DK1957644T3 - Enzymatiske kodnings metoder til effektiv syntese af store biblioteker - Google Patents

Enzymatiske kodnings metoder til effektiv syntese af store biblioteker

Info

Publication number
DK1957644T3
DK1957644T3 DK06818144.5T DK06818144T DK1957644T3 DK 1957644 T3 DK1957644 T3 DK 1957644T3 DK 06818144 T DK06818144 T DK 06818144T DK 1957644 T3 DK1957644 T3 DK 1957644T3
Authority
DK
Denmark
Prior art keywords
coding methods
large libraries
efficient synthesis
enzymatic
tag
Prior art date
Application number
DK06818144.5T
Other languages
English (en)
Inventor
Soeren Jakobsen
Anders Malling Soerensen
Birgitte Nystrup Husemoen
Johannes Dolberg
Thomas Franch
Anne Lee Andersen
Anette Holtmann
Anders Holm Hansen
Anne Goldbech
Leon Daen De
Frank Abilgaard Sloek
Kim Birkebaek Jensen
Lene Petersen
Mads Noerregaard-Madsen
Michael Anders Godskesen
Sanne Schroeder Glad
Soeren Neve
Thomas Thisted
Tine Titilola Akinleminu Kronborg
Christian Sams
Jakob Felding
Per-Ola Freskgaard
Alex Haahr Gouliaev
Henrik Pedersen
Mikkel Dybro Lundorf
Ditte Kievsmose Kaldor
Eva Kampmann Olsen
Original Assignee
Nuevolution As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuevolution As filed Critical Nuevolution As
Application granted granted Critical
Publication of DK1957644T3 publication Critical patent/DK1957644T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1068Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1089Design, preparation, screening or analysis of libraries using computer algorithms
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/04Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/06Biochemical methods, e.g. using enzymes or whole viable microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK06818144.5T 2005-12-01 2006-12-01 Enzymatiske kodnings metoder til effektiv syntese af store biblioteker DK1957644T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200501704 2005-12-01
US74149005P 2005-12-02 2005-12-02
PCT/DK2006/000685 WO2007062664A2 (en) 2005-12-01 2006-12-01 Enzymatic encoding methods for efficient synthesis of large libraries

Publications (1)

Publication Number Publication Date
DK1957644T3 true DK1957644T3 (da) 2011-03-28

Family

ID=38001974

Family Applications (5)

Application Number Title Priority Date Filing Date
DK10192717.6T DK2336315T3 (da) 2005-12-01 2006-12-01 Fremgangsmåde til enzymatisk kodning ved effektiv syntese af store biblioteker
DK17181547.5T DK3305900T3 (da) 2005-12-01 2006-12-01 Enzymatic encoding methods for efficient synthesis of large libraries
DK06818144.5T DK1957644T3 (da) 2005-12-01 2006-12-01 Enzymatiske kodnings metoder til effektiv syntese af store biblioteker
DK10192716.8T DK2341140T3 (da) 2005-12-01 2006-12-01 Fremgangsmåde til enzymatisk kodning ved effektiv syntese af store biblioteker
DK15188924.3T DK3018206T3 (da) 2005-12-01 2006-12-01 Enzymatic encoding methods for efficient synthesis of large libraries

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK10192717.6T DK2336315T3 (da) 2005-12-01 2006-12-01 Fremgangsmåde til enzymatisk kodning ved effektiv syntese af store biblioteker
DK17181547.5T DK3305900T3 (da) 2005-12-01 2006-12-01 Enzymatic encoding methods for efficient synthesis of large libraries

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK10192716.8T DK2341140T3 (da) 2005-12-01 2006-12-01 Fremgangsmåde til enzymatisk kodning ved effektiv syntese af store biblioteker
DK15188924.3T DK3018206T3 (da) 2005-12-01 2006-12-01 Enzymatic encoding methods for efficient synthesis of large libraries

Country Status (12)

