DK2576523T3 - Krystallinsk form af 4-[5-[3-chlor-5-(trifluormethyl)-phenyl]-4,5-dihydro-5- (trifluormethyl)-3-isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluorethyl)amino]ethyl]- 1-naphthalencarboxamid - Google Patents

Krystallinsk form af 4-[5-[3-chlor-5-(trifluormethyl)-phenyl]-4,5-dihydro-5- (trifluormethyl)-3-isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluorethyl)amino]ethyl]- 1-naphthalencarboxamid Download PDF

Info

Publication number
DK2576523T3
DK2576523T3 DK11727834.1T DK11727834T DK2576523T3 DK 2576523 T3 DK2576523 T3 DK 2576523T3 DK 11727834 T DK11727834 T DK 11727834T DK 2576523 T3 DK2576523 T3 DK 2576523T3
Authority
DK
Denmark
Prior art keywords
compound
solid
polymorph
spp
animal
Prior art date
Application number
DK11727834.1T
Other languages
English (en)
Inventor
Martin James Currie
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Application granted granted Critical
Publication of DK2576523T3 publication Critical patent/DK2576523T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Claims (7)

  1. KRYSTALLINSK FORM AF 4-[5-[3-CHLOR-5-(TRIFLUORMETHYL)-PHENYL]-4,5-DIHYDRO-5-(TRIFLUORMETHYL)-3-ISOXAZOLYL]-N-[2-OXO-2-[(2,2,2-TRIFLUORETHYL)AMINO]ETHYL]-
    1- NAPHTHALEN C ARBOX AMID
    1. Krystallinsk polymorf af 4-[5-[3-chlor-5-(trifhrormethyl)phenyl]-4,5-dihydro-5-(trifluormethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifhrorethylamino]ethyl]-1 -naphthalencarboxamid kendetegnet ved et røntgenpulverdiffraktionsmønster, der mindst har følgende 2Θ reflektionspositioner
  2. 2. Sammensætning, der omfatter polymorfen ifølge krav 1 og mindst én yderligere bestanddel, der er udvalgt fra gruppen bestående af overfladeaktive midler, solide opløsningsmidler og flydende opløsningsmidler, hvilken sammensætning eventuelt yderligere omfatter mindst én yderligere biologisk aktiv forbindelse eller et yderligere biologisk aktivt middel.
  3. 3. Sammensætning til beskyttelse af et dyr mod et hvirvelløst parasitisk skadedyr, hvilken sammensætning omfatter en parasitisk effektiv mængde af polymorfen ifølge krav 1 og mindst én bærer.
  4. 4. Sammensætning ifølge krav 3 i en doseringsform til oral administration.
  5. 5. Fremgangsmåde til bekæmpelse af et hvirvelløst skadedyr, hvilken fremgangsmåde omfatter etablering af kontakt mellem det hvirvelløse skadedyr eller dets miljø og en biologisk effektiv mængde af polymorfen ifølge krav 1, forudsat at fremgangsmåden ikke er en fremgangsmåde til behandling af menneske- eller dyrekroppen ved hjælp af terapi.
  6. 6. Fremgangsmåde ifølge krav 5, hvor miljøet er en plante.
  7. 7. Polymorf ifølge krav 1 til anvendelse til bekæmpelse af et hvirvelløst skadedyr.
DK11727834.1T 2010-05-27 2011-05-19 Krystallinsk form af 4-[5-[3-chlor-5-(trifluormethyl)-phenyl]-4,5-dihydro-5- (trifluormethyl)-3-isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluorethyl)amino]ethyl]- 1-naphthalencarboxamid DK2576523T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34895810P 2010-05-27 2010-05-27
PCT/US2011/037083 WO2011149749A1 (en) 2010-05-27 2011-05-19 Crystalline form of 4- [5 - [3 -chloro-5 - (trifluoromethyl) phenyl] -4, 5 - dihydro - 5 - (trifluoromethyl) -3 - isoxazolyl] -n- [2-0x0-2- [ ( 2, 2, 2 - trifluoroethyl) amino] ethyl] -1- naphthalenecarboxamide

Publications (1)

Publication Number Publication Date
DK2576523T3 true DK2576523T3 (da) 2016-04-18

Family

ID=44359642

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11727834.1T DK2576523T3 (da) 2010-05-27 2011-05-19 Krystallinsk form af 4-[5-[3-chlor-5-(trifluormethyl)-phenyl]-4,5-dihydro-5- (trifluormethyl)-3-isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluorethyl)amino]ethyl]- 1-naphthalencarboxamid

