BRPI0817312B1 - Métodos de inibição de uma célula metanógena, e composição farmacêutica - Google Patents

Métodos de inibição de uma célula metanógena, e composição farmacêutica Download PDF

Info

Publication number
BRPI0817312B1
BRPI0817312B1 BRPI0817312-5A BRPI0817312A BRPI0817312B1 BR PI0817312 B1 BRPI0817312 B1 BR PI0817312B1 BR PI0817312 A BRPI0817312 A BR PI0817312A BR PI0817312 B1 BRPI0817312 B1 BR PI0817312B1
Authority
BR
Brazil
Prior art keywords
phage
sequence
polypeptide
cell
dna
Prior art date
Application number
BRPI0817312-5A
Other languages
English (en)
Portuguese (pt)
Inventor
Heinz Altermann Eric
Leahy Sinead
Starr Ronimus Robert
Li Dong
Kong Zhanhao
Rose Schofield Linley
Dey Debjit
Mary Tootill Catherine
Sang Carrie
Diana Moon Christina
Hendricus Janssen Petrus
Trevor Attwood Graeme
John Kelly William
Original Assignee
Pastoral Greenhouse Gas Research Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pastoral Greenhouse Gas Research Limited filed Critical Pastoral Greenhouse Gas Research Limited
Publication of BRPI0817312A2 publication Critical patent/BRPI0817312A2/pt
Publication of BRPI0817312B1 publication Critical patent/BRPI0817312B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/641—Cysteine endopeptidases (3.4.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/20—Reduction of greenhouse gas [GHG] emissions in agriculture, e.g. CO2
    • Y02P60/22—Methane [CH4], e.g. from rice paddies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
BRPI0817312-5A 2007-09-25 2008-09-25 Métodos de inibição de uma célula metanógena, e composição farmacêutica BRPI0817312B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US97510407P 2007-09-25 2007-09-25
US60/975,104 2007-09-25
US98984107P 2007-11-22 2007-11-22
US98984007P 2007-11-22 2007-11-22
US60/989,841 2007-11-22
US60/989,840 2007-11-22
PCT/NZ2008/000248 WO2009041831A1 (en) 2007-09-25 2008-09-25 PHAGE ϕ-MRU POLYNUCLEOTIDES AND POLYPEPTIDES AND USES THEREOF

Publications (2)

Publication Number Publication Date
BRPI0817312A2 BRPI0817312A2 (pt) 2015-03-17
BRPI0817312B1 true BRPI0817312B1 (pt) 2018-05-29

Family

ID=40511642

Family Applications (5)

Application Number Title Priority Date Filing Date
BRPI0817312-5A BRPI0817312B1 (pt) 2007-09-25 2008-09-25 Métodos de inibição de uma célula metanógena, e composição farmacêutica
BR122020023381-8A BR122020023381B1 (pt) 2007-09-25 2008-09-25 Composição de vacina e kit para reduzir o crescimento de metanogênio ou a produção de metano em um ruminante
BR122021010737-8A BR122021010737B1 (pt) 2007-09-25 2008-09-25 Composição de vacina
BRPI0817299A BRPI0817299A8 (pt) 2007-09-25 2008-09-25 vacinas e componentes de vacina para inibição de células microbianas
BR122021010729-7A BR122021010729B1 (pt) 2007-09-25 2008-09-25 Composição de vacina

Family Applications After (4)

Application Number Title Priority Date Filing Date
BR122020023381-8A BR122020023381B1 (pt) 2007-09-25 2008-09-25 Composição de vacina e kit para reduzir o crescimento de metanogênio ou a produção de metano em um ruminante
BR122021010737-8A BR122021010737B1 (pt) 2007-09-25 2008-09-25 Composição de vacina
BRPI0817299A BRPI0817299A8 (pt) 2007-09-25 2008-09-25 vacinas e componentes de vacina para inibição de células microbianas
BR122021010729-7A BR122021010729B1 (pt) 2007-09-25 2008-09-25 Composição de vacina

Country Status (17)