Country Link
US (4) US9574189B2 (da)
EP (5) EP2341140B1 (da)
AT (1) ATE490318T1 (da)
DE (1) DE602006018648D1 (da)
DK (5) DK2336315T3 (da)
ES (2) ES2897529T3 (da)
HK (1) HK1245329A1 (da)
HU (1) HUE056836T2 (da)
LT (4) LT2336315T (da)
PT (2) PT3018206T (da)
SI (4) SI3305900T1 (da)
WO (1) WO2007062664A2 (da)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
EP2186897B1 (en) 2002-03-15 2016-02-17 Nuevolution A/S An improved method for synthesising templated molecules
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
WO2004028682A2 (en) 2002-09-27 2004-04-08 Carlsberg A/S Spatially encoded polymer matrix
ES2368215T3 (es) 2002-10-30 2011-11-15 Nuevolution A/S Codificación enzimática.
EP2175019A3 (en) 2002-12-19 2011-04-06 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
DE602006018648D1 (de) 2005-12-01 2011-01-13 Nuevolution As Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken
CA2684150C (en) 2007-05-14 2016-10-04 Research Foundation Of State University Of New York Decenoic acid dispersion inducers in the treatment of biofilms
WO2009086044A1 (en) * 2007-12-19 2009-07-09 Smith Kline Beecham Corporation Prolyl hydroxylase inhibitors
US8324405B2 (en) 2008-02-05 2012-12-04 Fibrogen, Inc. Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
AU2009314155B2 (en) 2008-11-14 2015-10-08 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
CA2749163A1 (en) 2009-01-14 2010-07-22 The Salk Institute For Biological Studies Methods for screening and compounds that protect against amyloid diseases
NZ594420A (en) * 2009-02-13 2013-06-28 Chem Inc X Methods of creating and screening dna-encoded libraries
DK2558577T3 (da) 2010-04-16 2019-04-01 Nuevolution As Bi-funktionelle komplekser og fremgangsmåder til fremstilling og anvendelse af sådanne komplekser
WO2012027547A2 (en) * 2010-08-25 2012-03-01 Columbia University Quantitative total definition of biologically active sequence elements
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
US9625469B2 (en) 2011-06-23 2017-04-18 Board Of Regents, The University Of Texas System Identifying peptides at the single molecule level
EP3828271A1 (en) 2011-09-07 2021-06-02 X-Chem, Inc. Methods for tagging dna-encoded libraries
IL236633B (en) * 2012-07-13 2022-07-01 X Chem Inc DNA-encoded libraries containing a conjugate containing conjugated oligonucleotide links
RU2519546C1 (ru) * 2013-01-16 2014-06-10 Общество С Ограниченной Ответственностью "Биоинтегратор" (Ооо "Биоинтегратор") КОНЪЮГАТЫ И МАЛЫЕ МОЛЕКУЛЫ, ВЗАИМОДЕЙСТВУЮЩИЕ С РЕЦЕПТОРОМ CD16а
WO2014152715A1 (en) * 2013-03-15 2014-09-25 University Of Rochester Use of inhibitors of binding between a par-1 receptor and its ligands for the treatment of glioma
US11384377B2 (en) 2013-04-02 2022-07-12 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
US11331643B2 (en) 2013-04-02 2022-05-17 Molecular Assemblies, Inc. Reusable initiators for synthesizing nucleic acids
CN104181221B (zh) 2013-05-21 2017-02-01 成都先导药物开发有限公司 一种药物靶标捕获方法
GB201322692D0 (en) 2013-12-20 2014-02-05 Philochem Ag Production of encoded chemical libraries
CA3208970A1 (en) 2014-09-15 2016-05-06 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
EP3218479A1 (en) 2014-11-11 2017-09-20 Nanocore ApS Method for identification of molecules with desired characteristics
KR102516168B1 (ko) 2016-05-02 2023-03-30 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
EP3472376A4 (en) 2016-06-16 2019-12-18 Richard Edward Watts DIRECTED AND RECORDED COMBINATORY SYNTHESIS OF OLIGONUCLEOTIDES OF CODED PROBE MOLECULES
CA3041645C (en) 2016-10-24 2021-11-02 Geneinfosec, Inc. Concealing information present within nucleic acids
US20180214476A1 (en) * 2017-02-01 2018-08-02 North Carolina State University Thrombin-responsive hydrogels and devices for auto-anticoagulant regulation
AU2018232883A1 (en) * 2017-03-09 2019-09-19 Mab Discovery Gmbh Antibodies specifically binding to human IL-1 R7
KR102222242B1 (ko) 2017-03-17 2021-03-04 히트젠 주식회사 코드 라이브러리 합성방법 및 조성물
US20180274001A1 (en) * 2017-03-21 2018-09-27 Molecular Assemblies, Inc. Nucleic acid synthesis using dna polymerase theta
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
CA3076755C (en) * 2017-09-25 2023-09-12 Haystack Sciences Corporation Multinomial encoding for oligonucleotide-directed combinatorial chemistry
US20200348307A1 (en) * 2017-10-31 2020-11-05 Encodia, Inc. Methods and compositions for polypeptide analysis
CA3081451A1 (en) * 2017-10-31 2019-05-09 Encodia, Inc. A method for assaying interactions between biological targets and binding agents
KR102556494B1 (ko) * 2017-10-31 2023-07-18 엔코디아, 인코포레이티드 핵산 암호화 및/또는 표지를 이용한 분석용 키트
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN108753861B (zh) * 2018-06-08 2022-02-01 福建省微生物研究所 一种毒三素链霉菌发酵产利普司他汀的培养基及方法
JP2022525340A (ja) * 2019-03-14 2022-05-12 ヘイスタック サイエンシーズ コーポレイション オリゴヌクレオチドコード化分子を加工または分析する方法および系
US11427814B2 (en) 2019-03-26 2022-08-30 Encodia, Inc. Modified cleavases, uses thereof and related kits
JP2022530966A (ja) 2019-04-30 2022-07-05 エンコディア, インコーポレイテッド 分析物を調製するための方法および関連キット
US11926820B2 (en) * 2019-09-13 2024-03-12 Google Llc Methods and compositions for protein and peptide sequencing
US11834664B2 (en) 2019-09-13 2023-12-05 Google Llc Methods and compositions for protein and peptide sequencing
US11834756B2 (en) 2019-09-13 2023-12-05 Google Llc Methods and compositions for protein and peptide sequencing
KR20220097404A (ko) 2019-10-10 2022-07-07 1859, 인크. 미세유체 스크리닝을 위한 방법 및 시스템
CN112779606A (zh) * 2019-11-06 2021-05-11 成都先导药物开发股份有限公司 一种On-DNA曼尼希反应的方法
EP4073263A4 (en) 2020-01-07 2023-11-08 Encodia, Inc. METHODS FOR FORMING A STABLE COMPLEX AND ASSOCIATED KITS
CN113105554B (zh) * 2020-01-13 2022-07-26 广东泰禾医药科技有限公司 一种抗肿瘤融合蛋白及其制法和应用
CN111269870A (zh) * 2020-03-06 2020-06-12 南京工业大学 一种高产胞苷酸的重组大肠杆菌及其应用
WO2022094148A1 (en) 2020-10-30 2022-05-05 Encodia, Inc. Conjugation reagents and methods using 1,2-cyclohexanediones
CN113444730A (zh) * 2021-03-17 2021-09-28 昆明市延安医院 一种原发性肝细胞klotho基因转导干细胞筛选构建方法
CN113416713A (zh) * 2021-05-11 2021-09-21 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 一种重组腺病毒的构建及其应用
KR20240056484A (ko) * 2021-06-17 2024-04-30 인시트로, 인코포레이티드 2가 분자 제조 방법
DE102021210272A1 (de) * 2021-09-16 2023-03-16 Continental Reifen Deutschland Gmbh Klebstoffzusammensetzung, Verfahren zum dauerhaften Verbinden einer ersten vulkanisierten Kautschukkomponente mit einer zweiten vulkanisierten Kautschukkomponente und Verbund umfassend eine erste vulkanisierte Kautschukkomponente und eine zweite vulkanisierte Kautschukkomponente
CN113755527B (zh) * 2021-10-21 2022-04-26 广东源心再生医学有限公司 一种同时表达plaur和gpld1基因的质粒载体及其构建方法
EP4206674A1 (en) 2021-12-28 2023-07-05 Encodia, Inc. High-throughput serotyping and antibody profiling assays

