DK2424896T3 - Anti-CEACAM1-antistoffer og fremgangsmåder til anvendelse deraf - Google Patents
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- DK2424896T3 DK2424896T3 DK10721207.8T DK10721207T DK2424896T3 DK 2424896 T3 DK2424896 T3 DK 2424896T3 DK 10721207 T DK10721207 T DK 10721207T DK 2424896 T3 DK2424896 T3 DK 2424896T3
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Claims (15)
1. Hybridomcelle, som er deponeret under ATCC-deponeringsnummer PTA-9974.
2. Isoleret anti-CEACAM1-antistof eller antistoffragment, som omfatter et antigengenkendelsesdomæne, som har CDR-sekvenserne og orienteringen af det antistof, der produceres ud fra den hybridomcelle, som er deponeret under ATCC-deponerings-nummer PTA-9974.
3. Isoleret antistof eller antistoffragment ifølge krav 2, hvor antistoffet eller antistoffragmentet er selektivt over for CEACAM1.
4. Isoleret antistof eller antistoffragment ifølge krav 3, som produceres ud fra den hybridomcelle, som er deponeret under ATCC-deponeringsnummer PTA-9974.
5. Isoleret antistof eller antistoffragment ifølge krav 2, som er bundet til en cytotoksisk del.
6. Isoleret antistof eller antistoffragment ifølge krav 5, hvor den cytotoksiske del omfatter et cytotoksin, et kemokin, en kemoterapi, et pro-apoptotikum, et interferon, en radioaktiv del eller kombinationer deraf.
7. Isoleret antistof eller antistoffragment ifølge krav 2, som er bundet til en identificerbar del.
8. Isoleret antistof eller antistoffragment ifølge krav 2 til behandling af cancer, fortrinsvis melanom.
9. Isoleret antistof eller antistoffragment ifølge krav 2 til immunmodulering af en CEA-CAM1-udtrykkende tumorcelle ved hjælp af en CEACAM1-udtrykkende lymfocyt; fortrinsvis hvor den CEACAM1-udtrykkende lymfocyt er en cytotoksisk T-celle.
10. Isoleret antistof eller antistoffragment ifølge krav 2 til inhibering af migration eller proliferation af en CEACAM1-udtrykkende tumorcelle, fortrinsvis hvor tumorcellen omfatter en melanomtumorcelle.
11. Fremgangsmåde til diagnose af cancer i et individ, som har behov derfor, hvilken fremgangsmåde omfatter, at en biologisk prøve, som er taget fra individet, bringes i kontakt med et antistof eller antistoffragment ifølge krav 2 eller 5, hvor celler af canceren er kendetegnet ved overekspression af CEACAM1 sammenlignet med upåvirkede celler, og hvor en kompleksdannelse ud over en forudbestemt tærskel er en indikation for cancer i individet.
12. Fremgangsmåde ifølge krav 11, hvor canceren er melanom.
13. Isoleret antistof eller antistoffragment ifølge krav 2 til inhibering af CEACAM1 ho-motypisk eller heterotypisk protein-protein-interaktion af en CEACAM1-udtrykkende lymfocyt.
14. Isoleret antistof eller antistoffragment ifølge krav 13, hvor den CEACAM1-udtrykkende lymfocyt er en tumorinfiltrerende lymfocyt eller NK-celle; eller hvor den CEA-CAM1-udtrykkende lymfocyt er en cytotoksisk T-celle.
15. Farmaceutisk præparat, der som aktiv bestanddel omfatter et antistof eller antistoffragment ifølge krav 2 eller 5.
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| PCT/IL2010/000348 WO2010125571A1 (en) | 2009-04-30 | 2010-04-29 | Anti ceacam1 antibodies and methods of using same |
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| CA2760385C (en) * | 2009-04-30 | 2021-04-20 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Anti ceacam1 antibodies and methods of using same |
| ES2753986T3 (es) * | 2009-07-21 | 2020-04-15 | Tel Hashomer Medical Res Infrastructure & Services Ltd | Un método de diagnóstico de cáncer |
| WO2013054320A1 (en) * | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
| CA2887528C (en) | 2012-10-12 | 2023-08-29 | The Brigham And Women's Hospital, Inc. | Enhancement of the immune response |
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2010
- 2010-04-29 CA CA2760385A patent/CA2760385C/en active Active
- 2010-04-29 LT LTEP15183297.9T patent/LT2990421T/lt unknown
- 2010-04-29 ES ES10721207.8T patent/ES2563527T3/es active Active
- 2010-04-29 DK DK10721207.8T patent/DK2424896T3/da active
- 2010-04-29 PL PL15183297T patent/PL2990421T3/pl unknown
- 2010-04-29 SI SI201031069T patent/SI2424896T1/sl unknown
- 2010-04-29 CN CN201080029465.XA patent/CN102482354B/zh active Active
- 2010-04-29 RU RU2011148598/10A patent/RU2598710C2/ru active
- 2010-04-29 KR KR1020117026290A patent/KR101875227B1/ko active IP Right Grant
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- 2010-04-29 KR KR1020187018477A patent/KR20180077322A/ko not_active Application Discontinuation
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