DK175420B1 - Hybridplasminogenaktivator, DNA-enhed, kloningsvektor plasmid, mikroorganisme eller cellekultur transformeret med vektoren, fremgangsmåde til fremstilling af plasminogenaktivatioren samt farmaceutisk præparat indeholdende denne - Google Patents

Hybridplasminogenaktivator, DNA-enhed, kloningsvektor plasmid, mikroorganisme eller cellekultur transformeret med vektoren, fremgangsmåde til fremstilling af plasminogenaktivatioren samt farmaceutisk præparat indeholdende denne Download PDF

Info

Publication number
DK175420B1
DK175420B1 DK198603856A DK385686A DK175420B1 DK 175420 B1 DK175420 B1 DK 175420B1 DK 198603856 A DK198603856 A DK 198603856A DK 385686 A DK385686 A DK 385686A DK 175420 B1 DK175420 B1 DK 175420B1
Authority
DK
Denmark
Prior art keywords
dna
plasminogen activator
amino acids
hybrid
urokinase
Prior art date
Application number
DK198603856A
Other languages
Danish (da)
English (en)
Other versions
DK385686A (da
DK385686D0 (da
Inventor
Paul Porwen Hung
Narender Kumar Kalyan
Shawguang Lin Lee
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of DK385686D0 publication Critical patent/DK385686D0/da
Publication of DK385686A publication Critical patent/DK385686A/da
Application granted granted Critical
Publication of DK175420B1 publication Critical patent/DK175420B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK198603856A 1985-08-14 1986-08-13 Hybridplasminogenaktivator, DNA-enhed, kloningsvektor plasmid, mikroorganisme eller cellekultur transformeret med vektoren, fremgangsmåde til fremstilling af plasminogenaktivatioren samt farmaceutisk præparat indeholdende denne DK175420B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76616385A 1985-08-14 1985-08-14
US76616385 1985-08-14
US06/884,835 US4916071A (en) 1985-08-14 1986-07-11 Poly-kringle plasminogen activator
US88483586 1986-07-11

Publications (3)

Publication Number Publication Date
DK385686D0 DK385686D0 (da) 1986-08-13
DK385686A DK385686A (da) 1987-02-15
DK175420B1 true DK175420B1 (da) 2004-10-04

Family

ID=27117699

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198603856A DK175420B1 (da) 1985-08-14 1986-08-13 Hybridplasminogenaktivator, DNA-enhed, kloningsvektor plasmid, mikroorganisme eller cellekultur transformeret med vektoren, fremgangsmåde til fremstilling af plasminogenaktivatioren samt farmaceutisk præparat indeholdende denne

Country Status (15)

Country Link
US (1) US4916071A (ja)
EP (1) EP0213794B1 (ja)
JP (2) JPH0829086B2 (ja)
KR (1) KR900007649B1 (ja)
AU (1) AU596369B2 (ja)
CA (1) CA1341449C (ja)
DE (1) DE3676760D1 (ja)
DK (1) DK175420B1 (ja)
GB (1) GB2179948B (ja)
GR (1) GR862076B (ja)
HU (1) HU200795B (ja)
IE (1) IE59380B1 (ja)
IL (1) IL79644A (ja)
PH (1) PH26199A (ja)
PT (1) PT83170B (ja)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112755A (en) * 1982-04-15 1992-05-12 Genentech, Inc. Preparation of functional human urokinase proteins
US4880776A (en) * 1983-12-24 1989-11-14 Beecham Group P.L.C. Plasmin A-chain urokinase B-chain hybrid protein
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
JP2581668B2 (ja) * 1985-11-27 1997-02-12 三井東圧化学株式会社 ヒト正常細胞由来のヒト組織プラスミノ−ゲン活性化因子をコ−ドする新しいｄｎａ配列とそれを含むベクタ−及び細胞
EP0289508A1 (en) * 1985-12-20 1988-11-09 The Upjohn Company Tissue plasminogen activator (tpa) analogs
US5204255A (en) * 1986-01-31 1993-04-20 Sagami Chemical Research Center Hybrid tissue plasminogen activator/urokinase polypeptides
EP0234051B1 (en) * 1986-02-17 1991-12-11 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Tissue-type plasminogen activator mutants; recombinant genetic information coding therefor and process for preparing said mutants; their use and pharmaceutical compositions
US5047241A (en) * 1986-07-11 1991-09-10 American Home Products Corporation Tris-Kringle plasminogen activator with novel K2 insert
US5242819A (en) * 1986-12-05 1993-09-07 Ciba-Geigy Corporation DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
US5580559A (en) * 1986-12-05 1996-12-03 Ciba-Geigy Corporation Hybrid plasminogen activator
FI100106B (fi) * 1986-12-05 1997-09-30 Novartis Ag Menetelmä plasminogeenin yksisäikeisen yhdistelmäaktivaattorin valmist amiseksi
GB2200640B (en) * 1987-01-30 1991-07-10 American Home Prod Des-epidermal growth factor plasminogen activators
GB8705377D0 (en) * 1987-03-07 1987-04-08 Beecham Group Plc Compounds
GB8711957D0 (en) * 1987-05-20 1987-06-24 Beecham Group Plc Compounds
NO882226L (no) * 1987-05-22 1988-11-23 Zymogenetics Inc Fibrinolytiske proteiner.
IE67036B1 (en) * 1987-06-04 1996-05-15 Zymogenetics Inc Tissue plasminogen activator analogs having modified growth factor domains
ZA884012B (en) * 1987-06-04 1989-02-22 Zymogenetics Inc Tissue plasminogen activator analogs having modified growth factor domains
US5149533A (en) * 1987-06-04 1992-09-22 Zymogenetics, Inc. Modified t-PA with kringle-/replaced by another kringle
DK359888A (da) * 1987-07-01 1989-01-02 Beecham Group Plc Fibrinolytisk enzym
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
WO1989000191A1 (en) * 1987-07-06 1989-01-12 Genetics Institute, Inc. Novel thrombolytic proteins
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型ｔＰＡ含有注射用組成物
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
US5100666A (en) * 1987-10-09 1992-03-31 Monsanto Company Modified tissue plasminogen activator K2K2SP
WO1989010401A1 (en) * 1988-04-22 1989-11-02 Collaborative Research, Inc. Plasminogene activators with increased fibrin selectivity
GB8826975D0 (en) * 1988-11-18 1988-12-21 Beecham Group Plc Novel compounds
US5326700A (en) * 1990-11-06 1994-07-05 Eli Lilly And Company DNA sequences encoding t-PA derivatives with cleavable sites
WO2003087393A2 (en) * 2002-04-09 2003-10-23 Global Biotech Inc. Human tissue urokinase type plasminogen activator production
WO2009086552A1 (en) * 2008-01-02 2009-07-09 The Trustees Of The University Of Pennsylvania Targeting recombinant therapeutics to circulating red blood cells
WO2019113224A1 (en) 2017-12-05 2019-06-13 The Trustees Of The University Of Pennsylvania Fusion proteins and antibodies targeting human red blood cell antigens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78180B (ja) * 1982-04-15 1984-09-26 Genentech Inc
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
GR79202B (ja) 1982-05-05 1984-10-22 Genentech Inc
KR840004781A (ko) * 1982-05-05 1984-10-24 월터 에이치·드레거 인체의 조직 플라스미노겐 활성화제
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
DE3781420T2 (de) * 1986-01-31 1993-02-25 Central Glass Co Ltd Hybrides plasminogenaktivatoraehnliches polypeptid.

