DK2656844T3 - Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin - Google Patents

Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin Download PDF

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Publication number
DK2656844T3
DK2656844T3 DK13169077.8T DK13169077T DK2656844T3 DK 2656844 T3 DK2656844 T3 DK 2656844T3 DK 13169077 T DK13169077 T DK 13169077T DK 2656844 T3 DK2656844 T3 DK 2656844T3
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Prior art keywords
compound
hki
vinorelbine
administered
unit dose
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DK13169077.8T
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English (en)
Inventor
Charles Zacharchuk
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Wyeth Llc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Radiation-Therapy Devices (AREA)

Claims (15)

1. Farmaceutisk kit til anvendelse i en fremgangsmåde til behandling af en neoplasme hos et individ, hvor det farmaceutiske kit omfatter en første forbindelse, der er valgt fra (E)-N-{4-[3-chlor-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamid, en ester, en ether, et carbamat eller et farmaceutisk acceptabelt salt deraf, og en anden forbindelse, der er valgt fra vinorelbin eller et farmaceutisk acceptabelt salt deraf, hvor den første forbindelse foreligger i en enhedsdosis, og hvor enhedsdosen indeholder 50 til 300 mg af den første forbindelse.
2. Farmaceutisk kit til anvendelse ifølge krav 1, hvor enhedsdosen indeholder 200 til 300 mg, 240 til 300 mg eller mindst 240 mg af den første forbindelse.
3. Farmaceutisk kit til anvendelse ifølge krav 1 eller 2, hvor enhedsdosen er en tablet.
4. Farmaceutisk kit til anvendelse ifølge et hvilket som helst af krav 1 til 3, hvor den anden forbindelse foreligger i en enhedsdosis, og enhedsdosen indeholder 5 til 500 mg, 10 til 250 mg eller mindst 240 mg af den anden forbindelse.
5. Farmaceutisk kit til anvendelse ifølge et hvilket som helst af krav 1 til 4, hvor den første forbindelse og den anden forbindelse kan indgives samtidigt, sekventielt, simultant, i en specifik rækkefølge eller i henhold til en specifik tidsmæssig sammenhæng.
6. Farmaceutisk kit til anvendelse ifølge et hvilket som helst af krav 1 til 5, hvor den første forbindelse er (E)-N-{4-[3-chlor-4-(2-pyridinylmethoxy)-anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamid, og/eller hvor den anden forbindelse er vinorelbin.
7. Farmaceutisk kit til anvendelse ifølge et hvilket som helst af krav 1 til 6, hvor neoplasmen er valgt fra gruppen bestående af lungecancer, brystcancer, myelom, prostatacancer, hoved- og halscancer, overgangscelle-karcinom, småcellet neuroendokrint karcinom i livmoderhalsen og storcellet neuroendokrint karcinom i livmoderhalsen.
8. Farmaceutisk kit til anvendelse til anvendelse ifølge krav 7, hvor neoplasmen er en brystcancer.
9. Farmaceutisk kit til anvendelse ifølge krav 7 eller 8, hvor neoplasmen er en fremskreden fast tumor.
10. Farmaceutisk kit til anvendelse ifølge et hvilket som helst af krav 7 til 9, hvor neoplasmen er metastatisk.
11. Farmaceutisk kit til anvendelse ifølge et hvilket som helst af kravene 7 til 10, hvor neoplasmen er associeret med overekspression eller amplifikation af HER-2.
12. Farmaceutisk kit til anvendelse ifølge et hvilket som helst af krav 1 til 11, hvor den første forbindelse indgives dagligt eller mindst én gang dagligt.
13. Farmaceutisk kit til anvendelse ifølge et hvilket som helst af krav 1 til 11, hvor den første forbindelse indgives på dag 1 eller 2 i et regime.
14. Farmaceutisk kit til anvendelse ifølge et hvilket som helst af krav 1 til 13, hvor (a) den første forbindelse indgives i mindst 2 kontinuerlige uger; (b) neoplasmen eller tumoren er en fast tumor, der er associeret med overekspression eller amplifikation af HER-2 hos et individ, hvor fremgangsmåden omfatter et regime, og hvor en cyklus i regimet omfatter 21 dage, og regimet omfatter oral indgivelse af mindst én enhedsdosis af den første forbindelse, startende på dag 1 i cyklussen, og intravenøs indgivelse af mindst én enhedsdosis af den anden forbindelse på dag 1 og 8 i cyklussen, eller (c) hvor neoplasmen eller tumoren er en metastatisk cancer associeret med overekspression eller amplifikation af HER-2 hos et individ, hvor fremgangsmåden omfatter et regime, og hvor en cyklus i regimet omfatter 21 dage, og regimet omfatter oral indgivelse af mindst én enhedsdosis af den første forbindelse, startende på dag 2 i cyklussen, og intravenøs indgivelse af mindst én enhedsdosis af den anden forbindelse på dag 1 og 8 i cyklussen.
15. Farmaceutisk kit til anvendelse ifølge et hvilket som helst af krav 1 til 14, hvor individet tidligere er blevet indgivet lapatinib.
DK13169077.8T 2008-06-17 2009-06-17 Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin DK2656844T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7333008P 2008-06-17 2008-06-17
EP09744245.3A EP2310011B1 (en) 2008-06-17 2009-06-17 Antineoplastic combinations containing hki-272 and vinorelbine

Publications (1)

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DK2656844T3 true DK2656844T3 (da) 2015-03-02

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Application Number Title Priority Date Filing Date
DK09744245.3T DK2310011T3 (da) 2008-06-17 2009-06-17 Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin
DK13169077.8T DK2656844T3 (da) 2008-06-17 2009-06-17 Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin

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DK09744245.3T DK2310011T3 (da) 2008-06-17 2009-06-17 Antineoplastiske kombinationer indeholdende hki-272 og vinorelbin

Country Status (23)

Country Link
US (4) US20090312360A1 (da)
EP (6) EP3135285B1 (da)
JP (6) JP2011524423A (da)
KR (4) KR20180128078A (da)
CN (2) CN102641270A (da)
AU (1) AU2009271419B2 (da)
BR (1) BRPI0914790A2 (da)
CA (1) CA2725598C (da)
CY (1) CY1114552T1 (da)
DK (2) DK2310011T3 (da)
ES (6) ES2958968T3 (da)
HK (1) HK1214178A1 (da)
HR (1) HRP20130842T1 (da)
IL (2) IL209412A (da)
MX (2) MX2010013196A (da)
NZ (3) NZ616613A (da)
PL (2) PL2656844T3 (da)
PT (1) PT2310011E (da)
RU (3) RU2492860C2 (da)
SG (1) SG191676A1 (da)
SI (1) SI2310011T1 (da)
WO (1) WO2010008744A2 (da)
ZA (1) ZA201008166B (da)

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