Family Cites Families (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719667A (en) 1970-08-24 1973-03-06 Lilly Co Eli Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters
US3840556A (en) 1971-05-28 1974-10-08 Lilly Co Eli Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby
JPS60222842A (ja) 1984-04-19 1985-11-07 Fuji Photo Film Co Ltd ハロゲン化銀写真乳剤およびその製造方法
US6040166A (en) * 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4822731A (en) 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
DE3788914T2 (de) 1986-09-08 1994-08-25 Ajinomoto Kk Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US5025388A (en) 1988-08-26 1991-06-18 Cramer Richard D Iii Comparative molecular field analysis (CoMFA)
JPH04504651A (ja) 1988-11-18 1992-08-20 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 自然に存在しないアミノ酸をタンパク質に部位特異的に導入する方法
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
KR0185192B1 (ko) 1989-10-05 1999-04-01 제임스 더블유. 데이비 신규의 유전자 및 폴리펩티드의 무세포 합성 및 분리
US5670633A (en) 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5646265A (en) 1990-01-11 1997-07-08 Isis Pharmceuticals, Inc. Process for the preparation of 2'-O-alkyl purine phosphoramidites
CA2039517C (en) * 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
WO1992002536A1 (en) 1990-08-02 1992-02-20 The Regents Of The University Of Colorado Systematic polypeptide evolution by reverse translation
US5843701A (en) * 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US6037120A (en) 1995-10-12 2000-03-14 Benner; Steven Albert Recognition of oligonucleotides containing non-standard base pairs
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
AU2313392A (en) 1991-08-01 1993-03-02 University Research Corporation Systematic polypeptide evolution by reverse translation
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
CA2118806A1 (en) 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
US6197556B1 (en) * 1991-12-20 2001-03-06 The University Of Chicago Nucleic acid amplification using modular branched primers
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US6503759B1 (en) * 1992-10-01 2003-01-07 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
WO1994008051A1 (en) 1992-10-01 1994-04-14 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5684169A (en) * 1992-11-27 1997-11-04 Ensuiko Sugar Refining Co., Ltd. Cyclodextrin inclusion complex of taxol, and method for its production and its use
AU5827294A (en) 1992-12-11 1994-07-04 Chiron Corporation Synthesis of encoded polymers
DE69433010T2 (de) 1993-04-12 2004-06-09 Northwestern University, Evanston Verfahren zur darstellung von oligonukleotiden
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
NZ267843A (en) * 1993-05-27 1997-10-24 Selectide Corp Libraries of synthetic test compound attached to separate phase synthesis supports
US5840485A (en) * 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
EP0706531A4 (en) * 1993-07-02 1998-11-25 Lynx Therapeutics Inc SYNTHESIS OF BRANCHED NUCLEIC ACIDS
US5473060A (en) * 1993-07-02 1995-12-05 Lynx Therapeutics, Inc. Oligonucleotide clamps having diagnostic applications
US5571903A (en) 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
US6087186A (en) * 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
AU7390994A (en) 1993-08-25 1995-03-21 Symbicom Aktiebolag Molecular modelling and drug design
CN1154640C (zh) * 1993-10-01 2004-06-23 纽约市哥伦比亚大学理事 用标示物编码的多元组合化学库
CN1134156A (zh) 1993-11-02 1996-10-23 阿菲马克斯技术公司 合成和筛选多种分子
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6165778A (en) 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
JPH09506629A (ja) * 1993-12-17 1997-06-30 キュビッチョッティ,ロジャー・エス ヌクレオチドに支配された生体分子および多分子薬物の集合並びに装置
ZA95260B (en) * 1994-01-13 1995-09-28 Univ Columbia Synthetic receptors libraries and uses thereof
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5449613A (en) 1994-03-01 1995-09-12 The University Of Iowa Research Foundation Reacting an enzyme in a non-aqueous solvent by adding a lyophilizate of enzyme and salt to the solvent
US6936477B2 (en) * 1994-04-13 2005-08-30 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5643722A (en) * 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US5663046A (en) 1994-06-22 1997-09-02 Pharmacopeia, Inc. Synthesis of combinatorial libraries
JPH10507160A (ja) 1994-06-23 1998-07-14 アフィマックス テクノロジーズ エヌ.ブイ. 光活性化合物およびその使用方法
WO1996003418A1 (en) 1994-07-26 1996-02-08 The Scripps Research Institute Soluble combinatorial libraries
