DK1210123T3 - Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation - Google Patents

Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation

Info

Publication number
DK1210123T3
DK1210123T3 DK00959442.5T DK00959442T DK1210123T3 DK 1210123 T3 DK1210123 T3 DK 1210123T3 DK 00959442 T DK00959442 T DK 00959442T DK 1210123 T3 DK1210123 T3 DK 1210123T3
Authority
DK
Denmark
Prior art keywords
effective
oligodeoxynucleotides
mutation
vectors suitable
stranded oligodeoxynucleotide
Prior art date
Application number
DK00959442.5T
Other languages
English (en)
Inventor
Richard A Metz
Bruce L Frank
Debra M Walther
Original Assignee
Valigen Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valigen Us Inc filed Critical Valigen Us Inc
Application granted granted Critical
Publication of DK1210123T3 publication Critical patent/DK1210123T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102Mutagenizing nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DK00959442.5T 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation DK1210123T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/384,960 US6271360B1 (en) 1999-08-27 1999-08-27 Single-stranded oligodeoxynucleotide mutational vectors
PCT/US2000/023457 WO2001015740A1 (en) 1999-08-27 2000-08-25 Single-stranded oligodeoxynucleotide mutational vectors

Publications (1)

Publication Number Publication Date
DK1210123T3 true DK1210123T3 (da) 2010-12-20

Family

ID=23519459

Family Applications (3)

Application Number Title Priority Date Filing Date
DK10008602.4T DK2266627T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer
DK10183960.3T DK2324856T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer
DK00959442.5T DK1210123T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK10008602.4T DK2266627T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer
DK10183960.3T DK2324856T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer

Country Status (15)