Country Link
US (7) US9296789B2 (enExample)
EP (5) EP2203470A4 (enExample)
JP (5) JP5552053B2 (enExample)
CN (4) CN107129524B (enExample)
AR (3) AR068553A1 (enExample)
AU (4) AU2008304019A1 (enExample)
BR (5) BRPI0817312B1 (enExample)
CA (3) CA2700162C (enExample)
CL (3) CL2008002859A1 (enExample)
DK (3) DK3327030T3 (enExample)
ES (3) ES2625144T3 (enExample)
MX (3) MX2010003321A (enExample)
NZ (1) NZ745324A (enExample)
RU (1) RU2528854C2 (enExample)
UY (3) UY31361A1 (enExample)
WO (3) WO2009041830A2 (enExample)
ZA (1) ZA201001933B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107129524B (zh) 2007-09-25 2023-11-21 田园温室气体研究有限公司 用于抑制微生物细胞的疫苗和疫苗组分
GB0815484D0 (en) 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
EA037202B1 (ru) * 2009-06-26 2021-02-18 Катхолике Университейт Лёвен, К.У. Лёвен Р Энд Д Слитые белки для лечения инфекций, вызванных грамотрицательными бактериями
CN102482655B (zh) * 2009-06-26 2018-04-10 莱桑多公司 抗微生物剂
AU2010287069B2 (en) 2009-08-27 2016-07-07 Lucidome Bio Limited Complete genome sequence of the methanogen Methanobrevibacter ruminantium
KR20130100062A (ko) * 2010-04-27 2013-09-09 뤼산도 아게 바이오필름의 감소 방법
JP6352923B2 (ja) * 2012-09-19 2018-07-04 ジェムバックス アンド カエル カンパニー，リミティド 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物
EP4234696A3 (en) * 2012-12-12 2023-09-06 The Broad Institute Inc. Crispr-cas component systems, methods and compositions for sequence manipulation
US10760064B2 (en) 2013-03-15 2020-09-01 The General Hospital Corporation RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
WO2014204578A1 (en) 2013-06-21 2014-12-24 The General Hospital Corporation Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
AU2014228981B2 (en) 2013-03-15 2019-11-28 The General Hospital Corporation Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
EP4372090A3 (en) 2013-11-07 2024-08-07 Editas Medicine, Inc. Crispr-related methods and compositions with governing grnas
CN107406838A (zh) * 2014-11-06 2017-11-28 纳幕尔杜邦公司 Rna引导的内切核酸酶向细胞中的肽介导的递送
CN104789675A (zh) * 2015-04-15 2015-07-22 江苏师范大学 一种检测荷斯坦奶牛瘤胃微生物的方法
US11845928B2 (en) * 2015-05-04 2023-12-19 Tsinghua University Methods and kits for fragmenting DNA
US9926546B2 (en) 2015-08-28 2018-03-27 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
US9512446B1 (en) 2015-08-28 2016-12-06 The General Hospital Corporation Engineered CRISPR-Cas9 nucleases
CN109477065A (zh) * 2016-07-14 2019-03-15 巴斯夫欧洲公司 包含螯合剂的发酵培养基
KR20250005529A (ko) * 2016-12-29 2025-01-09 일루미나, 인코포레이티드 세포 구획 내의 생체분자에 대한 직교 접근 및 그의 태그부착을 위한 분석 시스템
WO2018126499A1 (zh) 2017-01-05 2018-07-12 深圳迈瑞生物医疗电子股份有限公司 网织红细胞模拟粒子、血小板模拟粒子制备方法及质控物
US10745439B2 (en) * 2017-03-20 2020-08-18 Regents Of The University Of Minnesota Kinase substrates and methods of use thereof
WO2019147743A1 (en) 2018-01-26 2019-08-01 Massachusetts Institute Of Technology Structure-guided chemical modification of guide rna and its applications
AU2019239880B2 (en) * 2018-03-19 2023-11-30 Regeneron Pharmaceuticals, Inc. Transcription modulation in animals using CRISPR/Cas systems
CN113677359A (zh) * 2018-11-14 2021-11-19 鲁比克治疗股份有限公司 Cd25抗体
EP3880698A4 (en) 2018-11-14 2022-11-30 RubrYc Therapeutics, Inc. MANIPULATED CD25 POLYPEPTIDES AND USES THEREOF
CN109627301B (zh) * 2019-02-18 2022-08-05 浙江新银象生物工程有限公司 Nisin固体稳定剂开发及应用
AU2021238683A1 (en) * 2020-03-19 2022-10-13 Micreos Human Health B.V. A stabilized protein of interest
WO2021207687A1 (en) * 2020-04-10 2021-10-14 Liberty Biosecurity Llc Polypeptide compositions and uses thereof
CN112143747B (zh) * 2020-09-09 2022-09-13 昆明理工大学 一种噬菌体裂解酶及其基因、基因重组表达载体与应用
FI4037666T3 (fi) 2020-12-08 2024-06-24 Ruminant Biotech Corp Ltd Parannuksia laitteisiin ja menetelmiin aineiden toimittamiseksi eläimille
CN112961217B (zh) * 2021-03-19 2022-11-08 江苏元本生物科技有限公司 一种靶向Siglec-15的噬菌体多肽
CN113121705B (zh) * 2021-04-19 2023-03-24 成都英普博集生物科技有限公司 用于制备短肽混合物的融合蛋白、目的多肽、短肽混合物的制备方法及应用
US20240009291A1 (en) * 2022-07-11 2024-01-11 Arkea Bio Corp. Compositions and methods for reducing methane emissions in ruminant populations
CN115417927A (zh) * 2022-09-08 2022-12-02 南京松天盛科生物科技有限公司 小鼠腹水致敏物及其应用
WO2024097397A1 (en) * 2022-11-03 2024-05-10 Helix Nanotechnologies, Inc. Ruminal and methanogen vaccines and uses thereof
CN115938486B (zh) * 2022-12-06 2023-11-10 内蒙古农业大学 基于图神经网络的抗菌性乳酸菌株筛选方法
WO2025219570A1 (en) 2024-04-17 2025-10-23 Johannes Kepler Universität Linz Composition for inhibiting protein translocation and methods using the same
WO2025233675A1 (en) * 2024-05-10 2025-11-13 Institut Pasteur Use of talosaminidase to regulate populations of archaeal methanogens in industrial, agricultural and medical settings

