DK3385395T3 - Fremgangsmåder til behandling af cancerpatienter med farnesyltransferase-inhibitorer - Google Patents

Fremgangsmåder til behandling af cancerpatienter med farnesyltransferase-inhibitorer Download PDF

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Publication number
DK3385395T3
DK3385395T3 DK18173134.0T DK18173134T DK3385395T3 DK 3385395 T3 DK3385395 T3 DK 3385395T3 DK 18173134 T DK18173134 T DK 18173134T DK 3385395 T3 DK3385395 T3 DK 3385395T3
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farcyl
methods
treating cancer
cancer patients
transferase inhibitors
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DK18173134.0T
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Danish (da)
English (en)
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Antonio Gualberto
Catherine Rose Scholz
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Kura Oncology Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK18173134.0T 2015-08-17 2016-08-16 Fremgangsmåder til behandling af cancerpatienter med farnesyltransferase-inhibitorer DK3385395T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562206194P 2015-08-17 2015-08-17
US201562218927P 2015-09-15 2015-09-15
US201562241019P 2015-10-13 2015-10-13
US201662310582P 2016-03-18 2016-03-18
US201662372662P 2016-08-09 2016-08-09
EP16757791.5A EP3277842B9 (en) 2015-08-17 2016-08-16 Methods of treating cancer patients with farnesyl transferase inhibitors

Publications (1)

Publication Number Publication Date
DK3385395T3 true DK3385395T3 (da) 2020-04-20

Family

ID=56802700

Family Applications (3)

Application Number Title Priority Date Filing Date
DK16757791.5T DK3277842T5 (da) 2015-08-17 2016-08-16 Fremgangsmåder til at behandle kræftpatienter med farnesyl-transferase-inhibitorer
DK19210527.8T DK3640345T3 (da) 2015-08-17 2016-08-16 Fremgangsmåder til at behandle kræftpatienter med farnesyltransferaseinhibitorer
DK18173134.0T DK3385395T3 (da) 2015-08-17 2016-08-16 Fremgangsmåder til behandling af cancerpatienter med farnesyltransferase-inhibitorer

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK16757791.5T DK3277842T5 (da) 2015-08-17 2016-08-16 Fremgangsmåder til at behandle kræftpatienter med farnesyl-transferase-inhibitorer
DK19210527.8T DK3640345T3 (da) 2015-08-17 2016-08-16 Fremgangsmåder til at behandle kræftpatienter med farnesyltransferaseinhibitorer

Country Status (28)

Country Link
US (7) US10471055B2 (ja)
EP (4) EP3385395B9 (ja)
JP (4) JP6630742B2 (ja)
KR (4) KR102125496B1 (ja)
CN (5) CN114107497A (ja)
AU (3) AU2016308564B2 (ja)
CA (1) CA2985123C (ja)
CY (3) CY1122037T1 (ja)
DK (3) DK3277842T5 (ja)
EA (1) EA201890512A1 (ja)
ES (3) ES2901506T3 (ja)
HK (1) HK1254087A1 (ja)
HR (3) HRP20211976T1 (ja)
HU (3) HUE044698T2 (ja)
IL (1) IL257547B (ja)
LT (3) LT3277842T (ja)
MX (1) MX2018001769A (ja)
MY (1) MY195484A (ja)
NZ (1) NZ736853A (ja)
PH (1) PH12018500322A1 (ja)
PL (3) PL3277842T3 (ja)
PT (3) PT3385395T (ja)
RS (3) RS59158B9 (ja)
SG (1) SG10202101740QA (ja)
SI (3) SI3640345T1 (ja)
TW (3) TW202129012A (ja)
WO (1) WO2017031101A1 (ja)
ZA (2) ZA201801047B (ja)

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PT3385395T (pt) 2015-08-17 2020-05-06 Kura Oncology Inc Métodos de tratamento de doentes com cancro usando inibidores da farnesiltransferase
MX2019005065A (es) * 2016-11-03 2019-08-21 Kura Oncology Inc Metodos de tratamiento de pacientes con cancer con inhibidores de farnesiltransferasa.
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
KR20200051601A (ko) * 2017-08-07 2020-05-13 쿠라 온콜로지, 인크. 파르네실전달효소 억제제를 이용하여 암을 치료하는 방법
WO2019113269A1 (en) * 2017-12-08 2019-06-13 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
CN113286591A (zh) * 2018-11-01 2021-08-20 库拉肿瘤学公司 用法尼基转移酶抑制剂治疗癌症的方法
US20220071941A1 (en) * 2018-12-21 2022-03-10 Kura Oncology, Inc. Therapies for squamous cell carcinomas
CN110656172A (zh) * 2019-01-14 2020-01-07 南方医科大学珠江医院 一种预测小细胞肺癌对ep化疗方案敏感性的分子标志物及试剂盒
WO2020190604A1 (en) * 2019-03-15 2020-09-24 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
EP3942097A4 (en) * 2019-03-22 2024-03-27 Univ California CHMP2A AS A REGULATOR OF NATURAL KILLER CELL-MEDIATED ACTIVITY
WO2020205486A1 (en) * 2019-03-29 2020-10-08 Kura Oncology, Inc. Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors
CN110241461A (zh) * 2019-06-24 2019-09-17 厦门大学 一种构建人nk细胞免疫球蛋白样受体文库的多重pcr引物和方法
CN111097039B (zh) * 2020-01-16 2020-11-06 南京医科大学 Ras相关蛋白2的制药用途
CN111088349B (zh) * 2020-02-14 2023-04-28 深圳市宝安区妇幼保健院 Kir3dl1基因分型引物组及其应用
EP4146346A1 (en) * 2020-05-08 2023-03-15 Cardiff Oncology, Inc. Methods of monitoring kras mutations
CN111863126B (zh) * 2020-05-28 2024-03-26 上海市生物医药技术研究院 构建结直肠肿瘤状态评估模型的方法及应用
US20240058321A1 (en) * 2021-11-02 2024-02-22 Semmelweis Egyetem Farnesyl-transferase inhibitors and kras inhibitors for treating kras mutant cancers
CN114045339B (zh) * 2021-11-05 2022-06-28 山东第一医科大学附属省立医院(山东省立医院) 铁死亡相关基因在弥漫大b细胞淋巴瘤预后评估中的应用
WO2023242104A1 (en) * 2022-06-13 2023-12-21 KHR Biotec GmbH Diaminoacridine derivatives as inhibitors of ras
WO2023242097A1 (en) * 2022-06-13 2023-12-21 KHR Biotec GmbH Mitoxanthrone derivatives as ras inhibitors

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