DK2510001T3 - Monoklonale antistoffer mod rgm a-proteinet til anvendelse til behandling af degeneration af det retinale nervefiberlag - Google Patents
Monoklonale antistoffer mod rgm a-proteinet til anvendelse til behandling af degeneration af det retinale nervefiberlag Download PDFInfo
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- DK2510001T3 DK2510001T3 DK10794938.0T DK10794938T DK2510001T3 DK 2510001 T3 DK2510001 T3 DK 2510001T3 DK 10794938 T DK10794938 T DK 10794938T DK 2510001 T3 DK2510001 T3 DK 2510001T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (17)
1. Bindeprotein til humant "Repulsive Guidance Molecule" A (RGM A) til anvendelse til behandling af degeneration af det retinale nervefiberlag (RNFL).
2. Bindeprotein til anvendelse ifølge krav 1, hvor behandlingen er en terapeutisk eller profylaktisk, neuroregenerativ eller neurobeskyttende, lokal eller systemisk behandling.
3. Bindeprotein til anvendelse ifølge krav 1 eller 2, hvor der som et resultat af behandlingen a) observeres fremkomst af retinale neuroner, og/eller b) hvor RGC (retinale gangliecelle)-axoner i retina beskyttes mod degeneration.
4. Bindeprotein til anvendelse ifølge et af de foregående krav, hvor RNFL-degenerationen er associeret med en sygdom valgt blandt: diabetisk retinopati, iskæmisk optisk neuropati, X-kromosomforbundet retinoskise, lægemiddelinduceret optisk neuropati, retinal dystrofi, aldersrelateret makuladegeneration, øjensygdomme kendetegnet ved synsnervehoveddrusen, øjensygdom kendetegnet ved genetiske determinanter for fotoreceptordegeneration, autosomal recessiv tap-stavdystrofi og mitokondriesygdomme med optisk neuropati.
5. Bindeprotein til anvendelse ifølge et af de foregående krav, hvilket bindeprotein dissocieres fra humant RGM A med en KD på 1 x 10_7M eller derunder og en k0ff-hastighedskonstant på 1 x 10'2S'1 eller derunder, begge bestemt ved hjælp af overfladeplasmonresonans.
6. Bindeprotein til anvendelse ifølge et af de foregående krav, hvilket bindeprotein binder sig til humant RGM A og neutraliserer den neuritudvækst-hæmmende aktivitet af humant RGM A som bestemt i et standard-in vitro-assay.
7. Bindeprotein til anvendelse ifølge et af de foregående krav, hvilket bindeprotein er et humaniseret antistof.
8. Bindeprotein til anvendelse ifølge et af de foregående krav, hvor bindeproteinet omfatter et antigenbindende domæne, hvilket bindeprotein kan binde sig til en epitop på et RGM-molekyle, og hvilket antigenbindende domæne omfatter mindst én CDR valgt fra gruppen bestående af: a) aminosyresekvenserne fra CDR-H3-gruppen bestående af SEQ ID NO: 59 og 65 og modificerede CDR-aminosyresekvenser, som udviser en sekvensidentitet på mindst 50% med én af sekvenserne; og/eller b) aminosyresekvenserne fra CDR-L3-gruppen bestående af SEQ ID NO: 62 og 68 og modificerede CDR-aminosyresekvenser, som udviser en sekvensidentitet på mindst 50% med én af sekvenserne.
9. Bindeprotein til anvendelse ifølge et af de foregående krav, som endvidere omfatter mindst én CDR valgt blandt: a) aminosyresekvenserne fra CDR-H1-gruppen bestående af SEQ ID NO: 57 og 63; og/eller b) aminosyresekvenserne fra CDR-L1-gruppen bestående af SEQ ID NO: 60 og 66; og/eller c) aminosyresekvenserne fra CDR-H2-gruppen bestående af SEQ ID NO: 58 og 64; og/eller d) aminosyresekvenserne fra CDR-L2-gruppen bestående af SEQ ID NO: 61 og 67 og modificerede CDR-aminosyresekvenser, som udviser en sekvensidentitet på mindst 50% med én af sekvenserne.
10. Bindeprotein til anvendelse ifølge krav 9, hvilket bindeprotein omfatter mindst 3 CDR, som er valgt fra et CDR-sæt fra et variabelt domæne, bestående af:
3
eller et sæt fra et variabelt domæne, hvor mindst én af de 3 CDRs er en modificeret CDR-aminosyresekvens, som udviser en sekvensidentitet på mindst 50% med stamsekvensen. 5
11. Bindeprotein til anvendelse ifølge krav 10, hvilket bindeprotein omfatter mindst to CDR-sæt fra variable domæner.
12. Bindeprotein til anvendelse ifølge krav 11, hvor de mindst to CDR-sæt fra 10 variable domæner er valgt fra en gruppe bestående af: VH 5F9-sæt og VL 5F9-sæt; og VH 8D1-sæt og VL 8D1-sæt.
13. Bindeprotein til anvendelse ifølge et af de foregående krav, hvilket 15 bindeprotein endvidere omfatter et humant acceptorframework.
14. Bindeprotein til anvendelse ifølge et af de foregående krav, hvilket bindeprotein omfatter mindst ét domæne af en tung kæde valgt blandt SEQ ID NO: 35, 36, 37, 38, 39, 40, 41,42 og 43; og/eller mindst ét variabelt domæne af 20 en let kæde valgt blandt SEQ ID NO: 44, 45 oq 46.
