DK3653617T3 - Fremgangsmåde til fremstillingen af (s)-nikotin fra myosmin - Google Patents
Fremgangsmåde til fremstillingen af (s)-nikotin fra myosmin Download PDFInfo
- Publication number
- DK3653617T3 DK3653617T3 DK18206826.2T DK18206826T DK3653617T3 DK 3653617 T3 DK3653617 T3 DK 3653617T3 DK 18206826 T DK18206826 T DK 18206826T DK 3653617 T3 DK3653617 T3 DK 3653617T3
- Authority
- DK
- Denmark
- Prior art keywords
- myosmin
- nicotin
- procedure
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Addiction (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18206826.2A EP3653617B1 (en) | 2018-11-16 | 2018-11-16 | Process for the preparation of (s)-nicotin from myosmine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3653617T3 true DK3653617T3 (da) | 2020-12-07 |
Family
ID=64331961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18206826.2T DK3653617T3 (da) | 2018-11-16 | 2018-11-16 | Fremgangsmåde til fremstillingen af (s)-nikotin fra myosmin |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP3653617B1 (da) |
| JP (1) | JP7068554B2 (da) |
| KR (1) | KR102393478B1 (da) |
| CN (2) | CN118005607A (da) |
| AU (1) | AU2019382117B2 (da) |
| BR (1) | BR112021009328B1 (da) |
| CA (1) | CA3118774C (da) |
| DK (1) | DK3653617T3 (da) |
| ES (1) | ES2836481T3 (da) |
| HR (1) | HRP20201895T1 (da) |
| HU (1) | HUE051799T2 (da) |
| MX (1) | MX2021005584A (da) |
| PL (1) | PL3653617T3 (da) |
| PT (1) | PT3653617T (da) |
| SI (1) | SI3653617T1 (da) |
| WO (1) | WO2020098978A1 (da) |
| ZA (1) | ZA202103223B (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113373188B (zh) * | 2020-03-10 | 2024-02-20 | 重庆博腾制药科技股份有限公司 | 一种(s)-尼古丁的合成方法 |
| CN112795603B (zh) * | 2020-12-14 | 2022-06-24 | 山东金城医药化工有限公司 | 一种制备(s)-2-(3-吡啶)-吡咯烷的方法 |
| US20220154231A1 (en) * | 2020-11-18 | 2022-05-19 | Shandong Jincheng Pharmaceutical Chemical Co., Ltd | Methods for preparing nicotine and intermediates thereof |
| CN112409327A (zh) * | 2020-11-18 | 2021-02-26 | 山东金城医药化工有限公司 | 一种高光学纯度烟碱的制备方法 |
| CN115404250A (zh) * | 2021-05-29 | 2022-11-29 | 重庆博腾制药科技股份有限公司 | 一种利用还原方式制备(s)-尼古丁的方法 |
| CN115404249A (zh) * | 2021-05-29 | 2022-11-29 | 重庆博腾制药科技股份有限公司 | 一种(s)-尼古丁中间体的制备方法及其应用 |
| CN115491364A (zh) | 2021-06-20 | 2022-12-20 | 陈泽聪 | 亚胺还原酶突变体、亚胺还原酶和葡萄糖脱氢酶共表达酶及其应用 |
| CN115927216A (zh) * | 2021-08-10 | 2023-04-07 | 深圳瑞德林生物技术有限公司 | 一种s-尼古丁的制备方法 |
| CN114195759B (zh) * | 2021-08-26 | 2023-10-20 | 上海零诺生物科技有限公司 | 一种2-甲基-5-（1-甲基吡咯烷-2-基）吡啶制备方法 |
| CN113999084B (zh) * | 2021-11-03 | 2024-04-16 | 成昌梅 | 一种（s）-（-）-尼古丁的合成制备方法 |
| CN114437029A (zh) * | 2022-01-24 | 2022-05-06 | 深圳市华加生物科技有限公司 | 不对称合成手性尼古丁的制备方法及手性尼古丁 |
| CN114807265A (zh) * | 2022-03-31 | 2022-07-29 | 上海锐康生物技术研发有限公司 | 一种s-烟碱的合成方法 |
| CN114671852A (zh) * | 2022-04-24 | 2022-06-28 | 仙居两山生物科技有限公司 | 一种高纯度左旋烟碱医药中间体的制备方法 |
| CN114702475B (zh) * | 2022-05-17 | 2023-12-26 | 大连天源基化学有限公司 | 一种单一构型烟碱的合成工艺 |
| EP4332098A1 (en) | 2022-08-31 | 2024-03-06 | Siegfried AG | Chiral synthesis of nornicotine and nicotine |
| CN116218803B (zh) * | 2023-01-31 | 2024-03-19 | 河北工业大学 | 亚胺还原酶及其制备方法和编码亚胺还原酶的dna |
| CN115820762B (zh) | 2023-02-20 | 2023-05-16 | 山东金城医药化工有限公司 | 合成(s)-烟碱及其中间体的方法 |