Country Status (30)

Country Link
US (1) US8598087B2 (da)
EP (1) EP2576523B1 (da)
JP (1) JP5933530B2 (da)
KR (3) KR102060464B1 (da)
CN (1) CN102947278B (da)
AR (2) AR081226A1 (da)
AU (1) AU2011258621B2 (da)
BR (1) BR112012030151B8 (da)
CA (1) CA2799963C (da)
CL (1) CL2012003272A1 (da)
DK (1) DK2576523T3 (da)
ES (1) ES2566402T3 (da)
GT (1) GT201200316A (da)
HK (1) HK1183875A1 (da)
HR (1) HRP20160355T1 (da)
HU (1) HUE028501T2 (da)
IL (1) IL223002A (da)
MA (1) MA34247B1 (da)
MD (1) MD4363C1 (da)
MX (1) MX2012013758A (da)
MY (1) MY156670A (da)
NZ (1) NZ603584A (da)
PL (1) PL2576523T3 (da)
RS (1) RS54677B1 (da)
SI (1) SI2576523T1 (da)
TN (1) TN2012000557A1 (da)
UA (1) UA108881C2 (da)
UY (1) UY33397A (da)
WO (1) WO2011149749A1 (da)
ZA (1) ZA201208760B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
PL2755473T3 (pl) 2011-09-12 2019-05-31 Merial Inc Kompozycje przeciwpasożytniczne zawierające izoksazolinową substancję czynną, sposoby i ich zastosowania
AP2014007874A0 (en) * 2012-02-06 2014-08-31 Merial Ltd Parasiticidal oral veterinary compositions comprising systemetically- acting active agents, methods and uses thereof
RU2646483C2 (ru) 2012-04-04 2018-03-05 Интервет Интернэшнл Б.В. Твердые фармацевтические композиции для перорального введения на основе изоксазолиновых соединений
AR093771A1 (es) 2012-10-01 2015-06-24 Basf Se Metodo para controlar insectos resistentes a insecticidas
KR20150067270A (ko) 2012-10-01 2015-06-17 바스프 에스이 안트라닐아미드 화합물을 포함하는 살충적으로 활성인 혼합물
AR093828A1 (es) 2012-10-01 2015-06-24 Basf Se Mezclas activas como plaguicidas, que comprenden compuestos de antranilamida
EP2903439A1 (en) 2012-10-01 2015-08-12 Basf Se Method of controlling ryanodine-modulator insecticide resistant insects
US20150250174A1 (en) 2012-10-01 2015-09-10 Basf Se Use of n-thio-anthranilamide compounds on cultivated plants
WO2014053401A2 (en) 2012-10-01 2014-04-10 Basf Se Method of improving plant health
WO2014053407A1 (en) 2012-10-01 2014-04-10 Basf Se N-thio-anthranilamide compounds and their use as pesticides
US9532946B2 (en) 2012-11-20 2017-01-03 Intervet Inc. Manufacturing of semi-plastic pharmaceutical dosage units
WO2014079820A1 (en) 2012-11-22 2014-05-30 Basf Se Use of anthranilamide compounds for reducing insect-vectored viral infections
EP2984074A1 (en) 2012-12-14 2016-02-17 Basf Se Malononitrile compounds for controlling animal pests
US20150368236A1 (en) 2012-12-27 2015-12-24 Basf Se 2-(pyridin-3-yl)-5-hetaryl-thiazole compounds carrying an imine or imine-derived substituent for combating invertebrate pests
MY172725A (en) 2013-02-06 2019-12-11 Vetoquinol Sa Halogen-substituted pyrazol derivatives as pest-control agents
JPWO2014126208A1 (ja) * 2013-02-14 2017-02-02 日産化学工業株式会社 イソキサゾリン置換ベンズアミド化合物の結晶性多形体及びその製造方法
