 Yeda Research And Development Co. Ltd. Mononuclear phagocytes and their use to promote axonal regeneration
US5942253A (en) * 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
US6080409A (en) * 1995-12-28 2000-06-27 Dendreon Corporation Immunostimulatory method
US6821516B1 (en) 1997-07-18 2004-11-23 I.D.M. Immuno-Designed Molecules Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
US5891432A (en) 1997-07-29 1999-04-06 The Immune Response Corporation Membrane-bound cytokine compositions comprising GM=CSF and methods of modulating an immune response using same
JP2002529707A (ja) * 1998-11-03 2002-09-10 セル ジェネシス インコーポレイテッド 癌関連抗原およびそれらの同定の方法
WO2000069456A2 (en) * 1999-05-13 2000-11-23 American Cyanamid Company Adjuvant combination formulations
CA2721011A1 (en) 1999-10-22 2001-05-03 Aventis Pasteur Limited Modified gp100 and uses thereof
US6911204B2 (en) * 2000-08-11 2005-06-28 Favrille, Inc. Method and composition for altering a B cell mediated pathology
EP1309373A2 (en) * 2000-08-11 2003-05-14 Favrille, Inc. Method and composition for altering a t cell mediated pathology
HUP0600589A2 (en) 2000-11-10 2006-11-28 Wyeth Corp Adjuvant combination formulations
US20070128229A1 (en) * 2002-04-12 2007-06-07 Wyeth Surface proteins of Streptococcus pyogenes
JP2004533236A (ja) * 2001-04-13 2004-11-04 ワイエス 化膿性連鎖球菌(Streptococcuspyogenes)の表面タンパク質
EP2258842A1 (en) 2001-04-16 2010-12-08 Wyeth Holdings Corporation Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
MXPA04008890A (es) * 2002-03-15 2005-10-18 Wyeth Corp Mutantes de la proteina p4 de haemophilus influenzae no tipicable con actividad enzimatica reducida.
US7785608B2 (en) * 2002-08-30 2010-08-31 Wyeth Holdings Corporation Immunogenic compositions for the prevention and treatment of meningococcal disease
US7301554B2 (en) * 2002-09-20 2007-11-27 Ricoh Company, Ltd. Light scanning device, scanning line adjusting method, scanning line adjusting control method, image forming apparatus, and image forming method
EP1551444B1 (en) 2002-10-16 2018-03-21 Samuel F. Hunter Method for treatment of demyelinating central nervous system disease using gm-csf
US20040197312A1 (en) 2003-04-02 2004-10-07 Marina Moskalenko Cytokine-expressing cellular vaccine combinations
WO2005020902A2 (en) * 2003-08-21 2005-03-10 Cytokine Pharmasciences, Inc. Compositions and methods for treating and diagnosing irritable bowel syndrome
HUE026000T2 (en) 2003-12-17 2016-04-28 Wyeth Llc Immunogenic peptide-bearing conjugates and methods for their preparation
SG182189A1 (en) 2003-12-17 2012-07-30 Elan Pharma Int Ltd A(beta) immunogenic peptide carrier conjugates and methods of producing same
PL2295056T3 (pl) * 2004-03-15 2016-07-29 Sunesis Pharmaceuticals Inc Zastosowanie SNS-595 do leczenia białaczki
GB0410220D0 (en) 2004-05-07 2004-06-09 Kirkham Lea Ann Mutant pneumolysin proteins
US7674456B2 (en) * 2004-06-14 2010-03-09 Charles Wiseman Breast cancer cell lines and uses thereof
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
EP1768700B1 (en) * 2004-07-16 2010-12-15 Nektar Therapeutics Conjugates comprising gm-csf and a polymer
US20060062764A1 (en) * 2004-08-25 2006-03-23 Seshidar-Reddy Police Fiber-modified adenoviral vectors for enhanced transduction of tumor cells
US20060057127A1 (en) * 2004-09-10 2006-03-16 Pocheng Liu Cytokine-expressing cellular vaccines for treatment of prostate cancer
EP1802335A2 (en) 2004-10-21 2007-07-04 Wyeth a Corporation of the State of Delaware Immunogenic compositions of staphylococcus epidermidis polypeptide and polynucleotide antigens
US20080193376A1 (en) * 2004-10-28 2008-08-14 The General Hospital Corporation Methods of Enhanced Detection and Therapy of Inflamed Tissues Using Immune Modulation