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5846719A (en) * 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5985356A (en) 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6045671A (en) 1994-10-18 2000-04-04 Symyx Technologies, Inc. Systems and methods for the combinatorial synthesis of novel materials
WO1996024847A1 (en) 1995-02-10 1996-08-15 Smithkline Beecham Corporation A process for identifiying pharmaceutically active agents using an epitope-tagged library
US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US5679519A (en) * 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
IL118054A0 (en) 1995-05-09 1996-08-04 Basf Ag (Het) aryloxy-,(-thio- and -amino-)-crotonates their preparation and pharmaceutical compositions containing them
US6210900B1 (en) * 1995-05-23 2001-04-03 Smithkline Beecham Corporation Method of encoding a series of combinatorial libraries and developing structure activity relationships
US5830658A (en) 1995-05-31 1998-11-03 Lynx Therapeutics, Inc. Convergent synthesis of branched and multiply connected macromolecular structures
US5824471A (en) * 1995-06-05 1998-10-20 Brigham And Women's Hospital Detection of mismatches by cleavage of nucleic acid heteroduplexes
HUP9900910A2 (hu) 1995-06-07 1999-07-28 Lynx Therapeutics, Inc. Oligonukleotid jelzések osztályozáshoz és azonosításhoz
US5958792A (en) 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
US5795976A (en) * 1995-08-08 1998-08-18 The Board Of Trustees Of The Leland Stanford Junior University Detection of nucleic acid heteroduplex molecules by denaturing high-performance liquid chromatography and methods for comparative sequencing
US5723320A (en) * 1995-08-29 1998-03-03 Dehlinger; Peter J. Position-addressable polynucleotide arrays
US6495314B1 (en) 1995-09-29 2002-12-17 The Scripps Research Institute Process for characterizing proteins
DE19646372C1 (de) 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
US5763175A (en) * 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
WO1997019039A1 (en) 1995-11-17 1997-05-29 Novartis Ag Solid phase synthesis of heterocyclic compounds and combinatorial compound library
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス,インコーポレイティド 核酸分析法
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US5880972A (en) * 1996-02-26 1999-03-09 Pharmacopeia, Inc. Method and apparatus for generating and representing combinatorial chemistry libraries
EP0904540A1 (en) 1996-03-22 1999-03-31 Ontogen Corporation Methods for spatially-dispersed positionally-encoded combinatorial library synthesis
US6294325B1 (en) 1996-07-05 2001-09-25 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of thermostable multi genes and proteins and uses thereof
US5821356A (en) * 1996-08-12 1998-10-13 The Perkin Elmer Corporation Propargylethoxyamino nucleotides
US6355490B1 (en) 1996-09-13 2002-03-12 Jill Edie Hochlowski Attached tags for use in combinatorial chemistry synthesis
DE19642751A1 (de) 1996-10-16 1998-04-23 Deutsches Krebsforsch Saccharid-Bibliothek
DE69739163D1 (de) 1996-10-17 2009-01-22 Mitsubishi Chem Corp Molekül, welches Genotyp und Phänotyp zusammenführt und dessen Anwendungen
US5954874A (en) 1996-10-17 1999-09-21 Hunter; Charles Eric Growth of bulk single crystals of aluminum nitride from a melt
CN1238366C (zh) 1997-01-21 2006-01-25 综合医院公司 利用rna-蛋白融合体筛选蛋白
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US6127533A (en) 1997-02-14 2000-10-03 Isis Pharmaceuticals, Inc. 2'-O-aminooxy-modified oligonucleotides
US5739314A (en) 1997-04-25 1998-04-14 Hybridon, Inc. Method for synthesizing 2'-O-substituted pyrimidine nucleosides
ATE250668T1 (de) 1997-05-28 2003-10-15 Discerna Ltd Ribosom-komplexe als selektionspartikel für die in vitro anzeige und evolution von proteinen
US6969584B2 (en) 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
AU8147798A (en) 1997-06-16 1999-01-04 University Of North Carolina At Chapel Hill, The Peptido oligonucleotides (pons) and their combinatorial libraries
US6607878B2 (en) 1997-10-06 2003-08-19 Stratagene Collections of uniquely tagged molecules
US6348322B1 (en) 1997-10-17 2002-02-19 Duke University Method of screening for specific binding interactions
US20030004122A1 (en) 1997-11-05 2003-01-02 Leonid Beigelman Nucleotide triphosphates and their incorporation into oligonucleotides
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