JP6378702B2 (ja) 2013-03-15 2018-08-22 アルジェンタ マニュファクチャリング リミティド チュアブル製剤
US20160050923A1 (en) 2013-04-19 2016-02-25 Basf Se N-substituted acyl-imino-pyridine compounds and derivatives for combating animal pests
BR112015031439A2 (pt) 2013-06-21 2017-07-25 Basf Se métodos para o combate ou controle das pragas, para o tratamento, prevenção e proteção de culturas de soja, para o controle e proteção do material de propagação dos vegetais de soja, para o combate ou controle das pragas e utilização de um composto de fórmula i
PL3022185T3 (pl) 2013-07-15 2018-02-28 Basf Se Związki szkodnikobójcze
CA2922506A1 (en) 2013-09-19 2015-03-26 Basf Se N-acylimino heterocyclic compounds
WO2015055497A1 (en) 2013-10-16 2015-04-23 Basf Se Substituted pesticidal pyrazole compounds
EA201600326A1 (ru) 2013-10-18 2016-10-31 Басф Агрокемикэл Продактс Б.В. Применение пестицидного активного производного карбоксамида в способах применения и обработки семян и почвы
CN105829296A (zh) 2013-12-18 2016-08-03 巴斯夫欧洲公司 带有亚胺衍生的取代基的唑类化合物
JP2017502022A (ja) 2013-12-18 2017-01-19 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ Ｎ−置換イミノ複素環式化合物
EP3089972B1 (de) 2014-01-03 2018-05-16 Bayer Animal Health GmbH Neue pyrazolyl-heteroarylamide als schädlingsbekämpfungsmittel
WO2015104422A1 (en) 2014-01-13 2015-07-16 Basf Se Dihydrothiophene compounds for controlling invertebrate pests
TW201607938A (zh) 2014-07-15 2016-03-01 拜耳作物科學股份有限公司 作為殺蟲劑之新穎芳基三唑基吡啶類
UY36570A (es) * 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
US20170020848A1 (en) * 2015-04-08 2017-01-26 Merial Inc. Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
UY37137A (es) * 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
JP2019535655A (ja) 2016-10-14 2019-12-12 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 殺虫性及び殺寄生虫性ビニルイソオキサゾリン化合物
UY37665A (es) * 2017-04-05 2018-10-31 Merial Inc Formas cristalinas de (s)-afoxolaner
KR101988442B1 (ko) * 2017-06-30 2019-06-12 주식회사 삼양사 결정형 기능성 감미료
EP3668866B1 (en) 2017-08-14 2023-01-18 Boehringer Ingelheim Animal Health USA Inc. Pesticidal and parasiticidal pyrazole-isoxazoline compounds
WO2019091940A1 (en) 2017-11-07 2019-05-16 Intervet International B.V. Process for preparing large size isoxazoline particles
BR122023023401A2 (pt) * 2017-11-07 2024-02-20 Intervet International B.V. Composição farmacêutica injetável, usos de um composto isoxazolina e kit compreendendo o referido composto
AU2021278871A1 (en) 2020-05-28 2023-01-19 Boehringer Ingelheim Animal Health USA Inc. Bi-modal release intra-ruminal capsule device and methods of use thereof
WO2021254445A1 (zh) * 2020-06-19 2021-12-23 东莞市东阳光仿制药研发有限公司 一种gaba抑制剂的晶型及其制备方法
CA3205997A1 (en) 2020-12-21 2022-06-30 University Of Georgia Research Foundation Inc. Parasiticidal collar comprising isoxazoline compounds

