DK2266627T3 - Enkeltstrengede oligodeoxynukleotide mutationsvektorer - Google Patents

Enkeltstrengede oligodeoxynukleotide mutationsvektorer Download PDF

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Publication number
DK2266627T3
DK2266627T3 DK10008602.4T DK10008602T DK2266627T3 DK 2266627 T3 DK2266627 T3 DK 2266627T3 DK 10008602 T DK10008602 T DK 10008602T DK 2266627 T3 DK2266627 T3 DK 2266627T3
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Denmark
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effective
oligodeoxynucleotides
stranded oligodeoxynucleotide
mutation vectors
oligodeoxynucleotide
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DK10008602.4T
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English (en)
Inventor
Bruce L Frank
Debra M Walther
Richard A Metz
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Cibus Internat Lp
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Publication of DK2266627T3 publication Critical patent/DK2266627T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DK10008602.4T 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer DK2266627T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/384,960 US6271360B1 (en) 1999-08-27 1999-08-27 Single-stranded oligodeoxynucleotide mutational vectors
EP00959442A EP1210123B1 (en) 1999-08-27 2000-08-25 Single-stranded oligodeoxynucleotide mutational vectors

Publications (1)

Publication Number Publication Date
DK2266627T3 true DK2266627T3 (da) 2015-06-15

Family

ID=23519459

Family Applications (3)

Application Number Title Priority Date Filing Date
DK10008602.4T DK2266627T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer
DK00959442.5T DK1210123T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation
DK10183960.3T DK2324856T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK00959442.5T DK1210123T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation
DK10183960.3T DK2324856T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer

Country Status (15)

