HRP20161050T1 - Her2/neu specifična protutijela i postupci njihovog korištenja - Google Patents
Her2/neu specifična protutijela i postupci njihovog korištenja Download PDFInfo
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- HRP20161050T1 HRP20161050T1 HRP20161050TT HRP20161050T HRP20161050T1 HR P20161050 T1 HRP20161050 T1 HR P20161050T1 HR P20161050T T HRP20161050T T HR P20161050TT HR P20161050 T HRP20161050 T HR P20161050T HR P20161050 T1 HRP20161050 T1 HR P20161050T1
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- amino acid
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- 101150029707 ERBB2 gene Proteins 0.000 title claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 108010021472 Fc gamma receptor IIB Proteins 0.000 claims 2
- 102100029205 Low affinity immunoglobulin gamma Fc region receptor II-b Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010021468 Fc gamma receptor IIA Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 1
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 1
- 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940034982 antineoplastic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (11)
1. Protutijelo koje se može specifično vezati na HER2/neu koje sadrži:
(A) prvi polipeptid koji sadrži varijabilnu domenu kimernog 4D5 imunoglobulinskog lakog lanca koji sadrži sekvencu amino kiseline iz SEQ ID NO: 4; i
(B) drugi polipeptid koji sadrži varijantu 4D5 imunoglobulinskog teškog lanca koji sadrži sekvencu amino kiseline koja se bira iz skupine koju čine SEQ ID NO: 9, SEQ ID NO: 11, i SEQ ID NO: 13.
2. Protutijelo prema zahtjevu 1, naznačeno time da navedeni prvi polipeptid sadrži laki lanac koji ima sekvencu amino kiseline iz SEQ ID NO: 2.
3. Protutijelo prema zahtjevu 1 ili zahtjevu 2, naznačeno time da navedeni drugi polipeptid sadrži teški lanac koji ima sekvencu amino kiseline iz SEQ ID NO: 9.
4. Protutijelo prema zahtjevu 1 ili zahtjevu 2, naznačeno time da navedeni drugi polipeptid sadrži teški lanac koji ima sekvencu amino kiseline iz SEQ ID NO: 11.
5. Protutijelo prema zahtjevu 1 ili zahtjevu 2, naznačeno time da navedeni drugi polipeptid sadrži teški lanac koji ima sekvencu amino kiseline iz SEQ ID NO: 13.
6. Protutijelo prema bilo kojem od zahtjeva 1 do 5, naznačeno time da navedeni teški lanac sadrži varijantu Fc domene koja, u usporedbi s divljim tipom Fc domene iskazuje:
(A) poboljšanu staničnu citotoksičnost ovisnu o protutijelima (ADCC);
(B) povećano vezivanje na FcγRIIA ili na FcγRIIIA;
(C) smanjeno vezivanje na FcγRIIB; ili
(D) povećano vezivanje na FcγRIIB.
7. Protutijelo prema zahtjevu 1, naznačeno time da navedeno protutijelo je monoklonsko protutijelo.
8. Uporaba protutijela prema bilo kojem od zahtjeva 1 do 7 naznačena time da je za proizvodnju lijeka za liječenje karcinoma koji eksprimira HER2/neu kod pacijenta.
9. Uporaba prema zahtjevu 8, naznačena time da navedeno liječenje dodatno obuhvaća korak davanja terapeutskog sredstva, koje se bira iz skupine koju čine anti-angiogeno sredstvo, antineoplastično sredstvo, kemoterapijsko sredstvo, te citotoksično sredstvo.
10. Protutijelo prema bilo kojem od zahtjeva 1 do 7 naznačeno time da je za uporabu za liječenje karcinoma koji eksprimira HER2/neu kod pacijenta.
11. Farmaceutski pripravak naznačen time da sadrži protutijelo prema bilo kojem od zahtjeva 1 do 7, te farmaceutski prihvatljiv nosač ili pomoćnu tvar.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4164908P | 2008-04-02 | 2008-04-02 | |
PCT/US2009/038201 WO2009123894A2 (en) | 2008-04-02 | 2009-03-25 | Her2/neu-specific antibodies and methods of using same |
EP09727180.3A EP2247304B1 (en) | 2008-04-02 | 2009-03-25 | Her2/neu-specific antibodies and methods of using same |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20161050T1 true HRP20161050T1 (hr) | 2016-11-18 |
Family
ID=41136073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20161050TT HRP20161050T1 (hr) | 2008-04-02 | 2016-08-19 | Her2/neu specifična protutijela i postupci njihovog korištenja |
Country Status (22)
Country | Link |
---|---|
US (6) | US8802093B2 (hr) |
EP (2) | EP2247304B1 (hr) |
JP (1) | JP5555223B2 (hr) |
KR (1) | KR101606386B1 (hr) |
CN (3) | CN102046195A (hr) |
AU (1) | AU2009231991B2 (hr) |
BR (1) | BRPI0906309A2 (hr) |
CA (1) | CA2720368C (hr) |
CY (1) | CY1117922T1 (hr) |
DK (1) | DK2247304T3 (hr) |
ES (1) | ES2587937T3 (hr) |
HK (1) | HK1144248A1 (hr) |
HR (1) | HRP20161050T1 (hr) |
HU (1) | HUE029925T2 (hr) |
IL (1) | IL208204A (hr) |
LT (1) | LT2247304T (hr) |
MX (1) | MX2010010737A (hr) |
PL (1) | PL2247304T3 (hr) |
PT (1) | PT2247304T (hr) |
SG (1) | SG189730A1 (hr) |
SI (1) | SI2247304T1 (hr) |
WO (1) | WO2009123894A2 (hr) |
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