US20080260650A1 (en) * 2004-10-28 2008-10-23 The General Hospital Corporation Methods of Detection and Therapy of Inflamed Tissues Using Immune Modulation
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
US9868961B2 (en) 2006-03-30 2018-01-16 The Regents Of The University Of California Methods and compositions for localized secretion of anti-CTLA-4 antibodies
US7919079B2 (en) 2006-03-31 2011-04-05 Biosante Pharmaceuticals, Inc. Cancer immunotherapy compositions and methods of use
US20070231298A1 (en) * 2006-03-31 2007-10-04 Cell Genesys, Inc. Cytokine-expressing cancer immunotherapy combinations
TW200806315A (en) * 2006-04-26 2008-02-01 Wyeth Corp Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
US8124773B2 (en) 2006-06-12 2012-02-28 Sunesis Pharmaceuticals, Inc. 1,8-naphthyridine compounds for the treatment of cancer
PT2495307T (pt) 2006-07-13 2018-05-10 Wyeth Llc Produção do fator ix de coagulação com padrão melhorado de glicosilação
EP2395077A1 (en) 2006-11-03 2011-12-14 Wyeth LLC Glycolysis-inhibiting substances in cell culture
ES2528166T3 (es) * 2006-11-15 2015-02-04 Eli Lilly And Company Métodos y composiciones para tratar la gripe
AR064642A1 (es) 2006-12-22 2009-04-15 Wyeth Corp Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
AU2008223133A1 (en) 2007-03-02 2008-09-12 Wyeth Use of copper and glutamate in cell culture for production of polypeptides
EP2117579A4 (en) * 2007-03-07 2011-08-24 Mayo Foundation TREATMENT OF CANCER USING A GRANULOCYTIC MACROPHAGE COLONY STIMULATING FACTOR
US20100255513A1 (en) * 2007-03-30 2010-10-07 Denson Lee A Serological markers of inflammatory bowel disease phenotype and disease progression
US20080267935A1 (en) * 2007-04-06 2008-10-30 Cell Genesys, Inc. AraC in combination with a cytokine-secreting cell and methods of use thereof
US20090028857A1 (en) * 2007-07-23 2009-01-29 Cell Genesys, Inc. Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
US8425897B2 (en) * 2007-08-30 2013-04-23 Immutep S.A. Compositions containing LAG-3 and cells that secrete GM-CSF and methods of use
AU2008340319A1 (en) * 2007-12-21 2009-07-02 Wyeth Llc Genetically modified attenuated vesicular stomatitis virus, compositions and methods of use thereof
CN102316894A (zh) 2008-06-20 2012-01-11 惠氏有限责任公司 来自β-溶血性链球菌菌株的ORF1358的组合物和使用方法
CN102203122A (zh) 2008-11-05 2011-09-28 惠氏有限责任公司 用于预防β-溶血链球菌(BHS)疾病的多组分免疫原性组合物
RU2531234C2 (ru) 2009-06-22 2014-10-20 ВАЙЕТ ЭлЭлСи КОНЪЮГАТ ПОЛИСАХАРИД-БЕЛОК ДЛЯ ИНДУЦИРОВАНИЯ ИММУННОГО ОТВЕТА И ЗАЩИТЫ ПРОТИВ ИНФЕКЦИИ Staphylococcus aureus, СПОСОБЫ ПОЛУЧЕНИЯ КОНЪЮГАТА (ВАРИАНТЫ), КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ КОНЪЮГАТ И СПОСОБЫ ИНДУЦИРОВАНИЯ ИММУННОГО ОТВЕТА И ПРЕДОТВРАЩЕНИЯ ИНФЕКЦИИ Staphylococcus aureus
TWI469789B (zh) 2009-06-22 2015-01-21 Wyeth Llc 金黃色葡萄球菌抗原之免疫原性組合物
EP2335730A1 (en) 2009-12-18 2011-06-22 Deutsches Krebsforschungszentrum Fusion polypeptides and their use for prevention and treatment of cancer
PL2575870T3 (pl) 2010-06-04 2017-05-31 Wyeth Llc Preparaty szczepionek
SI3246044T2 (sl) 2010-08-23 2024-06-28 Wyeth Llc Stabilne formulacije antigenov neisseria meningitidis RLP2086
ES2585328T5 (es) 2010-09-10 2022-12-14 Wyeth Llc Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis
EP2654784B1 (en) 2010-12-22 2016-12-07 Wyeth LLC Stable immunogenic compositions of staphylococcus aureus antigens
ITMI20111182A1 (it) 2011-06-28 2012-12-29 Canio Buonavoglia Vaccino per coronavirus canino
RU2665841C2 (ru) 2012-03-09 2018-09-04 Пфайзер Инк. Композиции neisseria meningitidis и способы их применения
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
MX2015000789A (es) 2012-07-19 2015-05-07 Zoetis Llc Composiciones de virus de la gripe bovina.
