DK3297977T3 - Fremgangsmåde til udførelse af en flerhed af synteseprocesser til fremstilling af et radiofarmaceutikum i serie, indretning og kassette til udførelse af denne fremgangsmåde - Google Patents

Fremgangsmåde til udførelse af en flerhed af synteseprocesser til fremstilling af et radiofarmaceutikum i serie, indretning og kassette til udførelse af denne fremgangsmåde Download PDF

Info

Publication number
DK3297977T3
DK3297977T3 DK16725811.0T DK16725811T DK3297977T3 DK 3297977 T3 DK3297977 T3 DK 3297977T3 DK 16725811 T DK16725811 T DK 16725811T DK 3297977 T3 DK3297977 T3 DK 3297977T3
Authority
DK
Denmark
Prior art keywords
radiopharmaceutical
cassette
series
producing
carrying
Prior art date
Application number
DK16725811.0T
Other languages
English (en)
Inventor
Vincent Luc Antoine Tadino
Guillaume André René Villeret
Original Assignee
Out And Out Chemistry S P R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Out And Out Chemistry S P R L filed Critical Out And Out Chemistry S P R L
Application granted granted Critical
Publication of DK3297977T3 publication Critical patent/DK3297977T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24Stationary reactors without moving elements inside
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01DCOMPOUNDS OF ALKALI METALS, i.e. LITHIUM, SODIUM, POTASSIUM, RUBIDIUM, CAESIUM, OR FRANCIUM
    • C01D3/00Halides of sodium, potassium or alkali metals in general
    • C01D3/02Fluorides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24Halogenated derivatives
    • C07C39/40Halogenated derivatives with at least one hydroxy group on a condensed ring system containing more than two rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/16Halogenated acetic acids
    • C07C53/18Halogenated acetic acids containing fluorine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91Nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/24Stationary reactors without moving elements inside
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/40Ortho- or ortho- and peri-condensed systems containing four condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK16725811.0T 2015-05-20 2016-05-19 Fremgangsmåde til udførelse af en flerhed af synteseprocesser til fremstilling af et radiofarmaceutikum i serie, indretning og kassette til udførelse af denne fremgangsmåde DK3297977T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2014828A NL2014828B1 (en) 2015-05-20 2015-05-20 Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method.
PCT/EP2016/061319 WO2016184980A1 (en) 2015-05-20 2016-05-19 Method of performing a plurality of synthesis processes of preparing a radiopharmaceutical in series, a device and cassette for performing this method

Publications (1)

Publication Number Publication Date
DK3297977T3 true DK3297977T3 (da) 2020-03-16

Family

ID=53502792

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16725811.0T DK3297977T3 (da) 2015-05-20 2016-05-19 Fremgangsmåde til udførelse af en flerhed af synteseprocesser til fremstilling af et radiofarmaceutikum i serie, indretning og kassette til udførelse af denne fremgangsmåde

Country Status (13)

Country Link
US (3) US10344045B2 (da)
EP (1) EP3297977B1 (da)
JP (1) JP6664856B2 (da)
KR (1) KR102632284B1 (da)
CN (1) CN107635949B (da)
BE (1) BE1023528B1 (da)
BR (1) BR112017024734B1 (da)
CA (1) CA2986186A1 (da)
DK (1) DK3297977T3 (da)
IL (1) IL255721B (da)
NL (1) NL2014828B1 (da)
RU (1) RU2721551C2 (da)
WO (1) WO2016184980A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201805283D0 (en) * 2018-03-29 2018-05-16 Ge Healthcare Ltd Method of synthesizing a radiopharmaceutical
FR3111133A1 (fr) * 2020-06-04 2021-12-10 Université du Mans Procede de traitement chimique automatise d’un substrat solide par une ligne de fluoration
CN113413840A (zh) * 2021-06-04 2021-09-21 四川玖谊源粒子科技有限公司 一种用于制备多核素放射性药物的合成系统
KR20230077672A (ko) 2021-11-22 2023-06-01 가천대학교 산학협력단 방사성 플루오로화 나트륨의 연속 제조 방법