Country Link
US (3) US6271360B1 (da)
EP (3) EP2324856B1 (da)
JP (2) JP5697187B2 (da)
CN (1) CN1384759B (da)
AT (1) ATE478687T1 (da)
AU (2) AU773242C (da)
BR (1) BR0013590A (da)
CA (1) CA2382120C (da)
DE (1) DE60044876D1 (da)
DK (3) DK2266627T3 (da)
ES (3) ES2544727T3 (da)
NZ (1) NZ517942A (da)
PT (3) PT2266627E (da)
WO (1) WO2001015740A1 (da)
ZA (1) ZA200201228B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6652607B2 (en) 1999-07-07 2003-11-25 The Lubrizol Corporation Concentrated emulsion for making an aqueous hydrocarbon fuel
AU6923300A (en) * 1999-08-20 2001-03-19 University Of Delaware Cell-free assay for plant gene targeting and conversion
US6271360B1 (en) * 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
AR025996A1 (es) 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
AU4948801A (en) * 2000-03-27 2001-10-08 Univ Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
US6936467B2 (en) * 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
EP1284985A2 (en) * 2000-05-17 2003-02-26 University Of Delaware Plant gene targeting using oligonucleotides
WO2002010364A2 (en) * 2000-07-27 2002-02-07 University Of Delaware Methods for enhancing targeted gene alteration using oligonucleotides
US7053195B1 (en) * 2001-06-12 2006-05-30 Syngenta Participatious Ag Locked nucleic acid containing heteropolymers and related methods
US20040096880A1 (en) * 2001-08-07 2004-05-20 Kmiec Eric B. Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation
WO2003013437A2 (en) * 2001-08-07 2003-02-20 University Of Delaware Compositions and methods for the prevention and treatment of huntington's disease
WO2003027264A2 (en) * 2001-09-27 2003-04-03 University Of Delaware Coisogenic eukaryotic cell collections
WO2003027265A2 (en) * 2001-09-27 2003-04-03 University Of Delaware Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration
WO2003075856A2 (en) * 2002-03-07 2003-09-18 University Of Delaware Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phage beta protein, or hydroxyurea
GB0218803D0 (en) * 2002-08-13 2002-09-18 Nl Kanker I Targeted gene modification by single-standed DNA oligonucleotides
WO2004033708A2 (en) * 2002-10-07 2004-04-22 University Of Delaware Methods and compositions for reducing screening in oligonucleotide-directed nucleic acid sequence alteration
US6929917B2 (en) * 2002-11-18 2005-08-16 Pregentis Method for cloning of a rare, specifically mutated cell
US20070072815A1 (en) * 2004-05-04 2007-03-29 Kmiec Eric B Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration
ES2531882T3 (es) 2006-01-12 2015-03-20 Cibus Europe B.V. EPSPS mutantes
NZ574390A (en) 2006-06-28 2012-04-27 Coh Inc Fatty acid blends and uses therefor in fuel
ES2531391T3 (es) 2006-10-06 2015-03-13 Basf Plant Science Gmbh Delta-5 desaturasas y procedimiento para la preparación de ácidos grasos poliinsaturados en organismos transgénicos no humanos
US9102948B2 (en) 2006-11-17 2015-08-11 22Nd Century Limited, Llc Regulating alkaloids
EP2700721B1 (en) * 2007-10-05 2019-01-02 Cibus Europe B.V. Mutated acetohydroxyacid synthase genes in brassica
US20110023352A1 (en) * 2007-12-27 2011-02-03 Knuth Mark E Alkylester fatty acid blends and uses therefor
WO2009143490A1 (en) 2008-05-23 2009-11-26 Cibus International, L.P. Production of squalene using yeast
AP2011005671A0 (en) 2008-09-26 2011-04-30 Basf Agrochemical Products Bv Herbicide-resistant AHAS-mutants and methods of use.
CA2744930C (en) 2008-12-12 2018-03-20 Basf Plant Science Gmbh Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms
AU2010321722B2 (en) 2009-11-23 2016-03-24 Cibus Europe B.V. Methods and compositions for producing squalene using yeast
US20120122223A1 (en) 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
UA112969C2 (uk) 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
WO2012028673A1 (en) 2010-09-02 2012-03-08 Ludwig-Maximilians-Universitaet Muenchen Spontaneous organogenesis in plants
EP2426204A1 (en) 2010-09-02 2012-03-07 Ludwig-Maximilians-Universität München Spontaneous nodule organogenesis in plants
KR101137285B1 (ko) 2010-10-28 2012-04-20 위월드 주식회사 초소형 광대역 송수신 안테나 피더
CA3116898C (en) 2012-08-17 2022-09-27 Dow Agrosciences Llc Use of a maize untranslated region for transgene expression in plants
US9790515B2 (en) 2013-03-14 2017-10-17 Cibus Us Llc Mutated allene oxide synthase 2 (AOS2) genes
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
CN105338805A (zh) 2013-03-15 2016-02-17 希博斯美国有限公司 采用寡核苷酸介导的基因修复提高靶向基因修饰的效率的方法和组合物
PL3527068T3 (pl) 2013-03-15 2022-10-10 Cibus Us Llc Sposoby i kompozycje do zwiększania skuteczności ukierunkowanej modyfikacji genu z użyciem naprawy genu, w której pośredniczy oligonukleotyd
PT3116305T (pt) 2014-03-14 2024-03-07 Cibus Us Llc Métodos e composições para aumentar a eficiência da modificação genética direccionada utilizando a reparação genética mediada por oligonucleótidos
JP2019506170A (ja) 2016-02-09 2019-03-07 キブス ユーエス エルエルシー オリゴヌクレオチド介在性遺伝子修復を利用した標的遺伝子修飾の効率を上昇させるための方法および組成物
US10584363B2 (en) 2016-06-03 2020-03-10 Takara Bio Usa, Inc. Methods of producing and using single-stranded deoxyribonucleic acids and compositions for use in practicing the same
CN111819285A (zh) 2018-01-09 2020-10-23 希博斯美国有限公司 防碎基因和突变

