DK2568049T3 - Mice expressing a hybrid immunoglobulin light chain with a human variable region - Google Patents
Mice expressing a hybrid immunoglobulin light chain with a human variable region Download PDFInfo
- Publication number
- DK2568049T3 DK2568049T3 DK12195716.1T DK12195716T DK2568049T3 DK 2568049 T3 DK2568049 T3 DK 2568049T3 DK 12195716 T DK12195716 T DK 12195716T DK 2568049 T3 DK2568049 T3 DK 2568049T3
- Authority
- DK
- Denmark
- Prior art keywords
- mouse
- light chain
- gene
- human
- endogenous
- Prior art date
Links
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- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01K2267/035—Animal model for multifactorial diseases
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| EP11728508.0A EP2480675B1 (en) | 2010-06-22 | 2011-06-22 | Mice expressing a light chain with human lambda variable and mouse constant regions |
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| DK11728508.0T DK2480675T3 (en) | 2010-06-22 | 2011-06-22 | Mice expressing a light chain with the human lambda variable and constant regions from mouse |
| DK11728509.8T DK2480676T3 (en) | 2010-06-22 | 2011-06-22 | MICE EXPRESSING A HYDRIDE immunoglobulin light chain |
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