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2191853A (en) 1936-02-24 1940-02-27 Holmes Eric Leighton Use of synthetic resins
BE895821A (fr) 1983-02-04 1983-05-30 Ecolochem Inc Systeme mobile pour la purification de fluides
JPH11295494A (ja) 1998-04-08 1999-10-29 Nippon Meji Physics Kk [f−18]−フッ化物イオンの製造方法
US6599484B1 (en) * 2000-05-12 2003-07-29 Cti, Inc. Apparatus for processing radionuclides
US6567492B2 (en) 2001-06-11 2003-05-20 Eastern Isotopes, Inc. Process and apparatus for production of F-18 fluoride
JP2006527367A (ja) * 2003-04-22 2006-11-30 モレキュラー テクノロジーズ インコーポレイテッド Fdg等の分子画像化プローブを合成するためのシステム及び方法
JP4113053B2 (ja) 2003-06-13 2008-07-02 株式会社東芝 ウラン廃棄物の湿式処理方法および装置
GB201420094D0 (en) 2014-11-12 2014-12-24 Ge Healthcare Ltd Flouride trapping arrangement
US8898229B2 (en) * 2005-04-29 2014-11-25 Barclays Capital Inc. Contact management system and method
US7235216B2 (en) 2005-05-01 2007-06-26 Iba Molecular North America, Inc. Apparatus and method for producing radiopharmaceuticals
CN100374453C (zh) * 2005-11-18 2008-03-12 南方医科大学南方医院 2-18f-2-脱氧-d-葡萄糖的合成工艺
US7586102B2 (en) 2006-08-14 2009-09-08 Board Of Regents The University Of Texas System Automated system for formulating radiopharmaceuticals
BRPI0720884A2 (pt) * 2007-01-09 2014-03-25 Bayer Schering Pharma Ag Radiorrotulação por meio de fluoração de aziridinas
CN101104627A (zh) 2007-07-20 2008-01-16 张锦明 18f-fdg自动化合成方法及设备
EP2110367A1 (en) * 2008-04-14 2009-10-21 Bayer Schering Pharma Aktiengesellschaft Purification strategy for direct nucleophilic procedures
US20110184159A1 (en) 2008-07-07 2011-07-28 Bayer Schering Pharma Aktiengesellschaft Process for production of radiopharmaceuticals
CN101333138B (zh) 2008-07-23 2011-01-19 北京师范大学 一种能同时制备三种不同18f放射性药物的装置与工艺
US20110305618A1 (en) 2008-12-22 2011-12-15 Bayer Schering Pharma Aktiengesellschaft Method for synthesis of a radionuclide-labeled compound using an exchange resin
US8435454B2 (en) 2009-07-09 2013-05-07 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
PT2534136T (pt) * 2010-02-08 2017-12-15 Lantheus Medical Imaging Inc Métodos para sintetizar agentes de imagiologia, e seus intermediários
WO2011127345A1 (en) 2010-04-08 2011-10-13 Siemens Medical Solutions Usa, Inc. Synthesis of 18f-labeled tracers in hydrous organic solvents
WO2011141410A1 (en) 2010-05-10 2011-11-17 Technische Universität München Method for the direct elution of reactive [18f]fluoride from an anion exchange resin in an organic medium suitable for radiolabelling without any evaporation step by the use of alkalimetal and alkaline earth metal cryptates
US20140039074A1 (en) * 2010-09-09 2014-02-06 Piramal Imaging Sa Method for rapid preparation of suitable [18f]fluoride for nucleophilic [18f]fluorination
WO2012083094A1 (en) 2010-12-17 2012-06-21 Ge Healthcare Limited Shielding collar
US11504430B2 (en) * 2010-12-29 2022-11-22 Ge Healthcare Limited Eluent solution
US20130102772A1 (en) 2011-07-15 2013-04-25 Cardinal Health 414, Llc Systems, methods and devices for producing, manufacturing and control of radiopharmaceuticals-full
EP2760577A2 (en) * 2011-09-30 2014-08-06 GE Healthcare UK Limited Reactor for multi-step radiochemistry
JP2015501418A (ja) 2011-09-30 2015-01-15 ジーイー・ヘルスケア・リミテッド 放射性医薬品合成用カセット
JP2015507602A (ja) * 2011-09-30 2015-03-12 ジーイー・ヘルスケア・リミテッド 区画反応器
CN104169592B (zh) 2012-02-28 2017-02-22 完全化学私人有限公司 用于对阀进行控制的压缩空气装置
WO2013188459A2 (en) 2012-06-11 2013-12-19 Hns International, Inc. Lancet devices without needle and related methods
US9663375B2 (en) 2012-07-21 2017-05-30 K-Technologies, Inc. Processes for the recovery of fluoride and silica products and phosphoric acid from wet-process phosphoric acid facilities and contaminated waste waters
CN104762666A (zh) 2013-11-13 2015-07-08 通用电气健康护理有限公司 双重运行盒