Country Link
US (3) US6271360B1 (da)
EP (3) EP2324856B1 (da)
JP (2) JP5697187B2 (da)
CN (1) CN1384759B (da)
AT (1) ATE478687T1 (da)
AU (2) AU773242C (da)
BR (1) BR0013590A (da)
CA (1) CA2382120C (da)
DE (1) DE60044876D1 (da)
DK (3) DK2266627T3 (da)
ES (3) ES2542530T3 (da)
NZ (1) NZ517942A (da)
PT (3) PT1210123E (da)
WO (1) WO2001015740A1 (da)
ZA (1) ZA200201228B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6652607B2 (en) 1999-07-07 2003-11-25 The Lubrizol Corporation Concentrated emulsion for making an aqueous hydrocarbon fuel
WO2001014531A1 (en) * 1999-08-20 2001-03-01 University Of Delaware Cell-free assay for plant gene targeting and conversion
US6271360B1 (en) * 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
AR025996A1 (es) 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
AP2002002638A0 (en) * 2000-03-27 2002-09-30 Univ Delaware Targeted chromosomal genomic alternations with modified single stranded oligonucleotides.
US6936467B2 (en) 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
CA2409172A1 (en) * 2000-05-17 2001-11-22 University Of Delaware Plant gene targeting using oligonucleotides
NZ524366A (en) * 2000-07-27 2005-12-23 Univ Delaware Methods for enhancing targeted gene alteration using oligonucleotides
US7053195B1 (en) * 2001-06-12 2006-05-30 Syngenta Participatious Ag Locked nucleic acid containing heteropolymers and related methods
US20040096880A1 (en) * 2001-08-07 2004-05-20 Kmiec Eric B. Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation
AU2002326589B2 (en) * 2001-08-07 2008-06-05 University Of Delaware Compositions and methods for the prevention and treatment of Huntington's disease
WO2003027264A2 (en) * 2001-09-27 2003-04-03 University Of Delaware Coisogenic eukaryotic cell collections
EP1446503A2 (en) * 2001-09-27 2004-08-18 University Of Delaware Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration
JP2005518817A (ja) * 2002-03-07 2005-06-30 ユニバーシティー、オブ、デラウェア ヒストン・デアセチラーゼ・インヒビタ、ラムダファージベータ蛋白、またはヒドロキシウレアを含む組成物を使用してオリゴヌクレオチド媒介性核酸配列改変を高める方法、組成物およびキット
GB0218803D0 (en) * 2002-08-13 2002-09-18 Nl Kanker I Targeted gene modification by single-standed DNA oligonucleotides
AU2003282477A1 (en) * 2002-10-07 2004-05-04 Napro Bio Therapeutics, Inc. Methods and compositions for reducing screening in oligonucleotide-directed nucleic acid sequence alteration
US6929917B2 (en) * 2002-11-18 2005-08-16 Pregentis Method for cloning of a rare, specifically mutated cell
US20070072815A1 (en) * 2004-05-04 2007-03-29 Kmiec Eric B Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration
ES2532112T3 (es) 2006-01-12 2015-03-24 Cibus Europe B.V. EPSPS mutantes
RU2483057C2 (ru) 2006-06-28 2013-05-27 Ньюселис Инк. Смеси жирных кислот и их применение
AU2007304229B2 (en) 2006-10-06 2013-09-19 Basf Plant Science Gmbh Processes for producing polyunsaturated fatty acids in transgenic organisms
US9102948B2 (en) 2006-11-17 2015-08-11 22Nd Century Limited, Llc Regulating alkaloids
CN108342376A (zh) 2007-10-05 2018-07-31 赛布斯欧洲公司 芸苔属中突变的乙酰羟酸合酶基因
US20110023352A1 (en) * 2007-12-27 2011-02-03 Knuth Mark E Alkylester fatty acid blends and uses therefor
EP3260549A1 (en) 2008-05-23 2017-12-27 Nucelis LLC Production of squalene using yeast
EA025732B9 (ru) 2008-09-26 2017-09-29 Басф Агрокемикал Продактс Б.В. Резистентные к гербицидам ahas-мутанты и способы применения
CA2744930C (en) 2008-12-12 2018-03-20 Basf Plant Science Gmbh Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms
CN102666837A (zh) 2009-11-23 2012-09-12 纽塞利斯公司 使用酵母产生角鲨烯的方法和组合物
US20120122223A1 (en) 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
UA112969C2 (uk) 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
WO2012028673A1 (en) 2010-09-02 2012-03-08 Ludwig-Maximilians-Universitaet Muenchen Spontaneous organogenesis in plants
EP2426204A1 (en) 2010-09-02 2012-03-07 Ludwig-Maximilians-Universität München Spontaneous nodule organogenesis in plants
KR101137285B1 (ko) 2010-10-28 2012-04-20 위월드 주식회사 초소형 광대역 송수신 안테나 피더
JP2015524672A (ja) 2012-08-17 2015-08-27 ダウ アグロサイエンシィズ エルエルシー 植物における導入遺伝子発現のためのトウモロコシ非翻訳領域の使用
CN105358696A (zh) 2013-03-14 2016-02-24 希博斯美国有限公司 突变的丙二烯氧合酶2(aos2)基因
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
MY191390A (en) 2013-03-15 2022-06-22 Cibus Us Llc Methods and compositions for increasing efficiency of increased efficiency of targeted gene modification using oligonucleotide-mediated gene repair
RS63427B1 (sr) 2013-03-15 2022-08-31 Cibus Us Llc Postupci i kompozicije za povećanje efikasnosti modifikacije ciljnog gena korišćenjem genske reparacije posredovane oligonukleotidom
UA124375C2 (uk) 2014-03-14 2021-09-08 Кібус Юс Ллс Спосіб здійснення спрямованої генетичної зміни днк в клітині рослини з використанням нуклеази crispr і модифікованого gron
CA3014036A1 (en) 2016-02-09 2017-08-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
US10584363B2 (en) 2016-06-03 2020-03-10 Takara Bio Usa, Inc. Methods of producing and using single-stranded deoxyribonucleic acids and compositions for use in practicing the same
CN111819285A (zh) 2018-01-09 2020-10-23 希博斯美国有限公司 防碎基因和突变

