ATE462005T1 - Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie - Google Patents

Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie

Info

Publication number
ATE462005T1
ATE462005T1 AT06785057T AT06785057T ATE462005T1 AT E462005 T1 ATE462005 T1 AT E462005T1 AT 06785057 T AT06785057 T AT 06785057T AT 06785057 T AT06785057 T AT 06785057T AT E462005 T1 ATE462005 T1 AT E462005T1
Authority
AT
Austria
Prior art keywords
nucleic acid
iterated
pathways via
via nucleic
mediated chemistry
Prior art date
Application number
AT06785057T
Other languages
English (en)
Inventor
Christopher Calderone
David Liu
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Application granted granted Critical
Publication of ATE462005T1 publication Critical patent/ATE462005T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT06785057T 2005-06-17 2006-06-16 Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie ATE462005T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69162805P 2005-06-17 2005-06-17
PCT/US2006/023654 WO2006138666A2 (en) 2005-06-17 2006-06-16 Iterated branching reaction pathways via nucleic acid-mediated chemistry

Publications (1)

Publication Number Publication Date
ATE462005T1 true ATE462005T1 (de) 2010-04-15

Family

ID=37571264

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06785057T ATE462005T1 (de) 2005-06-17 2006-06-16 Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie

Country Status (5)

Country Link
US (1) US8183178B2 (de)
EP (1) EP1899465B1 (de)
AT (1) ATE462005T1 (de)
DE (1) DE602006013134D1 (de)
WO (1) WO2006138666A2 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002306777C1 (en) 2001-03-19 2008-04-24 President And Fellows Of Harvard College Evolving new molecular function
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
DK1487978T3 (da) 2002-03-15 2009-03-23 Nuevolution As Forbedret fremgangsmåde til syntese af templatemolekyler
US10730906B2 (en) 2002-08-01 2020-08-04 Nuevolutions A/S Multi-step synthesis of templated molecules
EP1540013B1 (de) 2002-08-19 2015-07-08 The President and Fellows of Harvard College Entwicklung einer neuen molekularen funktion
PT1558744E (pt) 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
DK1670939T3 (da) 2003-09-18 2010-03-01 Nuevolution As Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser
WO2007008276A2 (en) * 2005-05-03 2007-01-18 Ensemble Discovery Corporation Turnover probes and use thereof for nucleic acid detection
ATE462005T1 (de) 2005-06-17 2010-04-15 Harvard College Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
EP2341140B1 (de) 2005-12-01 2017-07-19 Nuevolution A/S Enzymvermittelnde Kodierungsmethoden für eine effiziente Synthese von grossen Bibliotheken
US8338565B2 (en) * 2008-08-20 2012-12-25 Ensemble Therapeutics Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha
ES2713873T3 (es) 2010-04-16 2019-05-24 Nuevolution As Complejos bifuncionales y métodos para hacer y utilizar tales complejos
WO2013066438A2 (en) 2011-07-22 2013-05-10 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9340799B2 (en) 2013-09-06 2016-05-17 President And Fellows Of Harvard College MRNA-sensing switchable gRNAs
AU2015298571B2 (en) 2014-07-30 2020-09-03 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
US20180340174A1 (en) 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
IL294014B2 (en) 2015-10-23 2024-07-01 Harvard College Nucleobase editors and uses thereof
JP7283727B2 (ja) 2016-06-16 2023-05-30 ヘイスタック サイエンシィズ コーポレーション コードプローブ分子のコンビナトリアル合成が指令されかつ記録されたオリゴヌクレオチド
KR102827276B1 (ko) 2016-08-03 2025-07-01 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 아데노신 핵염기 편집제 및 그의 용도
CN109804066A (zh) 2016-08-09 2019-05-24 哈佛大学的校长及成员们 可编程cas9-重组酶融合蛋白及其用途
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
WO2018165631A1 (en) 2017-03-09 2018-09-13 President And Fellows Of Harvard College Cancer vaccine
EP3592853A1 (de) 2017-03-09 2020-01-15 President and Fellows of Harvard College Unterdrückung von schmerzen durch geneditierung
WO2018165629A1 (en) 2017-03-10 2018-09-13 President And Fellows Of Harvard College Cytosine to guanine base editor
US11795580B2 (en) 2017-05-02 2023-10-24 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
US11560566B2 (en) 2017-05-12 2023-01-24 President And Fellows Of Harvard College Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
WO2019023680A1 (en) 2017-07-28 2019-01-31 President And Fellows Of Harvard College METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE)
WO2019139645A2 (en) 2017-08-30 2019-07-18 President And Fellows Of Harvard College High efficiency base editors comprising gam
CN111757937A (zh) 2017-10-16 2020-10-09 布罗德研究所股份有限公司 腺苷碱基编辑器的用途
EP3724214A4 (de) 2017-12-15 2021-09-01 The Broad Institute Inc. Systeme und verfahren zur vorhersage von reparaturergebnissen in der gentechnik
US12157760B2 (en) 2018-05-23 2024-12-03 The Broad Institute, Inc. Base editors and uses thereof
EP3820495A4 (de) 2018-07-09 2022-07-20 The Broad Institute Inc. Rna-programmierbare epigenetische rna-modifikatoren und deren verwendungen
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
WO2020124213A1 (en) 2018-12-20 2020-06-25 Krylov Sergey N Binder selection using capillary electrophoresis
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
JP7657726B2 (ja) 2019-03-19 2025-04-07 ザ ブロード インスティテュート，インコーポレーテッド 編集ヌクレオチド配列を編集するための方法および組成物
WO2020214842A1 (en) 2019-04-17 2020-10-22 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
JP2023525304A (ja) 2020-05-08 2023-06-15 ザ ブロード インスティテュート，インコーポレーテッド 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2346989A1 (en) 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry
AU2002306777C1 (en) * 2001-03-19 2008-04-24 President And Fellows Of Harvard College Evolving new molecular function
EP1540013B1 (de) * 2002-08-19 2015-07-08 The President and Fellows of Harvard College Entwicklung einer neuen molekularen funktion
AU2003260291A1 (en) 2002-09-12 2004-04-30 Nuevolution A/S Proximity-aided synthesis of templated molecules
PT1558744E (pt) 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
WO2006130669A2 (en) * 2005-05-31 2006-12-07 Ensemble Discovery Corporation Anchor-assisted fragment selection and directed assembly
WO2006135654A2 (en) * 2005-06-07 2006-12-21 President And Fellows Of Harvard College Polymer evolution via templated synthesis related applications
DE602006012971D1 (de) * 2005-06-07 2010-04-29 Harvard College Vermittelter chemie
WO2006138560A2 (en) * 2005-06-17 2006-12-28 President And Fellows Of Harvard College Nucleic acid-templated chemistry in organic solvents
ATE462005T1 (de) 2005-06-17 2010-04-15 Harvard College Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie
US20110059458A1 (en) * 2008-02-22 2011-03-10 Yumei Huang Compositions and methods for catalyzing dna-programmed chemistry
US8338565B2 (en) * 2008-08-20 2012-12-25 Ensemble Therapeutics Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha

Also Published As

Publication number Publication date
WO2006138666A2 (en) 2006-12-28
EP1899465A2 (de) 2008-03-19
US8183178B2 (en) 2012-05-22
US20080318807A1 (en) 2008-12-25
EP1899465B1 (de) 2010-03-24
WO2006138666A3 (en) 2007-07-19
DE602006013134D1 (de) 2010-05-06

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