Also Published As

Publication number Publication date
US10344045B2 (en) 2019-07-09
BR112017024734B1 (pt) 2021-10-13
EP3297977A1 (en) 2018-03-28
EP3297977B1 (en) 2019-12-18
US20240059724A1 (en) 2024-02-22
JP2018515543A (ja) 2018-06-14
WO2016184980A1 (en) 2016-11-24
JP6664856B2 (ja) 2020-03-13
BE1023528A1 (fr) 2017-04-21
RU2017143907A (ru) 2019-06-20
IL255721B (en) 2020-01-30
CA2986186A1 (en) 2016-11-24
KR102632284B1 (ko) 2024-02-01
CN107635949A (zh) 2018-01-26
BR112017024734A2 (pt) 2018-07-31
US20190276487A1 (en) 2019-09-12
US20180118774A1 (en) 2018-05-03
RU2017143907A3 (da) 2019-10-28
US11820790B2 (en) 2023-11-21
RU2721551C2 (ru) 2020-05-20
NL2014828B1 (en) 2017-01-31
NL2014828A (en) 2016-11-28
BE1023528B1 (fr) 2017-04-21
KR20180016418A (ko) 2018-02-14
CN107635949B (zh) 2021-02-02
IL255721A (en) 2018-01-31

Similar Documents

Publication Publication Date Title
DK3275334T3 (da) Gelnegleklistermærke og fremgangsmåde til fremstilling deraf
DK3218511T3 (da) Fremgangsmåder og arrays til frembringelse og sekventering af monoklonale klynger af nukleinsyre
DK3474669T3 (da) Fremgangsmåde til generering af stregkodede kombinatoriske biblioteker
DK3191809T3 (da) System og fremgangsmåde til fremstilling af en farmaceutisk forbindelse
DK3381102T3 (da) Husenergianlæg og driftsfremgangsmåde til drift af et husenergianlæg
DK3149025T3 (da) Cellepenetrerende peptider og fremgangsmåder til frembringelse og anvendelse deraf
DK3230044T3 (da) Transplantationsstøttestruktur til bruskreparation og fremgangsmåde til fremstilling af denne
DK3215601T3 (da) Fremgangsmåder til transduktion og celleforarbejdning
DK3145437T3 (da) Ortodontisk apparatur og fremgangsmåde til fremstilling af et ortodontisk apparatur
DK3828277T3 (da) Sammensætninger, fremgangsmåder og apparatur til syntese af oligonukleotider
DK3098209T3 (da) Fremgangsmåde til fremstilling af en magnesiumfluorid-sintreret kompakt masse og en fremgangsmåde til fremstilling af en neutronmoderator
DK3259759T3 (da) Atombrændselspille og fremgangsmåde til fremstilling deraf
DK3325422T3 (da) Fremgangsmåde og indretning til fremstilling af et ekspanderet granulat
DK3936669T3 (da) En fremgangsmåde, et system og et computerprogram-produkt til bestemmelse af jordbundsegenskaber
DK3102935T3 (da) Bioreaktoranordning og fremgangsmåde til fremstilling af en biopolymer
GB2526406B (en) Method and apparatus for performing a plurality of multiplication operations
DK3275040T3 (da) Fremgangsmåde og indretning til dannelse af et batteri
DK3188051T3 (da) Systemer og fremgangsmåder til generering af søgeskabeloner
DK3303923T3 (da) Indretning til fremstilling af metangas og anvendelse af en sådan indretning
DK3095296T3 (da) Fremgangsmåde og anordning til fremstilling af et produkt eller færdiggørelse af et produkt
DK3215598T3 (da) Fremgangsmåde til drift af en røreindretning og en forgasningsbeholder
DK3397919T3 (da) Fremgangsmåde og anordning til tårnsimulation
DK3366831T3 (da) Indretning og fremgangsmåde til identifikation af en stoftype
DK3297977T3 (da) Fremgangsmåde til udførelse af en flerhed af synteseprocesser til fremstilling af et radiofarmaceutikum i serie, indretning og kassette til udførelse af denne fremgangsmåde
DK3093891T3 (da) Halvledersubstrat, halvlederindretning og fremgangsmåde til fremstilling af halvledersubstrat