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1815604A (en) 1922-10-31 1931-07-21 Winthrop Chem Co Organic mercury compound
US1679404A (en) 1926-02-04 1928-08-07 Rockwood Sprinkler Co Massachusetts Constant-alarm device for alarm valves
BE392862A (da) 1931-12-08
US2891855A (en) 1954-08-16 1959-06-23 Geigy Ag J R Compositions and methods for influencing the growth of plants
US3235361A (en) 1962-10-29 1966-02-15 Du Pont Method for the control of undesirable vegetation
US3060084A (en) 1961-06-09 1962-10-23 Du Pont Improved homogeneous, readily dispersed, pesticidal concentrate
US3299566A (en) 1964-06-01 1967-01-24 Olin Mathieson Water soluble film containing agricultural chemicals
US3309192A (en) 1964-12-02 1967-03-14 Du Pont Method of controlling seedling weed grasses
US4144050A (en) 1969-02-05 1979-03-13 Hoechst Aktiengesellschaft Micro granules for pesticides and process for their manufacture
US3852416A (en) 1971-05-27 1974-12-03 L Grubb Tick and flea collar of solid solution plasticized vinylic resin-carbamate insecticide
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
US3984564A (en) 1972-06-08 1976-10-05 Sankyo Company Limited Antibiotic substances B-41, their production and their use as insecticides and acaricides
US3920442A (en) 1972-09-18 1975-11-18 Du Pont Water-dispersible pesticide aggregates
US3854216A (en) 1973-05-14 1974-12-17 Owatonna Tool Co Disc brake tool
US3879532A (en) 1974-01-18 1975-04-22 Shell Oil Co Control by isoxazoles of endoparasitic nematodes
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4172714A (en) 1976-12-20 1979-10-30 E. I. Du Pont De Nemours And Company Dry compactible, swellable herbicidal compositions and pellets produced therefrom
US4129568A (en) 1977-05-12 1978-12-12 Monsanto Company 2-[3-Aryl-2-isoxazolin-5-yl]benzoates
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
ES8104203A1 (es) 1979-02-05 1981-04-16 Schering Corp Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol
US4224901A (en) 1979-04-16 1980-09-30 Carey Jr Sam H Combination inner flea-tick collar and outer protective collar, for animals
GB2095558B (en) 1981-03-30 1984-10-24 Avon Packers Ltd Formulation of agricultural chemicals
US4820695A (en) 1982-09-13 1989-04-11 Eli Lilly And Company C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics
DE3246493A1 (de) 1982-12-16 1984-06-20 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von wasserdispergierbaren granulaten
IT1173213B (it) 1984-02-03 1987-06-18 Zambon Spa Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi
US5105009A (en) 1983-06-02 1992-04-14 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives
US5332835A (en) 1984-02-03 1994-07-26 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
US4582918A (en) 1984-09-19 1986-04-15 Schering Corporation Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4973750A (en) 1984-09-19 1990-11-27 Schering Corporation Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
ES8800986A1 (es) 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
US4916154A (en) 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
US5180587A (en) 1988-06-28 1993-01-19 E. I. Du Pont De Nemours And Company Tablet formulations of pesticides
US4876352A (en) 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
US5227494A (en) 1988-09-14 1993-07-13 Schering Corporation Process for preparing oxazoline compounds
EP0415688B1 (en) 1989-08-30 1998-12-23 Aeci Ltd Dosage device and use thereof
BR9106147A (pt) 1990-03-12 1993-03-09 Du Pont Granulos de pesticidas dispersaveis em agua ou soluveis em agua feitos a partir de ligantes termo-ativados
IL98599A (en) 1990-06-28 1995-06-29 Merck & Co Inc Stable salts of "4-deoxy-" 4-epi-methylamino abramectin and insecticides containing them
ES2091878T3 (es) 1990-10-11 1996-11-16 Sumitomo Chemical Co Composicion plaguicida.
AU646910B2 (en) 1990-10-25 1994-03-10 Schering Corporation Process for preparing florfenicol, its analogs and oxazoline intermediates thereto
US5184573A (en) 1992-02-21 1993-02-09 Stevens Jr John L Animal collar
US5352832A (en) 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US5399717A (en) 1993-09-29 1995-03-21 Merck & Co., Inc. Glycosidation route to 4"-epi-methylamino-4"-deoxyavermectin B1
US5849736A (en) 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
GB9505651D0 (en) 1995-03-21 1995-05-10 Agrevo Uk Ltd AgrEvo UK Limited
US5555848A (en) 1995-05-17 1996-09-17 Trujillo; Wendy J. Pet/flea collar
AU1671097A (en) 1996-04-26 1997-11-19 Nippon Soda Co., Ltd. Benzene derivatives substituted by heterocycles and herbicides
AR007292A1 (es) 1996-06-06 1999-10-27 Rohm & Haas Compuestos aromaticos benciloxi sustituidos, una composicion fungicida, un metodo para controlar hongos fitopatogenicos y un metodo para controlarinsectos.