JP2002540380A (ja) 1998-02-21 2002-11-26 ウィッシス・テクノロジー・ファウンデーション・インコーポレイテッド 一次元の化学化合物アレイ及びそれらのアセイ方法
US6316616B1 (en) 1998-04-02 2001-11-13 President And Fellows Of Harvard College Parallel combinatorial approach to the discovery and optimization of catalysts and uses thereof
JP2002510505A (ja) 1998-04-03 2002-04-09 フィロス インク. 位置特定可能な蛋白質アレイ
EP1073730A1 (en) 1998-04-17 2001-02-07 Whitehead For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
CA2332862A1 (en) 1998-05-15 1999-11-25 Isis Innovation Ltd. Libraries of oligomers labelled with different tags
US6287765B1 (en) 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
US6096875A (en) * 1998-05-29 2000-08-01 The Perlein-Elmer Corporation Nucleotide compounds including a rigid linker
US5948648A (en) * 1998-05-29 1999-09-07 Khan; Shaheer H. Nucleotide compounds including a rigid linker
EP1086064A2 (en) 1998-06-10 2001-03-28 Glycodesign Inc. Directed combinatorial compound library and high throughput assays for screening same
GB0002310D0 (en) 2000-02-01 2000-03-22 Solexa Ltd Polynucleotide sequencing
WO2000020639A1 (en) 1998-10-05 2000-04-13 Lynx Therapeutics, Inc. Enzymatic synthesis of oligonucleotide tags
AU6295999A (en) 1998-10-09 2000-05-01 Pharmacopeia, Inc. Selecting codes to be used for encoding combinatorial libraries
US6175001B1 (en) 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
CA2346989A1 (en) 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
CA2343878A1 (en) 1998-10-28 2000-05-04 Novozymes A/S Method for generating a gene library
US5942609A (en) 1998-11-12 1999-08-24 The Porkin-Elmer Corporation Ligation assembly and detection of polynucleotides on solid-support
AU775997B2 (en) 1998-12-02 2004-08-19 Bristol-Myers Squibb Company DNA-protein fusions and uses thereof
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
CA2360407A1 (en) 1999-01-08 2000-07-13 Nickolai Alexandrov Sequence-determined dna fragments and corresponding polypeptides encoded thereby
CA2403209A1 (en) 1999-04-08 2000-10-19 Pavel V. Sergeev Synthesis of biologically active compounds in cells
WO2000075373A2 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
CA2376623C (en) 1999-06-25 2011-04-19 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
CA2377468C (en) 1999-07-27 2010-04-20 Phylos, Inc. Peptide acceptor ligation methods
WO2001016151A1 (fr) 1999-08-27 2001-03-08 Japan Science And Technology Corporation Acide nucleique a photocouplage reversible et phosphoroamidite
GB9920194D0 (en) 1999-08-27 1999-10-27 Advanced Biotech Ltd A heat-stable thermostable DNA polymerase for use in nucleic acid amplification
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US20020048760A1 (en) * 1999-12-10 2002-04-25 Hyseq, Inc. Use of mismatch cleavage to detect complementary probes
CA2396810A1 (en) 2000-01-24 2001-07-26 Phylos, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
WO2001056955A1 (en) 2000-02-03 2001-08-09 Nanoscale Combinatorial Synthesis, Inc. Nonredundant split/pool synthesis of combinatorial libraries
US20020127598A1 (en) 2000-03-27 2002-09-12 Wenqiang Zhou Solution-phase combinatorial library synthesis and pharmaceutically active compounds produced thereby
US6368801B1 (en) * 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase
US7682837B2 (en) 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
EP1290222B1 (en) 2000-05-19 2007-08-08 Richard B. Williams In vitro evolution of nucleic acids and encoded polypeptide
US7244560B2 (en) 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
EP1297338B1 (en) * 2000-06-05 2007-04-18 Novartis Vaccines and Diagnostics, Inc. Microarrays for performing proteomic analyses
US20020115068A1 (en) 2000-06-23 2002-08-22 Ian Tomlinson Matrix screening method
CA2415098A1 (en) 2000-07-03 2002-01-10 Merck & Co., Inc. Methods for encoding combinatorial libraries
WO2002010186A1 (en) 2000-07-27 2002-02-07 California Institute Of Technology A rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping
US20020072887A1 (en) * 2000-08-18 2002-06-13 Sandor Szalma Interaction fingerprint annotations from protein structure models
US20020107302A1 (en) 2000-09-08 2002-08-08 Escano Nelson Zamora Monomeric dye inkjet printing ink formulations for invisible marking / identification
US7718600B2 (en) 2000-09-29 2010-05-18 The Trustees Of Princeton University IAP binding compounds
WO2002034948A2 (en) 2000-10-25 2002-05-02 City Of Hope Candidate region mismatch scanning for genotyping and mutation detection
