DK2718269T3 - Spaltelige lipider - Google Patents
Spaltelige lipider Download PDFInfo
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- DK2718269T3 DK2718269T3 DK12728004.8T DK12728004T DK2718269T3 DK 2718269 T3 DK2718269 T3 DK 2718269T3 DK 12728004 T DK12728004 T DK 12728004T DK 2718269 T3 DK2718269 T3 DK 2718269T3
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- lipid
- mrna
- polynucleotides
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Claims (17)
1. Lipidnanopartikel omfattende en forbindelse med strukturen:
hvor Ri er valgt fra gruppen bestående af imidazol, guanidinium, imin, enamin, amino, en eventuelt-substitueret alkylamino og pyridyl; R3 og R4 er hver uafhængigt et eventuelt substitueret, umættet C6-C20 alkyl, hvor disse eventuelle substituenter er en eller flere af alkyl, halo, alkoxyl, hydroxy, amino, aryl, ether, ester eller amid; og n er nul eller et hvilket som helst positivt heltal; endvidere omfattende et eller flere polynukleotider indkapslet inden i lipidnanopartiklen, eventuelt hvor et eller flere af polynukleotiderne omfatter en kemisk modificering.
2. Lipidnanopartikel ifølge krav 1, hvor R3 og R4 hver er (i) et eventuelt substitueret, poly-umættet C6-C20 alkyl; (ii) et eventuelt substitueret, poly-umættet Cis alkyl; eller (iii) et ikke-substitueret, poly-umættet Cis alkyl.
3. Lipidnanopartikel ifølge krav 1 eller 2, hvor Ri er amino, imidazol eller guanidinium.
4. Lipidnanopartikel ifølge krav 3, hvor R3 og R4 hver er et ikke-substitueret, poly-umættet Cie-alkyl, og n er 1.
5. Lipidnanopartikel ifølge krav 1, hvor forbindelsens struktur er:
6. Lipidnanopartikel ifølge krav 1, hvor forbindelsens struktur er:
7. Lipidnanopartikel ifølge et hvilket som helst af kravene 1-6, endvidere omfattende en eller flere forbindelser valgt fra gruppen bestående af et kationisk lipid, et PEG-modificeret lipid, et ikke-kationisk lipid og et hjælper-lipid.
8. Lipidnanopartikel ifølge krav 7, hvor det kationiske lipid er valgt fra gruppen bestående af C12-200, DOTAP (l,2-dioleyl-3-trimethylammoniumpropan), DODAP (l,2-dioleyl-3-dimethylammoniumpropan), DOTMA (l,2-di-0-octadecenyl-3-trimethylammoniumpropan), DLinDMA (l,2-dilinoleyloxy-/V,/V-dimethylpropylamin), DLinKC2-DMA (l,2-dilinoleyl-4-(2-dimethylaminoethyl)-[l,3]-dioxolan), HGT4003 (2-((2,3-Bis((9Z, 12Z)-octadeca-9,12-dien-l-yloxy)propyl)disulfanyl)-N,N-dimethylethanamin), HGT5001 ((15Z,18Z)-N,N-dimethyl-6-((9Z,12Z)-octadeca-9,12-dien-l-yl)tetracosa-4,15,18-trien-l-amin), og ICE (imidazolcholesterolester).
9. Lipidnanopartikel ifølge krav 7 eller 8, hvor nanopartiklen omfatter et eller flere PEG-modificerede lipider, eventuelt hvor det ene eller flere PEG-modificerede lipider omfatter en poly(ethylen)glycolkæde med op til 5kDa i længden kovalent bundet til et lipid omfattende en eller flere alkylkæder med C6-C20 i længden.
10. Lipidnanopartikel ifølge et hvilket som helst af de foregående krav, hvor lipidnanopartiklen omfatter et kationisk lipid, et PEG-modificeret lipid, et ikke-kationisk lipid og cholesterol.
11. Lipidnanopartikel ifølge et hvilket som helst af de foregående krav, hvor det ene eller flere polynukleotider er valgt fra gruppen bestående af et antisense oligonukleotid, siRNA, miRNA, snRNA, snoRNA og kombinationer deraf.
12. Lipidnanopartikel ifølge et hvilket som helst af kravene 1-11, hvor det ene eller flere polynukleotider omfatter et eller flere af LNA, DNA eller RNA.
13. Lipidnanopartikel ifølge krav 13, hvor RNA'et koder for et enzym, eventuelt, hvor enzymet er valgt fra gruppen bestående af cystisk fibrose transmembran konduktans regulator (CFTR), agalsidase alfa, alpha-L-iduronidase, iduronat-2-sulfatase, N-acetylglucosamin-l-phosphat-transferase, N-acetylglucosaminidase, alpha-glucosaminide-acetyltransferase, N-acetylglucosamin-6-sulfatase, N-acetylgalactosamin-4-sulfatase, beta-glucosidase, galactose-6-sulfat-sulfatase, beta-galactosidase, beta-glucuronidase, glucocerebrosidase, heparan sulfamidase, hyaluronidase, galactocerebrosidase, ornithin transcarbamylase (OTC), carbamoyl-phosphat-synthetase 1 (CPS1), argininosuccinat-synthetase 1 (ASSI), argininosuccinat-lyase (ASL), og arginase 1 (ARGI).
14. Farmaceutisk sammensætning omfattende lipidnanopartiklen ifølge et hvilket som helst af de foregående krav.
15. Farmaceutisk sammensætning ifølge krav 14 omfattende lipidnanopartiklen i lyofiliseret form.
16. Farmaceutisk sammensætning ifølge krav 15, hvor sammensætningen endvidere omfatter en eller flere lyobeskyttelsesmidler.
17. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 14-16 til anvendelse som et medikament, især, til anvendelse til behandling af en sygdom forbundet med afvigende ekspression af et gen eller en nukleinsyre hos et individ.
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US201161494882P | 2011-06-08 | 2011-06-08 | |
US201161494745P | 2011-06-08 | 2011-06-08 | |
PCT/US2012/041663 WO2012170889A1 (en) | 2011-06-08 | 2012-06-08 | Cleavable lipids |
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DK2718269T3 true DK2718269T3 (da) | 2018-04-09 |
Family
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DK12728004.8T DK2718269T3 (da) | 2011-06-08 | 2012-06-08 | Spaltelige lipider |
DK18153312.6T DK3336082T3 (da) | 2011-06-08 | 2012-06-08 | Spaltelige lipider |
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DK18153312.6T DK3336082T3 (da) | 2011-06-08 | 2012-06-08 | Spaltelige lipider |
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US (6) | US9717690B2 (da) |
EP (7) | EP3674292B1 (da) |
JP (5) | JP6022557B2 (da) |
CN (2) | CN103748078B (da) |
AU (1) | AU2012267578B2 (da) |
CA (2) | CA2838063C (da) |
DK (2) | DK2718269T3 (da) |
ES (2) | ES2663360T3 (da) |
WO (1) | WO2012170889A1 (da) |
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