BR112013008511A2 - tipagem com base em determinantes moleculares de alelos de kir e de ligantes de kir - Google Patents
tipagem com base em determinantes moleculares de alelos de kir e de ligantes de kirInfo
- Publication number
- BR112013008511A2 BR112013008511A2 BR112013008511A BR112013008511A BR112013008511A2 BR 112013008511 A2 BR112013008511 A2 BR 112013008511A2 BR 112013008511 A BR112013008511 A BR 112013008511A BR 112013008511 A BR112013008511 A BR 112013008511A BR 112013008511 A2 BR112013008511 A2 BR 112013008511A2
- Authority
- BR
- Brazil
- Prior art keywords
- kir
- typing
- ligands
- alleles
- molecular determinants
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
tipagem com base em determinantes moleculares de alelos de kir e de ligantes de kir. a presente invenção diz respeito a um ensaio com base em determinantes moleculares para realizar a tipagem de alelos funcionais e a tipagem de ligantes de receptores semelhantes à imunoglobulina de células natural killer (kir) e para a tipagem de ligantes. especificamente, a presente invenção provê métodos, composições e kits para um ensaio de polimorfismo de nucleotídeo único (snp) para classificar o tipo de vários grupos de alelos de kir2dl1 e de ligantes de kir com propriedades funcionais distintas com base em polimorfismo na posição 245 em kir2dl1, posição 77 em hla-c e na posição 83 em hla-b e hla-a. os ensaios são adequados para uso em predizer a atividade de células nk na saúde, doença e processos de transplante.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39047310P | 2010-10-06 | 2010-10-06 | |
PCT/US2011/054906 WO2012047985A1 (en) | 2010-10-06 | 2011-10-05 | Molecular determinant-based typing of kir alleles and kir-ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013008511A2 true BR112013008511A2 (pt) | 2017-07-25 |
Family
ID=45928116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013008511A BR112013008511A2 (pt) | 2010-10-06 | 2011-10-05 | tipagem com base em determinantes moleculares de alelos de kir e de ligantes de kir |
Country Status (5)
Country | Link |
---|---|
US (1) | US20130267613A1 (pt) |
EP (1) | EP2625188A4 (pt) |
CN (1) | CN103209988B (pt) |
BR (1) | BR112013008511A2 (pt) |
WO (1) | WO2012047985A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104032025B (zh) * | 2014-06-25 | 2016-04-27 | 上海荻硕贝肯生物科技有限公司 | 用于kir基因快速分型的引物、试剂盒及方法 |
ES2901506T3 (es) | 2015-08-17 | 2022-03-22 | Kura Oncology Inc | Métodos para tratar pacientes con cáncer con inhibidores de la farnesiltransferasa |
CN108624665A (zh) * | 2018-05-18 | 2018-10-09 | 韩瑜 | 一种kir及配体基因分型实验方法 |
CN111088349B (zh) * | 2020-02-14 | 2023-04-28 | 深圳市宝安区妇幼保健院 | Kir3dl1基因分型引物组及其应用 |
CN112442525B (zh) * | 2020-11-20 | 2022-11-04 | 江苏伟禾生物科技有限公司 | 用于检测人类自然杀伤细胞免疫球蛋白样受体kir基因分型的试剂盒 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5874212A (en) * | 1993-05-13 | 1999-02-23 | Thomas Jefferson University | Detection of single base mutations and other variations in double stranded DNA by conformation-sensitive gel electrophoresis |
AU6004699A (en) * | 1998-11-26 | 2000-06-13 | Shionogi & Co., Ltd. | Method for distinguishing hla class i allele type |
SI1639013T1 (sl) * | 2003-07-02 | 2013-01-31 | Innate Pharma | Pan-kir2dl nk-receptorska protitelesca in njihova uporaba pri diagnosticiranju in terapiji |
GB0322037D0 (en) * | 2003-09-19 | 2003-10-22 | Animal Health Inst | Method and polynucleotides therefor |
EP1685149A4 (en) * | 2003-10-22 | 2007-03-28 | Pel Freez Clinical Systems Inc | PRIMER, METHOD AND KITS FOR DETECTING ALL KILLER-CELL IMMUNOGLOBULIN-LIKE RECEPTOR |
US7374927B2 (en) * | 2004-05-03 | 2008-05-20 | Affymetrix, Inc. | Methods of analysis of degraded nucleic acid samples |
AU2005259221B2 (en) * | 2004-07-01 | 2011-02-10 | Innate Pharma | Antibodies binding to receptors KIR2DL1, -2, 3 but not KIR2DS4 and their therapeutic use |
US7919279B2 (en) * | 2005-09-29 | 2011-04-05 | Children's Hospital & Research Center At Oakland | Methods and compositions for KIR genotyping |
WO2008121894A2 (en) * | 2007-03-30 | 2008-10-09 | Escape Therapeutics, Inc. | Endogenous expression of hla-g and/or hla-e by mesenchymal cells |
GB0724131D0 (en) * | 2007-12-11 | 2008-01-23 | Uutech Ltd | Use of KIR genes for predicting response to therapy |
-
2011
- 2011-10-05 EP EP11831508.4A patent/EP2625188A4/en not_active Withdrawn
- 2011-10-05 CN CN201180055075.4A patent/CN103209988B/zh not_active Expired - Fee Related
- 2011-10-05 BR BR112013008511A patent/BR112013008511A2/pt not_active IP Right Cessation
- 2011-10-05 US US13/877,006 patent/US20130267613A1/en not_active Abandoned
- 2011-10-05 WO PCT/US2011/054906 patent/WO2012047985A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20130267613A1 (en) | 2013-10-10 |
CN103209988A (zh) | 2013-07-17 |
WO2012047985A1 (en) | 2012-04-12 |
CN103209988B (zh) | 2016-11-09 |
EP2625188A4 (en) | 2014-05-07 |
EP2625188A1 (en) | 2013-08-14 |
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Legal Events
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B08F | Application fees: application dismissed [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |