MX2021012548A - Composiciones topicas y metodos para el tratamiento de enfermedades inflamatorias de la piel. - Google Patents

Composiciones topicas y metodos para el tratamiento de enfermedades inflamatorias de la piel.

Info

Publication number
MX2021012548A
MX2021012548A MX2021012548A MX2021012548A MX2021012548A MX 2021012548 A MX2021012548 A MX 2021012548A MX 2021012548 A MX2021012548 A MX 2021012548A MX 2021012548 A MX2021012548 A MX 2021012548A MX 2021012548 A MX2021012548 A MX 2021012548A
Authority
MX
Mexico
Prior art keywords
methods
skin diseases
topical compositions
inflammatory skin
treating inflammatory
Prior art date
Application number
MX2021012548A
Other languages
English (en)
Inventor
Matthew Davidson
Julie Saiki
Johan Andreasson
Original Assignee
Azora Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Azora Therapeutics Inc filed Critical Azora Therapeutics Inc
Publication of MX2021012548A publication Critical patent/MX2021012548A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen composiciones y métodos para tratar afecciones, dolencias o enfermedades de la piel, tales como enfermedades cutáneas autoinflamatorias como psoriasis, dermatitis, pioderma gangrenoso, pustulosis palmoplantar, prurigo nodular y/o hidradenitis supurativa. Las composiciones comprenden un agente que modula el receptor de hidrocarburos de arilos, en particular un agente que agoniza el receptor. En una modalidad, el agente es el índigo o un derivado del índigo, tal como la indirrubina.
MX2021012548A 2019-04-17 2020-04-16 Composiciones topicas y metodos para el tratamiento de enfermedades inflamatorias de la piel. MX2021012548A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962835451P 2019-04-17 2019-04-17
US201962924611P 2019-10-22 2019-10-22
PCT/US2020/028581 WO2020214855A1 (en) 2019-04-17 2020-04-16 Topical compositions and methods for treating inflammatory skin diseases

Publications (1)

Publication Number Publication Date
MX2021012548A true MX2021012548A (es) 2023-01-05

Family

ID=70614619

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2021012548A MX2021012548A (es) 2019-04-17 2020-04-16 Composiciones topicas y metodos para el tratamiento de enfermedades inflamatorias de la piel.
MX2023000291A MX2023000291A (es) 2019-04-17 2021-10-13 Composiciones topicas y metodos para el tratamiento de enfermedades inflamatorias de la piel.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023000291A MX2023000291A (es) 2019-04-17 2021-10-13 Composiciones topicas y metodos para el tratamiento de enfermedades inflamatorias de la piel.

Country Status (10)

Country Link
US (2) US11154533B2 (es)
EP (2) EP3955889A1 (es)
JP (2) JP7085073B2 (es)
KR (2) KR20220022115A (es)
CN (1) CN114206312A (es)
AU (2) AU2020258452B2 (es)
CA (1) CA3132958A1 (es)
MX (2) MX2021012548A (es)
TW (1) TW202106295A (es)
WO (1) WO2020214855A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
MX2021012548A (es) 2019-04-17 2023-01-05 Azora Therapeutics Inc Composiciones topicas y metodos para el tratamiento de enfermedades inflamatorias de la piel.
WO2022020332A1 (en) 2020-07-21 2022-01-27 Chembeau LLC Diester cosmetic formulations and uses thereof
CN117881649A (zh) * 2021-07-02 2024-04-12 安基生技新药股份有限公司 二甲基姜黄素的外用调配物
CN117794893A (zh) * 2021-08-06 2024-03-29 元启(苏州)生物制药有限公司 苯烯莫德的前药
CN113462770B (zh) * 2021-08-25 2023-03-31 中国医科大学附属第一医院 趋化因子作为玫瑰痤疮诊断的分子标志物
WO2023159120A1 (en) * 2022-02-16 2023-08-24 Insmed Incorporated Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating hidradenitis suppurativa
WO2024050431A2 (en) * 2022-08-30 2024-03-07 Dermavant Sciences GmbH Tapinarof and analogs thereof for use in treating ahr mediated diseases
WO2024076731A1 (en) * 2022-10-06 2024-04-11 Regranion, Llc Methods and compositions for treating hidradenitis suppurativa
WO2024078468A1 (zh) * 2022-10-10 2024-04-18 上海泽德曼医药科技有限公司 二苯乙烯衍生物用于预防和或治疗溃疡的用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981586A (en) * 1997-05-23 1999-11-09 Pershadsingh; Harrihar A. Methods for treating proliferative and inflammatory skin diseases
KR20110090892A (ko) * 2008-10-31 2011-08-10 모베르그 데르마 아베 두 개 이상의 침투 증강제의 조합으로 구성되는 국소 조성물
CN107648216B (zh) 2010-07-27 2021-03-30 波士顿大学管理委员会 作为新型癌症疗法的芳烃受体(AhR)调节剂
US10967031B2 (en) 2010-12-28 2021-04-06 Kamedis Ltd. Synergistic herbal compositions with prebiotic properties for treatment of skin infections, allergies and inflammation
TWI438000B (zh) * 2011-02-18 2014-05-21 Galderma Res & Dev 青黛之經油萃取的產物及其製備方法與用途
US9821059B2 (en) * 2014-10-17 2017-11-21 Alteogen Inc. Composition for stabilizing protein and pharmaceutical formulation comprising the same
CN104435505A (zh) * 2015-01-09 2015-03-25 于成伟 一种治疗直肠炎的灌肠剂及其制备方法
TW201642890A (zh) * 2015-04-09 2016-12-16 高德美公司 以青黛或產靛藍植物提取物治療異位性皮膚炎
WO2016162485A1 (en) * 2015-04-09 2016-10-13 Galderma Sa A pharmaceutical composition and the use thereof
US11122997B2 (en) 2015-04-17 2021-09-21 Mayo Foundation For Medical Education And Research Modulating the aryl hydrocarbon receptor system to treat major depressive disorder
EP3093016A1 (en) * 2015-05-14 2016-11-16 DIEFFETTI Cosmetici S.r.l. semplificata Compositions for the treatment of psoriasis
ES2914112T3 (es) * 2015-05-21 2022-06-07 Dermavant Sciences GmbH Composiciones farmacéuticas tópicas
MX2021012548A (es) 2019-04-17 2023-01-05 Azora Therapeutics Inc Composiciones topicas y metodos para el tratamiento de enfermedades inflamatorias de la piel.