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2731844B2 (ja) * 1987-04-22 1998-03-25 ザ・ユニヴァーシティー・オブ・コネチカット 哺乳動物の細胞にポリヌクレオチドを導入するキャリア及び水溶性高分子複合体並びにその導入方法
DE59108644D1 (de) * 1990-07-02 1997-05-07 Hoechst Ag Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen
WO1993004701A1 (en) 1991-09-05 1993-03-18 University Of Connecticut Targeted delivery of poly- or oligonucleotides to cells
US5556959A (en) 1993-01-22 1996-09-17 Pharmacia P-L Biochemicals Inc. Indocarbocyanine-linked phosphoramidites
US5808044A (en) * 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
ATE196311T1 (de) 1993-12-09 2000-09-15 Univ Jefferson Verbindungen und verfahren zur ortsspezifischen mutation in eukaryotischen zellen
US5780296A (en) 1995-01-17 1998-07-14 Thomas Jefferson University Compositions and methods to promote homologous recombination in eukaryotic cells and organisms
AU6328696A (en) * 1995-06-07 1996-12-30 Yale University Treatment of hemoglobinopathies
US5908777A (en) * 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
FR2736926B1 (fr) 1995-07-19 1997-08-22 Rhone Poulenc Agrochimie 5-enol pyruvylshikimate-3-phosphate synthase mutee, gene codant pour cette proteine et plantes transformees contenant ce gene
US5760012A (en) 1996-05-01 1998-06-02 Thomas Jefferson University Methods and compounds for curing diseases caused by mutations
US5731181A (en) 1996-06-17 1998-03-24 Thomas Jefferson University Chimeric mutational vectors having non-natural nucleotides
US5888983A (en) 1996-05-01 1999-03-30 Thomas Jefferson University Method and oligonucleobase compounds for curing diseases caused by mutations
AU749348B2 (en) * 1997-02-26 2002-06-27 General Hospital Corporation, The Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease
JP2002511851A (ja) 1997-04-30 2002-04-16 リージェンツ オブ ジ ユニバーシティー オブ ミネソタ 肝細胞の遺伝的病変を修正するためのリコンビナジェニックオリゴヌクレオ塩基のｉｎ ｖｉｖｏでの使用
US6524613B1 (en) 1997-04-30 2003-02-25 Regents Of The University Of Minnesota Hepatocellular chimeraplasty
GB9711015D0 (en) 1997-05-28 1997-07-23 Zeneca Ltd Improvements in or relating to organic compounds
US5986086A (en) * 1997-06-20 1999-11-16 Amersham Pharmacia Biotech Inc. Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides
JP2001512687A (ja) 1997-08-05 2001-08-28 キメラジェン，インコーポレーテッド 植物に局在性遺伝子変化を生じさせるための混合二本鎖オリゴヌクレオチドの使用
CA2309719A1 (en) 1997-11-18 1999-05-27 Pioneer Hi-Bred International, Inc. Targeted manipulation of genes in plants
US6004804A (en) 1998-05-12 1999-12-21 Kimeragen, Inc. Non-chimeric mutational vectors
US6271360B1 (en) * 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
CN107124878B (zh) 2014-08-21 2020-09-29 康宁股份有限公司 防止层叠玻璃制品中的气泡的方法以及由此形成的层叠玻璃制品

Also Published As

Publication number Publication date
ZA200201228B (en) 2003-05-28
ATE478687T1 (de) 2010-09-15
AU7076700A (en) 2001-03-26
EP1210123A4 (en) 2004-08-18
US20040023392A1 (en) 2004-02-05
AU773242B2 (en) 2004-05-20
US6479292B1 (en) 2002-11-12
JP5697187B2 (ja) 2015-04-08
DE60044876D1 (de) 2010-10-07
PT2324856E (pt) 2015-09-03
NZ517942A (en) 2004-07-30
AU2004205139B2 (en) 2008-01-10
EP2324856A1 (en) 2011-05-25
JP2012184246A (ja) 2012-09-27
JP5813571B2 (ja) 2015-11-17
CA2382120A1 (en) 2001-03-08
CA2382120C (en) 2013-10-29
JP2003508451A (ja) 2003-03-04
ES2542530T3 (es) 2015-08-06
AU2004205139A1 (en) 2004-09-16
EP2324856B1 (en) 2015-05-06
AU773242C (en) 2005-04-07
EP2266627B1 (en) 2015-04-22
EP1210123B1 (en) 2010-08-25
CN1384759B (zh) 2013-05-22
EP1210123A1 (en) 2002-06-05
DK1210123T3 (da) 2010-12-20
EP2266627A1 (en) 2010-12-29
ES2358292T3 (es) 2011-05-09
BR0013590A (pt) 2002-05-07
PT2266627E (pt) 2015-08-25
US7060500B2 (en) 2006-06-13
CN1384759A (zh) 2002-12-11
ES2544727T3 (es) 2015-09-03
WO2001015740A1 (en) 2001-03-08
US6271360B1 (en) 2001-08-07
DK2324856T3 (da) 2015-08-03
PT1210123E (pt) 2010-11-30

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