DK3099298T3 - Kombinationsterapier med zidovudin til behandling af mikrobielle infektioner - Google Patents

Kombinationsterapier med zidovudin til behandling af mikrobielle infektioner Download PDF

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Publication number
DK3099298T3
DK3099298T3 DK15704827.3T DK15704827T DK3099298T3 DK 3099298 T3 DK3099298 T3 DK 3099298T3 DK 15704827 T DK15704827 T DK 15704827T DK 3099298 T3 DK3099298 T3 DK 3099298T3
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Denmark
Prior art keywords
microbible
zidovudin
infections
treatment
combination therapies
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DK15704827.3T
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English (en)
Inventor
Yanmin Hu
Anthony Coates
Original Assignee
Helperby Therapeutics Ltd
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Publication of DK3099298T3 publication Critical patent/DK3099298T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/08Antibacterial agents for leprosy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK15704827.3T 2014-01-30 2015-01-29 Kombinationsterapier med zidovudin til behandling af mikrobielle infektioner DK3099298T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1401617.4A GB201401617D0 (en) 2014-01-30 2014-01-30 Novel combination and use
PCT/GB2015/050209 WO2015114340A1 (en) 2014-01-30 2015-01-29 Zidovudine combination therapies for treating microbial infections

Publications (1)

Publication Number Publication Date
DK3099298T3 true DK3099298T3 (da) 2019-05-27

Family

ID=50344128

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15704827.3T DK3099298T3 (da) 2014-01-30 2015-01-29 Kombinationsterapier med zidovudin til behandling af mikrobielle infektioner

Country Status (14)

Country Link
US (1) US10098904B2 (da)
EP (1) EP3099298B8 (da)
JP (1) JP6633529B2 (da)
CN (1) CN106170286B (da)
CA (1) CA2936714A1 (da)
DK (1) DK3099298T3 (da)
ES (1) ES2719557T3 (da)
GB (1) GB201401617D0 (da)
HR (1) HRP20190637T1 (da)
HU (1) HUE043702T2 (da)
PL (1) PL3099298T3 (da)
PT (1) PT3099298T (da)
SI (1) SI3099298T1 (da)
WO (1) WO2015114340A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201305277D0 (en) * 2013-03-22 2013-05-01 Helperby Therapeutics Ltd Novel combination and use
JP6854752B2 (ja) * 2014-07-30 2021-04-07 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Hdl上昇剤又はhdl模倣剤を用いた治療に対する応答性を予測するための遺伝マーカー
GB201521771D0 (en) * 2015-12-10 2016-01-27 Helperby Therapeutics Ltd Formulation
BR112018016517B1 (pt) 2016-02-12 2024-03-12 Cipla Limited Composições farmacêuticas incluindo uma droga antirretroviral e um intensificador farmacocinético, métodos operacionais das composições e kit com antirretroviral e intensificador
GB201610869D0 (en) * 2016-06-22 2016-08-03 Helperby Therapeutics Ltd Combination
GB201612093D0 (en) * 2016-07-12 2016-08-24 Helperby Therapeutics Ltd Combination
GB201704620D0 (en) * 2017-03-23 2017-05-10 Helperby Therapeautics Ltd Combinations
KR102118198B1 (ko) * 2018-02-28 2020-06-02 주식회사 엠디헬스케어 리조비움 속 세균 유래 나노소포 및 이의 용도
GB201807046D0 (en) * 2018-04-30 2018-06-13 Helperby Therapeutics Ltd Combination
GB201910787D0 (en) * 2019-07-29 2019-09-11 Helperby Therapeutics Ltd Pharmaceutical development
GB201913068D0 (en) 2019-09-10 2019-10-23 Helperby Therapeutics Ltd Combination
GB201914847D0 (en) 2019-10-14 2019-11-27 Helperby Therapeutics Ltd Combination
CN114196586B (zh) * 2021-12-20 2023-04-11 郑州大学 一株蒙氏肠球菌及其在发酵中草药中的应用
CN117243966A (zh) * 2022-06-10 2023-12-19 香港城市大学 一种治疗耐碳青霉烯肺炎克雷伯氏菌感染的组合物
GB202213753D0 (en) 2022-09-20 2022-11-02 Helperby Therapeutics Ltd Antimicrobial combinations
GB202213750D0 (en) 2022-09-20 2022-11-02 Helperby Therapeutics Ltd Antimicrobial
GB202314387D0 (en) 2023-09-20 2023-11-01 Helperby Therapeutics Ltd Antimicrobial combinations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA39896C2 (uk) 1993-10-22 2001-07-16 Смітклайн Бічам Корпорейшн Фармацевтична або ветеринарна композиція мупіроцину та спосіб її приготування
PT1129212E (pt) 1998-11-09 2004-11-30 Helperby Therapeutics Ltd Processo de triagem para agentes antibacterianos
US6974585B2 (en) 2001-08-01 2005-12-13 Medlogic Global Limited Durable multi-component antibiotic formulation for topical use
AU2003209674A1 (en) * 2002-03-12 2003-09-22 Council Of Scientific And Industrial Research Bioavailability/bioefficacy enhancing activity of cuminum cyminum and extracts and fractions thereof
JP2003310752A (ja) * 2002-04-25 2003-11-05 Toray Ind Inc 生理活性物質固定化成型品の製造方法
JP2007501809A (ja) 2003-08-08 2007-02-01 ユリシーズ・ファーマシューティカル・プロダクツ・インコーポレイテッド 抗菌剤としてのハロゲン化キナゾリニルニトロフラン
KR20070091613A (ko) 2004-11-08 2007-09-11 그렌마크 파머수티칼스 엘티디. 항여드름 화합물 및 항생제 화합물을 함유하는 국소적 제약조성물
ES2279707B1 (es) * 2005-11-10 2008-06-01 Combino Pharm, S.L. Formulaciones orales que comprenden 3'-azidonucleosidos.

Also Published As

Publication number Publication date
JP6633529B2 (ja) 2020-01-22
US20160331773A1 (en) 2016-11-17
EP3099298B8 (en) 2019-05-22
CN106170286B (zh) 2019-07-23
CA2936714A1 (en) 2015-08-06
PL3099298T3 (pl) 2019-10-31
EP3099298A1 (en) 2016-12-07
HUE043702T2 (hu) 2019-09-30
ES2719557T3 (es) 2019-07-11
JP2017504647A (ja) 2017-02-09
SI3099298T1 (sl) 2019-09-30
PT3099298T (pt) 2019-05-27
EP3099298B1 (en) 2019-03-20
HRP20190637T1 (hr) 2019-10-04
HK1231389A1 (en) 2017-12-22
US10098904B2 (en) 2018-10-16
GB201401617D0 (en) 2014-03-19
WO2015114340A1 (en) 2015-08-06
CN106170286A (zh) 2016-11-30

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