US5958888A (en) 1996-07-02 1999-09-28 Merial, Inc. Water miscible macrolide solutions
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
US5663361A (en) 1996-08-19 1997-09-02 Schering Corporation Process for preparing intermediates to florfenicol
HRP980291A2 (en) * 1997-06-16 1999-04-30 Lin-Hua Zhang Crystalline roxifiban
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
JP2003512290A (ja) 1997-09-10 2003-04-02 メルク エンド カムパニー インコーポレーテッド 家畜抗菌剤としての８ａ−アザライド
AP9801420A0 (en) 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6239112B1 (en) 1998-07-09 2001-05-29 Merial, Inc. Water miscible macrolide solutions
CZ299375B6 (cs) 1998-11-30 2008-07-09 Nihon Nohyaku Co., Ltd. Ftalamidové deriváty nebo jejich soli, zemedelsko-zahradnický insekticid je obsahující a jeho použití
CA2411293A1 (en) 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
GB2351081A (en) 1999-06-18 2000-12-20 Lilly Forschung Gmbh Pharmaceutically active imidazoline compounds and analogues thereof
PT1250343E (pt) 2000-01-27 2003-11-28 Pfizer Prod Inc Composicoes de antibioticos de azalida
MY138097A (en) 2000-03-22 2009-04-30 Du Pont Insecticidal anthranilamides
DE10114597A1 (de) 2001-03-23 2002-10-02 Bayer Cropscience Gmbh Arylisoxazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel
MXPA03009786A (es) 2001-04-27 2004-01-29 Pfizer Prod Inc Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-sustituidos.
TWI312274B (en) 2001-08-13 2009-07-21 Du Pont Method for controlling particular insect pests by applying anthranilamide compounds
TW200724033A (en) 2001-09-21 2007-07-01 Du Pont Anthranilamide arthropodicide treatment
CN1649829A (zh) 2002-03-08 2005-08-03 先灵-普劳有限公司 新型氟苯尼考类抗生素
EP1538138A4 (en) 2002-08-26 2007-07-25 Nissan Chemical Ind Ltd SUBSTITUTED BENZANILIDE COMPOUND AND PROTECTIVE AGENTS
DK1599463T3 (da) 2003-01-28 2013-09-02 Du Pont Cyan-anthranilamidinsekticider
DE10320782A1 (de) 2003-05-09 2004-11-25 Bayer Cropscience Ag Substituierte Oxyarene
JP2005272452A (ja) 2004-02-23 2005-10-06 Nissan Chem Ind Ltd 置換ベンズアニリド化合物及び有害生物防除剤
EA014881B1 (ru) 2004-03-05 2011-02-28 Ниссан Кемикал Индастриз, Лтд. Производные замещенного алкилбензола
BRPI0507818A (pt) 2004-03-26 2007-07-10 Cytokine Pharmasciences Inc composto e métodos de inibição
JP5051340B2 (ja) 2005-06-06 2012-10-17 日産化学工業株式会社 置換イソキサゾリン化合物及び有害生物防除剤
MY146795A (en) 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
EP1932836B1 (en) 2005-09-02 2013-11-06 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and harmful organism-controlling agent
JP2007106756A (ja) 2005-09-14 2007-04-26 Nissan Chem Ind Ltd 置換イソキサゾリン化合物及び有害生物防除剤
EP1965645A2 (en) 2005-12-14 2008-09-10 E.I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
US7700808B2 (en) 2005-12-26 2010-04-20 Nissan Chemical Industries, Ltd. 1-3-bis(substituted phenyl)-3-hydroxypropan-1-one or 2-propen-1-one compound, and salt thereof
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
DE602007006288D1 (de) 2006-03-10 2010-06-17 Nissan Chemical Ind Ltd Substituierte isoxazolin-verbindung und schädlingsbekämpfungsmittel
MX2008013307A (es) 2006-04-20 2008-10-27 Du Pont Pirazolinas para controlar plagas de invertebrados.
WO2007125984A1 (ja) 2006-04-28 2007-11-08 Nihon Nohyaku Co., Ltd. イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
EP2151437A4 (en) 2007-03-07 2012-05-02 Nissan Chemical Ind Ltd ISOXAZOLINE SUBSTITUTED BENZAMIDE COMPOUND AND PEST CONTROL AGENT
WO2008122375A2 (en) 2007-04-10 2008-10-16 Bayer Cropscience Ag Insecticidal aryl isoxazoline derivatives
BRPI0809770B8 (pt) 2007-06-13 2022-12-06 Du Pont Composto e composição para controlar uma praga de invertebrados
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
BRPI0810929B8 (pt) 2007-06-27 2022-12-06 Du Pont uso de um composto de fórmula 1
EP2172462A4 (en) 2007-06-27 2010-12-15 Nissan Chemical Ind Ltd METHOD FOR PRODUCING A 3-HYDROXYPROPAN-1-ON COMPOUND, METHOD FOR PRODUCING A 2-PROPENE-1-ON COMPOUND, AND METHOD FOR PRODUCING AN ISOXAZOLINE COMPOUND
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TWI649303B (zh) * 2007-08-17 2019-02-01 杜邦股份有限公司 製備４-乙醯基-ｎ-〔２-側氧基-２-〔（２，２，２-三氟乙基）胺基〕乙基〕-１-萘甲醯胺之化合物及方法
KR20100064382A (ko) 2007-09-10 2010-06-14 닛산 가가쿠 고교 가부시키 가이샤 치환 이속사졸린 화합물 및 유해생물 방제제
WO2009045999A1 (en) 2007-10-03 2009-04-09 E. I. Du Pont De Nemours And Company Naphthalene isoxazoline compounds for control of invertebrate pests
TWI518076B (zh) 2008-04-09 2016-01-21 杜邦股份有限公司 製備雜環化合物之方法
EP2308857B1 (en) * 2008-07-09 2016-04-27 Nissan Chemical Industries, Ltd. Process for production of isoxazoline-substituted benzoic acid amide compound
CN102458104B (zh) * 2009-04-28 2014-12-31 巴斯夫公司 农药组合物和施用器

