DK2305301T3 - Fremgangsmåder til behandling af præeklampsi - Google Patents

Fremgangsmåder til behandling af præeklampsi Download PDF

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DK2305301T3
DK2305301T3 DK10180400T DK10180400T DK2305301T3 DK 2305301 T3 DK2305301 T3 DK 2305301T3 DK 10180400 T DK10180400 T DK 10180400T DK 10180400 T DK10180400 T DK 10180400T DK 2305301 T3 DK2305301 T3 DK 2305301T3
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sflt
eclampsia
vegf
antibody
pigf
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DK10180400T
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Vikas Sukhatme
Sharon Maynard
S Ananth Karumanchi
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Beth Israel Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1891—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12N2310/14—Type of nucleic acid interfering N.A.
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

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  • General Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)

Claims (11)

1. Oprenset anti-opløseligt Flt-1 (sFlt-1)-antistof eller sFlt-1-antigenbindende fragment deraf, som er i stand til at blokere binding af VEGF eller PIGF, til anvendelse til behandling eller forebyggelse af præeklampsi hos et individ.
2. Anti-sFlt-1-antistof eller sFlt-1-antigenbindende fragment deraf til anvendelse ifølge krav 1, hvor a) antistoffet kompetitivt hæmmer bindingen af vaskulær endotelvækstfaktor (VEGF) eller placental vækstfaktor (PIGF) til sFlt-1, eller b) antistoffet binder sig til sFlt-1 og ikke binder sig til Flt-1.
3. Anti-sFlt-1-antistof eller sFlt-1-antigenbindende fragment deraf til anvendelse ifølge krav 1 eller 2, hvor antistoffet er et monoklonalt antistof, et kimært antistof, et humant antistof eller et humaniseret antistof.
4. Anti-sFlt-1-antistof eller sFlt-1-antigenbindende fragment til anvendelse ifølge krav 1 eller 2, hvor det antigenbindende fragment er et Fv-, Fab-, Fab'-, F(ab')2- fragment eller scFv.
5. Anti-sFlt-1-antistof eller sFlt-1-antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1-4, hvor anvendelsen endvidere omfatter anvendelse af et antihypertensivum.
6. Anti-sFlt-1-antistof eller sFlt-1-antigenbindende fragment deraf til anvendelse ifølge krav 5, hvor nævnte antihypertensivum er valgt fra gruppen bestående af methyldopa, hydralazinhydrochlorid, labetalol, adenosin, nifedipin, minoxidil og magnesiumsulfat.
7. Anti-sFlt-1-antistof eller sFlt-1-antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1-6, hvor individet er en gravid kvinde, en kvinde post-partum eller et ikke-humant dyr.
8. Anti-sFlt-1-antistof eller sFlt-1-antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1-7, hvor anti-sFlt-1-antistoffet eller det antigenbindende fragment deraf' foreligger i en dosering på fra ca. 0,01 til ca. 10 mg/kg af indidets vægt.
9. Anti-sFlt-1-antistof eller sFlt-1-antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af kravene 1-8, hvor præeklampsien er kendetegnet ved forøgede ekspressionsniveauer af sFlt-1-polypeptid eller sFlt-1-nukleinsyre i forhold til en normal referenceprøve eller et normalt referenceniveau.
10. Anti-sFlt-1-antistof eller sFlt-1-antigenbindende fragment deraf til anvendelse ifølge et hvilket som helst af de foregående krav, hvor behandlingen eller forebyggelsen endvidere omfatter a) hæmning af bindingen af VEGF eller PIGF til et sFlt-1-polypeptid hos et individ, der har præeklampsi, hvor anti-sFlt-antistoffet eller det sFlt-1-antigenbindende fragment deraf kompetitivt hæmmer bindingen af VEGF eller PIGF til sFlt-1, eller b) reduktion af niveauet eller den biologiske aktivitet af sFlt-1-polypeptid hos et individ, der har præeklampsi eller er tilbøjelig til at udvikle præeklampsi.
11. Anvendelse af et oprenset anti-opløseligt Flt-1 (sFlt-1)-antistof eller et sFlt-1-antigenbindende fragment deraf, som er i stand til at blokere binding af VEGF eller PIGF, til fremstilling af et lægemiddel til anvendelse til behandling eller forebyggelse af præeklampsi hos et individ.
DK10180400T 2002-07-19 2003-07-21 Fremgangsmåder til behandling af præeklampsi DK2305301T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39748102P 2002-07-19 2002-07-19
US45179603P 2003-03-03 2003-03-03
US46739003P 2003-05-02 2003-05-02
EP03765913.3A EP1575416B1 (en) 2002-07-19 2003-07-21 Methods of diagnosing pre-eclampsia

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DK2305301T3 true DK2305301T3 (da) 2015-04-13

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DK03765913T DK1575416T3 (da) 2002-07-19 2003-07-21 Fremgangsmåder til diagnosticering af præeklampsi
DK10180400T DK2305301T3 (da) 2002-07-19 2003-07-21 Fremgangsmåder til behandling af præeklampsi
DK10180382T DK2308507T3 (da) 2002-07-19 2003-07-21 Fremgangsmåder til behandling af præeklampsi

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DK03765913T DK1575416T3 (da) 2002-07-19 2003-07-21 Fremgangsmåder til diagnosticering af præeklampsi

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DK10180382T DK2308507T3 (da) 2002-07-19 2003-07-21 Fremgangsmåder til behandling af præeklampsi

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US (2) US7407659B2 (da)
EP (3) EP2308507B1 (da)
JP (2) JP5650876B2 (da)
KR (1) KR101215701B1 (da)
CN (1) CN1777443B (da)
AP (1) AP2005003230A0 (da)
AU (2) AU2003265294B8 (da)
BR (1) BRPI0312818B8 (da)
CA (2) CA2922031C (da)
DK (3) DK1575416T3 (da)
EA (1) EA200500232A1 (da)
EC (1) ECSP055608A (da)
ES (3) ES2534926T3 (da)
HK (3) HK1085368A1 (da)
IL (2) IL166393A (da)
MX (1) MXPA05000832A (da)
OA (1) OA12890A (da)
PT (3) PT2305301E (da)
WO (1) WO2004008946A2 (da)

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