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2731844B2 (ja) * 1987-04-22 1998-03-25 ザ・ユニヴァーシティー・オブ・コネチカット 哺乳動物の細胞にポリヌクレオチドを導入するキャリア及び水溶性高分子複合体並びにその導入方法
EP0464638B1 (de) * 1990-07-02 1997-04-02 Hoechst Aktiengesellschaft Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen
KR100252547B1 (ko) 1991-09-05 2000-09-01 프레드 마리얀스키 폴리-또는 올리고누클레오티드의 세포로의 표적화된 전달
US5808044A (en) * 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US5556959A (en) 1993-01-22 1996-09-17 Pharmacia P-L Biochemicals Inc. Indocarbocyanine-linked phosphoramidites
WO1995015972A1 (en) 1993-12-09 1995-06-15 Thomas Jefferson University Compounds and methods for site-directed mutations in eukaryotic cells
US5780296A (en) 1995-01-17 1998-07-14 Thomas Jefferson University Compositions and methods to promote homologous recombination in eukaryotic cells and organisms
WO1996040271A1 (en) * 1995-06-07 1996-12-19 Yale University Treatment of hemoglobinopathies
US5908777A (en) * 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
FR2736926B1 (fr) 1995-07-19 1997-08-22 Rhone Poulenc Agrochimie 5-enol pyruvylshikimate-3-phosphate synthase mutee, gene codant pour cette proteine et plantes transformees contenant ce gene
US5731181A (en) 1996-06-17 1998-03-24 Thomas Jefferson University Chimeric mutational vectors having non-natural nucleotides
US5760012A (en) 1996-05-01 1998-06-02 Thomas Jefferson University Methods and compounds for curing diseases caused by mutations
US5888983A (en) 1996-05-01 1999-03-30 Thomas Jefferson University Method and oligonucleobase compounds for curing diseases caused by mutations
EP0975651A4 (en) * 1997-02-26 2005-03-09 Gen Hospital Corp TRANSGENIC ANIMALS AND CELL LINES FOR THE SCREENING OF MEDICAMENTS FOR THE TREATMENT OR PREVENTION OF ALZHEIMER'S DISEASE
US6524613B1 (en) 1997-04-30 2003-02-25 Regents Of The University Of Minnesota Hepatocellular chimeraplasty
AU749410B2 (en) 1997-04-30 2002-06-27 Regents Of The University Of Minnesota In vivo use of recombinagenic oligonucleobases to correct genetic lesions in hepatocytes
GB9711015D0 (en) 1997-05-28 1997-07-23 Zeneca Ltd Improvements in or relating to organic compounds
US5986086A (en) * 1997-06-20 1999-11-16 Amersham Pharmacia Biotech Inc. Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides
KR20010022652A (ko) 1997-08-05 2001-03-26 키메라젠, 인크. 식물에서 국소적인 유전자변형을 유발하기 위한 혼성 이중나선올리고뉴클레오티드의 용도
WO1999025853A1 (en) 1997-11-18 1999-05-27 Pioneer Hi-Bred International, Inc. Targeted manipulation of herbicide-resistance genes in plants
US6004804A (en) 1998-05-12 1999-12-21 Kimeragen, Inc. Non-chimeric mutational vectors
US6271360B1 (en) * 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
JP2017533158A (ja) 2014-08-21 2017-11-09 コーニング インコーポレイテッド 積層ガラス物品においてブリスターを防ぐ方法およびそれにより形成された積層ガラス物品

Also Published As

Publication number Publication date
US6271360B1 (en) 2001-08-07
US6479292B1 (en) 2002-11-12
BR0013590A (pt) 2002-05-07
PT1210123E (pt) 2010-11-30
US7060500B2 (en) 2006-06-13
EP2324856A1 (en) 2011-05-25
DE60044876D1 (de) 2010-10-07
ES2544727T3 (es) 2015-09-03
ES2542530T3 (es) 2015-08-06
JP2012184246A (ja) 2012-09-27
WO2001015740A1 (en) 2001-03-08
EP1210123B1 (en) 2010-08-25
AU773242C (en) 2005-04-07
EP2266627B1 (en) 2015-04-22
AU2004205139A1 (en) 2004-09-16
EP1210123A4 (en) 2004-08-18
PT2266627E (pt) 2015-08-25
DK2266627T3 (da) 2015-06-15
JP5813571B2 (ja) 2015-11-17
ZA200201228B (en) 2003-05-28
PT2324856E (pt) 2015-09-03
JP2003508451A (ja) 2003-03-04
CA2382120C (en) 2013-10-29
AU773242B2 (en) 2004-05-20
EP2266627A1 (en) 2010-12-29
EP2324856B1 (en) 2015-05-06
EP1210123A1 (en) 2002-06-05
CA2382120A1 (en) 2001-03-08
CN1384759A (zh) 2002-12-11
DK2324856T3 (da) 2015-08-03
ATE478687T1 (de) 2010-09-15
AU7076700A (en) 2001-03-26
US20040023392A1 (en) 2004-02-05
NZ517942A (en) 2004-07-30
ES2358292T3 (es) 2011-05-09
AU2004205139B2 (en) 2008-01-10
CN1384759B (zh) 2013-05-22
JP5697187B2 (ja) 2015-04-08

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