Also Published As

Publication number Publication date
MX2023000291A (es) 2023-02-09
US20210186931A1 (en) 2021-06-24
EP3955889A1 (en) 2022-02-23
CN114206312A (zh) 2022-03-18
TW202106295A (zh) 2021-02-16
US11154533B2 (en) 2021-10-26
AU2020258452B2 (en) 2022-10-20
KR20230110821A (ko) 2023-07-25
CA3132958A1 (en) 2020-10-22
WO2020214855A1 (en) 2020-10-22
AU2022246403A1 (en) 2022-11-03
JP7085073B2 (ja) 2022-06-15
EP4252844A3 (en) 2023-12-06
KR20220022115A (ko) 2022-02-24
JP2022522540A (ja) 2022-04-19
EP4252844A2 (en) 2023-10-04
AU2020258452A1 (en) 2021-11-04
JP2022116295A (ja) 2022-08-09
US20220023259A1 (en) 2022-01-27

Similar Documents

Publication Publication Date Title
MX2023000291A (es) Composiciones topicas y metodos para el tratamiento de enfermedades inflamatorias de la piel.
CL2017002494A1 (es) Inhibidores de indolamina-2, 3- dioxigenasa para el tratamiento de cancer
MX2021013830A (es) Inhibidores de ezh2 para tratar linfomas.
CL2020002146A1 (es) Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida y compuestos relacionados como inhibidores hpki para tratar el cáncer.
BR112017013022A2 (pt) métodos para tratar uma doença inflamatória e/ou autoimune aguda num mamífero que a necessite onde a terapia de corticosteróides é utilizada como terapia de primeira ou segunda linha e/ou para tratar uma doença inflamatória e/ou autoimune num mamífero que a necessite, onde a terapia de corticosteróides é utilizada como terapia de manutenção de primeira ou segunda linha e/ou para eliminar ou reduzir dose terapêutica de corticosteróides utilizado no tratamento de uma doença inflamatória e/ou autoimune num mamífero que a necessite, onde a terapia de corticosteróides é utilizada como terapia de manutenção crônica de primeira ou segunda linha e/ou de tratamento de uma doença autoimune e/ou inflamatória num mamífero que a necessite
CL2017000080A1 (es) Métodos para tratar el cáncer con inhibidores de tigit y agentes contra el cáncer
CO2021016768A2 (es) Inhibidores de la autofagia de heteroarilaminopirimidina amida y métodos de uso de estos
CO2021016765A2 (es) Inhibidores de la autofagia de heteroarilaminopirimidina amida y métodos de uso de estos
BR112018073920A2 (pt) inibidores de pd-1/pd-l1 para tratamento de câncer".
BR112016014481A2 (pt) tratamento de câncer utilizando combinações de inibidores de erk e raf
MX2015016277A (es) Tratamiento de canceres utilizando moduladores de la isoforma pi3 cinasa.
MX2016007351A (es) Terapia de combinacion para tratar cancer.
BR112018012255A2 (pt) método para tratar câncer
BR112017007975A2 (pt) composições e métodos para o tratamento de disfunção das glândulas meibomianas
CR20220325A (es) Fluoroalquil-oxadiazoles y sus usos
EA201692334A1 (ru) Кортикостероидные композиции для местного применения
FI20115135L (fi) Mikrofibrilloitu selluloosa käytettäväksi erityisesti atooppisen ihotulehduksen ja psoriasiksen hoidossa
BR112016000335A8 (pt) método de tratamento da rosácea papulopustular, de tratamento de lesões inflamatórias da rosácea papulopustular e uso de uma composição farmacêutica
PL410665A1 (pl) Inhibitory arginazy oraz ich zastosowania terapeutyczne
MX2020004837A (es) Inhibidores de la vía de adenosina para el tratamiento del cáncer.
CL2019001014A1 (es) Métodos de tratamiento de afecciones relacionadas con la inflamación utilizando moduladores metabólicos y anti inflamatorios pluripotentes.
ZA201901367B (en) Inhibition of olig2 activity
CL2021001656A1 (es) Compuestos de imidazopiridina e imidazopiridina y sus usos.
CL2023001637A1 (es) Inhibidores de la vía jak1 para el tratamiento del vitíligo.
BR112016030275A2 (pt) Métodos para tratamento e redução dos sintomas da síndrome mão-pé (eritrodisestesia palmo-plantar)