AU2013295770A1 (en) 2012-07-27 2015-01-29 Zoetis Services Llc Tick toxin compositions
EP4169929A1 (en) 2012-12-20 2023-04-26 Pfizer Inc. Immunogenic compositions comprising pn-serotype 12f
WO2014102799A1 (en) 2012-12-30 2014-07-03 Carmel-Haifa University Economic Corporation Ltd CD11blow MACROPHAGES AND CONDITIONED MEDIA THEREOF FOR TREATING CANCER AND/OR FIBROSIS
JP6446377B2 (ja) 2013-03-08 2018-12-26 ファイザー・インク 免疫原性融合ポリペプチド
JP2016512841A (ja) 2013-03-15 2016-05-09 ゾエティス・サービシーズ・エルエルシー 多価ワクチンによるb.トレハロシ感染に対するウシの干渉効果
DE102013004595A1 (de) 2013-03-15 2014-09-18 Emergent Product Development Germany Gmbh RSV-Impfstoffe
EP3041502A2 (en) 2013-09-08 2016-07-13 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
GB201322626D0 (en) 2013-12-19 2014-02-05 Immutep S A Combined preparations for the treatment of cancer
WO2016130569A1 (en) 2015-02-09 2016-08-18 Mj Biologics, Inc. A composition comprising pedv antigens and methods for making and using the composition
WO2015138455A1 (en) 2014-03-11 2015-09-17 Regents Of The University Of Minnesota Porcine epidemic diarrhea virus vaccines and methods of use thereof
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer
RU2723045C2 (ru) 2015-02-19 2020-06-08 Пфайзер Инк. Композиции neisseria meningitidis и способы их получения
EP3268380B1 (en) 2015-03-12 2018-12-26 Zoetis Services LLC Pyolysin methods and compositions
IL297740A (en) 2015-05-04 2022-12-01 Pfizer Protein-polysaccharide conjugates of group b streptococcus, methods for preparing the conjugates, immunogenic preparations containing conjugates and their uses
CN108135989B (zh) 2015-08-14 2022-08-09 硕腾服务有限责任公司 牛支原体组合物
WO2017123201A1 (en) 2016-01-11 2017-07-20 Zoetis Services Llc Novel cross protective vaccine compositions for porcine epidemic diarrhea virus
WO2017210215A1 (en) 2016-05-31 2017-12-07 The Government Of The United States Of America As Represented By The Secretary Of The Army Zika virus vaccine and methods of production
CN109789097B (zh) 2016-10-05 2021-05-18 硕腾服务有限责任公司 提供用作强效活疫苗的稳定脱水的原生动物的冻干方法
US10751402B2 (en) 2016-11-09 2020-08-25 Pfizer Inc. Immunogenic compositions and uses thereof
IL267733B2 (en) 2017-01-31 2023-10-01 Pfizer NEISSERIA MENINGITIDIS preparations and methods therefor
GB201703529D0 (en) 2017-03-06 2017-04-19 Cambridge Entpr Ltd Vaccine composition
WO2021211279A1 (en) 2020-04-17 2021-10-21 Regents Of The University Of Minnesota SARS-CoV-2 SPIKE RECEPTOR BINDING DOMAIN AND COMPOSITIONS AND METHODS THEREOF
CA3192786A1 (en) 2020-08-26 2022-03-03 Pfizer Inc. Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof
EP4241790A1 (en) 2022-03-07 2023-09-13 InnaTher Gene Therapy S.à.r.l. Expression system for the treatment of cancer
EP4241791A1 (en) 2022-03-07 2023-09-13 InnaTher Gene Therapy S.à.r.l. Combined gene and radio therapy for the treatment of cancer
WO2024069420A2 (en) 2022-09-29 2024-04-04 Pfizer Inc. Immunogenic compositions comprising an rsv f protein trimer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342828A (en) * 1979-07-20 1982-08-03 Morinaga Milk Industry Co., Ltd. Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
JPS59137417A (ja) * 1983-01-28 1984-08-07 Morinaga Milk Ind Co Ltd 人尿由来コロニ−形成刺激因子及びカリクレインの製造法
JPS59169489A (ja) * 1983-03-15 1984-09-25 Otsuka Pharmaceut Co Ltd ヒト培養株化細胞
AU594014B2 (en) * 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
PT81513B (pt) * 1984-11-20 1988-03-03 Schering Biotech Corp Clones de dna codificando polipeptideos que apresentam actividade de factor de crescimento celular para granulocitos, madrofagos e eosinofilos humanos
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
DE3545568A1 (de) * 1985-12-21 1987-07-16 Hoechst Ag Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung

Also Published As

