DK2170920T3 - Stabile salte af s-adenosylmethionin og fremgangsmåde til fremstilling deraf - Google Patents

Stabile salte af s-adenosylmethionin og fremgangsmåde til fremstilling deraf Download PDF

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Publication number
DK2170920T3
DK2170920T3 DK07849705.4T DK07849705T DK2170920T3 DK 2170920 T3 DK2170920 T3 DK 2170920T3 DK 07849705 T DK07849705 T DK 07849705T DK 2170920 T3 DK2170920 T3 DK 2170920T3
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DK
Denmark
Prior art keywords
acid
same
salts
salt
range
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DK07849705.4T
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English (en)
Inventor
Ermanno Valoti
Daniele Giovannone
Marco Berna
Original Assignee
Gnosis Spa
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Publication of DK2170920T3 publication Critical patent/DK2170920T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (8)

1. Salt af S-adenosylmethionin (SAMe) med formel (I):
W hvor HX er en stærk mineralsyre med en syredissociationskonstant (pKa) på mindre end 2,5 valgt fra saltsyre, svovlsyre, phosphorsyre, phosphonsyre, disulfonsyre og/eller 1,4-butandisulfonsyre; n og m er uafhængigt af hinanden et tal i området på 0,5 - 2,0; Y er et calciumoxid, magnesiumoxid, calciumchlorid, magnesiumchlorid, calciumsulfat, magnesiumsulfat og/eller en blanding deraf.
2. Salt ifølge krav 1, hvor Y er MgCL·.
3. Salt ifølge krav 1, hvor Y er CaCL·.
4. Salt ifølge et hvilket som helst af de foregående krav i form af ovale eller sfæriske partikler.
5. Salt ifølge et hvilket som helst af de foregående krav med en partikelstørrelse i området på 20 - 500 pm.
6. Salt ifølge krav 5, med en partikelstørrelse i området på 50 - 300 pm.
7. Salt ifølge et hvilket som helst af de foregående krav, omfattende mindst 70 vægtprocent SAMe, fortrinsvis fra 75 til 90%.
8. Anvendelse af mindst ét salt ifølge kravene 1-7 til fremstillingen af et medikament til behandlingen af depressive tilstande.
DK07849705.4T 2007-07-10 2007-10-22 Stabile salte af s-adenosylmethionin og fremgangsmåde til fremstilling deraf DK2170920T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001374A ITMI20071374A1 (it) 2007-07-10 2007-07-10 Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
PCT/IT2007/000736 WO2009008019A1 (en) 2007-07-10 2007-10-22 Stable salts of s-adenosylmethionine and process for the preparation thereof

Publications (1)

Publication Number Publication Date
DK2170920T3 true DK2170920T3 (da) 2015-05-11

Family

ID=39639465

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07849705.4T DK2170920T3 (da) 2007-07-10 2007-10-22 Stabile salte af s-adenosylmethionin og fremgangsmåde til fremstilling deraf

Country Status (19)

Country Link
US (1) US8258115B2 (da)
EP (1) EP2170920B1 (da)
JP (2) JP2010533165A (da)
KR (1) KR101455208B1 (da)
CN (1) CN101730704B (da)
AU (1) AU2007356297B2 (da)
BR (1) BRPI0721887B8 (da)
CA (1) CA2707344C (da)
CY (1) CY1116266T1 (da)
DK (1) DK2170920T3 (da)
ES (1) ES2536402T3 (da)
IT (1) ITMI20071374A1 (da)
NO (1) NO343103B1 (da)
NZ (1) NZ582149A (da)
PL (1) PL2170920T3 (da)
PT (1) PT2170920E (da)
RS (1) RS54021B1 (da)
SI (1) SI2170920T1 (da)
WO (1) WO2009008019A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014113609A1 (en) * 2013-01-16 2014-07-24 Hebert Sam-E Llc Stable indole-3-propionate salts of s-adenosyl-l-methionine
WO2015028927A1 (en) * 2013-08-25 2015-03-05 Mahesh Kandula Compositions and methods for the treatment of metabolic diseases
WO2016185413A1 (en) 2015-05-20 2016-11-24 Nestec S.A. Modified release formulations
CN106349311B (zh) * 2016-08-23 2018-04-13 北京金阳利康医药有限公司 从酵母发酵液中提取s‑腺苷蛋氨酸的方法
IT201700074957A1 (it) * 2017-07-04 2019-01-04 Gnosis Spa Sale di (ss)-adenosil metionina con inositolo esafosfato e procedimento per ottenerlo
IT202000030914A1 (it) 2020-12-15 2022-06-15 Mario Antonio Basile Composizione farmaceutica solida di ademetionina e cannabidiolo e procedimento per ottenerla

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* Cited by examiner, † Cited by third party
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JPS5817392B2 (ja) * 1978-11-10 1983-04-06 大阪瓦斯株式会社 微粒子状凍結物製造装置
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Also Published As

Publication number Publication date
NZ582149A (en) 2012-02-24
CN101730704B (zh) 2013-08-14
US8258115B2 (en) 2012-09-04
CA2707344C (en) 2014-12-16
BRPI0721887B8 (pt) 2021-05-25
NO343103B1 (no) 2018-11-05
US20100184715A1 (en) 2010-07-22
EP2170920A1 (en) 2010-04-07
EP2170920B1 (en) 2015-03-11
KR101455208B1 (ko) 2014-10-28
NO20100192L (no) 2010-02-08
CA2707344A1 (en) 2009-01-15
BRPI0721887B1 (pt) 2019-06-25
AU2007356297A1 (en) 2009-01-15
SI2170920T1 (sl) 2015-06-30
PL2170920T3 (pl) 2015-07-31
RS54021B1 (en) 2015-10-30
AU2007356297B2 (en) 2012-05-24
CN101730704A (zh) 2010-06-09
ES2536402T3 (es) 2015-05-25
JP2015028043A (ja) 2015-02-12
PT2170920E (pt) 2015-07-06
JP2010533165A (ja) 2010-10-21
ITMI20071374A1 (it) 2009-01-11
KR20100032893A (ko) 2010-03-26
WO2009008019A1 (en) 2009-01-15
BRPI0721887A2 (pt) 2014-03-25
CY1116266T1 (el) 2017-02-08

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