DK3176159T3 - 4-phenyl-6-(2,2,2-trifluor-1-phenylethoxy)pyrimidin-baserede forbindelser og fremgangsmåder til anvendelse deraf - Google Patents

4-phenyl-6-(2,2,2-trifluor-1-phenylethoxy)pyrimidin-baserede forbindelser og fremgangsmåder til anvendelse deraf Download PDF

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Publication number
DK3176159T3
DK3176159T3 DK16206493.5T DK16206493T DK3176159T3 DK 3176159 T3 DK3176159 T3 DK 3176159T3 DK 16206493 T DK16206493 T DK 16206493T DK 3176159 T3 DK3176159 T3 DK 3176159T3
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phenylethoxy
trifluoro
pyrimidine
phenyl
procedures
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DK16206493.5T
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English (en)
Inventor
Chengmin Zhang
Ying Wang
Ashok Tunoori
Zhi-Cai Shi
Haihong Jin
Arokiasamy Devasagayaraj
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Lexicon Pharmaceuticals Inc
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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DK16206493.5T 2006-12-12 2007-12-11 4-phenyl-6-(2,2,2-trifluor-1-phenylethoxy)pyrimidin-baserede forbindelser og fremgangsmåder til anvendelse deraf DK3176159T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87459606P 2006-12-12 2006-12-12
EP13153803.5A EP2589600B1 (en) 2006-12-12 2007-12-11 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use

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DK3176159T3 true DK3176159T3 (da) 2021-01-18

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ID=39432875

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DK16206493.5T DK3176159T3 (da) 2006-12-12 2007-12-11 4-phenyl-6-(2,2,2-trifluor-1-phenylethoxy)pyrimidin-baserede forbindelser og fremgangsmåder til anvendelse deraf
DK07865487.8T DK2091940T6 (da) 2006-12-12 2007-12-11 4-Phenyl-6-(2,2,2-trifluor-1-phenylethoxy)pyrimidin-baserede forbindelser samt fremgangsmåder til disses anvendelse

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DK07865487.8T DK2091940T6 (da) 2006-12-12 2007-12-11 4-Phenyl-6-(2,2,2-trifluor-1-phenylethoxy)pyrimidin-baserede forbindelser samt fremgangsmåder til disses anvendelse

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US (4) US7553840B2 (da)
EP (4) EP3176159B1 (da)
JP (1) JP5361734B2 (da)
KR (1) KR101464391B1 (da)
AR (1) AR064279A1 (da)
AU (1) AU2007333120B2 (da)
BR (1) BRPI0720270B8 (da)
CA (1) CA2672233C (da)
CO (1) CO6220855A2 (da)
DK (2) DK3176159T3 (da)
EA (1) EA018150B1 (da)
EC (1) ECSP099413A (da)
ES (3) ES2856871T3 (da)
HU (3) HUE027896T2 (da)
IL (2) IL198806A (da)
MX (1) MX2009006195A (da)
NL (1) NL300929I2 (da)
NO (2) NO345062B1 (da)
NZ (1) NZ577004A (da)
PL (2) PL3176159T3 (da)
PT (2) PT2091940E (da)
TW (1) TWI412365B (da)
UA (1) UA99270C2 (da)
WO (1) WO2008073933A2 (da)
ZA (1) ZA200903367B (da)

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TWI439457B (zh) 2007-09-28 2014-06-01 Lexicon Pharmaceuticals Inc （ｓ）－２－胺基－３－（４－（２－胺基－６－（（ｒ）－１－（４－氯－２－（３－甲基－１ｈ－吡唑－１－基）苯基）－２，２，２－三氟乙氧）－嘧啶－４－基）苯基）丙酸乙酯之固體形式與其使用方法
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AU2009231892A1 (en) 2008-03-31 2009-10-08 The Trustees Of Columbia University In The City Of New York Methods of diagnosing, preventing and treating bone mass diseases
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JP2012156602A (ja) * 2011-01-21 2012-08-16 Ricoh Co Ltd 情報処理装置、通信制御方法、及び通信制御システム
KR101682417B1 (ko) * 2011-02-25 2016-12-06 주식회사유한양행 다이아미노피리미딘 유도체 및 그의 제조방법
CN103987381B (zh) 2011-10-17 2017-07-04 莱西肯医药有限公司 (s)‑2‑氨基‑3‑(4‑(2‑氨基‑6‑((r)‑1‑(4‑氯‑2‑(3‑甲基‑1h‑吡唑‑1‑基)苯基)‑2,2,2‑三氟乙氧基)嘧啶‑4‑基)苯基)丙酸乙酯的固体剂型
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