15. Bindeprotein til anvendelse ifølge et hvilket som helst af kravene 13 og 14, hvor det humane acceptorframework omfatter mindst én substitution af en aminosyrerest i en nøgleposition i frameworkregionen, hvilken nøglerest er valgt fra gruppen bestående af: (position i tungkæde-sekvens): 1,5, 37, 48, 49, 88, 98; (position i letkæde-sekvens): 2, 4,41,51.
16. Bindeprotein ifølge et hvilket som helst af de foregående krav, hvor bindeproteinet omfatter mindst ét (framework-muteret) variabelt domæne med en aminosyresekvens valgt fra gruppen bestående af: (tungkæde-sekvenser) SEQ ID NO: 47, 48, 49, 50; og (letkæde-sekvenser) SEQ ID NO: 51,52, 53 og 54.
17. Bindeprotein til anvendelse ifølge et hvilket som helst af de foregående krav, hvilket bindeprotein er et antistof valgt blandt 5F9 og 8D1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26744609P | 2009-12-08 | 2009-12-08 | |
PCT/EP2010/069120 WO2011070045A1 (en) | 2009-12-08 | 2010-12-08 | Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2510001T3 true DK2510001T3 (da) | 2016-02-29 |
Family
ID=43806839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10794938.0T DK2510001T3 (da) | 2009-12-08 | 2010-12-08 | Monoklonale antistoffer mod rgm a-proteinet til anvendelse til behandling af degeneration af det retinale nervefiberlag |
Country Status (17)
Country | Link |
---|---|
US (4) | US9175075B2 (da) |
EP (1) | EP2510001B1 (da) |
JP (5) | JP5951498B2 (da) |
KR (1) | KR20120118002A (da) |
CN (2) | CN113717286A (da) |
AU (1) | AU2010329955A1 (da) |
BR (1) | BR112012013734A2 (da) |
CA (1) | CA2780069C (da) |
DK (1) | DK2510001T3 (da) |
EC (1) | ECSP12012029A (da) |
ES (1) | ES2562832T3 (da) |
IL (1) | IL219766A0 (da) |
MX (1) | MX2012006560A (da) |
PL (1) | PL2510001T3 (da) |
SG (1) | SG181563A1 (da) |
WO (1) | WO2011070045A1 (da) |
ZA (1) | ZA201204106B (da) |
Families Citing this family (15)
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AU2002231736A1 (en) | 2000-12-22 | 2002-07-08 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Use of repulsive guidance molecule (rgm) and its modulators |
EP1928905B1 (de) | 2005-09-30 | 2015-04-15 | AbbVie Deutschland GmbH & Co KG | Bindungsdomänen von proteinen der repulsive guidance molecule (rgm) proteinfamilie und funktionale fragmente davon sowie deren verwendung |
US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
MX2012006560A (es) | 2009-12-08 | 2012-10-05 | Abbott Gmbh & Co Kg | Anticuerpos monoclonales contra la proteina rgm a para utilizarse en el tratamiento de degeneracion de capa de fibra de nervio retinal. |
AU2012352168C1 (en) | 2011-12-14 | 2018-01-25 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
CN104136462B (zh) | 2011-12-14 | 2017-06-09 | 艾伯维德国有限责任两合公司 | 用于诊断和治疗铁相关病症的组合物和方法 |
IL297229A (en) | 2012-01-27 | 2022-12-01 | Abbvie Inc | The composition and method for the diagnosis and treatment of diseases related to the degeneration of nerve cells |
WO2013113107A1 (en) * | 2012-02-03 | 2013-08-08 | University Health Network | Methods for promoting neuron survival, axonal growth and/or regeneration |
CN105793284A (zh) * | 2013-09-17 | 2016-07-20 | 大学健康网络(Uhn):技术开发和商业化公司 | 针对顺式RGMa/再生蛋白相互作用或脂筏的试剂及其在治疗方法中的应用 |
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AU2021259440A1 (en) * | 2020-04-21 | 2022-12-08 | University Of Massachusetts | Methods and compositions for treatment of age-related macular degeneration |
WO2022081436A1 (en) * | 2020-10-15 | 2022-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Antibody specific for sars-cov-2 receptor binding domain and therapeutic methods |
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JP6430438B2 (ja) | 2018-11-28 |
EP2510001B1 (en) | 2015-12-02 |
CA2780069C (en) | 2018-07-17 |
JP2016198099A (ja) | 2016-12-01 |
JP2013512942A (ja) | 2013-04-18 |
WO2011070045A1 (en) | 2011-06-16 |
SG181563A1 (en) | 2012-07-30 |
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KR20120118002A (ko) | 2012-10-25 |
CA2780069A1 (en) | 2011-06-16 |
MX2012006560A (es) | 2012-10-05 |
US20110135664A1 (en) | 2011-06-09 |
CN113717286A (zh) | 2021-11-30 |
PL2510001T3 (pl) | 2016-06-30 |
IL219766A0 (en) | 2012-07-31 |
ES2562832T3 (es) | 2016-03-08 |
US20210277097A1 (en) | 2021-09-09 |
ECSP12012029A (es) | 2012-08-31 |
US20160075773A1 (en) | 2016-03-17 |
BR112012013734A2 (pt) | 2017-01-10 |
US9175075B2 (en) | 2015-11-03 |
JP2021100954A (ja) | 2021-07-08 |
AU2010329955A1 (en) | 2012-05-24 |
CN102656190A (zh) | 2012-09-05 |
ZA201204106B (en) | 2013-02-27 |
US20170114129A1 (en) | 2017-04-27 |
JP2023075266A (ja) | 2023-05-30 |
JP2019059731A (ja) | 2019-04-18 |
JP5951498B2 (ja) | 2016-07-13 |
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