JP2002315577A (ja) 2000-11-14 2002-10-29 Gencom Co 核酸ライブラリーの作製方法
ATE335754T1 (de) * 2001-03-19 2006-09-15 Harvard College Entwicklung neuer molekularer funktionen
US7678554B2 (en) 2001-03-19 2010-03-16 President And Fellows Of Harvard College Nucleic acid shuffling
WO2002083951A1 (en) 2001-04-10 2002-10-24 Northeastern University Multiplexed ligand/protein binding assays with pna labels
US20040137458A1 (en) 2001-05-03 2004-07-15 Christian Archambault Molecular tag code for monitoring a product and process using same
AU2003303395A1 (en) 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
AU2002312389A1 (en) 2001-06-05 2002-12-16 Irm Llc Functional proteomic profiling
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
WO2004001042A2 (en) 2002-06-20 2003-12-31 Nuevolution A/S Microarrays displaying encoded molecules
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
ATE371026T1 (de) 2001-06-20 2007-09-15 Nuevolution As Eine methode zur synthese von matrizenabhängigen molekülen
US20040161741A1 (en) * 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
DE10145226A1 (de) 2001-09-13 2003-04-10 Lifebits Ag Herstellung von trägergebundenen Molekülen
CA2466164A1 (en) 2001-10-30 2003-05-08 Nanomics Biosystems Pty, Ltd. Device and methods for directed synthesis of chemical libraries
WO2003062417A1 (fr) 2002-01-22 2003-07-31 Mitsubishi Chemical Corporation Produit de ligation arn-adn, et utilisation correspondante
US20070213519A1 (en) 2002-03-01 2007-09-13 Nuevolution A/S Building Block Forming A C=C Double Bond Upon Reaction
AU2002310846B2 (en) 2002-03-08 2008-03-20 Eidgenossische Technische Hochschule Zurich Encoded self-assembling chemical libraries (ESACHEL)
EP1490384A2 (en) * 2002-03-15 2004-12-29 Nuevolution A/S A building block forming a c-c bond upon reaction
WO2003078446A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c or a c-hetero atom bond upon reaction
EP1487851A2 (en) * 2002-03-15 2004-12-22 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
EP2186897B1 (en) 2002-03-15 2016-02-17 Nuevolution A/S An improved method for synthesising templated molecules
AU2003226008A1 (en) 2002-03-22 2003-10-13 Emory University Template-driven processes for synthesizing polymers and components related to such processes
DK2226316T3 (da) 2002-05-30 2016-04-11 Scripps Research Inst Kobberkatalyseret ligation af azider og acetylener
GB0213816D0 (en) 2002-06-14 2002-07-24 Univ Aston Method of producing DNA and protein libraries
AU2003242516A1 (en) 2002-07-23 2004-02-09 Nuevolution A/S Gene shuffling by template switching
EP1539980B1 (en) 2002-08-01 2016-02-17 Nuevolution A/S Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules
EP1540013B1 (en) * 2002-08-19 2015-07-08 The President and Fellows of Harvard College Evolving new molecular function
US20040197845A1 (en) 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
WO2004024929A2 (en) 2002-09-12 2004-03-25 Nuevolution A/S Proximity-aided synthesis of templated molecules
EP1551986B1 (en) * 2002-09-30 2014-08-27 Affymetrix, Inc. Polynucleotide synthesis and labeling by kinetic sampling ligation
EP1576126A3 (en) 2002-10-30 2005-10-26 Pointilliste, Inc. Systems for capture and analysis of biological particles and methods using the systems
ES2368215T3 (es) * 2002-10-30 2011-11-15 Nuevolution A/S Codificación enzimática.
EP1576188B1 (en) * 2002-11-21 2008-10-15 Epicentre Technologies Methods for using riboprimers for strand displacement replication of target sequences
AU2003297682A1 (en) 2002-12-03 2004-06-23 Archemix Corporation Method for in vitro selection of 2'-substituted nucleic acids
EP2175019A3 (en) 2002-12-19 2011-04-06 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2005003375A2 (en) 2003-01-29 2005-01-13 454 Corporation Methods of amplifying and sequencing nucleic acids
WO2004074501A2 (en) * 2003-02-21 2004-09-02 Nuevolution A/S A method for obtaining structural information about an encoded molecule
US20070026397A1 (en) * 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
JP4054871B2 (ja) 2003-02-24 2008-03-05 独立行政法人産業技術総合研究所 耐熱性dnaリガーゼ
US7915201B2 (en) * 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
EP1625230A2 (en) 2003-05-09 2006-02-15 Thorleif Möller Selection and evolution of chemical libraries
WO2004110964A2 (en) 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