Publication number Publication date
EP0211684A3 (en) 1988-06-08
DE3685918D1 (de) 1992-08-13
DK382986D0 (da) 1986-08-11
AU586876B2 (en) 1989-07-27
EP0211684A2 (en) 1987-02-25
JPH0780781B2 (ja) 1995-08-30
US5078996A (en) 1992-01-07
CA1341142C (en) 2000-11-21
JPS6289621A (ja) 1987-04-24
AU6103186A (en) 1987-02-19
DK174603B1 (da) 2003-07-14
ATE77958T1 (de) 1992-07-15
EP0211684B1 (en) 1992-07-08
DE3685918T2 (de) 1993-02-04

Similar Documents

Publication Publication Date Title
DK382986A (da) Aktivering af makrofag tumoricid aktivitet med granulocytmakrofag kolonistimulationsfaktor
Hiltz et al. α-MSH peptides inhibit acute inflammation induced in mice by rIL-1β, rIL-6, rTNF-α and endogenous pyrogen but not that caused by LTB4, PAF and rIL-8
ATE81984T1 (de) Verwendung von granulozyt-makrophagen-kolonie erregenden faktor zur herstellung eines medikaments zur behandlung von bakterieller krankheiten.
DE69333321D1 (de) Verwendung eines Consensus-Interferons zur Reduzierung der Nebeneffekte in der Interferon Behandlung von viralen Hepatiten.
ATE74510T1 (de) Adoptivimmuntherapie als behandlungsmodalitaet bei menschen.
DE69034018D1 (de) Kombinierte verwendung von hyaluronsäure und therapeutischen wirkstoffen zur verbesserung des therapeutischen effekts
HUT38125A (en) Process for preparing lymphokines /cytotoxic factors/ and pharmaceutical compositions containing such active substance
NO880929D0 (no) Produksjon og bruk av il-6.
Hideo et al. Production of an interleukin-8-like chemokine by cytokine-stimulated rat NRK-49F fibroblasts and its suppression by anti-inflammatory steroids
Ralph et al. Molecular and biological properties of human macrophage growth factor, CSF-1
Rathjen et al. Differential effects of small tumour necrosis factor-alpha peptides on tumour cell cytotoxicity, neutrophil activation and endothelial cell procoagulant activity.
Morita et al. lnterleukin-8 Production from Cultured Human Dermal Fibroblasts by Stimulation with Supernatant of Cultured Human Epidermal Cells
EP0502599A1 (en) Use of IL-4 to enhance the reparitive phase of wound healing and repair and to enhance the healing of infected wounds and the wounds of diabetic mammals
MY107071A (en) Treatment of squamous cell carcinoma intralesionally with recombinant human alpha interferon
Hornicek et al. Production and partial characterization of interleukin 2 induced by periodic acid oxidation of lymphocyte membranes
Seki et al. Induction of eosinophil chemotactic factor production from human peripheral blood mononuclear cells by solubilized BALL-1, a B cell lymphoma line
IT1212658B (it) Procedimento per la purificazione di una sostanza fisiologicamente attiva avente attivita antitumorale
Uenoa et al. AB Cell Lymphoma Line, BALL-1 Stimulates! Cells to Produce a Unique Eosinophil Chemotactic Factor
Iwasaka et al. Antitumor activities of human recombinant Interferon‐γ against cervical tumor transplanted into nude mice
Fujikawa et al. Augmentation of depressed lymphokine activated killer activity by continuous intravenous-administration of recombinant interleukin 2 to patients with hepatocellular carcinoma
DE68918197D1 (de) Methode zur Herstellung von rekombinantem menschlichem beta-Interleukin-1 in homogener Form.
Arimoto et al. Effect of Combination Therapy with OK-432 and Recombinant Interleukin-2 (rIL-2) by Splenic Injection to Inhibit Liver Metastasis on Mouse Model In Comparison to Subcutaneous Injection
IT1283945B1 (it) Uso dell'interferone alfa naturale umano da cellule linfoblastoidi per la terapia delle epatiti virali, neoplasie e sindromi da
SU1356291A1 (ru) Способ получения интерферона
ATE46260T1 (de) Rueckenstuetze zur physikalischen therapie von erkrankungen der wirbelsaeule.

Legal Events

Date Code Title Description
PUP Patent expired