| CN116217544B (zh) * | 2023-05-08 | 2023-08-29 | 济南悟通生物科技有限公司 | 一种(s)-降烟碱的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102617547B (zh) | 2011-01-27 | 2016-02-10 | 上海特化医药科技有限公司 | 一种制备消旋尼古丁的方法 |
| US8378111B2 (en) | 2011-02-02 | 2013-02-19 | Divi's Laboratories, Ltd. | Process for the resolution of (R,S)-nicotine |
| US8367837B2 (en) * | 2011-02-14 | 2013-02-05 | Divi's Laboratories, Ltd. | Process for the preparation of (R,S)-nicotine |
| CN104428313B (zh) | 2012-05-11 | 2017-11-17 | 科德克希思公司 | 工程化亚胺还原酶以及用于酮和胺化合物的还原胺化的方法 |
| IL225900A0 (en) | 2013-04-22 | 2014-03-31 | Perrigo Api Ltd | A process for the preparation of nicotine that includes the enzymatic reduction of 4-(methylamino)-1-(3-pyridinyl)-1-butanone |
| JP6643987B2 (ja) | 2013-11-13 | 2020-02-12 | コデクシス， インコーポレイテッド | ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法 |
| US9556142B2 (en) | 2014-10-22 | 2017-01-31 | Next Generation Labs, LLC | Process for the preparation of (R,S)-nicotine |
-
2018
- 2018-11-16 HU HUE18206826A patent/HUE051799T2/hu unknown
- 2018-11-16 SI SI201830153T patent/SI3653617T1/sl unknown
- 2018-11-16 EP EP18206826.2A patent/EP3653617B1/en active Active
- 2018-11-16 DK DK18206826.2T patent/DK3653617T3/da active
- 2018-11-16 PT PT182068262T patent/PT3653617T/pt unknown
- 2018-11-16 ES ES18206826T patent/ES2836481T3/es active Active
- 2018-11-16 PL PL18206826T patent/PL3653617T3/pl unknown
-
2019
- 2019-03-12 MX MX2021005584A patent/MX2021005584A/es unknown
- 2019-03-12 CN CN202410133134.4A patent/CN118005607A/zh active Pending
- 2019-03-12 AU AU2019382117A patent/AU2019382117B2/en active Active
- 2019-03-12 BR BR112021009328-1A patent/BR112021009328B1/pt active IP Right Grant
- 2019-03-12 WO PCT/EP2019/056194 patent/WO2020098978A1/en active Application Filing
- 2019-03-12 KR KR1020217018020A patent/KR102393478B1/ko active IP Right Review Request
- 2019-03-12 CA CA3118774A patent/CA3118774C/en active Active
- 2019-03-12 CN CN201980058561.8A patent/CN113272289A/zh active Pending
- 2019-03-12 JP JP2021526250A patent/JP7068554B2/ja active Active
-
2020
- 2020-11-27 HR HRP20201895TT patent/HRP20201895T1/hr unknown
-
2021
- 2021-05-12 ZA ZA2021/03223A patent/ZA202103223B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3653617B1 (en) | 2020-10-28 |
| KR102393478B1 (ko) | 2022-05-03 |
| CA3118774C (en) | 2022-02-08 |
| SI3653617T1 (sl) | 2021-01-29 |
| WO2020098978A1 (en) | 2020-05-22 |
| CA3118774A1 (en) | 2020-05-22 |
| JP2022507375A (ja) | 2022-01-18 |
| ES2836481T3 (es) | 2021-06-25 |
| BR112021009328A2 (pt) | 2021-08-17 |
| ZA202103223B (en) | 2022-10-26 |
| PL3653617T3 (pl) | 2021-04-06 |
| EP3653617A1 (en) | 2020-05-20 |
| BR112021009328B1 (pt) | 2022-05-10 |
| HUE051799T2 (hu) | 2021-03-29 |
| CN118005607A (zh) | 2024-05-10 |
| JP7068554B2 (ja) | 2022-05-16 |
| PT3653617T (pt) | 2020-12-11 |
| MX2021005584A (es) | 2022-02-25 |
| CN113272289A (zh) | 2021-08-17 |
| HRP20201895T1 (hr) | 2021-04-16 |
| KR20210082532A (ko) | 2021-07-05 |
| AU2019382117B2 (en) | 2021-05-27 |
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