DK3327030T3 - Vacciner og vaccinebestanddele til hæmning af mikrobielle celler - Google Patents

Vacciner og vaccinebestanddele til hæmning af mikrobielle celler Download PDF

Info

Publication number
DK3327030T3
DK3327030T3 DK17206527.8T DK17206527T DK3327030T3 DK 3327030 T3 DK3327030 T3 DK 3327030T3 DK 17206527 T DK17206527 T DK 17206527T DK 3327030 T3 DK3327030 T3 DK 3327030T3
Authority
DK
Denmark
Prior art keywords
vaccines
inhibition
microbial cells
vaccine components
vaccine
Prior art date
Application number
DK17206527.8T
Other languages
Danish (da)
English (en)
Inventor
Eric Heinz Altermann
Graeme Trevor Attwood
Dong Li
William John Kelly
Zhanhao Kong
Sinead Leahy
Original Assignee
Pastoral Greenhouse Gas Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pastoral Greenhouse Gas Res Ltd filed Critical Pastoral Greenhouse Gas Res Ltd
Application granted granted Critical
Publication of DK3327030T3 publication Critical patent/DK3327030T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/641—Cysteine endopeptidases (3.4.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/20—Reduction of greenhouse gas [GHG] emissions in agriculture, e.g. CO2
    • Y02P60/22—Methane [CH4], e.g. from rice paddies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
DK17206527.8T 2007-09-25 2008-09-25 Vacciner og vaccinebestanddele til hæmning af mikrobielle celler DK3327030T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US97510407P 2007-09-25 2007-09-25
US98984007P 2007-11-22 2007-11-22
US98984107P 2007-11-22 2007-11-22
EP08833501A EP2203470A4 (en) 2007-09-25 2008-09-25 VACCINES AND VACCUMENT COMPONENTS FOR THE INHIBITION OF MICROBIAL CELLS

Publications (1)

Publication Number Publication Date
DK3327030T3 true DK3327030T3 (da) 2021-10-04

Family

ID=40511642

Family Applications (3)

Application Number Title Priority Date Filing Date
DK17206527.8T DK3327030T3 (da) 2007-09-25 2008-09-25 Vacciner og vaccinebestanddele til hæmning af mikrobielle celler
DK08834643.2T DK2203467T3 (en) 2007-09-25 2008-09-25 POLYNUCLEOTIDES AND POLYPEPTIDES OF THE SUBJECT -? - MRU AND USE THEREOF
DK08834203.5T DK2203466T3 (en) 2007-09-25 2008-09-25 Cell permeabilizing peptides and polypeptides for microbial cells

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK08834643.2T DK2203467T3 (en) 2007-09-25 2008-09-25 POLYNUCLEOTIDES AND POLYPEPTIDES OF THE SUBJECT -? - MRU AND USE THEREOF
DK08834203.5T DK2203466T3 (en) 2007-09-25 2008-09-25 Cell permeabilizing peptides and polypeptides for microbial cells

Country Status (17)