Also Published As

Publication number Publication date
DE3676760D1 (de) 1991-02-14
IL79644A (en) 1991-06-10
KR870002264A (ko) 1987-03-30
DK385686A (da) 1987-02-15
KR900007649B1 (ko) 1990-10-17
US4916071A (en) 1990-04-10
JPH07147984A (ja) 1995-06-13
PT83170A (en) 1986-09-01
GB2179948B (en) 1989-08-16
CA1341449C (en) 2003-12-09
PT83170B (pt) 1988-07-29
JPH0829086B2 (ja) 1996-03-27
AU596369B2 (en) 1990-05-03
PH26199A (en) 1992-03-18
GB2179948A (en) 1987-03-18
HUT41443A (en) 1987-04-28
HU200795B (en) 1990-08-28
DK385686D0 (da) 1986-08-13
JP2610783B2 (ja) 1997-05-14
AU6110286A (en) 1987-02-19
EP0213794A1 (en) 1987-03-11
GB8619154D0 (en) 1986-09-17
IE59380B1 (en) 1994-02-23
JPS62104577A (ja) 1987-05-15
IE862178L (en) 1987-02-14
EP0213794B1 (en) 1991-01-09
GR862076B (en) 1986-12-24
IL79644A0 (en) 1986-11-30

Similar Documents

Publication Publication Date Title
DK175420B1 (da) Hybridplasminogenaktivator, DNA-enhed, kloningsvektor plasmid, mikroorganisme eller cellekultur transformeret med vektoren, fremgangsmåde til fremstilling af plasminogenaktivatioren samt farmaceutisk præparat indeholdende denne
EP0092182B1 (en) Preparation of functional human urokinase polypeptides
KR920007666B1 (ko) 변형된 섬유소 용해제의 제조방법
KR950000303B1 (ko) 조직 플라스미노겐 활성화 인자(tpa) 상사체를 제조하는 방법
EP0143081B1 (en) Synthesis of tissue plasminogen activator(tpa) by yeast
EP0234051B1 (en) Tissue-type plasminogen activator mutants; recombinant genetic information coding therefor and process for preparing said mutants; their use and pharmaceutical compositions
DK175483B1 (da) Enkeltkædehybridplasminogenaktivator, DNA-sekvens, som koder derfor, hybridvektor indeholdende DNA-sekvensen, eukaryotisk værtscelle transformeret med hybridvektoren, fremgangsmåde til fremstilling af enkeltkædehybridplasminogenaktivatoren,......
JPH09173081A (ja) ヒト第ｉｘ因子ポリペプチド前駆体をコードする人工ｄｎａ
FI101306B (fi) Menetelmä kudostyyppisen plasminogeeniaktivaattorin analogien, joissa on muokatut kasvutekijädomeenit, valmistamiseksi
WO1988005081A2 (en) Novel plasminogen activator
EP0299706A2 (en) Nonglycosylated plasminogen activator and method of preparation
JPH01501996A (ja) 脱―表皮細胞成長因子プラスミノーゲンアクチベーター
US4997766A (en) Poly-kringle plasminogen activator
US5045315A (en) Process for treating thrombosis by administering poly-kringle plasminogen activator
JP3126381B2 (ja) 減少されたクリアランスを有する組織プラスミノーゲンアクチベーター変異体
WO1989007146A1 (en) Rearranged tissue plasminogen activators and method for producing same
EP0316068A1 (en) Modified low molecular weight plasminogen activator and method of preparation
CA1312028C (en) Expression vectors containing the heat shock regulatory dna sequences from a heat shock protein 83 (hsp83) gene and inducible expression by use of the vectors
EP0400054A1 (en) Modified gene sequences encoding modified tpa and products therefrom
JPH0550271B2 (ja)

Legal Events

Date Code Title Description
PUP Patent expired