WO2005003778A2 (en) 2003-07-02 2005-01-13 Nuevolution A/S A method for identifying a synthetic molecule having affinity towards a target
US20070134662A1 (en) 2003-07-03 2007-06-14 Juswinder Singh Structural interaction fingerprint
EP1533385A1 (en) 2003-09-05 2005-05-25 Nuevolution A/S Templated compounds for generation of encoded molecules and directional methods using such compounds
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
BRPI0417830B1 (pt) 2003-12-17 2021-02-17 Praecis Pharmaceuticals Inc métodos para síntese de uma molécula compreendendo uma porção funcional operativamente ligada a um oligonucleotídeo de codificação
US7972994B2 (en) * 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
WO2005078122A2 (en) 2004-02-17 2005-08-25 Nuevolution A/S Method for enrichment involving elimination by mismatch hybridisation
US20050208503A1 (en) * 2004-03-16 2005-09-22 Handy Yowanto Chemical ligation of nucleic acids
DK1730277T3 (da) 2004-03-22 2010-03-01 Nuevolution As Kodning ved ligering under anvendelse af byggebloksoligonukleotider
GB2413796B (en) 2004-03-25 2006-03-29 Global Genomics Ab Methods and means for nucleic acid sequencing
WO2005116213A2 (en) 2004-04-15 2005-12-08 President And Fellows Of Harvard College Directed evolution of proteins
ZA200704520B (en) 2004-11-08 2008-09-25 Vipergen Aps Structural nucleic acid guided chemical synthesis
EP1828381B1 (en) 2004-11-22 2009-01-07 Peter Birk Rasmussen Template directed split and mix systhesis of small molecule libraries
DE602005022936D1 (de) 2004-12-20 2010-09-23 Genentech Inc Pyrrolidine als inhibitoren von iap
WO2006079061A2 (en) 2005-01-21 2006-07-27 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
WO2007008276A2 (en) 2005-05-03 2007-01-18 Ensemble Discovery Corporation Turnover probes and use thereof for nucleic acid detection
WO2006128138A2 (en) 2005-05-26 2006-11-30 Ensemble Discovery Corportion Biodetection by nucleic acid-templated chemistry
US20090163371A1 (en) 2005-05-31 2009-06-25 Stern Andrew M Anchor-Assisted Fragment Selection and Directed Assembly
DE602006012971D1 (de) * 2005-06-07 2010-04-29 Harvard College Vermittelter chemie
WO2006135654A2 (en) 2005-06-07 2006-12-21 President And Fellows Of Harvard College Polymer evolution via templated synthesis related applications
RU2459869C2 (ru) 2005-06-09 2012-08-27 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Соединение, содержащее кодирующий олигонуклеотид, способ его получения, библиотека соединений, способ ее получения, способ идентификации соединения, связывающегося с биологической мишенью (варианты)
WO2006138666A2 (en) 2005-06-17 2006-12-28 President And Fellows Of Harvard College Iterated branching reaction pathways via nucleic acid-mediated chemistry
US20090035824A1 (en) * 2005-06-17 2009-02-05 Liu David R Nucleic acid-templated chemistry in organic solvents
WO2007011722A2 (en) 2005-07-15 2007-01-25 President And Fellows Of Harvard College Reaction discovery system
US20090005256A1 (en) 2005-07-29 2009-01-01 Bittker Joshua A Analysis of Encoded Chemical Libraries
CA2626325A1 (en) * 2005-10-28 2007-05-10 Praecis Pharmaceuticals Incorporated Methods for identifying compounds of interest using encoded libraries
DE602006018648D1 (de) 2005-12-01 2011-01-13 Nuevolution As Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken
WO2007124758A1 (en) 2006-05-03 2007-11-08 Vipergen Aps A method for preparing compounds by nucleic acid directed synthesis
WO2008014238A2 (en) 2006-07-24 2008-01-31 Tetralogic Pharmaceuticals Corporation Dimeric iap inhibitors
JP2010503860A (ja) 2006-09-18 2010-02-04 アンサンブル ディスカバリー コーポレイション 受容体ファミリーのプロファイリング
JP2010504983A (ja) 2006-09-28 2010-02-18 アンサンブル ディスカバリー コーポレイション 核酸を鋳型とする化学による生物学的検出のための組成物および方法
US8383370B2 (en) 2007-01-30 2013-02-26 The Rockefeller University Modified RNA ligase for efficient 3′ modification of RNA
GB0712245D0 (en) * 2007-06-25 2007-08-01 Cythera Technologies Ltd Combinatorial libraries and related methods
US20100159446A1 (en) 2007-07-27 2010-06-24 Haff Lawrence A Detection Assays and Use Thereof
WO2009077173A2 (en) 2007-12-19 2009-06-25 Philochem Ag Dna-encoded chemical libraries
TW201011006A (en) 2008-06-16 2010-03-16 Nuevolution As IAP binding compounds
DK2558577T3 (da) 2010-04-16 2019-04-01 Nuevolution As Bi-funktionelle komplekser og fremgangsmåder til fremstilling og anvendelse af sådanne komplekser
US10597650B2 (en) * 2012-12-21 2020-03-24 New England Biolabs, Inc. Ligase activity