Country Link
US (7) US8592556B2 (enExample)
EP (5) EP2203470A4 (enExample)
JP (5) JP6067209B2 (enExample)
CN (4) CN107129524B (enExample)
AR (3) AR068552A1 (enExample)
AU (4) AU2008305846A1 (enExample)
BR (5) BR122020023381B1 (enExample)
CA (3) CA2700129C (enExample)
CL (3) CL2008002859A1 (enExample)
DK (3) DK3327030T3 (enExample)
ES (3) ES2895908T3 (enExample)
MX (3) MX2010003321A (enExample)
NZ (1) NZ745324A (enExample)
RU (1) RU2528854C2 (enExample)
UY (3) UY31359A1 (enExample)
WO (3) WO2009041832A2 (enExample)
ZA (1) ZA201001933B (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107129524B (zh) * 2007-09-25 2023-11-21 田园温室气体研究有限公司 用于抑制微生物细胞的疫苗和疫苗组分
GB0815484D0 (en) 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
US20120195872A1 (en) * 2009-06-26 2012-08-02 Lysando Ag Antimicrobial agents
PL2445515T3 (pl) 2009-06-26 2016-10-31 Środki przeciwdrobnoustrojowe
AU2010287069B2 (en) 2009-08-27 2016-07-07 Lucidome Bio Limited Complete genome sequence of the methanogen Methanobrevibacter ruminantium
DK2563916T3 (en) * 2010-04-27 2015-10-05 Lysando Ag METHOD FOR REDUCING biofilms
EP3736282B1 (en) * 2012-09-19 2023-06-21 Gemvax & Kael Co., Ltd. Cell penetrating peptide, conjugate comprising same, and composition comprising conjugate
KR102955556B1 (ko) * 2012-12-12 2026-04-22 더 브로드 인스티튜트, 인코퍼레이티드 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물
US10760064B2 (en) 2013-03-15 2020-09-01 The General Hospital Corporation RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
CN105408483A (zh) 2013-03-15 2016-03-16 通用医疗公司 遗传和表观遗传调节蛋白至特定基因组基因座的rna引导的靶向
US10011850B2 (en) 2013-06-21 2018-07-03 The General Hospital Corporation Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
CN111218447B (zh) 2013-11-07 2024-10-11 爱迪塔斯医药有限公司 使用统治型gRNA的CRISPR相关方法和组合物
DK3597740T3 (da) * 2014-11-06 2022-06-20 Dupont Us Holding Llc Peptidmedieret indføring af rna-styret endonuklease i celler
CN104789675A (zh) * 2015-04-15 2015-07-22 江苏师范大学 一种检测荷斯坦奶牛瘤胃微生物的方法
EP3292219B9 (en) * 2015-05-04 2022-05-18 Ramot at Tel-Aviv University Ltd. Methods and kits for fragmenting dna
US9512446B1 (en) 2015-08-28 2016-12-06 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
US9926546B2 (en) 2015-08-28 2018-03-27 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
EP3484996B1 (en) * 2016-07-14 2020-09-09 Basf Se Fermentation medium comprising chelating agent
CN110431237A (zh) * 2016-12-29 2019-11-08 伊鲁米纳公司 用于在细胞区室中正交接近和标签化生物分子的分析系统
WO2018126499A1 (zh) 2017-01-05 2018-07-12 深圳迈瑞生物医疗电子股份有限公司 网织红细胞模拟粒子、血小板模拟粒子制备方法及质控物
US10745439B2 (en) * 2017-03-20 2020-08-18 Regents Of The University Of Minnesota Kinase substrates and methods of use thereof
US20190233816A1 (en) 2018-01-26 2019-08-01 Massachusetts Institute Of Technology Structure-guided chemical modification of guide rna and its applications
EP3592140A1 (en) * 2018-03-19 2020-01-15 Regeneron Pharmaceuticals, Inc. Transcription modulation in animals using crispr/cas systems
CA3120096A1 (en) 2018-11-14 2020-05-22 Rubryc Therapeutics, Inc. Cd25 antibodies
CN113646330A (zh) 2018-11-14 2021-11-12 鲁比克治疗股份有限公司 工程化cd25多肽及其用途
CN109627301B (zh) * 2019-02-18 2022-08-05 浙江新银象生物工程有限公司 Nisin固体稳定剂开发及应用
CN115942932A (zh) * 2020-03-19 2023-04-07 迈克瑞欧斯人体健康有限公司 感兴趣的稳定蛋白
WO2021207687A1 (en) * 2020-04-10 2021-10-14 Liberty Biosecurity Llc Polypeptide compositions and uses thereof
CN112143747B (zh) * 2020-09-09 2022-09-13 昆明理工大学 一种噬菌体裂解酶及其基因、基因重组表达载体与应用
US11529310B2 (en) 2020-12-08 2022-12-20 Ruminant Biotech Corp Limited Devices and methods for delivery of substances to animals
CN112961217B (zh) * 2021-03-19 2022-11-08 江苏元本生物科技有限公司 一种靶向Siglec-15的噬菌体多肽
CN113121705B (zh) * 2021-04-19 2023-03-24 成都英普博集生物科技有限公司 用于制备短肽混合物的融合蛋白、目的多肽、短肽混合物的制备方法及应用
WO2024015366A1 (en) * 2022-07-11 2024-01-18 Arkea Bio Corp. Compositions and methods for reducing methane emissions in ruminant populations
