DE602006013134D1 - Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie - Google Patents

Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie

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Publication number
DE602006013134D1
DE602006013134D1 DE602006013134T DE602006013134T DE602006013134D1 DE 602006013134 D1 DE602006013134 D1 DE 602006013134D1 DE 602006013134 T DE602006013134 T DE 602006013134T DE 602006013134 T DE602006013134 T DE 602006013134T DE 602006013134 D1 DE602006013134 D1 DE 602006013134D1
Authority
DE
Germany
Prior art keywords
nucleic acid
iterated
transactions
mediated chemistry
addressing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006013134T
Other languages
English (en)
Inventor
Christopher T Calderone
David R Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of DE602006013134D1 publication Critical patent/DE602006013134D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
DE602006013134T 2005-06-17 2006-06-16 Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie Active DE602006013134D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69162805P 2005-06-17 2005-06-17
PCT/US2006/023654 WO2006138666A2 (en) 2005-06-17 2006-06-16 Iterated branching reaction pathways via nucleic acid-mediated chemistry

Publications (1)

Publication Number Publication Date
DE602006013134D1 true DE602006013134D1 (de) 2010-05-06

Family

ID=37571264

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006013134T Active DE602006013134D1 (de) 2005-06-17 2006-06-16 Iterierte verzweigende reaktionswege über nukleinsäure-vermittelte chemie

Country Status (5)

Country Link
US (1) US8183178B2 (de)
EP (1) EP1899465B1 (de)
AT (1) ATE462005T1 (de)
DE (1) DE602006013134D1 (de)
WO (1) WO2006138666A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2332896A3 (de) 2001-03-19 2012-09-26 President and Fellows of Harvard College Entwicklung neuer molekularer Funktionen
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
CN101006177B (zh) 2002-03-15 2011-10-12 纽韦卢森公司 改善的用于合成模制分子的方法
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
JP4657919B2 (ja) 2002-08-19 2011-03-23 プレジデント アンド フェローズ オブ ハーバード カレッジ 進化する新しい分子機能
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
EP2175019A3 (de) 2002-12-19 2011-04-06 Nuevolution A/S Durch Quasizufallsstrukturen und Funktionen geführte Synthesemethoden
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
US8017323B2 (en) 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
EP1670939B1 (de) 2003-09-18 2009-11-04 Nuevolution A/S Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
EP1885892A2 (de) * 2005-05-03 2008-02-13 Ensemble Discovery Corporation Umsatzsonden und ihre verwendung zum nachweis von nukleinsäuren
WO2006138666A2 (en) 2005-06-17 2006-12-28 President And Fellows Of Harvard College Iterated branching reaction pathways via nucleic acid-mediated chemistry
DK2341140T3 (da) 2005-12-01 2017-11-06 Nuevolution As Fremgangsmåde til enzymatisk kodning ved effektiv syntese af store biblioteker
WO2010022249A2 (en) * 2008-08-20 2010-02-25 Ensemble Discovery Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha
US11225655B2 (en) 2010-04-16 2022-01-18 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
US20150044192A1 (en) 2013-08-09 2015-02-12 President And Fellows Of Harvard College Methods for identifying a target site of a cas9 nuclease
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
WO2016022363A2 (en) 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
WO2016074683A1 (en) 2014-11-11 2016-05-19 Lundorf Pedersen Materials Aps Method for identification of molecules with desired characteristics
WO2017218293A1 (en) 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
CN109804066A (zh) 2016-08-09 2019-05-24 哈佛大学的校长及成员们 可编程cas9-重组酶融合蛋白及其用途
WO2018039438A1 (en) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
US11898179B2 (en) 2017-03-09 2024-02-13 President And Fellows Of Harvard College Suppression of pain by gene editing
US11542496B2 (en) 2017-03-10 2023-01-03 President And Fellows Of Harvard College Cytosine to guanine base editor
WO2018204420A1 (en) 2017-05-02 2018-11-08 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
US11560566B2 (en) 2017-05-12 2023-01-24 President And Fellows Of Harvard College Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
EP3658573A1 (de) 2017-07-28 2020-06-03 President and Fellows of Harvard College Verfahren und zusammensetzungen zur entwicklung von basiseditoren unter verwendung von phagenunterstützter kontinuierlicher entwicklung (pace)
US11319532B2 (en) 2017-08-30 2022-05-03 President And Fellows Of Harvard College High efficiency base editors comprising Gam
EP3697906A1 (de) 2017-10-16 2020-08-26 The Broad Institute, Inc. Verwendungen von adenosinbasiseditoren
EP3899521A4 (de) 2018-12-20 2022-08-24 Sergey N. Krylov Auswahl von bindemitteln unter verwendung von kapillarelektrophorese
DE112020001342T5 (de) 2019-03-19 2022-01-13 President and Fellows of Harvard College Verfahren und Zusammensetzungen zum Editing von Nukleotidsequenzen
JP2023525304A (ja) 2020-05-08 2023-06-15 ザ ブロード インスティテュート，インコーポレーテッド 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7479472B1 (en) 1998-10-19 2009-01-20 The Board Of Trustees Of The Leland Stanford Junior University DNA-templated combinatorial library chemistry
EP2332896A3 (de) * 2001-03-19 2012-09-26 President and Fellows of Harvard College Entwicklung neuer molekularer Funktionen
JP4657919B2 (ja) * 2002-08-19 2011-03-23 プレジデント アンド フェローズ オブ ハーバード カレッジ 進化する新しい分子機能
WO2004024929A2 (en) 2002-09-12 2004-03-25 Nuevolution A/S Proximity-aided synthesis of templated molecules
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
WO2006130669A2 (en) * 2005-05-31 2006-12-07 Ensemble Discovery Corporation Anchor-assisted fragment selection and directed assembly
WO2006133312A2 (en) * 2005-06-07 2006-12-14 President And Fellows Of Harvard College Ordered multi-step synthesis by nucleic acid-mediated chemistry
WO2006135654A2 (en) * 2005-06-07 2006-12-21 President And Fellows Of Harvard College Polymer evolution via templated synthesis related applications
US20090035824A1 (en) * 2005-06-17 2009-02-05 Liu David R Nucleic acid-templated chemistry in organic solvents
WO2006138666A2 (en) 2005-06-17 2006-12-28 President And Fellows Of Harvard College Iterated branching reaction pathways via nucleic acid-mediated chemistry
WO2009105657A1 (en) * 2008-02-22 2009-08-27 Ensemble Discovery Corporation Compositions and methods for catalyzing dna-programmed chemistry
WO2010022249A2 (en) * 2008-08-20 2010-02-25 Ensemble Discovery Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha

Also Published As

Publication number Publication date
WO2006138666A2 (en) 2006-12-28
US20080318807A1 (en) 2008-12-25
EP1899465B1 (de) 2010-03-24
US8183178B2 (en) 2012-05-22
WO2006138666A3 (en) 2007-07-19
ATE462005T1 (de) 2010-04-15
EP1899465A2 (de) 2008-03-19

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