DK2870160T3 - Hæmmere af hepatitis c-virus - Google Patents

Hæmmere af hepatitis c-virus Download PDF

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Publication number
DK2870160T3
DK2870160T3 DK13739324.5T DK13739324T DK2870160T3 DK 2870160 T3 DK2870160 T3 DK 2870160T3 DK 13739324 T DK13739324 T DK 13739324T DK 2870160 T3 DK2870160 T3 DK 2870160T3
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mmol
preparation
added
mixture
concentrated
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DK13739324.5T
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Inventor
Kyla Bjornson
Eda Canales
Jeromy J Cottell
Kapil Kumar Karki
Ashley Anne Katana
Darryl Kato
Tetsuya Kobayashi
John O Link
Ruben Martinez
Barton W Phillips
Hyung-Jung Pyun
Michael Sangi
Adam James Schrier
Dustin Siegel
James G Taylor
Chinh Viet Tran
Martin Teresa Alejandra Trejo
Randall W Vivian
Zheng-Yu Yang
Jeff Zablocki
Sheila Zipfel
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Gilead Sciences Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/10—Antimycotics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
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    • C07K5/08—Tripeptides
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    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Claims (13)

  1. HÆMMERE AF HEPATITIS C-VIRUS
    1. Forbindelse med formel IVa:
    (fVa) eller et farmaceutisk acceptabelt salt deraf.
  2. 2. Forbindelse ifølge krav 1, der er en forbindelse med formel IVb:
    (iVb) eller et farmaceutisk acceptabelt salt deraf.
  3. 3. Forbindelse ifølge krav 1, der er en forbindelse med formel IVb:
    (IVb),
  4. 4. Forbindelse med formel IVc:
    (SVo) eller et farmaceutisk acceptabelt salt deraf. Forbindelse ifølge krav 4, der er en forbindelse med formel TVd:
    (iVd) eller et farmaceutisk acceptabelt salt deraf. Forbindelse ifølge krav 4, der er en forbindelse med formel IVd:
    (IVd). Forbindelse med formel IVe:
    (IVe) eller et farmaceutisk acceptabelt salt deraf.
  5. 8. Forbindelse ifølge krav 7, der er en forbindelse med formel IVf:
    (IVf) eller et farmaceutisk acceptabelt salt deraf.
  6. 9. Forbindelse ifølge krav 7, der er en forbindelse med formel IVf:
    {IVf}
  7. 10. Forbindelse med formel IVg:
    (IVg) eller et farmaceutisk acceptabelt salt deraf.
  8. 11. Forbindelse ifølge krav 10, der er en forbindelse med formel IVh:
    (fVh) eller et farmaceutisk acceptabelt salt deraf.
  9. 12. Forbindelse ifølge krav 10, der er en forbindelse med formel IVh:
    (IVh).
  10. 13. Farmaceutisk sammensætning, der omfatter en forbindelse ifølge et hvilket som helst af kravene 1-12, eller et farmaceutisk acceptabelt salt deraf, og et farmaceutisk acceptabelt excipiens.
  11. 14. Forbindelse ifølge et hvilket som helst af kravene 1 til 12, eller et farmaceutisk acceptabelt salt deraf til anvendelse i medicinsk terapi.
  12. 15. Farmaceutisk sammensætning ifølge krav 13 til anvendelse til behandling af hepatitis C-virusinfektion.
  13. 16. Forbindelse ifølge et hvilket som helst af kravene 1 til 12 eller et farmaceutisk acceptabelt salt deraf til anvendelse i den profylaktiske eller terapeutiske behandling af en hepatitis C-virusinfektion.
DK13739324.5T 2012-07-03 2013-07-02 Hæmmere af hepatitis c-virus DK2870160T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261667806P 2012-07-03 2012-07-03
US201361798524P 2013-03-15 2013-03-15
PCT/US2013/049119 WO2014008285A1 (en) 2012-07-03 2013-07-02 Inhibitors of hepatitis c virus

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DK2870160T3 true DK2870160T3 (da) 2017-01-23

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DK13739324.5T DK2870160T3 (da) 2012-07-03 2013-07-02 Hæmmere af hepatitis c-virus
DK16190694.6T DK3159345T3 (da) 2012-07-03 2013-07-02 Inhibitorer af hepatitis c virus

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DK16190694.6T DK3159345T3 (da) 2012-07-03 2013-07-02 Inhibitorer af hepatitis c virus

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US (7) US20150175655A1 (da)
EP (4) EP3825312A1 (da)
JP (4) JP6025977B2 (da)
KR (3) KR102040023B1 (da)
CN (2) CN104540832B (da)
AP (1) AP3903A (da)
AR (1) AR091661A1 (da)
AU (6) AU2013286729B2 (da)
BR (2) BR112014033080B1 (da)
CA (1) CA2877005C (da)
CL (1) CL2014003634A1 (da)
CO (1) CO7160104A2 (da)
CR (1) CR20150045A (da)
CY (2) CY1118379T1 (da)
DK (2) DK2870160T3 (da)
EA (2) EA027390B1 (da)
EC (1) ECSP15002066A (da)
ES (3) ES2605383T3 (da)
HK (2) HK1209416A1 (da)
HR (2) HRP20161379T1 (da)
HU (2) HUE042345T2 (da)
IL (4) IL236500B (da)
IN (1) IN2014MN02598A (da)
LT (2) LT2870160T (da)
MD (2) MD4602B1 (da)
ME (2) ME02547B (da)
MX (2) MX360597B (da)
MY (1) MY173342A (da)
NZ (2) NZ739248A (da)
PE (1) PE20150204A1 (da)
PH (3) PH12014502862A1 (da)
PL (2) PL2870160T3 (da)
PT (2) PT2870160T (da)
RS (2) RS58409B1 (da)
SG (3) SG10201702950TA (da)
SI (2) SI3159345T1 (da)
SM (1) SMT201600470B (da)
TW (1) TWI602822B (da)
UA (1) UA119315C2 (da)
UY (1) UY34888A (da)
WO (1) WO2014008285A1 (da)

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