CN115417927A (zh) * 2022-09-08 2022-12-02 南京松天盛科生物科技有限公司 小鼠腹水致敏物及其应用
IL319970A (en) * 2022-11-03 2025-05-01 Helix Nanotechnologies Inc Ruminal and methanogen vaccines and their uses
CN115938486B (zh) * 2022-12-06 2023-11-10 内蒙古农业大学 基于图神经网络的抗菌性乳酸菌株筛选方法
WO2025207521A1 (en) * 2024-03-25 2025-10-02 Silage Labs, Inc. Bacteria expressing lysins for inhibition of methanogenesis
WO2025219570A1 (en) 2024-04-17 2025-10-23 Johannes Kepler Universität Linz Composition for inhibiting protein translocation and methods using the same
WO2025233675A1 (en) * 2024-05-10 2025-11-13 Institut Pasteur Use of talosaminidase to regulate populations of archaeal methanogens in industrial, agricultural and medical settings
CN120249257B (zh) * 2025-05-08 2026-05-05 浙江大学 与PeiR裂解酶具有相同蛋白家族注释的产甲烷菌裂解酶及其应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US159861A (en) * 1875-02-16 Improvement in brooms
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
IT1180166B (it) * 1983-05-03 1987-09-23 Ssm Int Chem Co Ltd Composizione ad attivita' farmaceutica perfezionata e sua utilizzazione per usi veterinari
GB8815968D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Veterinary devices
JPH05219927A (ja) * 1992-02-14 1993-08-31 Gumma Pref Gov 飼料の混合装置及び混合飼料の製造方法
WO1995011995A1 (en) 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
JP3651915B2 (ja) * 1993-06-30 2005-05-25 財団法人神奈川科学技術アカデミー シグナル配列ペプチドをコードするdna断片の探索法及びそのためのベクター
DK0724454T3 (da) * 1993-10-19 2004-07-12 Commw Scient Ind Res Org Fremgangsmåde til forbedring af drövtyggerdyrs eller drövtyggerlignende dyrs udnyttelse af næringsstoffer
PT739198E (pt) 1994-01-20 2004-02-27 Agres Ltd Dispositivo para administracao de substancias beneficas a ruminantes
NZ278977A (en) 1994-01-20 1997-03-24 Pastoral Agric Res Inst Nz Ltd Sustained release bolus for ruminants
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
AUPN353695A0 (en) 1995-06-14 1995-07-06 Commonwealth Scientific And Industrial Research Organisation Immunogenic preparation and method for improving the productivity of ruminant animals
WO1998007830A2 (en) * 1996-08-22 1998-02-26 The Institute For Genomic Research COMPLETE GENOME SEQUENCE OF THE METHANOGENIC ARCHAEON, $i(METHANOCOCCUS JANNASCHII)
US5985907A (en) * 1998-08-12 1999-11-16 Health Research, Inc. Method for inhibiting growth of methanogens
AU2002306849A1 (en) 2001-03-21 2002-10-08 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
US20030219467A1 (en) 2001-09-18 2003-11-27 The Board Of Regents Of The University Of Nebraska Method for the inhibition of methanogensis
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
US20060068386A1 (en) * 2002-03-04 2006-03-30 Alexei Slesarev Complete genome and protein sequence of the hyperthermophile methanopyrus kandleri av19 and monophyly of archael methanogens and methods of use thereof
SE523209C2 (sv) * 2002-05-14 2004-04-06 Akzo Nobel Nv Förfarande för att reducera metanbildningen från matspjälkningsaktiviteter hos djur
US20100048595A1 (en) 2005-03-23 2010-02-25 Washington University In St. Louis Use of archaea to modulate the nutrient harvesting functions of the gastrointestinal microbiota
CN107129524B (zh) * 2007-09-25 2023-11-21 田园温室气体研究有限公司 用于抑制微生物细胞的疫苗和疫苗组分
CN101434924A (zh) * 2008-12-17 2009-05-20 中南大学 一种分离严格厌氧产甲烷古菌的方法
AU2010287069B2 (en) * 2009-08-27 2016-07-07 Lucidome Bio Limited Complete genome sequence of the methanogen Methanobrevibacter ruminantium
CN101864362B (zh) * 2010-05-19 2012-05-09 江苏加德绿色能源有限公司 一种复合微生物菌剂及其应用
DE102011119230B4 (de) * 2011-11-23 2013-07-11 Audi Ag Kraftwagen-Blinkleuchte und Verfahren zum Betreiben einer Blinkleuchte
EP2935364A2 (en) * 2012-12-21 2015-10-28 Danisco US Inc. Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway