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US159861A (en) * 1875-02-16 Improvement in brooms
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
IT1180166B (it) * 1983-05-03 1987-09-23 Ssm Int Chem Co Ltd Composizione ad attivita' farmaceutica perfezionata e sua utilizzazione per usi veterinari
GB8815968D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Veterinary devices
JPH05219927A (ja) * 1992-02-14 1993-08-31 Gumma Pref Gov 飼料の混合装置及び混合飼料の製造方法
WO1995011995A1 (en) 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
JP3651915B2 (ja) * 1993-06-30 2005-05-25 財団法人神奈川科学技術アカデミー シグナル配列ペプチドをコードするｄｎａ断片の探索法及びそのためのベクター
WO1995011041A1 (en) 1993-10-19 1995-04-27 Commonwealth Scientific And Industrial Research Organisation Method for improving utilisation of nutrients by ruminant or ruminant-like animals
AU697144B2 (en) 1994-01-20 1998-10-01 Agresearch Limited Device for administration of beneficial materials to ruminants
NZ278977A (en) 1994-01-20 1997-03-24 Pastoral Agric Res Inst Nz Ltd Sustained release bolus for ruminants
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
AUPN353695A0 (en) 1995-06-14 1995-07-06 Commonwealth Scientific And Industrial Research Organisation Immunogenic preparation and method for improving the productivity of ruminant animals
WO1998007830A2 (en) * 1996-08-22 1998-02-26 The Institute For Genomic Research COMPLETE GENOME SEQUENCE OF THE METHANOGENIC ARCHAEON, $i(METHANOCOCCUS JANNASCHII)
US5985907A (en) * 1998-08-12 1999-11-16 Health Research, Inc. Method for inhibiting growth of methanogens
AU2002306849A1 (en) 2001-03-21 2002-10-08 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
US20030219467A1 (en) 2001-09-18 2003-11-27 The Board Of Regents Of The University Of Nebraska Method for the inhibition of methanogensis
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
WO2003076575A2 (en) * 2002-03-04 2003-09-18 Fidelity Systems, Inc., Et Al. The complete genome and protein sequence of the hyperthermophile methanopyrus kandleri av19 and monophyly of archael methanogens and methods of use thereof
SE523209C2 (sv) * 2002-05-14 2004-04-06 Akzo Nobel Nv Förfarande för att reducera metanbildningen från matspjälkningsaktiviteter hos djur
EP1861490A4 (en) 2005-03-23 2010-11-17 Univ St Louis USE OF ARRAYS TO MODULATE NUTRIENT CAPTURE FUNCTIONS BY THE GASTROINTESTINAL MICROBIOTE
CN107129524B (zh) * 2007-09-25 2023-11-21 田园温室气体研究有限公司 用于抑制微生物细胞的疫苗和疫苗组分
CN101434924A (zh) * 2008-12-17 2009-05-20 中南大学 一种分离严格厌氧产甲烷古菌的方法
AU2010287069B2 (en) * 2009-08-27 2016-07-07 Lucidome Bio Limited Complete genome sequence of the methanogen Methanobrevibacter ruminantium
CN101864362B (zh) * 2010-05-19 2012-05-09 江苏加德绿色能源有限公司 一种复合微生物菌剂及其应用
DE102011119230B4 (de) * 2011-11-23 2013-07-11 Audi Ag Kraftwagen-Blinkleuchte und Verfahren zum Betreiben einer Blinkleuchte
US20160002672A1 (en) * 2012-12-21 2016-01-07 Danisco Us Inc. Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway

