DK2484696T3 - Antagonistiske hLIGHT-specifikke humane monoklonale antistoffer - Google Patents

Antagonistiske hLIGHT-specifikke humane monoklonale antistoffer Download PDF

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DK2484696T3
DK2484696T3 DK12162958.8T DK12162958T DK2484696T3 DK 2484696 T3 DK2484696 T3 DK 2484696T3 DK 12162958 T DK12162958 T DK 12162958T DK 2484696 T3 DK2484696 T3 DK 2484696T3
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antibody
hlight
pta
seq
nos
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DK12162958.8T
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Steven W Granger
Shinichiro Kato
Carl F Ware
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Kyowa Hakko Kirin Co Ltd
Lajolla Inst For Allergy And Immunology
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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Claims (21)

1. Isoleret antistof eller et hLIGHT-bindingsfragment deraf, hvor antistoffet og fragmentet deraf binder sig til den trimere men ikke til den monomere form af hLIGHT, hvor binding til hLIGHT-epitopen fra antistoffets og fragmentets side blokeres kompetitivt af et antistof dannet af hybridomet med ATCC-tilgangsnummer PTA-7819, og hvor bindingen ikke blokeres kompetitivt af antistofferne dannet af hybridomerne med ATCC-tilgangsnumrene PTA-7729, PTA-7842 og PTA-7818, hvor antistoffet og fragmentet hæmmer binding af HVEM og LTpR til hLIGHT, og hvor antistoffet og fragmentet binder sig til enkeltnukleotidpolymor-fisme(SNP)hLIGHT-varianterne 214E-32S og 214K-32S, 214E-32L og 214K-32L, hvor antistoffet er et antagonistantistof.
2. Antistof eller hLIGHT-bindingsfragment deraf ifølge krav 1, hvor binding til hLIGHT-epitopen fra antistoffets og fragmentets side blokeres kompetitivt af et antistof dannet af hybridomet med ATCC-tilgangsnummer PTA-7728.
3. Antistof eller hLIGHT-bindingsfragment deraf ifølge krav 1 eller krav 2, hvor antistoffet konkurrerer med HVEM, LTPR eller et fusionsprotein deraf om binding til celleoverfla-deudtrykt hLIGHT eller opløselig hLIGHT.
4. Antistof eller hLIGHT-bindingsfragment deraf ifølge et hvilket som helst af kravene 1 til 3, hvor antistoffet omfatter: et VH-domæne med aminosyresekvensen fra rest 27 til rest 143 i SEQ ID NO: 5 og et VL-domæne med aminosyresekvensen fra rest 23 til rest 129 i SEQ ID NO: 10.
5. Antistof eller hLIGHT-bindingsfragment deraf ifølge et hvilket som helst af kravene 1 til 3, hvor antistoffet omfatter: (a) en variabel tungkæderegion omfattende VH CDR1 med aminosyresekvensen ifølge SEQ ID NO:23, en VH CDR2 med aminosyresekvensen ifølge SEQ ID NO:24 og en VH CDR3 med aminosyresekvensen ifølge SEQ ID NO:25; og (b) en variabel letkæderegion omfattende VL CDR1 med aminosyresekvensen ifølge SEQ ID NO:38, en VL CDR2 med aminosyresekvensen ifølge SEQ ID NO:39 og en VL CDR3 med aminosyresekvensen ifølge SEQ ID NO:40.
6. Antistof eller hLIGHT-bindingsfragment deraf ifølge et hvilket som helst af kravene 1 til 3, hvor antistoffet omfatter en VH og en VL af et antistof dannet af et hybridom med ATCC-tilgangsnummer PTA-7728.
7. Antistof eller hLIGHT-bindingsfragment deraf ifølge et hvilket som helst af kravene 1 til 3, hvor antistoffet omfatter (a) en VH CDR1, VH CDR2 og VH CDR3 og (b) en VL CDR1, VL CDR2 og VL CDR3 af et antistof dannet af et hybridom med ATCC-tilgangsnummer PTA-7728.
8. Antistof eller hLIGHT-bindingsfragment deraf ifølge krav 1, hvor antistoffet dannes af et hybridom med ATCC-tilgangsnummer PTA-7728.
9. Antistof eller hLIGHT-bindingsfragment deraf ifølge et hvilket som helst af kravene 1 til 8, hvor antistoffet er et fuldstændigt humant antistof, et kimært antistof eller et humaniseret antistof.
10. Antistof eller hLIGHT-bindingsfragment deraf ifølge et hvilket som helst af kravene 1 til 9, hvor antistoffet er et monoklonalt antistof.
11. Antistof eller hLIGHT-bindingsfragment deraf ifølge et hvilket som helst af kravene 1 til 10, hvor antistoffet er et rekombinant antistof.
12. hLIGHT-bindingsfragmentet ifølge et hvilket som helst af kravene 1 til 11, hvor fragmentet er et Fab-fragment, F(ab')2-fragment, enkeltkæde-Fv (scFv), diaantistof, triaan-tistof eller miniantistof.
13. Sammensætning omfattende antistoffet eller hLIGHT-bindingsfragmentet deraf ifølge et hvilket som helst af kravene 1 til 12.
14. Isoleret nukleinsyremolekyle kodende for antistoffet eller hLIGHT-bindingsfragmentet deraf ifølge et hvilket som helst af kravene 1 til 12.
15. Vektor, som omfatter nukleinsyremolekylet ifølge krav 14.
16. Værtscelle, som omfatter vektoren ifølge krav 15.
17. Fremgangsmåde til frembringelse af antistoffet eller hLIGHT-bindingsfragmentet deraf ifølge et hvilket som helst af kravene 1-12, hvilken fremgangsmåde omfatter; at dyrke værtscellen ifølge krav 16, at udtrykke antistoffet eller hLIGHT-bindingsfragmentet deraf, og at indvinde antistoffet eller hLIGHT-bindingsfragmentet deraf.
18. Hybridom, der danner antistoffet ifølge et hvilket som helst af kravene 1 til 8.
19. Hybridom ifølge krav 18, som danner antistoffet ifølge et hvilket som helst af kravene 1 eller 3 til 12, hvor hybridomet har ATCC-tilgangsnummeret PTA-7728 (124 F23).
20. Farmaceutisk sammensætning indeholdende antistoffet eller hLIGHT-bindingsfragmentet deraf ifølge et hvilket som helst af kravene 1 til 12 i et farmaceutisk acceptabelt bærestof.
21. Sæt, som omfatter antistoffet eller hLIGHT-bindingsfragmentet deraf ifølge et hvilket som helst af kravene 1 til 12, eller et sæt, som omfatter sammensætningen ifølge krav 13.
DK12162958.8T 2006-08-28 2007-08-24 Antagonistiske hLIGHT-specifikke humane monoklonale antistoffer DK2484696T3 (da)

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US84077406P 2006-08-28 2006-08-28
US89787507P 2007-01-25 2007-01-25
EP10172151.2A EP2292663B1 (en) 2006-08-28 2007-08-24 Antagonistic human light-specific human monoclonal antibodies

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