Also Published As

Publication number Publication date
BRPI0817299A2 (pt) 2015-06-16
CN107129524A (zh) 2017-09-05
WO2009041832A9 (en) 2009-10-22
RU2010116163A (ru) 2011-11-10
CL2008002860A1 (es) 2009-06-05
AU2008304019A1 (en) 2009-04-02
CN101918431A (zh) 2010-12-15
US9296789B2 (en) 2016-03-29
CL2008002861A1 (es) 2009-03-06
MX2010003319A (es) 2010-09-10
BRPI0817312B1 (pt) 2018-05-29
EP2203470A2 (en) 2010-07-07
JP2017046704A (ja) 2017-03-09
JP5558356B2 (ja) 2014-07-23
EP2203467A4 (en) 2011-04-13
WO2009041831A9 (en) 2009-11-05
CN101918431B (zh) 2014-10-08
CA2700164A1 (en) 2009-04-02
CA2700164C (en) 2018-05-29
JP2015042166A (ja) 2015-03-05
CN101932595B (zh) 2016-02-10
US20140220636A1 (en) 2014-08-07
AR068552A1 (es) 2009-11-18
CN101932595A (zh) 2010-12-29
US20210332087A1 (en) 2021-10-28
WO2009041830A3 (en) 2009-07-02
EP2203466A2 (en) 2010-07-07
RU2528854C2 (ru) 2014-09-20
ZA201001933B (en) 2013-10-30
BR122021010729B1 (pt) 2022-02-15
EP3936516A1 (en) 2022-01-12
WO2009041830A9 (en) 2009-08-27
EP2203470A4 (en) 2011-04-13
US20100209999A1 (en) 2010-08-19
MX2010003328A (es) 2010-08-16
JP2010539927A (ja) 2010-12-24
BRPI0817299A8 (pt) 2019-01-29
NZ780936A (en) 2024-08-30
ES2587595T3 (es) 2016-10-25
AU2014210649B2 (en) 2016-09-08
WO2009041832A2 (en) 2009-04-02
UY31359A1 (es) 2009-04-30
CA2700162C (en) 2018-08-14
JP2010539926A (ja) 2010-12-24
ES2895908T3 (es) 2022-02-23
US10590170B2 (en) 2020-03-17
EP2203466B1 (en) 2016-04-06
US8586709B2 (en) 2013-11-19
WO2009041832A3 (en) 2009-06-11
AU2008304018A1 (en) 2009-04-02
DK2203467T3 (en) 2017-03-27
JP6067209B2 (ja) 2017-01-25
CA2700129C (en) 2021-07-20
AR068553A1 (es) 2009-11-18
UY31361A1 (es) 2009-04-30
UY31360A1 (es) 2009-04-30
US20200325180A1 (en) 2020-10-15
MX2010003321A (es) 2010-08-03
EP3327030A1 (en) 2018-05-30
CL2008002859A1 (es) 2009-03-06
CN102015755A (zh) 2011-04-13
AR068551A1 (es) 2009-11-18
CN107129524B (zh) 2023-11-21
JP2010539928A (ja) 2010-12-24
US20100221185A1 (en) 2010-09-02
WO2009041831A1 (en) 2009-04-02
ES2625144T3 (es) 2017-07-18
BRPI0817312A2 (pt) 2015-03-17
DK2203466T3 (en) 2016-07-25
BR122021010737B1 (pt) 2021-09-21
US10995120B2 (en) 2021-05-04
EP2203467B1 (en) 2016-12-14
JP5552053B2 (ja) 2014-07-16
WO2009041830A2 (en) 2009-04-02
NZ745324A (en) 2023-02-24
AU2008305846A1 (en) 2009-04-02
BR122020023381B1 (pt) 2021-09-08
EP2203466A4 (en) 2011-04-13
US8592556B2 (en) 2013-11-26
AU2014210649A1 (en) 2014-09-04
US20170342112A1 (en) 2017-11-30
EP3327030B1 (en) 2021-07-21
EP2203467A1 (en) 2010-07-07
MX340736B (es) 2016-07-22
CA2700129A1 (en) 2009-04-02
US20100209998A1 (en) 2010-08-19
US11926647B2 (en) 2024-03-12
CA2700162A1 (en) 2009-04-02