Also Published As

Publication number Publication date
JP2010539928A (ja) 2010-12-24
US10590170B2 (en) 2020-03-17
ES2625144T3 (es) 2017-07-18
WO2009041830A2 (en) 2009-04-02
EP2203466A2 (en) 2010-07-07
BRPI0817312A2 (pt) 2015-03-17
EP2203470A2 (en) 2010-07-07
EP2203467B1 (en) 2016-12-14
CL2008002861A1 (es) 2009-03-06
CN107129524A (zh) 2017-09-05
CA2700162C (en) 2018-08-14
MX2010003328A (es) 2010-08-16
AR068552A1 (es) 2009-11-18
AR068551A1 (es) 2009-11-18
EP3936516A1 (en) 2022-01-12
BRPI0817299A8 (pt) 2019-01-29
MX2010003321A (es) 2010-08-03
CN101932595A (zh) 2010-12-29
BR122020023381B1 (pt) 2021-09-08
JP5552053B2 (ja) 2014-07-16
WO2009041830A3 (en) 2009-07-02
US8592556B2 (en) 2013-11-26
CA2700129A1 (en) 2009-04-02
EP3327030A1 (en) 2018-05-30
DK2203467T3 (en) 2017-03-27
US20140220636A1 (en) 2014-08-07
RU2528854C2 (ru) 2014-09-20
US10995120B2 (en) 2021-05-04
BR122021010737B1 (pt) 2021-09-21
BR122021010729B1 (pt) 2022-02-15
US20170342112A1 (en) 2017-11-30
WO2009041831A9 (en) 2009-11-05
JP5558356B2 (ja) 2014-07-23
CA2700129C (en) 2021-07-20
WO2009041832A9 (en) 2009-10-22
US20210332087A1 (en) 2021-10-28
UY31361A1 (es) 2009-04-30
US8586709B2 (en) 2013-11-19
WO2009041832A2 (en) 2009-04-02
JP2010539926A (ja) 2010-12-24
AR068553A1 (es) 2009-11-18
CN101918431B (zh) 2014-10-08
JP2015042166A (ja) 2015-03-05
CN101932595B (zh) 2016-02-10
US9296789B2 (en) 2016-03-29
AU2008305846A1 (en) 2009-04-02
CN107129524B (zh) 2023-11-21
DK3327030T3 (da) 2021-10-04
CL2008002859A1 (es) 2009-03-06
CN102015755A (zh) 2011-04-13
EP2203467A1 (en) 2010-07-07
JP2017046704A (ja) 2017-03-09
US20100221185A1 (en) 2010-09-02
NZ780936A (en) 2024-08-30
US20200325180A1 (en) 2020-10-15
UY31360A1 (es) 2009-04-30
NZ745324A (en) 2023-02-24
JP6067209B2 (ja) 2017-01-25
ES2587595T3 (es) 2016-10-25
CA2700164C (en) 2018-05-29
WO2009041832A3 (en) 2009-06-11
CN101918431A (zh) 2010-12-15
EP2203467A4 (en) 2011-04-13
WO2009041831A1 (en) 2009-04-02
RU2010116163A (ru) 2011-11-10
CA2700164A1 (en) 2009-04-02
US11926647B2 (en) 2024-03-12
AU2014210649A1 (en) 2014-09-04
DK2203466T3 (en) 2016-07-25
CL2008002860A1 (es) 2009-06-05
EP2203466A4 (en) 2011-04-13
ZA201001933B (en) 2013-10-30
AU2008304019A1 (en) 2009-04-02
EP2203466B1 (en) 2016-04-06
EP3327030B1 (en) 2021-07-21
ES2895908T3 (es) 2022-02-23
US20100209998A1 (en) 2010-08-19
US20100209999A1 (en) 2010-08-19
AU2008304018A1 (en) 2009-04-02
UY31359A1 (es) 2009-04-30
MX340736B (es) 2016-07-22
CA2700162A1 (en) 2009-04-02
MX2010003319A (es) 2010-09-10
AU2014210649B2 (en) 2016-09-08
JP2010539927A (ja) 2010-12-24
EP2203470A4 (en) 2011-04-13
BRPI0817299A2 (pt) 2015-06-16
WO2009041830A9 (en) 2009-08-27

Similar Documents

Publication Publication Date Title
US8592556B2 (en) Phage φmru polynucleotides and polypeptides and uses thereof
RU2520738C2 (ru) ПОЛИНУКЛЕОТИДЫ И ПОЛИПЕПТИДЫ ФАГА φ-mru, И ИХ ПРИМЕНЕНИЕ
AU2014210647A1 (en) Phage phimru polynucleotides and polypeptides and uses thereof
Class et al. Patent application title: PHAGE &phgr; MRU POLYNUCLEOTIDES AND POLYPEPTIDES AND USES THEREOF
AU2014213519B2 (en) Vaccines and vaccine components for inhibition of microbial cells
AU2019203617A1 (en) Vaccines and vaccine components for inhibition of microbial cells

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 25/09/2008, OBSERVADAS AS CONDICOES LEGAIS.