DK3097086T3 - (2S) -N - [(1S) -1-CYAN-2-PHENYLETHYL] -1,4-OXAZEPAN-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS - Google Patents
(2S) -N - [(1S) -1-CYAN-2-PHENYLETHYL] -1,4-OXAZEPAN-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS Download PDFInfo
- Publication number
- DK3097086T3 DK3097086T3 DK15701577.7T DK15701577T DK3097086T3 DK 3097086 T3 DK3097086 T3 DK 3097086T3 DK 15701577 T DK15701577 T DK 15701577T DK 3097086 T3 DK3097086 T3 DK 3097086T3
- Authority
- DK
- Denmark
- Prior art keywords
- carboxamide
- ethyl
- phenyl
- oxazepan
- oxo
- Prior art date
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Communicable Diseases (AREA)
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- Immunology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
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| US201461931090P | 2014-01-24 | 2014-01-24 | |
| PCT/GB2015/050155 WO2015110826A1 (en) | 2014-01-24 | 2015-01-23 | (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase i inhibitors |
Publications (1)
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| DK3097086T3 true DK3097086T3 (en) | 2018-02-05 |
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| DK15701577.7T DK3097086T3 (en) | 2014-01-24 | 2015-01-23 | (2S) -N - [(1S) -1-CYAN-2-PHENYLETHYL] -1,4-OXAZEPAN-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS |
| DK17195612.1T DK3323814T3 (da) | 2014-01-24 | 2015-01-23 | (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepan-2-carboxamider som dipeptidylpeptidase i-hæmmere |
| DK20173862.2T DK3744714T3 (da) | 2014-01-24 | 2015-01-23 | (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepan-2-carboxamider som dipeptidylpeptidase i-hæmmere |
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| DK20173862.2T DK3744714T3 (da) | 2014-01-24 | 2015-01-23 | (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepan-2-carboxamider som dipeptidylpeptidase i-hæmmere |
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| WO2018022978A1 (en) * | 2016-07-29 | 2018-02-01 | Insmed Incorporated | Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating bronchiectasis |
| US20190247400A1 (en) * | 2018-02-07 | 2019-08-15 | Insmed Incorporated | Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating granulomatosis with polyangiitis |
| US12059424B2 (en) * | 2018-03-01 | 2024-08-13 | Astrazeneca Ab | Pharmaceutical compositions comprising (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide |
| JP2021530513A (ja) * | 2018-07-17 | 2021-11-11 | インスメッド インコーポレイテッド | 炎症性腸疾患を処置するための特定の（２ｓ）−ｎ−［（１ｓ）−１−シアノ−２−フェニルエチル］−１，４−オキサゼパン−２−カルボキサミド |
| AU2019306532A1 (en) * | 2018-07-17 | 2021-03-04 | Insmed Incorporated | Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating Lupus Nephritis |
| CN111689923B (zh) * | 2019-03-12 | 2022-11-08 | 中国科学院上海药物研究所 | 一个具有逆转肿瘤多药耐药活性的环脂肽化合物、其制备方法及用途 |
| PH12022550895A1 (en) * | 2019-10-23 | 2023-03-27 | Chong Kun Dang Pharmaceutical Corp | Compositions for preventing or treating chronic obstructive pulmonary diseases (copd) |
| WO2022020245A1 (en) * | 2020-07-20 | 2022-01-27 | Insmed, Inc. | Methods for extracting neutrophil serine proteases and treating dipeptidyl peptidase 1-mediated conditions |
| HRP20241656T1 (hr) * | 2020-08-26 | 2025-02-14 | Haisco Pharmaceuticals Pte. Ltd. | Derivat nitrila koji djeluje kao inhibitor dipeptidil peptidaze 1 i njegova upotreba |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| CN114159446A (zh) * | 2020-09-11 | 2022-03-11 | 中国科学院上海营养与健康研究所 | 组织蛋白酶c抑制剂在治疗肿瘤转移中的应用 |
| WO2022117059A1 (zh) | 2020-12-04 | 2022-06-09 | 瑞石生物医药有限公司 | 组织蛋白酶c小分子抑制剂及其医药用途 |
| CN114591315A (zh) * | 2020-12-04 | 2022-06-07 | 瑞石生物医药有限公司 | 一种组织蛋白酶c小分子抑制剂 |
| WO2022140516A1 (en) * | 2020-12-22 | 2022-06-30 | Insmed Incorporated | Certain (25)-iv-[(ls')~ i-c yan0-2-phenylethyl·]- 1,4-oxazepane-2- carboxamides for treating behcet's disease |
| WO2022166721A1 (zh) * | 2021-02-05 | 2022-08-11 | 南京明德新药研发有限公司 | 含1，4-氧杂氮杂环庚烷的并环类衍生物 |
| US20240226112A1 (en) * | 2021-04-29 | 2024-07-11 | Insmed Incorporated | Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating cystic fibrosis |
| AU2022376535A1 (en) * | 2021-10-29 | 2024-05-02 | Insmed Incorporated | Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating chronic rhinosinusitis |
| CN115925696A (zh) * | 2021-10-29 | 2023-04-07 | 瑞石生物医药有限公司 | 一种1-氰基-2-苯基乙基甲酰胺衍生物及其用途 |
| CN116332937A (zh) * | 2021-12-23 | 2023-06-27 | 杭州邦顺制药有限公司 | 二肽基肽酶ⅰ抑制剂及其用途 |
| CN118475575A (zh) * | 2022-01-11 | 2024-08-09 | 上海壹典医药科技开发有限公司 | 一种肽基腈类化合物及其应用 |
| IL314769A (en) * | 2022-02-16 | 2024-10-01 | Insmed Inc | Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating hidradenitis suppurativa |
| JP2025505824A (ja) * | 2022-02-22 | 2025-02-28 | ハイスコ ファーマスーティカル プライベート リミテッド | ジペプチジルペプチダーゼ１阻害剤結晶多形体及びその製造方法と用途 |
| US20250179060A1 (en) * | 2022-02-22 | 2025-06-05 | Haisco Pharmaceuticals Pte. Ltd. | Preparation method of nitrogen-containing heterocyclic compound |
| WO2023160542A1 (zh) * | 2022-02-22 | 2023-08-31 | 四川海思科制药有限公司 | 二肽基肽酶抑制剂化合物的盐及晶型 |
| CN114644562B (zh) * | 2022-04-29 | 2023-08-22 | 常州大学 | 具有红移荧光发射的有机小分子荧光化合物、制备方法及应用 |
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