Similar Documents

Publication Publication Date Title
BRPI0817299A2 (pt) Vacinas e componentes de vacina para inibição de células microbianas
DK2220116T3 (da) Sammensætninger og fremgangsmåder til terapien og diagnosticeringen af influenza
DK2229360T3 (da) Indolinonderivater og fremgangsmåde til deres fremstilling
DK2209888T3 (da) Forbedrede fremgangsmåder til fremstilling af rpe-celler og sammensætninger af rpe-celler
DK2150275T3 (da) Ande-embryoniske afledte stamcellelinjer til fremstillingen af virale vacciner
DK3128014T3 (da) Midler og fremgangsmåder til sterilisering af biofunktionelle sammensætninger
DK2494039T3 (da) Fremgangsmåder til reprogrammering af celler og anvendelser deraf
DK2252342T3 (da) Indretninger og fremgangsmåder til behandling af skadet væv
DK3045043T3 (da) Orale farmaceutiske sammensætninger af 3-hydroxy-n-methylmorphinan med forlænget frigivelse og fremgangsmåde til anvendelse
DK3156069T3 (da) Sammensætninger, fremgangsmåder, og kits til fremkaldelse af et immunrespons
DK2334378T3 (da) Prodrugs af methylhydrogenfumarat, farmaceutiske sammensætninger deraf og fremgangsmåder til anvendelse
DK3795573T3 (da) Bestemte triazolopyraziner, sammensætninger deraf og fremgangsmåder til anvendelse deraf
FI20075654A0 (fi) Energiansiirtojärjestely ja -menetelmä
DK2414507T3 (da) Mutanter af aktiveringsinduceret cytidin-deaminase (aid) og til anvendelsesfremgangsmåder
DK2240155T3 (da) Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
DK2102398T3 (da) Fremgangsmåde til fremstilling af en ankelsok og ankelsok opnået derved
DK2356093T3 (da) Carbazolforbindelser og terapeutiske anvendelser af forbindelserne
DK2270818T3 (da) Polyelektrolyt og fremgangsmåde til fremstilling af polyelektrolytten
DK1896065T3 (da) Fremgangsmåde til fremstilling af vacciner
DK2264042T3 (da) Mikronisering af polyoler
DK2343362T4 (da) Forbedret fremgangsmåde til dyrkning af celler
DK2470656T3 (da) Sammensætning til hæmning af genekspression og anvendelser heraf
DK2029746T3 (da) Sammensætninger og fremgangsmåder til siRNA-hæmning af angiogenese
DK2170403T3 (da) Sammensætninger og fremgangsmåder til hæmning af ekspressionen af proapoptotiske gener
DK2493549T3 (da) Implantatindretning til stimulering af osteogenese og osseointegration