Also Published As

Publication number Publication date
US11702652B2 (en) 2023-07-18
EP3305900B1 (en) 2021-07-21
EP3018206A1 (en) 2016-05-11
ATE490318T1 (de) 2010-12-15
EP3305900A1 (en) 2018-04-11
US20170247688A1 (en) 2017-08-31
ES2897529T3 (es) 2022-03-01
US10287576B2 (en) 2019-05-14
DK3305900T3 (da) 2021-10-25
EP2336315B1 (en) 2017-07-19
EP2336315A3 (en) 2012-02-22
LT3018206T (lt) 2021-12-10
LT3305900T (lt) 2021-11-10
DE602006018648D1 (de) 2011-01-13
LT2341140T (lt) 2017-11-10
PT3018206T (pt) 2021-11-15
US20090264300A1 (en) 2009-10-22
EP2341140B1 (en) 2017-07-19
DK2341140T3 (da) 2017-11-06
EP1957644A2 (en) 2008-08-20
US20200216836A1 (en) 2020-07-09
WO2007062664A3 (en) 2007-08-02
PT3305900T (pt) 2021-10-27
EP2336315A2 (en) 2011-06-22
EP1957644B1 (en) 2010-12-01
SI3305900T1 (sl) 2022-02-28
HK1245329A1 (zh) 2018-08-24
SI3018206T1 (sl) 2022-02-28
DK2336315T3 (da) 2017-11-06
DK3018206T3 (da) 2021-11-15
HUE056836T2 (hu) 2022-03-28
US9574189B2 (en) 2017-02-21
WO2007062664A2 (en) 2007-06-07
SI2336315T1 (sl) 2017-12-29
LT2336315T (lt) 2017-11-10
US20190330618A1 (en) 2019-10-31
ES2901551T3 (es) 2022-03-22
SI2341140T1 (sl) 2017-12-29
EP2341140A1 (en) 2011-07-06
EP3018206B1 (en) 2021-08-11

Similar Documents

Publication Publication Date Title
HK1245329A1 (zh) 用於高效合成大文庫的酶編碼方法
DK3299463T3 (da) Enzymatisk kodning
DK2236606T3 (da) Kodning af små molekyler ved ligering
ATE462005T1 (de) Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
DE602005017370D1 (de) Ligationscodierung unter verwendung von oligonukleotidbausteinen
WO2006079061A3 (en) Free reactant use in nucleic acid-templated synthesis
WO2005030984A3 (en) Method for small volume nucleic acid synthesis
ATE407939T1 (de) 2ß-NITROBENZYL-MODIFIZIERTE RIBONUKLEOTIDE
WO2004074501A3 (en) A method for obtaining structural information about an encoded molecule
WO2003002752A3 (en) Methods of using nick translate libraries for snp analysis
Henry DNA synthesized from TNA template