RU2018137037A - Антинеопластические комбинации, содержащие hki-272 и винорелбин - Google Patents

Антинеопластические комбинации, содержащие hki-272 и винорелбин Download PDF

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RU2018137037A
RU2018137037A RU2018137037A RU2018137037A RU2018137037A RU 2018137037 A RU2018137037 A RU 2018137037A RU 2018137037 A RU2018137037 A RU 2018137037A RU 2018137037 A RU2018137037 A RU 2018137037A RU 2018137037 A RU2018137037 A RU 2018137037A
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treatment regimen
hki
administered
analogue
vinorelbine
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RU2018137037A
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Чарльз ЗАХАРЧУК
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УАЙТ ЭлЭлСи
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Radiation-Therapy Devices (AREA)

Claims (28)

1. Схема лечения новообразования у субъекта, где указанная схема включает введение винорелбина или его аналога; и введение HKI-272 или его аналога.
2. Схема лечения по п.1, где стадии введения осуществляются одновременно, последовательно, совместно, в определенном порядке или согласно определенной временной зависимости.
3. Схема лечения по п.1, где указанные винорелбин или его аналог вводят в виде разовой дозы.
4. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят в виде разовой дозы.
5. Схема лечения по п.1, где указанные винорелбин или его аналог означают винорелбин.
6. Схема лечения по п.1, где указанные HKI-272 или его аналог означают HKI-272.
7. Схема лечения по п.1, где один или оба указанных компонента, т.е. винорелбин или его аналог и HKI-272 или его аналог, вводят указанному субъекту внутривенно.
8. Схема лечения по п.1, где один или оба указанных компонента, т.е. винорелбин или его аналог и HKI-272 или его аналог, вводят указанному субъекту перорально.
9. Схема лечения по п.1, где указанное новообразование связано с избыточной экспрессией или амплификацией HER-2.
10. Схема лечения по п.1, где указанное новообразование является метастатическим.
11. Схема лечения по п.1, где указанное новообразование выбрано из группы, состоящей из рака легких, рака груди, миеломы, рака простаты, раковых образований головы и шеи, переходно-клеточной карциномы, мелкоклеточной нейроэндокринной карциномы шейки матки и крупноклеточной нейроэндокринной карциномы шейки матки.
12. Схема лечения по п.11, где указанное новообразование является раком груди.
13. Схема лечения по п.12, где указанный рак груди является HER-2-положительным раком груди с метастазами.
14. Схема лечения по п.1, где указанное новообразование является солидной опухолью на поздней стадии.
15. Схема лечения по п.1, где указанные винорелбин или его аналог вводят в количестве не менее чем примерно 20 мг/л.
16. Схема лечения по п.15, где указанные винорелбин или его аналог вводят в количестве от примерно 20 до примерно 25 мг/л.
17. Схема лечения по п.16, где указанные винорелбин или его аналог вводят в количестве примерно 25 мг/л.
18. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят в количестве не менее примерно 120 мг.
19. Схема лечения по п.18, где указанные HKI-272 или его аналог вводят в количестве не менее примерно 160 мг.
20. Схема лечения по п.19, где указанные HKI-272 или его аналог вводят в количестве не менее примерно 240 мг.
21. Схема лечения по п.4, где указанная разовая доза представляет собой таблетку.
22. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят ежедневно.
23. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят по меньшей мере один раз в день.
24. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят в день 1 указанной схемы лечения.
25. Схема лечения по п.10, где указанные HKI-272 или его аналог вводят в день 2 указанной схемы лечения.
26. Схема лечения по п.1, где указанные HKI-272 или его аналог вводят в течение по меньшей мере 2 последовательных недель.
27. Фармацевтическая композиция по п.1, дополнительно включающая по меньшей мере один фармацевтически приемлемый носитель.
28. Схема лечения по п.1, дополнительно включающая радиационное лечение.
RU2018137037A 2008-06-17 2018-10-22 Антинеопластические комбинации, содержащие hki-272 и винорелбин RU2018137037A (ru)

Applications Claiming Priority (2)

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US7333008P 2008-06-17 2008-06-17
US61/073,330 2008-06-17

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RU2010151787/15A RU2492860C2 (ru) 2008-06-17 2009-06-17 Антиопластические комбинации, содержащие нкi-272 и винорелбин
RU2013126140A RU2670974C2 (ru) 2008-06-17 2013-06-06 Антинеопластические комбинации, содержащие hki-272 и винорелбин
RU2018137037A RU2018137037A (ru) 2008-06-17 2018-10-22 Антинеопластические комбинации, содержащие hki-272 и винорелбин

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RU2013126140A RU2670974C2 (ru) 2008-06-17 2013-06-06 Антинеопластические комбинации, содержащие hki-272 и винорелбин

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US (4) US20090312360A1 (ru)
EP (6) EP3730139B1 (ru)
JP (6) JP2011524423A (ru)
KR (4) KR20130088908A (ru)
CN (2) CN102099034A (ru)
AU (1) AU2009271419B2 (ru)
BR (1) BRPI0914790A2 (ru)
CA (1) CA2725598C (ru)
CY (1) CY1114552T1 (ru)
DK (2) DK2310011T3 (ru)
ES (6) ES2958968T3 (ru)
HK (1) HK1214178A1 (ru)
HR (1) HRP20130842T1 (ru)
IL (2) IL209412A (ru)
MX (2) MX2010013196A (ru)
NZ (3) NZ590009A (ru)
PL (2) PL2656844T3 (ru)
PT (1) PT2310011E (ru)
RU (3) RU2492860C2 (ru)
SG (1) SG191676A1 (ru)
SI (1) SI2310011T1 (ru)
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SG191676A1 (en) 2013-07-31
RU2492860C2 (ru) 2013-09-20
ES2692769T3 (es) 2018-12-05
PL2656844T3 (pl) 2015-05-29
JP2016074745A (ja) 2016-05-12
EP2656844B1 (en) 2014-12-03
EP3730139A1 (en) 2020-10-28
US20140107147A1 (en) 2014-04-17
EP2915532B1 (en) 2016-10-19
EP3443961B1 (en) 2020-10-28
AU2009271419A1 (en) 2010-01-21
EP2310011A2 (en) 2011-04-20

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