DK2247304T3 - Her2/neu-specifikke antistoffer og fremgangsmåder til anvendelse deraf - Google Patents
Her2/neu-specifikke antistoffer og fremgangsmåder til anvendelse deraf Download PDFInfo
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- DK2247304T3 DK2247304T3 DK09727180.3T DK09727180T DK2247304T3 DK 2247304 T3 DK2247304 T3 DK 2247304T3 DK 09727180 T DK09727180 T DK 09727180T DK 2247304 T3 DK2247304 T3 DK 2247304T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (11)
1. Antistof, som er i stand til at binde specifikt til HER2/neu, hvilket antistof omfatter: (A) et første polypeptid omfattende et kimært variabelt 4D5-immunglobulindomæne af en let kæde omfattende aminosyresekvensen ifølge SEQ ID NO: 4; og (B) et andet polypeptid omfattende en 4D5-immunglobulin-tungkædevariant omfattende en aminosyresekvens valgt fra gruppen bestående af SEQ ID NO: 9, SEQ ID NO: 11 og SEQ ID NO: 13.
2. Antistof ifølge krav 1, hvor det første polypeptid omfatter en let kæde med aminosyresekvensen ifølge SEQ ID NO: 2.
3. Antistof ifølge krav 1 eller krav 2, hvor det andet polypeptid omfatter en tung kæde med aminosyresekvensen ifølge SEQ ID NO: 9.
4. Antistof ifølge krav 1 eller krav 2, hvor det andet polypeptid omfatter en tung kæde med aminosyresekvensen ifølge SEQ ID NO: 11.
5. Antistof ifølge krav 1 eller krav 2, hvor det andet polypeptid omfatter en tung kæde med aminosyresekvensen ifølge SEQ ID NO: 13.
6. Antistof ifølge et hvilket som helst af kravene 1 til 5, hvor den tunge kæde omfatter en Fc-domænevariant, som ved sammenligning med et vildtype-Fc-domæne udviser: (A) forøget antistofafhængig cellemedieret cytotoksicitet (ADCC); (B) forøget binding til FcyRIIA eller til FcyRIIIA; (C) reduceret binding til FcyRIIB eller (D) forøget binding til FcyRIIB.
7. Antistof ifølge krav 1, hvor antistoffet er et monoklonalt antistof.
8. Anvendelse af antistoffet ifølge et hvilket som helst af kravene 1 til 7 til fremstilling af et lægemiddel til behandling af HER2/neu-udtrykkende cancer hos en patient.
9. Anvendelse ifølge krav 8, hvor behandlingen yderligere omfatter det trin at administrere et terapeutisk middel valgt fra gruppen bestående af et anti-angiogenetisk middel, et anti-neoplastisk middel, et kemoterapeutisk middel, og et cytotoksisk middel.
10. Antistof ifølge et hvilket som helst af kravene 1 til 7 til anvendelse ved behandling af FIER2/neu-udtrykkende cancer hos en patient.
11. Farmaceutisk sammensætning, som omfatter antistoffet ifølge et hvilket som helst af kravene 1 til 7, og en farmaceutisk acceptabel bærer eller excipiens.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4164908P | 2008-04-02 | 2008-04-02 | |
PCT/US2009/038201 WO2009123894A2 (en) | 2008-04-02 | 2009-03-25 | Her2/neu-specific antibodies and methods of using same |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2247304T3 true DK2247304T3 (da) | 2016-09-26 |
Family
ID=41136073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09727180.3T DK2247304T3 (da) | 2008-04-02 | 2009-03-25 | Her2/neu-specifikke antistoffer og fremgangsmåder til anvendelse deraf |
Country Status (22)
Country | Link |
---|---|
US (6) | US8802093B2 (da) |
EP (2) | EP3067063A1 (da) |
JP (1) | JP5555223B2 (da) |
KR (1) | KR101606386B1 (da) |
CN (3) | CN107236044B (da) |
AU (1) | AU2009231991B2 (da) |
BR (1) | BRPI0906309A2 (da) |
CA (1) | CA2720368C (da) |
CY (1) | CY1117922T1 (da) |
DK (1) | DK2247304T3 (da) |
ES (1) | ES2587937T3 (da) |
HK (1) | HK1144248A1 (da) |
HR (1) | HRP20161050T1 (da) |
HU (1) | HUE029925T2 (da) |
IL (1) | IL208204A (da) |
LT (1) | LT2247304T (da) |
MX (1) | MX2010010737A (da) |
PL (1) | PL2247304T3 (da) |
PT (1) | PT2247304T (da) |
SG (1) | SG189730A1 (da) |
SI (1) | SI2247304T1 (da) |
WO (1) | WO2009123894A2 (da) |
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