Also Published As

Publication number Publication date
HRP20160355T1 (hr) 2016-05-06
IL223002A0 (en) 2012-12-31
KR102060464B1 (ko) 2019-12-30
UY33397A (es) 2011-12-01
GT201200316A (es) 2014-04-08
BR112012030151B8 (pt) 2022-11-08
IL223002A (en) 2016-06-30
US20130137735A1 (en) 2013-05-30
TN2012000557A1 (en) 2014-04-01
JP2013528177A (ja) 2013-07-08
UA108881C2 (xx) 2015-06-25
US8598087B2 (en) 2013-12-03
CN102947278A (zh) 2013-02-27
MD4363B1 (ro) 2015-08-31
BR112012030151A2 (pt) 2015-10-20
RS54677B1 (en) 2016-08-31
NZ603584A (en) 2015-02-27
KR20180093114A (ko) 2018-08-20
MD20120125A2 (en) 2013-05-31
CA2799963A1 (en) 2011-12-01
AU2011258621B2 (en) 2014-08-14
CN102947278B (zh) 2015-08-12
BR112012030151B1 (pt) 2019-10-08
WO2011149749A1 (en) 2011-12-01
HK1183875A1 (zh) 2014-01-10
MA34247B1 (fr) 2013-05-02
EP2576523B1 (en) 2016-01-13
EP2576523A1 (en) 2013-04-10
SI2576523T1 (sl) 2016-05-31
PL2576523T3 (pl) 2016-08-31
ES2566402T3 (es) 2016-04-12
ZA201208760B (en) 2014-03-26
KR20130124458A (ko) 2013-11-14
RU2012157267A (ru) 2014-07-10
MD4363C1 (ro) 2016-03-31
JP5933530B2 (ja) 2016-06-08
CL2012003272A1 (es) 2013-08-02
KR20170015549A (ko) 2017-02-08
AR081226A1 (es) 2012-07-04
MX2012013758A (es) 2013-01-24
AU2011258621A1 (en) 2012-12-06
AR117778A2 (es) 2021-08-25
MY156670A (en) 2016-03-15
CA2799963C (en) 2018-01-23
HUE028501T2 (en) 2016-12-28

Similar Documents

Publication Publication Date Title
DK2576523T3 (da) Krystallinsk form af 4-[5-[3-chlor-5-(trifluormethyl)-phenyl]-4,5-dihydro-5- (trifluormethyl)-3-isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluorethyl)amino]ethyl]- 1-naphthalencarboxamid
DK2158188T3 (da) Naphtalin-isoxazolin som middel til bekæmpelse af hvirvelløse skadedyr
CA2768702C (en) Mixtures of mesoionic pesticides
US20120122680A1 (en) Mesoionic pesticides
CA2684671A1 (en) Isoxazoline insecticides
WO2009051956A2 (en) Pyrazole-substituted isoxazoline insecticides
EP1966195A2 (en) 5-aryl isoxazolines for controlling invertebrate pests
WO2012087630A1 (en) Pyridine and pyrimidine compounds for controlling invertebrate
WO2012012366A1 (en) Pesticidal 3-(aryloxy)azacycloalkanes
AU2018202270B2 (en) Naphthalene isoxazoline invertebrate pest control agents
RU2575121C2 (ru) Кристаллическая форма 4-[5-[3-хлор-5-(трифторметил)фенил]-4,5-дигидро-5-(трифторметил)-3-изоксазолил]-n-[2-оксо-2-[(2,2,2-трифторэтил)амино]этил]-1-нафталинкарбоксамида
AU2015201191B2 (en) Mesoionic pesticides
AU2013273726B2 (en) Naphthalene isoxazoline invertebrate pest control agents
AU2014262192A1 (en) Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-n-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide