CN115135326A - 作为c-Met激酶抑制剂的化合物的联用药物组合物及其用途 - Google Patents
作为c-Met激酶抑制剂的化合物的联用药物组合物及其用途 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
本申请涉及作为c‑Met激酶抑制剂的化合物的联用药物组合物，其包括式(I)化合物或其可药用盐、水合物或前药，亚叶酸钙和5‑氟尿嘧啶，还包括奥沙利铂或者伊立替康或其可药用盐、水合物或前药中的一种，以及该联用药物组合物用于治疗结直肠癌的用途。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010183985 | 2020-03-16 | ||
| CN2020101839851 | 2020-03-16 | ||
| PCT/CN2021/081013 WO2021185234A1 (zh) | 2020-03-16 | 2021-03-16 | 作为c-Met激酶抑制剂的化合物的联用药物组合物及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115135326A true CN115135326A (zh) | 2022-09-30 |
Family
ID=77768029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180015738.3A Pending CN115135326A (zh) | 2020-03-16 | 2021-03-16 | 作为c-Met激酶抑制剂的化合物的联用药物组合物及其用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN115135326A (zh) |
| WO (1) | WO2021185234A1 (zh) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641270A (zh) * | 2008-06-17 | 2012-08-22 | 惠氏有限责任公司 | 含有hki-272和长春瑞滨的抗肿瘤组合 |
| CN105153028A (zh) * | 2010-09-12 | 2015-12-16 | 南京爱德程医药科技有限公司 | 作为c-Met激酶抑制剂的化合物 |
| CN106950384A (zh) * | 2017-04-14 | 2017-07-14 | 深圳人仁生物医药科技有限公司 | 直肠肿瘤标志物及其应用、试剂盒 |
| CN107281102A (zh) * | 2016-04-11 | 2017-10-24 | 江苏竞诺择生物医药科技有限公司 | 一种用于结直肠肿瘤治疗的药物微粒组合物 |
| CN110573178A (zh) * | 2018-01-05 | 2019-12-13 | 伊索弗尔医药公司 | 治疗结直肠癌和转移性结直肠癌的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2190429B1 (en) * | 2007-09-10 | 2016-04-20 | Boston Biomedical, Inc. | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
| MX2014002762A (es) * | 2011-09-09 | 2014-07-30 | Amgen Inc | Uso de proteina c-met para predecir la eficacia de anticuerpos de factor de crecimiento de anti-hepatocitos (hgf) en pacientes con cancer esofagico y gastrico. |
| WO2019083457A1 (en) * | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER IN A PATIENT IDENTIFIED AS MUTATION OF THE BETA-CATENIN PATHWAY |
-
2021
- 2021-03-16 WO PCT/CN2021/081013 patent/WO2021185234A1/zh active Application Filing
- 2021-03-16 CN CN202180015738.3A patent/CN115135326A/zh active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641270A (zh) * | 2008-06-17 | 2012-08-22 | 惠氏有限责任公司 | 含有hki-272和长春瑞滨的抗肿瘤组合 |
| CN105153028A (zh) * | 2010-09-12 | 2015-12-16 | 南京爱德程医药科技有限公司 | 作为c-Met激酶抑制剂的化合物 |
| CN107281102A (zh) * | 2016-04-11 | 2017-10-24 | 江苏竞诺择生物医药科技有限公司 | 一种用于结直肠肿瘤治疗的药物微粒组合物 |
| CN106950384A (zh) * | 2017-04-14 | 2017-07-14 | 深圳人仁生物医药科技有限公司 | 直肠肿瘤标志物及其应用、试剂盒 |
| CN110573178A (zh) * | 2018-01-05 | 2019-12-13 | 伊索弗尔医药公司 | 治疗结直肠癌和转移性结直肠癌的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021185234A1 (zh) | 2021-09-23 |
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